Regeneration in arthropods and amphibians follows an analogous principle making comparisons between the two phyla possible.Larval arthropods and amphibians possess powers of epimorphic regeneration which wane for many species of these phyla with the completion of metamorphosis or the cessation of moulting. In those species which retain, post-maturationally, the ability to form a regenerative blastema, larval characteristics are carried into the adult and reproductive stages of these organisms. These include many species of: urodeles, ametabolous insects, crustaceans, myriapods and arachnids. The (...) long-standing distinction between embryonic regulation and true epimorphosis would thus appear to be a difference of degree rather than kind. (shrink)

Variation or rearrangement of regulatory genes is responsible for cellular malignant change. These types of chromosomal variations also produce heterochrony or paedomorphic evolution at the organismal level. Analogously, neoplasia represents a cellular macroevolutionary event, and a tumour can be said to be an evolved population of cells. To understand this cellular evolution to malignancy, it may be necessary to go beyond a clonal selection (adaptationist) explanation of neoplastic alteration. In the pericellular environment natural selection consists of the organizational restraints of (...) surrounding cells as well as the host's immunological surveillance and non-specific monocyte-macrophage systems. Indirect evidence suggests that success for the neoplasm depends not upon clonal selection, but solely upon a genetic methodology—the function of which is to elude selection.The author has coined the term cellular heterochrony to illustrate analogic similarities in the molecular modes of speciation between anaplastic cancer cells and the heterochronic evolution of organisms. By reverting to a juvenile (embryonic) repertoire of cellular behaviour a tumour secures its own tenure or niche by usurping the host's armamentarium of selection forces, employing many of the same or similar methods by which implanting and invading tissues of the mammalian embryo forestall maternal detection and rejection. A number of ways by which the tumour blocks, subverts or evades selection are discussed. (shrink)

It is posited that the initiating event of amphibian regeneration of a limb, is retrodifferentiation* of what are to become the developing cells of the blastema. These cells reiterate a larval or premetamorphic ontogenic repertoire, induced by elevated levels of prolactin with adequate innervation. Subsequent redifferentiation of the blastema cells occurs, controlled by thyroxine and innervation.This temporal displacement of cellular morphologic characters in regeneration should be looked upon as a function of the ability to reiterate larval characters and subsequently metamorphose. (...) If correct, this would explain why amphibians which metamorphose only once, lose the ability to postmetamorphically regenerate. An exception to this,Xenopus laevis, an anuran which can epimorphically regenerate, to some extent, will be discussed.[/p]. (shrink)

When it comes to using patient data from the National Health Service for research, we are often told that it is a matter of trust: we need to trust, we need to build trust, we need to restore trust. Various policy papers and reports articulate and develop these ideas and make very important contributions to public dialogue on the trustworthiness of our research institutions. But these documents and policies are apparently constructed with little sustained reflection on the nature of trust (...) and trustworthiness, and therefore are missing important features that matter for how we manage concerns related to trust. We suggest that what we mean by ‘trust’ and ‘trustworthiness’ matters and should affect the policies and guidance that govern data sharing in the NHS. We offer a number of initial, general reflections on the way in which some of these features might affect our approach to principles, policies and strategies that are related to sharing patient data for research. This paper is the outcome of a ‘public ethics’ coproduction activity which involved members of the public and two academic ethicists. Our task was to consider collectively the accounts of trust developed by philosophers as they applied in the context of the NHS and to coproduce an argumentative position relevant to this context. (shrink)

Gregory Bateson’s career from anthropologist, through his development of cybernetics and systems theory, to developing ideas around ‘the sacred’, has parallels with Roy Bhaskar’s intellectual journey. This paper proposes that as well as Bateson’s theory of cybernetics and systemic thought making a contribution to basic and dialectic critical realism, his final and posthumously published Angels Fear: Towards and Epistemology of the Sacred adds to our understanding of Bhaskar’s metaReality. Similarities between the development of Bateson’s work from 1936 to 1987 and (...) Bhaskar’s work from 1975 to 2016 enable the development of theory that adds to both of their respective appreciations of metaReality and the sacred. Thus, by starting a conversation between Bateson and Bhaskar, we can develop a higher order understanding of the world than proposed by Bhaskar’s metaReality alone. (shrink)

In The Virtual, Rob Shields puts virtuality in with the key categories of contemporary social theory such as subjectivity, agency, structure, and the spaces and temporalities between the modern and the postmodern. Shields has rescued the term and the idea of the virtual from utopian futurists like Howard Rheingold and Nicholas Negroponte who use it to hype emergent technologies and forms of culture as the magical vehicles and entry points to new worlds and identities. The works of these digerati, ideologues (...) for multimedia technology and culture, now appear ideological, outdated, and no more than huckstering of the new when confronted with the current state of affairs in the technoculture and its attendant war- and terrorism-torn world. (shrink)

