The cellular machinery responsible for conveying proteins between the endoplasmic reticulum and the Golgi is being investigated using genetics and biochemistry. A role for vesicles in mediating protein traffic between the ER and the Golgi has been established by characterizing yeast mutants defective in this process, and by using recently developed cell‐free assays that measure ER to Golgi transport. These tools have also allowed the identification of several proteins crucial to intracellular protein trafficking. The characterization and possible functions of several (...) GTP‐binding proteins, peripheral membrane proteins, and an integral membrane protein during ER to Golgi transport are discussed here. (shrink)

The tutelage of our mentors as scientists included the analogy that writing a good scientific paper was an exercise in storytelling that omitted unessential details that did not move the story forward or that detracted from the overall message. However, the advice to not get lost in the details had an important flaw. In science, it is the many details of the data themselves and the methods used to generate and analyze them that give conclusions their probative meaning. Facts may (...) sometimes slow or distract from the clarity, tidiness, intrigue, or flow of the narrative, but nevertheless they are important for the assessment of what was done, the trustworthiness of the science, and the meaning of the findings. Nevertheless, many critical elements and facts about research studies may be omitted from the narrative and become hidden from scholarly scrutiny. We describe a “baker’s dozen” shortfalls in which such elements that are pertinent to evaluating the validity of scientific studies are sometimes hidden in reports of the work. Such shortfalls may be intentional or unintentional or lie somewhere in between. Additionally, shortfalls may occur at the level of the individual or an institution or of the entire system itself. We conclude by proposing countermeasures to these shortfalls. (shrink)

ブッダとは誰か?仏教とは何か?3・11の震災後の言葉を探して仏教に問いかける―仏教と真剣に向き合う僧侶、研究者との対話を通して、仏教の「新しいいま」が見えてくる。.

The purpose of this study was to determine if there is a relationship between the ethical climate of the organization and the development of person-organization fit. The relationship between an individual's stage of moral development and his/her perceived ethical work environment was examined using a sample of 86 working students. Results indicate that a match between individual preferences and present position proved most satisfying. Subjects expressing a match between their preferences for an ethical work climate and their present ethical work (...) climate indicated that they were less likely to leave their positions. (shrink)

This provocative book outlines a powerful and original theory of liberty structured by the liberal conception of justice and the rule of law. Drawing on insights from philosophy, political theory, economics, and law, he shows how this new conception of liberty can confront, and solve, the central societal problems of knowledge, interest, and power.

COVID-19 pandemic has claimed thousands of lives around the world. Among the casualties are doctors, nurses, and other health care professionals. Those who defy the danger of death and continue to render their services have to deal with psychological and mental stress due to the lack of protective measures and equipment, the overwhelming number of patients, and the experience of discrimination. In fact, some left their job. In this paper, I will argue that the motivation of health care professionals and (...) the outcome of their sacrifices, as against assuring personal safety, can be explained by the principle of the common good. First, they are faithful to their oath as health care professionals since it is their commitment as part of an institution that assumes the responsibility of providing health care to people in need. Second, restoring the patients’ condition goes beyond health issues since the recovery of each COVID-19 patient diminishes the spread of the virus, which, if not for the care of HCPs, could worsen the situation with snowballing consequences to society as a whole. While it is expected for any health care professional as a frontliner in times of pandemic, their motivation to serve exemplifies the greater value for the common good. (shrink)

Life threatening emergencies involving infants and children are inherently dramatic, tension-filled situations. It is no wonder, then, that depictions of such events can be found in literature by and about doctors. In many ways, too, such depictions can illuminate key aspects of such events, such as the physician's own anxiety and the tensions between the various people involved, better than the medical literature. Hence it is suggested that the study of literary depictions of pediatric emergencies might be a useful adjunct (...) for those, physicians and other health care providers, who are called upon to manage them. (shrink)

This article argues that we live in a highly technical world in which people are disappearing. Religion does not have the tools to help us resist this extinction since it has itself diminished humanity by positing a perfect Other Being, which controls our lives. The author argues that we need to reclaim a sense of ourselves as essentialising animals. We need to have a more body-based sense of humanity, which will lead to a fuller awareness and acceptance of difference and (...) combat hierarchical and alienating thinking. (shrink)

