For more than two thousand years, almost all doctors in the West used bloodletting to treat a great variety of diseases and conditions. In an attempt to find out why they acted thus, Dr Brain has translated the three works on bloodletting by the second-century physician Galen, which provide by far the most comprehensive account of the practice in antiquity. This is the first published version of these works in a modern language. After a brief summary of Galen's medical (...) system, the author goes on to consider the origins of Galen's ideas and methods, with particular reference to the Hippocratic writings, and the question why Galen, in common with most of the ancient physicians, believed in the efficacy of the comedy. The effects of bloodletting are considered in terms of modem physiology and medicine, and the possibility is explored that it may indeed have been beneficial in the conditions prevailing in Galen's time. (shrink)

The course of my experience is quite consistent with the hypothesis that it is being produced by a mad scientist who is feeding into my sensory receptors entirely delusive stimuli. Indeed, I could at this very moment be nothing more than a brain floating in a vat of nutrients, my nerve ends linked up to some infernal apparatus by means of which my unknown deceiver induces in me utterly erroneous beliefs about the world.So begins a familiar line of thought (...) which dramatizes an equally familiar sceptical problem about the relation between our experiences and the world. However, Hilary Putnam has recently offered a marvellously ambitious argument which is intended to kill stone-dead the philosophical fantasy that we might be deluded brains in a vat. (shrink)

For more than thirty years, in most of the world, the irreversible cessation of all brain function, more commonly known as brain death, has been accepted as a criterion of death. Yet the philosophical basis on which this understanding of death was originally grounded has been undermined by the long-term maintenance of bodily functions in brain dead patients. More recently, the American case of Jahi McMath has cast doubt on whether the standard tests for diagnosing brain (...) death exclude a condition in which the patient is not dead, but in a minimally conscious state. I argue that the evidence now clearly shows that brain death is not equivalent to the death of the human organism. We therefore face a choice: either we stop removing vital organs from brain dead patients, or we accept that it is not wrong to kill an innocent human who has irreversibly lost consciousness. (shrink)

The literature on deep brain stimulation (DBS) and adaptive DBS (aDBS) raises concerns that these technologies may affect personality, mood, and behavior. We conducted semi-structured interviews with researchers (n = 23) involved in developing next-generation DBS systems, exploring their perspectives on ethics and policy topics including whether DBS/aDBS can cause such changes. The majority of researchers reported being aware of personality, mood, or behavioral (PMB) changes in recipients of DBS/aDBS. Researchers offered varying estimates of the frequency of PMB changes. (...) A smaller majority reported changes in personality specifically. Some expressed reservations about the scientific status of the term ‘personality,’ while others used it freely. Most researchers discussed negative PMB changes, but a majority said that DBS/aDBS can also result in positive changes. Several researchers viewed positive PMB changes as part of the therapeutic goal in psychiatric applications of DBS/aDBS. Finally, several discussed potential causes of PMB changes other than the device itself. (shrink)

Contemporary discussions of epistemological skepticism - the view that we do not and cannot know anything about the world around us - focus very much on a certain kind of skeptical argument involving a skeptical scenario (a situation familiar from Descartes’ First Meditation). According to the argument, knowing some ordinary proposition about the world (one we usually take ourselves to know) requires knowing we are not in some such skeptical scenario SK; however, since we cannot know that we are not (...) in SK we also cannot know any ordinary proposition. One of the most prominent skeptical scenarios is the brain-in-the-vat-scenario: An evil scientist has operated on an unsuspecting subject, removed the subject’s brain and put it in a vat where it is kept functioning and is connected to some computer which feeds the brain the illusion that everything is “normal”. This paper looks at one aspect of this scenario after another – envatment, disembodiment, weird cognitive processes, lack of the right kind of epistemic standing, and systematic deception. The conclusion is that none of these aspects (in isolation or in combination) is of any relevance for a would-be skeptical argument; the brain-in-the-vat-scenario is irrelevant to and useless for skeptical purposes. Given that related scenarios (e.g., involving evil demons) share the defects of the brain-in-the-vat-scenario, the skeptic should not put any hopes on Cartesian topoi. (shrink)

The thesis of this bk is that the brain is innately constructed to initiate behaviors likely to promote the survival of the species & to sensitize sensory systems to stimuli required for those behaviors. Intended for behavioral & brain scientists.

