Many of our most important goals require months or even years of effort to achieve, and some never get achieved at all. As social psychologists have lately emphasized, success in pursuing such goals requires the capacity for perseverance, or "grit." Philosophers have had little to say about grit, however, insofar as it differs from more familiar notions of willpower or continence. This leaves us ill-equipped to assess the social and moral implications of promoting grit. We propose that grit has an (...) important epistemic component, in that failures of perseverance are often caused by a significant loss of confidence that one will succeed if one continues to try. Correspondingly, successful exercises of grit often involve a kind of epistemic resilience in the face of failure, injury, rejection, and other setbacks that constitute genuine evidence that success is not forthcoming. Given this, we discuss whether and to what extent displays of grit can be epistemically as well as practically rational. We conclude that they can be (although many are not), and that the rationality of grit will depend partly on features of the context the agent normally finds herself in. In particular, grit-friendly norms of deliberation might be irrational to use in contexts of severe material scarcity or oppression. (shrink)

The Limits of Free Will presents influential articles by Paul Russell concerning free will and moral responsibility. The problems arising in this field of philosophy, which are deeply rooted in the history of the subject, are also intimately related to a wide range of other fields, such as law and criminology, moral psychology, theology, and, more recently, neuroscience. These articles were written and published over a period of three decades, although most have appeared in the past decade. Among the (...) topics covered: the challenge of skepticism; moral sentiment and moral capacity; necessity and the metaphysics of causation; practical reason; free will and art; fatalism and the limits of agency; moral luck, and our metaphysical attitudes of optimism and pessimism. (shrink)

Suppose some person 'A' sets out to accomplish a difficult, long-term goal such as writing a passable Ph.D. thesis. What should you believe about whether A will succeed? The default answer is that you should believe whatever the total accessible evidence concerning A's abilities, circumstances, capacity for self-discipline, and so forth supports. But could it be that what you should believe depends in part on the relationship you have with A? We argue that it does, in the case where A (...) is yourself. The capacity for "grit" involves a kind of epistemic resilience in the face of evidence suggesting that one might fail, and this makes it rational to respond to the relevant evidence differently when you are the agent in question. We then explore whether similar arguments extend to the case of "believing in" our significant others -- our friends, lovers, family members, colleagues, patients, and students. (shrink)

What, if anything, is fanaticism? Philosophers including Locke, Hume, Shaftesbury, and Kant offered an account of fanaticism, analyzing it as (1) unwavering commitment to an ideal, together with (2) unwillingness to subject the ideal (or its premises) to rational critique and (3) the presumption of a non-rational sanction for the ideal. In the first part of the paper, I explain this account and argue that it does not succeed: among other things, it entails that a paradigmatically peaceful and tolerant individual (...) can be a fanatic. The following sections argue that the fanatic is distinguished by four features: (4) the adoption of sacred values; (5) the need to treat these values as unconditional in order to preserve a particular form of psychic unity; (6) the sense that the status of these values is threatened by lack of widespread acceptance; and (7) the identification with a group, where the group is defined by shared commitment to the sacred values. If the account succeeds, it not only reveals the nature of fanaticism, but also uncovers a distinctive form of ethical critique: we can critique a way of understanding values not on the grounds that it is false, but on the grounds that it promotes a particular form of social pathology. (shrink)

The immediate aim of this paper is to articulate the essential features of an alternative compatibilist position, one that is responsive to sources of resistance to the compatibilist program based on considerations of fate and luck. The approach taken relies on distinguishing carefully between issues of skepticism and pessimism as they arise in this context. A compatibilism that is properly responsive to concerns about fate and luck is committed to what I describe as free will pessimism, which is to be (...) distinguished from free will skepticism. Free will skepticism is the view that our vulnerability to conditions of fate and luck serve to discredit our view of ourselves as free and responsible agents. Free will pessimism rejects free will scepticism, since the basis of its pessimism rests with the assumption that we are free and responsible agents who are, nevertheless, subject to fate and luck in this aspect of our lives. According to free will pessimism, all the major parties and positions in the free will debate, including that of skepticism, are modes of evasion and distortion regarding our human predicament in respect of agency and moral life. (shrink)

In this work, Paul Bartha proposes a normative theory of analogical arguments and raises questions and proposes answers regarding the criteria for evaluating analogical arguments, the philosophical justification for analogical reasoning, and the place of scientific analogies in the context of theoretical confirmation.

