Xenotransplantation - the transfer of living tissue between species - has long been heralded as a potential solution to the severe organ shortage crisis experienced by the United Kingdom and other 'developed' nations. However, the significant risks which accompany this biotechnology led the United Kingdom to adopt a cautious approach to its regulation, with the establishment of a non-departmental public body - UKXIRA - to oversee the development of this technology on a national basis. In December 2006 UKXIRA was quietly (...) disbanded and replaced with revised guidance, which entrusts the regulation of xenotransplantation largely to research ethics committees. In this article we seek to problematize this new regulatory framework, arguing that specialist expertise and national oversight are necessary components of an adequate regulatory framework for a biotechnology which poses new orders of risk, challenges the adequacy of traditional understandings of autonomy and consent, and raises significant animal welfare concerns. We argue for a more considered and holistic approach, based on adequate consultation, to regulating biotechnological developments in the United Kingdom. (shrink)

On the dominant interpretation, Schopenhauer possesses a will to will view of boredom: boredom consists in the dissatisfaction of a second-order desire to pursue objects of first-order desire. I ch...

This paper details a three-credit-hour undergraduate ethics course that was delivered using traditional, distance, and compressed formats. OLS 263: Ethical Decisions in Leadership is a 200-level course offered by the Department of Organizational Leadership and Supervision in the Purdue School of Engineering and Technology at Indiana University Purdue University Indianapolis (IUPUI). Students in engineering, technology, business, nursing, and other majors take the course. In an effort to determine student perceptions of course and instructor effectiveness, end-of-course student survey data were compared (...) using data from traditional, distance, and compressed sections of the course. In addition, learning outcomes from the final course project were evaluated using a standardized assessment rubric and scores on the course project. (shrink)

Journal of Social Philosophy, EarlyView.

Sexual competition in the epics is looked at for examples of conflict between older or more powerful males and younger or subordinate males over fertile females, a pattern that would have characterized the human environment of evolutionary adaptation (EEA). In the Iliad and Odyssey, the Old Testament, the Arthurian Cycle (and its Celtic originals), the Volsunga Saga, and El Cid, this pattern is found to be the frame or prime mover or a central feature of the narrative. It is suggested (...) that changes through time in the literary treatment of the theme reflect a progressive dilution of the traditional power of older males over mate choice. (shrink)

Conley and colleagues (2023) conduct a fascinating analysis of how influential organizations in the global governance of human genome editing debate conceptualize and perform public engagement. Whi...

Polygenic scores (PGSs) have several limitations. They are confounded with environmental effects on behavior and cannot be used to study how mutations affect brain function and behavior. For this, mutations with large effects, which often arise in only one geographical population are needed. Genome-wide association studies (GWASs), commonly used for identifying mutations, have difficulty detecting these mutations. A strategy that overcomes this challenge is discussed.

This study uses the Religion and State round 2 dataset to examine the presence of religious freedom in 177 countries. There are many different conceptions of the meaning of religious freedom but they can be divided into two categories, those which focus on the free exercise of religion—that is the right to practice religion and maintain religious institutions—and those which focus on treating all religions equally, also known as the level playing field model. The results show that neither form of (...) religious freedom is common even among democracies and states which have constitutional clauses protecting religious freedom. This finding has serious implications for our understanding of the nature of liberal democracy. (shrink)

The Routledge Handbook of Philosophy and Media Ethics is an outstanding survey and assessment of this vitally important field. Essential reading for students and researchers in philosophy, media and communication studies, politics and law, as well as practicing media professionals and journalists.

One of Alfred North Whitehead’s Lowell lectures of 1925 encapsulated a common belief about the relations between science and romanticism. In a chapter on “The romantic reaction” in the published version of the lectures, Whitehead presented science and the romantic spirit as fundamentally at odds (Whitehead 1926, chapter 5). The romantic world view, for Whitehead, had no place for perceptions of nature as an unfeeling law-bound machine. Against the conventional scientific virtues of objectivity, it stressed subjectivity, and against the model (...) of inexorable determinism, it favored one closer to that of an organism, with the potential for growth and change. It is not hard to see the core of truth in Whitehead’s interpretation. When Wordsworth wrote “We murder to dissect,” he was voicing a romantic sensibility that saw the abstraction of science as, at best, scratching the surface of a natural world at once richer and closer to us as human beings than the one handed down by the mechanical .. (shrink)