Unchangeable. Unwavering. Let God's Truth Anchor You. The world is a sea of clashing beliefs and thoughts. Your own feelings and circumstances change from one day to the next. Your heart longs for something to hold on to...something to steer you in the right direction and give you peace. Only God's truth can satisfy that longing. Bestselling author Randy Alcorn shares daily meditations, Scripture readings, and inspirational quotes to help you grasp the wisdom and love found in the eternal (...) Word of God. When you know the truth, you'll be better prepared to... recognize your place in God's plan detect the deceit you encounter in the world point others to Jesus, who is Truth personified God's truth is real, alive, and able to transform you into the person you long to be. This is your invitation to refresh your heart and find lasting security. (shrink)

I. Introduction Two kinds of remedies have traditionally been employed for breach of contract: legal relief and equitable relief. Legal relief normally takes the form of money damages. Equitable relief normally consists either of specific performance or an injunction – that is, the party in breach may be ordered to perform an act or to refrain from performing an act. In this article I will use a “consent theory of contract” to assess the choice between money damages and specific performance. (...) According to such a theory, contractual obligation is dependent on more fundamental entitlements of the parties and arises as a result of the parties' consent to transfer alienable rights. My thesis will be that the normal rule favoring money damages should be replaced with one that presumptively favors specific performance unless the parties have consented to money damages instead. The principal obstacle to such an approach is the reluctance of courts to specifically enforce contracts for personal services. The philosophical distinction between alienable and inalienable rights bolsters this historical reticence, since a right to personal services may be seen as inalienable. I will then explain why, if the subject matter of a contract for personal services is properly confined to an alienable right to money damages for failure to perform, specific enforcement of such contracts is no longer problematic. Finally, I shall consider whether the subject matter of contracts for corporate services is properly confined to money damages like contracts for personal services, or whether performance of corporate services can be made the subject of a valid rights transfer and judicially compelled in the same manner as contracts for external resources. (shrink)

This study examines the influence of ethical fit on employee attitudes and intentions to turnover. The results of this investigation provides support for the conjecture that ethical work climate is an important variable in the study of person-organization fit. Ethical fit was found to be significantly related to turnover intentions, continuance commitment, and affective commitment, but not to job satisfaction. Results are discussed in regard to some of the affective and cognitive distinctions among satisfaction, commitment, and behavioral intentions.

It is hypothesized that human faces judged to be attractive by people possess two features—averageness and symmetry—that promoted adaptive mate selection in human evolutionary history by way of production of offspring with parasite resistance. Facial composites made by combining individual faces are judged to be attractive, and more attractive than the majority of individual faces. The composites possess both symmetry and averageness of features. Facial averageness may reflect high individual protein heterozygosity and thus an array of proteins to which parasites (...) must adapt. Heterozygosity may be an important defense of long-lived hosts against parasites when it occurs in portions of the genome that do not code for the essential features of complex adaptations. In this case heterozygosity can create a hostile microenvironment for parasites without disrupting adaptation. Facial bilateral symmetry is hypothesized to affect positive beauty judgments because symmetry is a certification of overall phenotypic quality and developmental health, which may be importantly influenced by parasites. Certain secondary sexual traits are influenced by testosterone, a hormone that reduces immunocompetence. Symmetry and size of the secondary sexual traits of the face (e.g., cheek bones) are expected to correlate positively and advertise immunocompetence honestly and therefore to affect positive beauty judgments. Facial attractiveness is predicted to correlate with attractive, nonfacial secondary sexual traits; other predictions from the view that parasite-driven selection led to the evolution of psychological adaptations of human beauty perception are discussed. The view that human physical attractiveness and judgments about human physical attractiveness evolved in the context of parasite-driven selection leads to the hypothesis that both adults and children have a species-typical adaptation to the problem of identifying and favoring healthy individuals and avoiding parasite-susceptible individuals. It is proposed that this adaptation guides human decisions about nepotism and reciprocity in relation to physical attractiveness. (shrink)