In this paper a new interactionistic model of mental causation is developed. By analysing the results of physics and neuroscience it is shown that the macroscopic cerebral activity and the resulting behavioural output is not strictly determined. This opens up the possibility that a non-physical mind can influence which of the physically allowed brain states is realised. Most models of mental causation postulate that there are coherent quantum states in the brain which could be influenced by a local (...) mind-brain interaction. Due to environmental decoherence, however, it is questionable whether coherent quantum states can exist in the warm and wet brain. The here presented `creative choice theory' solves the problem of environmental decoherence by including the environment. The whole universe is considered as a quantum system that is in superposition of alternative realities. It is then assumed that a universal mind collapses the universal wave-function whilst individual minds interact with individual brains. This leads to a holistic model of reality that could also provide an explanation for ESP-phenomena and mystical experiences. (shrink)

Philosophical, dynamical, neural, network-theoretical, and cognitive ingredients of Tsuda's brain theory are discussed and anayzed. The integrative approach emphasized by Tsuda would be a welcome one.

My recent article, “The challenge of brain death for the sanctity of life ethic” (Ethics & Bioethics (in Central Europe), 2018, 8 (3–4), pp. 153–165) elicited five commentaries. In this brief response, I clarify my own position in the light of some misunderstandings, and discuss whether the definition of death is best thought of as an ethical question, or as a matter of fact. I also comment on the suggestion that we should allow people to choose the criteria by (...) which they wish their own death to be determined, or their organs removed to be donated to others. (shrink)

Most children and families have not had direct contact with child psychological and psychiatric experts. Instead they encounter developmental theories, etiological explanations and depictions of childhood disorders through indirect channels such as newspapers. Drawing on actor–network theory, this article explores two child psychological and psychiatric modes of ordering children’s mental health discernible in Sweden’s largest morning newspaper, Dagens Nyheter, during the years 1980 to 2008: a psychodynamic mode and a neuro-centered mode. In the article I show how these two relatively (...) contemporaneous modes greatly differed in how they enacted children’s mental health. The psychodynamic mode stressed the parents’ role in structuring and affecting the child’s unconscious and saw them as the primary cause of any mental illness. In contrast, the neuro-centered mode highlighted that mental issues were related to the child’s brain and proposed different solutions depending on whether the child’s brain functioned in a ‘normal’ or ‘atypical’ manner. Each mode moreover suggested differing contexts to their discussions, with the psychodynamic mode solely discussing the parental milieu while the neuro-centered mode mainly focused on how society affected children with ‘atypical’ brains. The two modes thus had significantly diverging implications for the reader on how to understand and manage children and their psychological well-being. I further argue in the article for the relevance of actor–network theory in historical studies of psychology and psychiatry. (shrink)

Dogmatists often exploit the skeptical argument based on the brains-in-a-vat scenario as a test case for their epistemological enterprises. I argue that this ‘argument’ does not deserve our attention, so it should not be used as a test case. I first show that the possibilities of empirical knowledge and of skeptical scenarios are inconsistent. If so, the BIV-skeptic must make the case for preferring such scenarios over the possibility of empirical knowledge. The central argument of my paper is that the (...) BIV-skeptic can neither rely on any selection principle for this purpose, nor can she claim that she needs no such principle. Then I will show that we can even dispense with the Inconsistency Thesis: if the skeptic wishes, she may allow for the possibility of empirical knowledge. The essay concludes with considering the morals of the above argument for the dogmatist endeavor. (shrink)

What are the differences between philosophy and science, or between the methods of philosophy and the methods of science? Unlike some philosophers we do not find philosophy and the methods of philosophy to be sui generis. Science, and in particular neuroscience, has much to tell us about the nature of the world and the concepts that we must use to understand and explain it. Yet science cannot function well without reflective analysis of the concepts, methods, and practices that constitute it. (...) For example, experimental methods and their resulting empirical data are essential for understanding the world, yet such data is not a-conceptual. Understanding how and what theoretical assumptions, conceptual assumptions, and practical knowledge guide the use of experimental methods is relevant to understanding the results of that use. In this way, philosophy – whether done by philosophers or scientists – has a role to play in understanding the world. Neuroscience is typically individualistic in focus; nonetheless, the mechanisms of learning and linguistic ability that some neuroscientists study also have a role to play in understanding communication. Philosophy cannot offer adequate understanding, even conceptual clarity, in isolation from empirical investigation. Yet, this does not require that science or scientific concepts will replace or reduce philosophical concepts, let alone those of ordinary language. (shrink)