Various sexist and racist beliefs ascribe certain negative qualities to people of a given sex or race. Epistemic allies are people who think that in normal circumstances rationality requires the rejection of such sexist and racist beliefs upon learning of many counter-instances, i.e. members of these groups who lack the target negative quality. Accordingly, epistemic allies think that those who give up their sexist or racist beliefs in such circumstances are rationally responding to their evidence, while those who do not (...) are irrational in failing to respond to their evidence by giving up their belief. This is a common view among philosophers and non-philosophers. But epistemic allies face three problems. First, sexist and racist beliefs often involve generic propositions. These sorts of propositions are notoriously resilient in the face of counter-instances since the truth of generic propositions is typically compatible with the existence of many counter-instances. Second, background beliefs can enable one to explain away counter-instances to one’s beliefs. So even when counter-instances might otherwise constitute strong evidence against the truth of the generic, the ability to explain the counter-instances away with relevant background beliefs can make it rational to retain one’s belief in the generic despite the existence of many counter-instances. The final problem is that the kinds of judgements epistemic allies want to make about the irrationality of sexist and racist beliefs upon encountering many counter-instances is at odds with the judgements that we are inclined to make in seemingly parallel cases about the rationality of non-sexist and non-racist generic beliefs. Thus epistemic allies may end up having to give up on plausible normative supervenience principles. All together, these problems pose a significant prima facie challenge to epistemic allies. In what follows I explain how a Bayesian approach to the relation between evidence and belief can neatly untie these knots. The basic story is one of defeat: Bayesianism explains when one is required to become increasingly confident in chance propositions, and confidence in chance propositions can make belief in corresponding generics irrational. (shrink)

The historical development of the understanding of water is traced in the light of the development of the general concept of chemical substance. From the times of the earliest known ancient Greek philosophers, water has played a central role in the conception of the material constitution of the world. But it was Aristotle who developed the most sophisticated understanding of water to have come down to us from the ancients. He viewed it as part of an intricate and systematic theory (...) of chemical substance, which classified water as an element along with earth, fire and air. His view exerted a considerable influence on Arabic and European thinkers throughout the Middle Ages, and wasn’t successfully challenged until the eighteenth century. After Lavoisier, it was recognised that water, though unlike air a single substance and not a mixture, is neither an element nor always liquid. General features of chemical substances, distinguishing elements, compounds and mixtures, were elaborated in a general theory and harmonised with the mechanical features of matter towards the end of the nineteenth century. Finally, the continuous conception of matter underlying the Aristotelian view, which had been unsuccessfully challenged in the seventeenth century, was definitely overturned in the twentieth century, and the intricate microstructure of water was revealed. (shrink)

As you face a life-defining change, you might ask yourself: Who will I become? This can be understood as a question about the nature and character of your future life, asked from your first person, or subjective, perspective. The nature and character of your conscious, first person, lived experience is a defining constituent of what it is like to be you. Framed this way, knowing the nature of your future lived experience is a way of knowing your future self. In (...) this paper, I explore this way of understanding one’s self and its implications for understanding life-defining changes in high-stakes contexts. My exploration of this way of understanding one’s self highlights the role of experience in grasping perceptual truths, and the importance of imagination, empathy, and testimony in self-understanding and prediction. (shrink)