A caged animal in the heart of the city, thousands of miles from its natural habitat, neurotically pacing in its confinement . . . Zoos offer a convenient way to indulge a cultural appetite for novelty and diversion, and to teach us, albeit superficially, about animals. Yet what, conversely, do they tell us about the people who create, maintain, and patronize them, and about animal captivity in general? Rather than foster an appreciation for the lives and attributes of animals, zoos, (...) in Randy Malamud's view, reinforce the idea that we are, by nature, an imperial species: that our power and ingenuity entitles us to violate the natural order by tearing animals from the fabric of their ecosystems and displaying them in an "order" of our own making. In so doing, he argues, zoos not only contribute to the rapid disintegration of our ecosystems, but also deaden our very sensibilities to constraint, spatial disruption, and physical pain. Invoking an array of literary depictions of animals, from Albee's Zoo Story and Virginia Woolf's diaries to the films of Harold Pinter and the poetry of Marianne Moore, Reading Zoos links culture, literature, and nature in an engaging and accessible introduction to environmental ethics, animal rights, cultural critique, and literary representation. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Philosophy and Literature 29.2 (2005) 379-393 [Access article in PDF] Love, Self-Deception, and the Moral "Must" Randy Ramal Claremont Graduate University I One significant impact that conceptual relativism has had on current discussions in moral philosophy is the denial of intelligibility to discourses that affirm moral absolutism. The denial is typically based on two allied arguments. The first argument entails that the justification of absolute moral laws and (...) values presupposes the existence of an Archimedean standpoint, but since such viewpoint is unintelligible, a "view from nowhere" as it has been called, then affirming moral absolutism could only be the result of a confused temptation for metaphysical universality and objectivity. The second argument states that since all moral values and concepts are the products of particular cultural-linguistic contexts, it would not make sense to speak of absolute values that have application in other cultural-linguistic contexts.I sympathize with the critical spirit in which this dual argument is made. The unintelligibility of a neutral standpoint and the obvious contextuality of all moral discourses render meaningless any attempt to affirm metaphysically-based moral absolutes. But what this argument fails to acknowledge is that the ordinary language of moral absoluteness is not only infinitely distant from the metaphysical claims to Olympian grounds but also internally related to the absolute moral judgments and principles it invokes. Furthermore, it is doubtful that one could speak at all of moral discourse as needing metaphysical justification. It would not make sense to speak of moral discourse as either needing or not needing metaphysical backing because both notions ignore the ordinary contexts of moral discourse, where the issue of philosophical justification does not arise. The point here is not simply to reject the [End Page 379] metaphysical need for justifying moral discourse but to question the intelligibility of the attempt itself.1In what follows I argue that the ordinary claims to moral absoluteness, be it to give moral advice, to justify personal beliefs and actions, or to judge and criticize the conduct of other people, are perfectly intelligible practices that embody ordinary moral judgments and values. I elucidate the intelligibility of these moral claims by discussing Leo Tolstoy's "The Death of Ivan Ilych," Proust's Remembrance of Things Past, and Ann Beattie's "Learning to Fall." These works, I argue, portray an ethical notion of "need" that expresses natural, and intelligible, affirmations of moral necessity. The context of this affirmation concerns the ethical call to end all self-deception about one's love life.Traditionally, the relationship between love and self-deception has been interpreted to suggest that people often deceive themselves about love in order to fulfill a deep need in them to give meaning to their lives. This interpretation is often invoked to explain, on the one hand, why people who are in love might claim otherwise and, on the other hand, why those who are not in love at all convince themselves of the opposite. Although this interpretation is not philosophical in nature and does not necessarily entail the denial of all discourses of moral necessity, the idea that self-deception fulfils a deep need in people is often invoked as a philosophical explanation of the notion of "need." One example of such philosophical explanation is Martha Nussbaum's Love's Knowledge, where she endorses the traditional interpretation of the relation between love and self-deception through a discussion, among other works, of the above mentioned works by Proust and Beattie.There is no doubt that self-deception, whether in regards to one's love life or other aspects of it, could sometimes arise as a result of a need in people to give their existence some meaningful stability. But this interpretation cannot apply to all cases of love and self deception because the radical plurality of our notions of love prevents such explanatory reductionism. The insistence on this type of reductionism, it seems to me, rests on a common tendency among moral philosophers, Nussbaum included, to read into literature personal ethical views that are not intended by it. The task of the moral philosopher... (shrink)

Emotions change over time. A comprehensive understanding of emotions will require that their temporal nature be observed and analysed. By observing emotion over time, one can disentangle and simultaneously analyse temporal variability within individuals and between-individual variability using a two-step process approach. First, within-person temporal patterns (e.g., covariation, lead–lag relation, periodicity, etc.) are assessed for each subject. Second, between-person analyses are conducted on the within-person patterns. These two steps can be done simultaneously with hierarchical linear models (HLM) or in two (...) actual steps with the process approach. HLM is limited to the intra-individual analysis of linear patterns (e.g., slope, intercept), whereas the process approach can be used to examine non-linear aspects of intra-individual change, such as multivariate patterns, within-subject skew, or phase relations between oscillating processes. In this paper we provide a description of the process approach and present several examples of, as well as suggestions for, intra-individual analysis applied to emotion and individual differences. (shrink)

Introduction -- What is initiative, grit & perseverance? -- Goal setting -- Controlling projects -- Self-starting & self-control -- Research & ideas -- Time management -- Starting & finishing successfully.