The brain displays both the anatomical features of a vast amount of interconnected topological mappings as well as the functional features of a nonlinear, metastable system at the edge of chaos, equipped with a phase space where mental random walks tend towards lower energetic basins. Nevertheless, with the exception of some advanced neuro-anatomic descriptions and present-day connectomic research, very few studies have been addressing the topological path of a brain embedded or embodied in its external and internal environment. (...) Herein, by using new formal tools derived from algebraic topology, we provide an account of the metastable brain, based on the neuro-scientific model of Operational Architectonics of brain-mind functioning. We introduce a “topodynamic” description that shows how the relationships among the countless intertwined spatio-temporal levels of brain functioning can be assessed in terms of projections and mappings that take place on abstract structures, equipped with different dimensions, curvatures and energetic constraints. Such a topodynamical approach, apart from providing a biologically plausible model of brain function that can be operationalized, is also able to tackle the issue of a long-standing dichotomy: it throws indeed a bridge between the subjective, immediate datum of the naïve complex of sensations and mentations and the objective, quantitative, data extracted from experimental neuro-scientific procedures. Importantly, it opens the door to a series of new predictions and future directions of advancement for neuroscientific research. (shrink)

Some dichotomies related to modeling electrocortical activities are analyzed. Attractor neural networks versus biologically motivated models, near-equilibrium versus nonequilibrium processes, linear and nonlinear dynamics, stochastic and chaotic patterns, local and global scale simulation of cortical activities are discussed.

The expansion of research on deep brain stimulation (DBS) and adaptive DBS (aDBS) raises important neuroethics and policy questions related to data sharing. However, there has been little empirical research on the perspectives of experts developing these technologies. We conducted semi-structured, open-ended interviews with aDBS researchers regarding their data sharing practices and their perspectives on ethical and policy issues related to sharing. Researchers expressed support for and a commitment to sharing, with most saying that they were either sharing their (...) data or would share in the future and that doing so was important for advancing the field. However, those who are sharing reported a variety of sharing partners, suggesting heterogeneity in sharing practices and lack of the broad sharing that would reflect principles of open science. Researchers described several concerns and barriers related to sharing, including privacy and confidentiality, the usability of shared data by others, ownership and control of data (including potential commercialization), and limited resources for sharing. They also suggested potential solutions to these challenges, including additional safeguards to address privacy issues, standardization and transparency in analysis to address issues of data usability, professional norms and heightened cooperation to address issues of ownership and control, and streamlining of data transmission to address resource limitations. Researchers also offered a range of views on the sensitivity of neural activity data (NAD) and data related to mental health in the context of sharing. These findings are an important input to deliberations by researchers, policymakers, neuroethicists, and other stakeholders as they navigate ethics and policy questions related to aDBS research. (shrink)

We offer a critical assessment of the “exclusion argument” against free will, which may be summarized by the slogan: “My brain made me do it, therefore I couldn't have been free”. While the exclusion argument has received much attention in debates about mental causation (“could my mental states ever cause my actions?”), it is seldom discussed in relation to free will. However, the argument informally underlies many neuroscientific discussions of free will, especially the claim that advances in neuroscience seriously (...) challenge our belief in free will. We introduce two distinct versions of the argument, discuss several unsuccessful responses to it, and then present our preferred response. This involves showing that a key premise – the “exclusion principle” – is false under what we take to be the most natural account of causation in the context of agency: the difference-making account. We finally revisit the debate about neuroscience and free will. (shrink)

How can phenomenal consciousness exist as an integral part of a physical universe? How can the technicolour phenomenology of our inner lives be created out of the complex neural activities of our brains? Many have despaired of finding answers to these questions; and many have claimed that human consciousness is inherently mysterious. Peter Carruthers argues, on the contrary, that the subjective feel of our experience is fully explicable in naturalistic terms. Drawing on a variety of interdisciplinary resources, he develops (...) and defends a novel account in terms of higher-order thought. He shows that this can explain away some of the more extravagant claims made about phenomenal consciousness, while substantively explaining the key subjectivity of our experience. Written with characteristic clarity and directness, and surveying a wide range of extant theories, this book is essential reading for all those within philosophy and psychology interested in the problem of consciousness. (shrink)