The author argues that our best hope for addressing world problems (from climate change to violence, to poverty) is to teach critical thinking through the study of language and all symbol systems. This means removing disciplinary boundaries so that we can focus more effectively on solving common problems. Human survival also depends upon our critical analysis of electronic media and our wise uses of technology. Critical thinking via all symbol systems is more likely to generate humane actions. Therefore, education—not governments (...) or armies or institutions or private corporations—is our best hope. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Striving To Do Good:Well-Springs, Realities, and Paradoxes of Medical Humanitarian WorkRenée C. FoxThe voices that speak from the pages of these testimonial narratives are those of physicians who are engaged in medical humanitarian work. The preponderance of them are based in U.S. academic medical centers where they have clinical, teaching, and research responsibilities from which they regularly "commute" to care for patients in what the euphemistic language of "global (...) health" terms "resource-limited," rather than "poor" countries." This "hybrid life," as one of the physicians (Robert Riviello) refers to it, has transported them periodically to numerous African societies (to Algeria, Ethiopia, Gabon, Morocco, Rwanda, Sudan, Tanzania, and Uganda), to Haiti, to India and Nepal, and to Guatemala and Mexico. Three of the "stories" are written by physicians at work in the countries where they were born (Prasanta Tripathy in Eastern India, Sridevi Seetharam and colleagues in Southern India, and Paul Pierre, in Haiti).Only one group of physician-coauthors (Maricruz Merino, Jonathan Iralu, and Sonya Shin) write about their experiences in practicing medicine among poor and socially disadvantaged patients on the American mainland—in the setting of the Navajo Indian reservation in Gallup, New Mexico.All these physicians describe their involvement in humanitarian medicine as emanating from their commitment to "social justice," to "saving lives," and to "caring for the poor"; to their universalistic convictions about "human solidarity," and the non- otherness of others; to their indignation about the inequities and injustices of the world, particularly with regard to access to health care (in the words of Jeffrey Deal, "[They] deserve better. They all do"); and to their "passionate" desire, not just their "sense of duty," to help rectify these wrongs (Richard Keiden). I was struck by the fact that none of them uses the word "suffering" to describe the plight of the persons whom they feel they have been called to medically assist.Three of the physicians express the wellsprings of their motivation in religious terms. Richard Keiden refers to a "guiding principle of Judaism" on which his medical humanitarian work has been founded—"tzedakah"—which "translates as charity but actually means righteousness," is based on a "concept of social justice," and is "an obligation, not a choice." Robert Riveillo says that at the time of his graduation from high school he envisioned his "life's work as a long-term missionary surgeon"; he invokes "loving mercy," as well as justice, "in this work of solidarity" that he has undertaken; and he poignantly admits that "most days I still long to pack my things, my family, and our efforts and move to Africa for a life of direct service." What Jeffrey Deal writes is the most explicitly and ardently religious of all. He identifies his work as a physician in Sudan with Jesus's "desire for us to care [End Page 115] for the poor and downtrodden in His stead." He is haunted by his "failure" to deliver alive a "partially born" baby girl who for him incarnated "the least of the least" of whom Jesus "spoke passionately." And in touching "ever so briefly... [that] one, tiny being [he] encountered... [on ] that hot morning in Sudan," he attests, he "touched Jesus."Jeffrey Deal is not the only one who was so stricken by the death of a baby or a child. For a number of these physicians (Sadath Sayeed, Maneesh Batra, and for Sridevi Seetharam, Lisa Adams and their colleagues), it was a tragedy that they found hard to bear with "detached enlightenment" (Sayeed), or to accept. The most demonstrably heartbroken and morally outraged among them is Sadath Sayeed, who "wept uncontrollably" over the death of a baby boy, born "at home" in Haiti, "probably in one of the hundreds of make-shift tent cities." The baby was not breathing continuously, and was "handed" to him to care for. At the close of the "story " about this experience that he recounts, Sayeed lashes out with fury and angst at those who were likely to ask him, "How was it in Haiti?" Do you want to hear "my real answer?" he replies:... [L]et me summarize my last patient for you: Good luck Dad... (shrink)