In their important work on locus equations, Sussman and his colleagues have helped to simplify the theoretical problem of how human listeners identify place of articulation contrasts among consonants, but much work remains before this problem is solved.

A symphony of Gustav Mahler becomes a cathartic experience following the death of a beloved goat.

This paper examines the collective fraudulent behaviors taking place during the residential real estate bubble in the United States from 2002 to 2006 and the influence of others’ choices on decision making leading to a herd mentality. The antecedents of collective fraud are discussed in terms of the sociological theory behind human herding and the fraudulent behaviors during the real estate bubble are examined. Using archival witness testimony as a primary basis for analysis, this paper argues that without widespread collective (...) fraud, the bubble may not have developed and the herd mentality may have dissipated without the consequences of financial disaster. The aim of an analysis of this nature is to offer a plausible explanation of some of the preconditions to the event under study. (shrink)

The most recent work toward compiling a comprehensive database of adenosine‐to‐inosine RNA editing events suggests that the potential for RNA editing is much more pervasive than previously thought; indeed, it is manifest in more than 100 million potential editing events located primarily within Alu repeat elements of the human transcriptome. Pairs of inverted Alu repeats are found in a substantial number of human genes, and when transcribed, they form long double‐stranded RNA structures that serve as optimal substrates for RNA editing (...) enzymes. A small subset of edited Alu elements has been shown to exhibit diverse functional roles in the regulation of alternative splicing, miRNA repression, and cis‐regulation of distant RNA editing sites. The low level of editing for the remaining majority may be non‐functional, yet their persistence in the primate genome provides enhanced genomic flexibility that may be required for adaptive evolution. (shrink)

BackgroundThis paper discusses the contentious issue of reuse of stored biological samples and data obtained from research participants in past clinical research to answer future ethical and scientifically valid research questions. Many countries have regulations and guidelines that guide the use and exportation of stored biological samples and data. However, there are variations in regulations and guidelines governing the reuse of stored biological samples and data in Sub-Saharan Africa including Malawi.DiscussionThe current research ethics regulations and guidelines in Malawi do not (...) allow indefinite storage and reuse of biological samples and data for future unspecified research. This comes even though the country has managed to answer pertinent research questions using stored biological samples and data. We acknowledge the limited technical expertise and equipment unavailable in Malawi that necessitates exportation of biological samples and data and the genuine concern raised by the regulatory authorities about the possible exploitation of biological samples and data by researchers. We also acknowledge that Malawi does not have bio-banks for storing biological samples and data for future research purposes. This creates room for possible exploitation of biological samples and data collected from research participants in primary research projects in Malawi. However, research ethics committees require completion and approval of material transfer agreements and data transfer agreements for biological samples and data collected for research purposes respectively and this requirement may partly address the concern raised by the regulatory authorities. Our concern though is that there is no such requirement for biological samples and data collected from patients for clinical or diagnostic purposes.SummaryIn conclusion, we propose developing a medical data and material transfer agreement for biological samples and data collected from patients for clinical or diagnostic purposes in both public and private health facilities that may end up in research centers outside Malawi. We also propose revision of the current research ethics regulations and guidelines in Malawi in order to allow secondary use of biological samples and data collected from primary research projects as a way of maximizing the use of collected samples and data. Finally, we call for consultation of all stakeholders within the Malawi research community when regulatory authorities are developing policies that govern research in Malawi. (shrink)

The most important contemporary development in rhetoric for the theory of argumentation is Jeanne Fahnestock's program of figural logic, the ruling insight of which is that figures epitomize arguments. Working primarily with the antimetabolic formula at the heart of Gregor Mendel's paper “Experiments in Plant Hybridization,” I investigate the figural bases of the logic anchoring this foundational essay in genetics. In addition to antimetabole, the formula also depends crucially on ploche, polyptoton, onomatopoeia, antithesis, synecdoche, reification, and metaphor.

Research on the nature of science and science education enjoys a longhistory, with its origins in Ernst Mach's work in the late nineteenthcentury and John Dewey's at the beginning of the twentieth century.As early as 1909 the Central Association for Science and MathematicsTeachers published an article – ‘A Consideration of the Principles thatShould Determine the Courses in Biology in Secondary Schools’ – inSchool Science and Mathematics that reflected foundational concernsabout science and how school curricula should be informed by them. Sincethen (...) a large body of literature has developed related to the teaching andlearning about nature of science – see, for example, the Lederman and Meichtry reviews cited below. As well there has been intensephilosophical, historical and philosophical debate about the nature of scienceitself, culminating in the much-publicised ‘Science Wars’ of recent time. Thereferences listed here primarily focus on the empirical research related to thenature of science as an educational goal; along with a few influential philosophicalworks by such authors as Kuhn, Popper, Laudan, Lakatos, and others. Whilenot exhaustive, the list should prove useful to educators, and scholars in otherfields, interested in the nature of science and how its understanding can berealised as a goal of science instruction. The authors welcome correspondenceregarding omissions from the list, and on-going additions that can be made to it. (shrink)