Neuroscientists now approach some of the deepest problems of the human condition - from illnesses and disorders such as Alzheimer's disease and schizophrenia, to the search for the nature of consciousness itself - in the belief that their science can say something useful about these processes and how to intervene in them. At the same time, by addressing the biological mechanisms involved in phenomena as varied as street violence, drug addiction and sexual orientation, the new science raises profound ethical, legal, (...) social and medical questions. Over many of these issues there is no clear consensus but rather, intense debate. Is memory a molecular process? Is schizophrenia a genetic disorder? What does the future hold for psychopharmacology? Can consciousness be computed and is artificial intelligence a real prospect? From Brains to Consciousness? brings together fourteen of the world's leading neuroscientists, psychologists, computer modellers and philosophers, in a series of chapters that offer fascinating and up-to-the-minute insight into the debates that are taking place in this exciting area of research. (shrink)

Spaces in the brain can refer either to psychological spaces, which are derived from similarity judgments, or to neurocognitive spaces, which are based on the activities of neural structures. We want to show how psychological spaces naturally emerge from the underlying neural spaces by dimension reductions that preserve similarity structures and the relevant categorizations. Some neuronal representational formats that may generate the psychological spaces are presented, compared and discussed in relation to the mathematical principles of monotonicity, continuity and convexity. (...) In particular, we discuss the spatial structures involved in the connections between perception and action, for example eye-hand coordination, and argue that spatial organization of information makes such mappings more efficient. (shrink)

The Centered Mind offers a new view of the nature and causal determinants of both reflective thinking and, more generally, the stream of consciousness. Peter Carruthers argues that conscious thought is always sensory-based, relying on the resources of the working-memory system. This system enables sensory images to be sustained and manipulated through attentional signals directed at midlevel sensory areas of the brain. When abstract conceptual representations are bound into these images, we consciously experience ourselves as making judgments or (...) arriving at decisions. However, our amodal propositional attitudes are never actually among the contents of this stream of conscious reflection. Our beliefs, goals, and decisions are only ever active in the background of consciousness, working behind the scenes. They are never themselves conscious.Drawing on extensive knowledge of the scientific literature on working memory and related topics, Carruthers challenges the central assumptions of many philosophers. In addition to arguing that non-sensory propositional attitudes are never conscious, he also shows that they are never under direct intentional control. Written with his usual clarity and directness, The Centered Mind will be essential reading for all philosophers and cognitive scientists interested in the nature of human thought processes. (shrink)

Several million people are treated with neuroleptic medications in North America each year. A large percentage of these patients develop a chronic neurologic disorder-tardive dyskinesia-characterized by abnormal movements of the voluntary muscles. Most cases are permanent and there is no known treatment. Evidence has been accumulating that the neuroleptics also cause damage to the highest centers of the brain, producing chronic mental dysfunction, tardive dementia and tardive psychosis. These drug effects may be considered a mental equivalent of tardive dyskinesia. (...) Relevant data are derived from human autopsies, brain imaging , neurophysical tests, and clinical research. That the neuroleptics can damage higher brain centers is confirmed by their known neurotoxicity and neurophysiological impact, animal autopsies, and a comparison to diseases that mimic neuroleptic effects, such as Huntington's chorea and lethargic encephalitis. Patients and the public should be informed of the danger of both tardive dyskinesia and tardive dementia. The mental health professions should severely limit the use of neuroleptics and develop safer and better alternatives to these dangerous substances. (shrink)

This paper presents arguments and evidence from psychology and neuroscience supporting Lipton’s 2004 claim that scientists create knowledge through an abductive process that he calls “Inference to the Best Explanation”. The paper develops two conclusions. Conclusion 1 is that without conscious effort on our part, our brains use a process very similar to abduction as a powerful way of interpreting sensory information. To support Conclusion 1, evidence from psychology and neuroscience is presented that suggests that what we humans perceive through (...) our senses is not reality, but rather, our ‘brain’s “best guess” of the causes of its sensory input. The implication of this best guessing is that our brains use a process very similar to abduction throughout our lives to inform us of what is happening in the world around us. In addition, an argument based on Darwinian evolution is presented claiming that our brains do an excellent job of interpreting sensory information from the outside world. (If they did not, we, as a species, could hardly have survived.) Combining these two claims leads to Conclusion 1. Building on Conclusion 1, Conclusion 2 is that Lipton and others are correct in claiming that scientists use abduction when creating scientific theories. Abduction must be strong, because Nature chose abduction for its own sensemaking purposes. This paper’s contribution to knowledge is in pointing out that recent psychological and neuroscientific research has major implications for the philosophical world’s confidence in the probable validity of abductive inference. The punchline is simple: Nature chose abduction! (shrink)