In recent years, the concept of evolvability has been gaining in prominence both within evolutionary developmental biology (evo-devo) and the broader field of evolutionary biology. Despite this, there remains considerable disagreement about what evolvability is. This article offers a solution to this problem. I argue that, in focusing too closely on the role played by evolvability as an explanandum in evo-devo, existing philosophical attempts to clarify the evolvability concept have been overly narrow. Within evolutionary biology more broadly, evolvability offers a (...) robust explanation for the evolutionary trajectories of populations. Evolvability is an abstract, robust, dispositional property of populations, which captures the joint causal influence of their internal features on the outcomes of evolution (as opposed to the causal influence of selection, which is often characterized as external). When considering the nature of the physical basis of this disposition, it becomes clear that the many existing definitions of evolvability at play within evo-devo should be understood as capturing only aspects of a much broader phenomenon. 1 Introduction2 The Problem of Evolvability3 The Theoretical Role of Evolvability in Evolutionary Biology 3.1 The explanatory targets of evolutionary biology 3.2 Selection-based explanations 3.3 Lineage explanations 3.4 Evolvability-based explanations 3.5 What properties must evolvability have?4 What Evolvability Really Is 4.1 Making sense of ft 4.2 Making sense of x and b5 What of the Limbs? The Power of E6 Conclusion. (shrink)

Bandits in Print: The Water Margin and the Transformations of the Chinese Novel. By Scott W. Gregory. New York: Cornell University Press, 2023. Pp. xii + 179. $125 (cloth); $26.95 (paper); open access.

It is a platitude among decision theorists that agents should choose their actions so as to maximize expected value. But exactly how to define expected value is contentious. Evidential decision theory (henceforth EDT), causal decision theory (henceforth CDT), and a theory proposed by Ralph Wedgwood that this essay will call benchmark theory (BT) all advise agents to maximize different types of expected value. Consequently, their verdicts sometimes conflict. In certain famous cases of conflict—medical Newcomb problems—CDT and BT seem to get (...) things right, while EDT seems to get things wrong. In other cases of conflict, including some recent examples suggested by Andy Egan, EDT and BT seem to get things right, while CDT seems to get things wrong. In still other cases, EDT and CDT seems to get things right, while BT gets things wrong. It's no accident, this essay claims, that all three decision theories are subject to counterexamples. Decision rules can be reinterpreted as voting rules, where the voters are the agent's possible future selves. The problematic examples have the structure of voting paradoxes. Just as voting paradoxes show that no voting rule can do everything we want, decision-theoretic paradoxes show that no decision rule can do everything we want. Luckily, the so-called “tickle defense” establishes that EDT, CDT, and BT will do everything we want in a wide range of situations. Most decision situations, this essay argues, are analogues of voting situations in which the voters unanimously adopt the same set of preferences. In such situations, all plausible voting rules and all plausible decision rules agree. (shrink)

Risk-weighted expected utility theory permits preferences which violate the Sure-Thing Principle. But preferences that violate the STP can lead to bad decisions in sequential choice problems. In particular, they can lead decision-makers to adopt a strategy that is dominated – i.e. a strategy such that some available alternative leads to a better outcome in every possible state of the world.

G. E. M. Anscombe’s Intention is a classic of twentieth-century philosophy. The work has been enormously influential despite being a dense and largely misunderstood text. It is a standard reference point for anyone engaging with philosophy of action and philosophy of psychology. In this Routledge Philosophy GuideBook, Rachael Wiseman: situates _Intention_ in relation to Anscombe’s moral philosophy and philosophy of mind considers the influence of Aquinas, Aristotle, Frege, and Wittgenstein on the method and content of _Intention_ adopts a structure (...) for assessing the text that shows how Anscombe unifies the three aspects of the concept of intention considers the influence and implications of the piece whilst distinguishing it from subsequent work in the philosophy of action Ideal for anyone wanting to understand and gain a perspective on Elizabeth Anscombe’s seminal work, this guide is an essential introduction, useful in the study of the philosophy of action, ethics, philosophy of psychology and related areas. (shrink)