I challenge the common picture of the “Standard Story” of Action as a neutral account of action within which debates in normative ethics can take place. I unpack three commitments that are implicit in the Standard Story, and demonstrate that these commitments together entail a teleological conception of reasons, upon which all reasons to act are reasons to bring about states of affairs. Such a conception of reasons, in turn, supports a consequentialist framework for the evaluation of action, upon which (...) the normative status of actions is properly determined through appeal to rankings of states of affairs as better and worse. This covert support for consequentialism from the theory of action, I argue, has had a distorting effect on debates in normative ethics. I then present challenges to each of these three commitments, a challenge to the first commitment by T.M. Scanlon, a challenge to the second by recent interpreters of Anscombe, and a new challenge to the third commitment that requires only minimal and prima facie plausible modifications to the Standard Story. The success of any one of the challenges, I demonstrate, is sufficient to block support from the theory of action for the teleological conception of reasons and the consequentialist evaluative framework. I close by demonstrating the pivotal role that such arguments grounded in the theory of action play in the current debate between evaluator-relative consequentialists and their critics. (shrink)

A basic challenge to naturalistic moral realism is that, even if moral properties existed, there would be no way to naturalistically represent or track them. Here, the basic structure for a tracking account of moral epistemology is given in empirically respectable terms, based on a eudaimonist conception of morality. The goal is to show how this form of moral realism can be seen as consistent with the details of evolutionary biology as well as being amenable to the most current understanding (...) of representationalist or correspondence theories of truth. (shrink)

Teleological theories of reason and value, upon which all reasons are fundamentally reasons to realize states of affairs that are in some respect best, cannot account for the intuition that victims in non-identity cases have been wronged. Many philosophers, however, reject such theories in favor of alternatives that recognize fundamentally non-teleological reasons, second-personal reasons that reflect a moral significance each person has that is not grounded in the teleologist’s appeal to outcomes. Such deontological accounts appear to be better positioned to (...) identify the wrong committed against non-identity victims because a person wrongs another on such accounts if she violates his second-personal claims -- overall benefit to victims presents no obstacle to the identification of second-personal wrongdoing. Derek Parfit argues that non-identity is a problem for these deontological theories as well because the alleged victims are properly understood as consenting to the action in question, thereby waiving any such second-personal claim. But his arguments misrepresent the role of consent on such theories by articulating it through appeal to the very teleological theory of reasons that their advocates dismiss as inadequate. Properly understood, Parfit’s appeal to consent understood as retroactive endorsement only provides the answer on such deontological accounts to the question of whether, given that the non-identity victim is second-personally wronged, he is nonetheless better off existing. Indeed, it becomes clear that it is teleological theories for which non-identity poses a particular problem: they cannot -- while their deontological counterparts can – account for the intuition that non-identity victims have been wronged. (shrink)

“Because those who come after us may not be like us, or because those like us may not come after us, or because after a time there may be none to come after us, mankind must now set to work to insure that those who come after us will be more unlike us. In this there is at work the modern intellect’s penchant for species suicide.” With these words Paul Ramsey brings to a conclusion his provocative and surprising study (...) of the problems we are encountering – and will encounter – as scientific advances make the genetic control of man a real possibility. Now, increased knowledge of chromosome structure has taken the alteration of the human race out of the realm of science fiction and placed it in the hands of laboratory scientists. Ramsey sees this advance in science and technology as a mixed blessing. He examines the ramifications of genetic control, not only the now common measures of birth control and artificial insemination, but also the effect on the genetic pool of the increasing numbers of genetically poor individuals. His concern for humanistic values informs each argument as he tackles such issues as asexual reproduction of men, frozen semen banks, and the breeding of human beings for special purposes. No less than the future of man as we know him hangs on these issues. One must pay particular attention to this book. (shrink)

Philosophical food ethics or deliberative inquiry into the moral norms for production, distribution and consumption of food is contrasted with food ethics as an international social movement aimed at reforming the global food system. The latter yields an activist orientation that can become embroiled in self-defeating impotency when the complexity and internal contradictions of the food system are more fully appreciated. However, recent work in intersectionality offers resources that are useful to both philosophical and activist food ethics. For activists, intersectionality (...) provides a way to preserve and strengthen the meaningfulness of protest and resistance, even in the face of complexity and uncertain outcomes. For philosophers, intersectionality chastens the tendency to regard moral problems as inherently solvable, and provides a way use tensions inherent in food system reform as a source of ethical insight. (shrink)