The relevance to decision research of recent advances in the philosophy of social science is considered. The critical realism of Roy Bhaskar argues for the identification of contextually contingent explanatory mechanisms at multiple levels based on concepts grounded in intersubjectively shared reality. Using examples from the author’s and other’s research on the psychology of decisions involving risk and uncertainty, this paper explores the implications of taking a critical realist approach. It is argued that critical realism has the potential to advance (...) and unify disparate experimental and naturalistic lines of research. Furthermore, a diverse range of experimental, process-tracing and observational methods can play important complementary roles in developing fruitful critical realist explanations of decisions involving risk and uncertainty. (shrink)

This paper looks around among the major traditional fallacies — centering mainly around the so-called “gang of eighteen” — to discuss which of them should properly be classified as fallacies of relevance. The paper argues that four of these fallacies are fallacies primarily because they are failures of relevance in argumentation, while others are fallacies in a way that is more peripherally related to failures of relevance. Still others have an even more tangential relation to failures of relevance. This paper (...) is part of a larger research project on dialecical relevance in argumentative discourse, currently underway in collaboration with Frans van Eemeren and Rob Grootendorst. (shrink)

Plato provocatively characterizes truth $$ in terms of harmony $$ at various points throughout his dialogues. While limited attention has been directed toward the role of musical concepts in Plato's general cosmology, not any attention has been directed toward how musical concepts function in relation to Plato's characterization of truth. In fact, this issue has had little occasion for consideration. Almost every contemporary translator empties terms such as $\grave\alpha\rho\mu o\nu\acute\iota\alpha,$ when co-incidental with $\acute\alpha\lambda\acute\eta\theta\varepsilon\iota\alpha,$ of their musical content. As a consequence, (...) I argue, Plato's characterization of truth is made readily amenable to contemporary conceptions of truth-not necessarily a good thing since it robs us of the original richness of Plato's thought. The dissertation explores how retaining the aural meaning latent within $\grave\alpha\rho\mu o\nu\acute\iota\alpha$ and other terms of musical import serves to elucidate the rich complexion of Plato's notion of $\acute\alpha\lambda\acute\eta\theta\varepsilon\iota\alpha.$ Ultimately, I show how Plato's use of musical terminology to characterize truth informs other features of his philosophical outlook, illustrate the cohesiveness and consistency of key texts believed problematic by other commentators, and underscore significant differences between Plato's $\acute\alpha\lambda\acute\eta\theta\varepsilon\iota\alpha$ and ideas of truth prevalent today. ;For Plato, I argue $\acute\alpha\lambda\acute\eta\theta\varepsilon\iota\alpha$ bears a meaning different from its primitive sense of oracular unconcealment and its later sense of correctness $,$ and a meaning also different from other terminological alternatives $.$ Truth, accordingly, turns out for Plato to be neither mysterious and groundless nor a matter of simple correspondence to an objective reality. The value of Plato's conception of truth as harmony consists in its ability to avoid the polarity of contemporary conceptions of truth as either objectively determinate or subjectively determinate . Truth is neither arbitrarily imposed upon the world by us, nor artificially imposed upon us by an antecedently structured and independent reality. The dissertation concludes by articulating reasons for favoring Plato's theory of truth, while noting a few underlying assumptions likely problematic for some contemporary philosophers. (shrink)