Augmentative and alternative communication brain-computer interface systems are intended to offer communication access to people with severe speech and physical impairment without requiring volitional movement. As the field moves toward clinical implementation of AAC-BCI systems, research involving participants with SSPI is essential. Research has demonstrated variability in AAC-BCI system performance across users, and mixed results for comparisons of performance for users with and without disabilities. The aims of this systematic review were to describe study, system, and participant characteristics reported (...) in BCI research, summarize the communication task performance of participants with disabilities using AAC-BCI systems, and explore any differences in performance for participants with and without disabilities. Electronic databases were searched in May, 2018, and March, 2021, identifying 6065 records, of which 73 met inclusion criteria. Non-experimental study designs were common and sample sizes were typically small, with approximately half of studies involving five or fewer participants with disabilities. There was considerable variability in participant characteristics, and in how those characteristics were reported. Over 60% of studies reported an average selection accuracy ≤70% for participants with disabilities in at least one tested condition. However, some studies excluded participants who did not reach a specific system performance criterion, and others did not state whether any participants were excluded based on performance. Twenty-nine studies included participants both with and without disabilities, but few reported statistical analyses comparing performance between the two groups. Results suggest that AAC-BCI systems show promise for supporting communication for people with SSPI, but they remain ineffective for some individuals. The lack of standards in reporting outcome measures makes it difficult to synthesize data across studies. Further research is needed to demonstrate efficacy of AAC-BCI systems for people who experience SSPI of varying etiologies and severity levels, and these individuals should be included in system design and testing. Consensus in terminology and consistent participant, protocol, and performance description will facilitate the exploration of user and system characteristics that positively or negatively affect AAC-BCI use, and support innovations that will make this technology more useful to a broader group of people.Clinical trial registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42018095345, PROSPERO: CRD42018095345. (shrink)

The discrepancy between syntax and semantics is a painstaking issue that hinders a better comprehension of the underlying neuronal processes in the human brain. In order to tackle the issue, we at first describe a striking correlation between Wittgenstein's Tractatus, that assesses the syntactic relationships between language and world, and Perlovsky's joint language-cognitive computational model, that assesses the semantic relationships between emotions and “knowledge instinct”. Once established a correlation between a purely logical approach to the language and computable psychological (...) activities, we aim to find the neural correlates of syntax and semantics in the human brain. Starting from topological arguments, we suggest that the semantic properties of a proposition are processed in higher brain's functional dimensions than the syntactic ones. In a fully reversible process, the syntactic elements embedded in Broca's area project into multiple scattered semantic cortical zones. The presence of higher functional dimensions gives rise to the increase in informational content that takes place in semantic expressions. Therefore, diverse features of human language and cognitive world can be assessed in terms of both the logic armor described by the Tractatus, and the neurocomputational techniques at hand. One of our motivations is to build a neuro-computational framework able to provide a feasible explanation for brain's semantic processing, in preparation for novel computers with nodes built into higher dimensions. (shrink)

CHAPTER A Phenomenological Introduction to the Cognitive Neuroscience of Consciousness Peter G. Grossenbacher National Institute of Mental Health What is ...

Hank Greely’s target article, “Human Brain Surrogates Research: The Onrushing Ethical Dilemma” reviews the manifold scientific and ethical questions surrounding models of human brains used i...