Mesoamericans' rich spiritual beliefs about the importance of animals and about the correlation between the well-being of animals and that of human beings contrast with a diminutive respect accorded to animals in industrialized cultures. Some vestige of a parallel sensibility, however - granting animals an aura of dignity relatively independent of anthropocentric constructions - may be detected in the animal poetry of selected Western writers including Marianne Moore, Gary Snyder, and José Emilio Pacheco. Such animal poetry, although possessing no explicit (...) links to Mesoamerican spirituality, may represent an ethos extant in industrial-world culture that quietly celebrates - as Mesoamerican culture does more unabashedly - the sanctity and parity of nonhuman animals. (shrink)

This book calls scholars to avoid the temptation to reduce philosophy into a normative discipline. The author argues that philosophy's main responsibility does not reside in changing the world, but in safeguarding sense and intelligibility against unfounded forms of skepticism.

This article seeks to refine understandings of the governmental logics that comprise and shape urban governance. Drawing on research using ethnographic methods that explore the business improvement district and the condominium corporation it is argued that exclusive focus on urban neo-liberalism neglects an urban ”police.” This latter logic is most famously remarked upon in Michel Foucault’s writings as targeting “little things” in urban spaces. Both “police” and the ”free rider problem” it confronts predate and are irreducible to neo-liberalism. Ethnography helps (...) discern this “police” as well as how neo-liberalism relates to it in private urban realms typically hidden from view. Examining BIDs and condos in this way shows that neo-liberalism and “police” co-exist and combine in the governance of urban residential and commercial life. This matters because it reveals a more complex picture of urban governance than is sometimes assumed when neo-liberalism is exclusively invoked and one that is necessarily considered when conceiving of alternative governing arrangements. (shrink)

The generalised, automated reconstruction of the reasoning structures underlying persuasive communication is an enormously challenging task. While this work in argument mining is increasingly informed by the rich tradition of argumentation studies outside the computational field, the rhetorical perspective on argumentation is thus far largely ignored. To explore the application of rhetorical insights in argument mining, we conduct a pilot study on the connection between rhetorical figures and argumentation structure. Rhetorical figures are linguistic devices that perform a variety of functions (...) in argumentative discourse. The textual form of some of these figures is easy to identify automatically, such that an established connection between the figure and a preponderance of argumentative content would improve the performance of argument mining techniques. Furthermore, the automated mining of rhetorical figures could be used as an empirical, corpus-based testing ground for the claims made about these figures in the rhetorical literature. In the pilot study, we explore the connection between eight rhetorical figures the forms of which we expect to be relatively easy to identify computationally, and argumentation structure (concretely, we consider the six schemes ‘anadiplosis’, ‘epanaphora’, ‘epistrophe’, ‘epizeuxis’, ‘eutrepismus’, and ‘polyptoton’, and the two tropes ‘antithesis’ and ‘dirimens copulatio’, and relate their occurrences to relations of inference and conflict). The data of the study is collected in the MM2012c corpus of 39,694 words of argumentatively annotated transcripts from the BBC Radio 4’s Moral Maze discussion program. We show that some of the figures indeed correspond to passages of high argumentative density, relative to the text as a whole. (shrink)

This paper surveys ontological modeling of rhetorical concepts, developed for use in argument mining and other applications of computational rhetoric, projecting their future directions. We include ontological models of argument schemes applying Rhetorical Structure Theory (RST); the RhetFig proposal for modeling; the related RetFig Ontology of Rhetorical Figures for Serbian (developed by two of the authors); and the Lassoing Rhetoric project (developed by another of the authors). The Lassoing Rhetoric venture is interesting for its multifaceted approach to linguistic devices, prominently (...) including rhetorical figures, but also RST relations and stylistic models, like the use of historic present. This application takes a natural language text input and uses syntactic parsing tools to produce a knowledge base of linguistic entities using references to an OWL ontological framework, locating these devices using Semantic Web Rule Language (SWRL) logic rules. The paper also reports on a similar approach in research into detecting ironic tweets in a Serbian twitter corpus. The rhetorical schemes used for argument mining are also presented, as well as some suggestions for novel argument schemes based on the ontological approach to rhetorical figuration. (shrink)