_'Nagel and Newman accomplish the wondrous task of clarifying the argumentative outline of Kurt Godel's celebrated logic bomb.'_ _– The Guardian_ In 1931 the mathematical logician Kurt Godel published a revolutionary paper that challenged certain basic assumptions underpinning mathematics and logic. A colleague of physicist Albert Einstein, his theorem proved that mathematics was partly based on propositions not provable within the mathematical system. The importance of Godel's Proof rests upon its radical implications and has echoed throughout many fields, from maths (...) to science to philosophy, computer design, artificial intelligence, even religion and psychology. While others such as Douglas Hofstadter and Roger Penrose have published bestsellers based on Godel’s theorem, this is the first book to present a readable explanation to both scholars and non-specialists alike. A gripping combination of science and accessibility, _Godel’s Proof_ by Nagel and Newman is for both mathematicians and the idly curious, offering those with a taste for logic and philosophy the chance to satisfy their intellectual curiosity. _Kurt Godel_ Born in Brunn, he was a colleague of physicist Albert Einstein and professor at the Institute for Advanced Study in Princeton, N.J. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Philosophy and Rhetoric 33.2 (2000) 101-115 [Access article in PDF] Case Study of the Use of a Circumstantial Ad Hominem in Political Argumentation Douglas Walton In the 1860s, Northern newspapers attacked Lincoln's policies by attacking his character, using the terms drunk, baboon, too slow, foolish, and dishonest. Steadily on the increase in political argumentation since then, the argumentum ad hominem has been carefully refined as an instrument of (...) "oppo tactics" and "going negative" by the public relations experts who now craft political campaigns at the national level. It has been so prominently used in the major political campaigns, debates, and advertisements of the past few years that there has even been a reaction against it--a feeling that we have gone too far in this direction and that some kind of restraint is needed. 1 But there has been no evidence of such restraint in the argumentation used in recent campaigns. Perhaps what might be helpful is a better understanding on the part of voters and campaigners of how to evaluate ad hominem arguments critically.How does the ad hominem argument really work as a way of molding public opinion, why is it so often so effective, and how can it be defended against? How can it be evaluated as a clearly identifiable type of argument, by some kind of objective standards, in a way that can be applied to particular cases? These appear to be tough questions, but recent research has made some not inconsiderable progress toward answering them.The purpose of this article is to present a new case study of a type of argument commonly used in political discourse, a case study that makes use of the dialectical normative framework for identifying and evaluating personal attack (ad hominem) arguments that is developed in a series of works by Henry W. Johnstone Jr. (1952); Alan Brinton (1985, 1995); Frans H. van Eemeren and Rob Grootendorst (1984, 1995); Erik C. W. Krabbe and Douglas N. Walton (1993), Walton (1989, chap. 6; 1998); and van Eemeren, Grootendorst, Francisca Snoeck Henkemans et al. (1996). This particular case, although typical of so many ad hominem arguments currently [End Page 101] in use in political discourse, has some special features that turn out to be quite interesting not only in showing how the dialectical framework applies to cases, but also in advancing our knowledge of how the ad hominem type of argument works in political argumentation in a democratic system for which the media reportage of events is a big factor in influencing voting. 1. Framework for analysis and evaluation Although the argumentum ad hominem, or personal attack argument, has been traditionally treated as a fallacy in logic, recent research in argumentation (as cited above) shows that, in many cases,--including cases in political argumentation--ad hominem arguments, as used in conversational arguments, are not fallacious. Research has shown that, while some personal attack arguments can definitely be judged fallacious, many others are quite reasonable (when evaluated in the appropriate context), while still others should be evaluated as weak (insufficiently supported) but not fallacious. As shown in this case study, the real function of an ad hominem argument (when properly used) is to attack an arguer's credibility in order to criticize the argument she advocates.Before going any further, it is necessary to define some terminology brought to use in the research cited above. An ad hominem argument is the use of personal attack in a dialogue exchange between two parties, where the one party attacks the character of the other party as bad, in some respect, and then uses this attack as a basis for criticizing the other party's argument. An argument is fallacious if it is a special baptizable (Johnson 1987) type of argument that is used by one party in a dialogue exchange in such a way that it blocks or interferes with the collaborative realization of the goal of the type of dialogue in which the two participants are supposed to be engaged (Walton 1995). Thus, there is a difference between a weak... (shrink)

In 2016, this Journal published an article by Rob Lawlor1 on what we might call the acceptance-refusal asymmetry in competence requirements. This is the view that there can be cases in which a patient is sufficiently competent to accept a treatment, but not sufficiently competent to refuse it. Though the main purpose of Lawlor’s paper was to distinguish this asymmetry from various other asymmetries with which it has sometimes been confused,1 Lawlor also presented a brief case in favour of it. (...) Developing an earlier argument of Ian Wilks’,2 3 Lawlor argued that, when the risks associated with refusing a treatment are graver than those associated with accepting it, a higher level of competence may be required to refuse a treatment than to accept it. This claim could have important implications for the law, since determinations of competence often play a central role in determining the lawfulness of refusing or imposing a treatment. Indeed, the acceptance-refusal asymmetry in competence requirements, or something close to it, has played an important role in court judgments.2 However, Lawlor himself suggests that his conclusion will have practical implications only in a narrow range of cases.3 In this issue, Pickering, Giles Newton-Howes and Simon Walker respond to Lawlor’s piece.4 They deny that competence requirements should depend on the level of risk associated with a decision, and thus that there is any basis for the acceptance-refusal asymmetry in competence requirements. Part of the authors’ argument involves contesting the way in which Lawlor uses cases to support his view. In one case cited by Lawlor—and drawn from Wilks—we are invited to consider a whether …. (shrink)

The prelims comprise: Half Title Title Copyright Contents The Four Noble Truths Foreword by Charles Johnson Prologue: An Ancient Fable.