The article considers patterns of reactivity in organ systems mediated by the autonomic nervous system as they relate to central neural circuits activated by affectively arousing cues. The relationship of these data to the concept of discrete emotion and their relevance for the autonomic feedback hypothesis are discussed. Research both with animal and human participants is considered and implications drawn for new directions in emotion science. It is suggested that the proposed brain-based view has a greater potential for scientific (...) advance than the traditional model that emphasizes specific states of mind as mediators or reflectors of visceral action. (shrink)

The problem of explaining the mind persists essentially unchanged today since the time of Plato and Aristotle. For the ancients, of course, it was not a question of the relation of mind to brain, though the question was fundamentally the same nonetheless. For Plato, the mind was conceived as distinct from the body and was posited in order to explain knowledge which transcends that available to the senses. For his successor, Aristotle, the mind was conceived as intimately related to (...) the body as form is related to substance. On this conception, the mind is an abstract property or condition of the body itself -. (shrink)

First of all, we would like to gratefully thank all commentators for the attention and effort they have put into reading and responding to our review paper [this issue] and for useful observations that suggest novel applications for our framework. We understand and accept that some of our claims might appear controversial and raise skepticism, because the overall neural framework we have proposed is difficult to frame in established categories, given its strong multidisciplinary character. To make an example, Elsevier is (...) publishing the British Neuroscience Association (BNA) 2017 Special Issue Collection. However, our paper could not fully fit in any of their Special Issues—attention, motivation, behavior; sensory and motor systems; novel treatments and translational neuroscience; genetics and epigenetics; learning and memory; neurodegenerative disorders and ageing; developmental neuroscience; neuronal, glial and cellular mechanisms; neuroendocrine and autonomic nervous systems; psychiatry and mental health; methods and techniques. Perhaps because our paper was mathematically, physically, biologically (neuroscientifically), and phenomenologically motivated from the start? Nevertheless, venturing in novel, fresh, testable proposals is badly needed in contemporary neuroscience, so to break into “the utter darkness of the inner mechanism of psychic acts… during the production of the concomitant phenomena of perception and thought, namely, feelings, consciousness and volition”—as Cajal had already observed in his opus magnus ‘Textura’. But as he soberly confessed: “This ideal is still very distant” (Ramon y Cajal, 1899-1904, p. 1,141). In the pursuit of that very ideal, neuroscience and psychology have had, and continue to have, a plethora of movements and schools of thought: behaviorism, cognitivism, neural Darwinism, social constructivism, Bayesian optimization...In our paper, we propose to go a step further, via the notion of topodynamics, towards “projectionism.” In what follows, trying to elucidate the main features of this Emperor’s new clothing, we proceed with the responses to the comments received. (shrink)

Dynamic systems theory offers conceptual andmathematical tools for describing the performance ofneural systems at very different levels oforganization. Three aspects of the dynamic paradigmare discussed, namely neural rhythms, neural andmental development, and macroscopic brain theories andmodels.

How does the brain go about the business of being conscious? Though we cannot yet provide a complete answer, this book explains what is now known about the neural basis of human consciousness.The last decade has witnessed the dawn of an exciting new era of cognitive neuroscience. For example, combination of new imaging technologies and experimental study of attention has linked brain activity to specific psychological functions. The authors are leaders in psychology and neuroscience who have conducted original (...) research on consciousness. They wish to communicate the highlights of this research to both specialists and interested others, and hope that this volume will be read by students concerned with the neuroscientific underpinnings of subjective experience. As a whole, the book progresses from an overview of conscious awareness, through careful explanation of identified neurocognitive systems, and extends to theories which tackle global aspects of consciousness. (Series B). (shrink)

We clarify the arguments in Neural organization: Structure, function, and dynamics, acknowledge important contributions cited by our critics, and respond to their criticisms by charting directions for further development of our integrated approach to theoretical and empirical studies of neural organization. We first discuss functional organization in general (behavior versus cognitive functioning, the need to study body and brain together, function in ontogeny and phylogeny) and then focus on schema theory (noting that schema theory is not just a top-down (...) theory and discussing the transition from action-oriented perception to cognition). We then turn to dynamical organization, with a focus first on neural modeling and dynamics (clarifying the multiple functions of neurons and brain regions, and looking further at various forms of dynamics) and second on learning, development, and self-organization (looking at monoaminergic systems, reinforcement, self-organization, postnatal development, and disease). We close with a brief philosophical discussion of postmodernism and reductionism. (shrink)

Neural organization describes an approach to analyzing neural function in anatomically defined subsystems in the brain, the hippocampus, cerebellum, sensory systems, thalamus, basal ganglia, and cerebral cortex, combining information on neurocircuitry with mathematical models that link structure with function. It is an up-to-date source on the major schemes and background for neural modeling of the central nervous system and is combined with a Web site that includes tutorials and on-line modeling possibilities.