A number of recent authors (Galles and Pearl, Found Sci 3 (1):151–182, 1998; Hiddleston, Noûs 39 (4):232–257, 2005; Halpern, J Artif Intell Res 12:317–337, 2000) advocate a causal modeling semantics for counterfactuals. But the precise logical significance of the causal modeling semantics remains murky. Particularly important, yet particularly under-explored, is its relationship to the similarity-based semantics for counterfactuals developed by Lewis (Counterfactuals. Harvard University Press, 1973b). The causal modeling semantics is both an account of the truth conditions of counterfactuals, and (...) an account of which inferences involving counterfactuals are valid. As an account of truth conditions, it is incomplete. While Lewis's similarity semantics lets us evaluate counterfactuals with arbitrarily complex antecedents and consequents, the causal modeling semantics makes it hard to ascertain the truth conditions of all but a highly restricted class of counterfactuals. I explain how to extend the causal modeling language to encompass a wider range of sentences, and provide a sound and complete axiomatization for the extended language. Extending the truth conditions for counterfactuals has serious consequences concerning valid inference. The extended language is unlike any logic of Lewis's: modus ponens is invalid, and classical logical equivalents cannot be freely substituted in the antecedents of conditionals. (shrink)

David Lewis’s ‘Humean Supervenience’ (henceforth ‘HS’) combines realism about laws, chances, and dispositions with a sparse ontology according to which everything supervenes on the overall spatiotemporal distribution of non-dispositional properties (Lewis 1986a, Philosophical papers: Volume II, pp. ix–xvii, New York: Oxford Univesity Press, 1994, Mind 103:473–490). HS faces a serious problem—a “big bad bug” (Lewis 1986a, p. xiv): it contradicts the Principal Principle, a seemingly obvious norm of rational credence. Two authors have tried to rescue Lewis’s ontology from the ‘big (...) bad bug’ (henceforth ‘the Bug’) by rejecting realism about laws, chances, and dispositions (Halpin 1994, Aust J Phil 72:317–338, 1998, Phil Sci 65:349–360; Ward 2005, Phil Sci 71:241–261). I will argue that this strategy cannot possibly work: it is the ontology, not the realist thesis, that lies at the root of the problem. (shrink)

The historical figure of the cow as a symbol is treasured and ancient, yet simultaneously this animal in many societies exists de facto for people’s plates. The cow, like other animals, exists in parts: as treasured symbol, and as commodity. Looking at collections by contemporary Anglophone poets, Ariana Reines, and Selima Hill, I will consider how each writer’s self-reflexive critique of animal representation reorients the material subjects of their poems, intersecting these innovative poetries with contemporary thinkers on animal studies, to (...) realize the limits of a poetic perspective on animal bodies. Both writers work either against or deliberately within a lyric mode critiqued for its objectifying address in order to interrogate modes of rendering that position the animal’s existence as a resource. From Reines’s scatological slaughterhouse to Hill’s surreal landscapes I will explore how the symbolic and literal exploitation of an animal’s “flesh” in their poems is counteracted. (shrink)

Traditional ideas of mediator neutrality and impartiality have come under increasing attack in recent decades. There is, however, a lack of consensus on what should replace them. Mediation Ethics offers a response to this question, developing a new theory of mediation that emphasises its nature as a relational process.

You have a choice -- Decision-making steps -- What is a good choice? -- Identifying options -- Making predictions -- Pros and cons -- Weighing the consequences -- Values and motivations -- Thinking of others -- Choose wisely -- Glossary -- Index -- Primary source list -- Websites.

A recent report by Blumenthal et al.1 provides convincing evidence that at least 15% of Caenorhabditis elegans genes are co‐transcribed within over a thousand operons. Polycistronic transcription of gene clusters is very rare in eukaryotes. The widespread occurrence of operons in C. elegans thus raises some interesting questions about the origin and function of these multigenic transcriptional units. BioEssays 24:983–987, 2002. © 2002 Wiley‐Periodicals, Inc.

We calculate the complexity of Scott sentences of scattered linear orders. Given a countable scattered linear order L of Hausdorff rank $\alpha $ we show that it has a ${d\text {-}\Sigma _{2\alpha +1}}$ Scott sentence. It follows from results of Ash [2] that for every countable $\alpha $ there is a linear order whose optimal Scott sentence has this complexity. Therefore, our bounds are tight. We furthermore show that every Hausdorff rank 1 linear order has an optimal ${\Pi ^{\mathrm {c}}_{3}}$ (...) or ${d\text {-}\Sigma ^{\mathrm {c}}_{3}}$ Scott sentence and give a characterization of those linear orders of rank $1$ with ${\Pi ^{\mathrm {c}}_{3}}$ optimal Scott sentences. At last we show that for all countable $\alpha $ the class of Hausdorff rank $\alpha $ linear orders is $\boldsymbol {\Sigma }_{2\alpha +2}$ complete and obtain analogous results for index sets of computable linear orders. (shrink)