BackgroundInternational guidelines recommend ethical and scientific quality standards for managing and reporting adverse events occurring during clinical trials to competent research ethics committees and regulatory authorities. The purpose of this study was to determine whether clinical trial protocols in Cameroon are developed in line with national requirements and international guidelines as far as detecting, reporting and investigating of adverse events is concerned.MethodsIt was a documentary review of all approved clinical trial protocols that were submitted at the Cameroon National Ethics Committee (...) for evaluation from 1997 through 2012. Data were extracted using a preconceived and validated grid. Protocol review process targeted the title, abstract, objectives, methodology, resources, and the chapter on safety.ResultsIn total, 106 clinical trial protocols were identified from 2173 protocols seen in the archive and 104 included for review. Seventy six trials did not include the surveillance of adverse events as part of their objective. A total of 91 protocols did not budget for adverse event surveillance, 76 did not have a data safety management board, 11 included insurance for participants, 47 did not include a case definition for serious adverse events, 33 described procedures to detect adverse events, 33 described procedure for reporting and 22 described procedure for investigating adverse events.DiscussionsMost clinical trial protocols in Cameroon are developed to focus on benefits and pay little attention to harms. The development of national guidelines can improve the surveillance of adverse events in clinical trial research conducted in Cameroon. Adverse events surveillance tools and a budget are critical for an adequate planning for adverse event surveillance when developing trial protocols.ConclusionClinical trial protocols submitted in the Cameroon National Ethics Committee do not adequately plan to assess adverse events in clinical trial protocols. In order to improve on the safety of participants and marketed drug, there is a need to develop national guidelines for clinical trials by the government, and to improve evaluation procedures and monitoring of ongoing trials by the ethics committee. (shrink)

La définition platonicienne du philosophe; la philosophie comme mode de vie; rupture et continuité, le Moyen Age et les temps modernes. [SDM].

Dans cet article l’auteur définit sa notion de spaciogramme comme une représentation projective groupale de l’espace familial vécu. C’est une médiation thérapeutique favorisant un travail psychique de figurabilité. Il donne accès par un effet « squiggle » à une interfantasmatisation en thérapie psychanalytique. Le spaciogramme est décrit en analogie isomorphe avec l’image projective du génogramme, avec les contenants généalogiques, et avec l’image inconsciente du corps psychique groupal familial (le corps généalogique). Il traduit dans le transfert et la régression, une représentation (...) des mécanismes de défense groupaux, du maillage des liens de filiation et d’affiliation, de la transmission généalogique de l’héritage psychique de la famille. (shrink)

Like other members of the Vienna Circle, Carnap criticized traditional philosophy for its lack of clarity and precision, as is well-know from such papers as "The elimination of metaphysics through the logical analysis of language" (1932) and many other writings. In 'The Logical Syntax of Language' (1934), while still entertaining the idea that, in some sense, metaphysics is nonsense, Carnap's critique of philosophy is based on different grounds and aimed at different authors. In this book, his critique of philosophy actually (...) takes the form of an attempt at a reconstruction of philosophy on a new basis. I shall try to examine this attempt and to show why it fails. I shall also try to show how Carnap's thought evolved on this point in later writings, in particular in "Empiricism, Semantics, and Ontology" (1950). (shrink)

Some common notions about analytic philosophy - that it is uniformly anti-metaphysical or indifferent to the history of philosophy - are clearly misconceived. However the impression that analytic philosophers are essentially linguistic philosophers is not entirely false and hence less easy to refute.

Physicians anecdotally report inquiring about incarcerated patients’ crimes and their length of sentence, which has potential implications for the quality of care these patients receive. However, there is minimal research on how a physician’s awareness of their patient’s crimes/length of sentence impacts physician behaviours and attitudes. We performed regression modelling on a 27-question survey to analyse physician attitudes and behaviours towards incarcerated patients. We found that, although most physicians did not usually try to learn of their patients’ crimes, they often (...) became aware of them. We observed associations between awareness of a patient’s crime and poor physician disposition towards their patients and between physicians’ poor dispositions and lower reported quality of care. These associations suggest that awareness of a patient’s crime may reduce quality of care by negatively impacting physicians’ dispositions towards their patients. Future quantitative and qualitative studies, for example, involving physician interviews and direct patient outcome assessments, are needed to confirm these findings and further uncover and address hurdles incarcerated patients face in seeking medical care. (shrink)

Se recupera aquí para la discusión ética contemporánea la perspectiva universalista del logos presente en la Ética a Nicómaco de Aristóteles. En oposición a unas versiones comunitaristas de la ética aristotélica que dan lugar a posiciones particularistas o relativistas, el logos se liga a la naturaleza humana, y universal, del hombre.

Bien que Carnap soit surtout connu pour son appartenance à l’empirisme logique, qui rejette le synthétique a priori et la métaphysique kantienne en général, sa thèse sur l’espace (1922) fut rédigée dans le double contexte des multiples variétés du néokantisme et d’une réflexion mathématique, physique et philosophique sur le concept d’espace. Dans cette thèse et dans le mémoire de 1920 sur la géométrie, il s’efforce de surmonter les difficultés soulevées par le concept d’espace en en distinguant plusieurs significations et plusieurs (...) sortes. Ce faisant, il défend une position originale qui emprunte aux différentes formes du néokantisme de l’époque sans se réduire pour autant à aucune d’elles. (shrink)

L'oubli est précédé par sa mauvaise réputation. Pensé comme un manque de la mémoire, le symptôme d'une dégénérescence annoncée, on le redoute. On cherche à l'oublier bien que l'on sache qu'il sera toujours là. Pourtant, s'il ne faisait pas quotidiennement son œuvre, on ne pourrait plus vivre, agir ou créer. Oublier est une faculté universelle et vitale dont les modalités d'expression diffèrent de celles de la mémoire : une puissance enfouie en notre être, une force créatrice capable de nous régénérer. (...) À contre-courant des modes et humeurs de notre société, des philosophes, des anthropologues et surtout des artistes n'ont pas oublié d'oublier tous les fardeaux qui se présentent comme des obstacles à leur désir de création. Développer sa capacité à effacer les évènements pesants et traumatisants qui nous conduisent au désastre est moins un risque qu'un pari, dont l'enjeu est de rendre à chaque personne ce qu'elle désire peut-être le plus au monde : affirmer sa réelle singularité, notamment par et dans l'acte créatif."--Page 4 of cover. (shrink)

Analyse historique et sociologique de la connaissance scientifique.

Agent-Based Models are useful to describe and understand social, economic and spatial systems' dynamics. But, beside the facilities which this methodology offers, evaluation and comparison of simulation models are sometimes problematic. A rigorous conceptual frame needs to be developed. This is in order to ensure the coherence in the chain linking at the one extreme the scientist's hypotheses about the modeled phenomenon and at the other the structure of rules in the computer program. This also systematizes the model design from (...) the thematician conceptual framework as well. The aim is to reflect upon the role that a well defined ontology, based on the crossing of the philosophical and the computer science insights, can play to solve such questions and help the model building. We analyze different conceptions of ontology, introduce the 'ontological test' and show its usefulness to compare models. Then we focus on the model building and show the place of a systematic ABM ontology. The latter process is situated within a larger framework called the 'knowledge framework' in which not only the ontologies but also the notions of theory, model and empirical data take place. At last the relation between emergence and ontology is discussed. (shrink)