If dispositions are conceived as properties of systems that refer to possible causal relations, dispositions can be used in singular causal explanations. By means of these dispositional explanations, we can explain behavior B of a system x by (i) referring to a situation of type S that triggered B, given that x has a disposition D to do B in S, or (ii) by referring to a disposition D of x to do B in S, given that x is in (...) a situation of type S. Dispositional explanations are adequate and indispensable explanations: they can explain behavior B without explicitly referring to the underlying causal basis in x that constitutes a disposition to do B. Radical Behaviorist explanations are a sort of dispositional explanations, but the dispositional model is not restricted to these explanations. The dispositional model is compatible with, or can be applied to, several research programs. (shrink)

Genetic engineering evokes a number of objections that are not directed at the negative effects the technique might have on the health and welfare of the modified animals. The concept of animal integrity is often invoked to articulate these kind of objections. Moreover, in reaction to the advent of genetic engineering, the concept has been extended from the level of the individual animal to the level of the genome and of the species. However, the concept of animal integrity was not (...) developed in the context of genetic engineering. Given this external origin, the aim of this paper is to critically examine the assumption that the concept of integrity, including its extensions to the level of the genome and the species, is suitable to articulate and justify moral objections more specifically directed at the genetic engineering of animals. (shrink)

Epistemic Injustice The term “epistemic injustice” refers to the existence of a distinctive type of injustice in which a wrong is done to someone specifically in their capacity as a knower. Philosophers working at the intersection of epistemology and ethics under the general umbrella of virtue ethics have recognized that individuals are not given adequate … Continue reading Epistemic Injustice →.

In contrast to classical natural law theory and traditional individualist liberalism, James Luther Adams develops a version of natural law doctrine grounded in liberal religion. In its ontological dimension, his natural law doctrine is derived from a communal understanding of the character of reality. In its institutional dimension, his natural law doctrine promotes a kind of democracy in which freedom of association is central. From this perspective, law is a practice intended to empower persons through their several associations in the (...) constant formation and transformation of community under the direction of divine power. (shrink)

The speech Against Euergos and Mnesiboulos describes a dispute over some naval gear. The dispute occurred early in the year 357/6 b.c. π' γαθοκλους ρχοντος, Dem. 47.44), when the speaker was a trierarch and supervisor of his symmory , and he refers to ‘the law of Periandros, by which the symmories were organized’ . There is no other specific reference to the law of Periandros. If 357/6 was the first year of its operation, it was probably passed in 358/7, but (...) that is not known for certain. The identity of the man is likewise uncertain, though it has plausibly been suggested that he was Periandros son of Polyaratos and that he was the Periandros who proposed an alliance between Athens and Arkadia in 362/1 . However, his identity is of no importance for the present article. Here I am concerned only to try to reconstruct what the law said about the symmories. Despite a great deal of modern discussion this question has still not been satisfactorily solved. The word συμμορα means ‘group’ or ‘division’ and does not necessarily have a technical or legal sense. But most of the Attic instances do have the special sense of a group of persons formed for the purpose of making payments of a compulsory tax or levy: either the property tax called εσορ, which was imposed at irregular intervals, or payments towards the maintenance of ships in the Athenian navy, which were required every year. A fragment of Philokhoros says that Athenians were divided κατ συμμορας for the first time in 378/7, and it is generally agreed that this means that symmories were first formed in 378 for the payment of eisphora. For the navy, however, there is no trace of symmories before the 350s, and everyone agrees that it was the law of Periandros which introduced the use of symmories for maintaining ships, which had previously been the sole responsibility of one trierarch or a pair of syntrierarchs for each ship. (shrink)

Originally published in 1916. This book reviews the common problems of philosophy and then critiques the varied epistemological theories of the time. A theory of knowledge may be either dualistic or monistic and realistic or idealistic. Examining the resulting doctrines at the beginning, this book then goes on to consider mysticism, psychology, logic, consciousness, intellectualism and then scientific method. A fascinating insight into early Twentieth century philosophy.

This paper compares two approaches that attempt to explain the origin of life, or biogenesis. The more established approach is one based on chemical principles, whereas a new, yet not widely known approach begins from a physical perspective. According to the first approach, life would have begun with—often organic—compounds. After having developed to a certain level of complexity and mutual dependence within a non-compartmentalised organic soup, they would have assembled into a functioning cell. In contrast, the second, physical type of (...) approach has life developing within tiny compartments from the beginning. It emphasises the importance of redox reactions between inorganic elements and compounds found on two sides of a compartmental boundary. Without this boundary, “life” would not have begun, nor have been maintained; this boundary—and the complex cell membrane that evolved from it—forms the essence of life. (shrink)