This handbook presents a comprehensive introduction to the core areas of philosophy of education combined with an up-to-date selection of the central themes. It includes 95 newly commissioned articles that focus on and advance key arguments; each essay incorporates essential background material serving to clarify the history and logic of the relevant topic, examining the status quo of the discipline with respect to the topic, and discussing the possible futures of the field. The book provides a state-of-the-art overview of philosophy (...) of education, covering a range of topics: Voices from the present and the past deals with 36 major figures that philosophers of education rely on; Schools of thought addresses 14 stances including Eastern, Indigenous, and African philosophies of education as well as religiously inspired philosophies of education such as Jewish and Islamic; Revisiting enduring educational debates scrutinizes 25 issues heavily debated in the past and the present, for example care and justice, democracy, and the curriculum; New areas and developments addresses 17 emerging issues that have garnered considerable attention like neuroscience, videogames, and radicalization. The collection is relevant for lecturers teaching undergraduate and graduate courses in philosophy of education as well as for colleagues in teacher training. Moreover, it helps junior researchers in philosophy of education to situate the problems they are addressing within the wider field of philosophy of education and offers a valuable update for experienced scholars dealing with issues in the sub-discipline. Combined with different conceptions of the purpose of philosophy, it discusses various aspects, using diverse perspectives to do so. (shrink)

Ronald Giere has argued that at its best science gives us knowledge only from different “perspectives,” but that this knowledge still counts as scientific realism. Others have noted that his “perspectival realism” is in tension with scientific realism as traditionally understood: How can different, even conflicting, perspectives give us what there is really? This essay outlines a program that makes good on Giere’s idea with a fresh understanding of “realism” that eases this tension.

Testimony is a source of knowledge. On many occasions, the explanation of one’s knowing that p is that a speaker, S, told one that p. Our testimonial sources—the referents of ‘S’—can be other individuals, and they can be collectives; that is, in addition to learning from individuals, we learn things from committees, commissions, councils, clubs, teams, research groups, departments, administrations, churches, states and other social groups. North Korea might make a declaration about its missile programme, the church about the ordination (...) of women priests, the council about its deficit, the research group about its findings, and so on. We will look at a few examples in detail shortly, but the starting point is that social groups can be a source of testimony, and we can learn things from such collective testimony. The question this paper pursues is, what explains our learning that p from collective testimony to p? (shrink)

Many philosophers claim that ‘ought’ implies ‘can’. In light of recent empirical evidence, however, some skeptics conclude that philosophers should stop assuming the principle unconditionally. Streumer, however, does not simply assume the principle’s truth; he provides arguments for it. In this article, we argue that his arguments fail to support the claim that ‘ought’ implies ‘can’.

In GS, Nietzsche utters for the first time the paradoxical formula that sums up a good deal of his ethical thought: "What does your conscience say?—'You should become who you are'".1 The paradox, of course, lies in the odd juxtaposition of becoming and being: how can one become what one already is? Nietzsche repeats the formula toward the end of the original edition of GS, connecting it explicitly to the idea of self-creation: "We, however, want to become who we are—human (...) beings who are new, unique, incomparable, who give themselves laws, who create themselves!". What exactly such self-creation involves for Nietzsche, how it relates to "who we are," and whether it ultimately coheres as a... (shrink)

I modify and generalize Carnap’s notion of frameworks as a way of unpacking Goodman’s metaphor of “making worlds with symbols”. My frameworks provide, metaphorically, a way of making worlds out of symbols in as much as all our framework-bound access to the world is through frameworks that always stand to be improved in accuracy, precision, and usually both. Such improvement is characterized in pragmatist terms.

Objects partially resemble when they are alike in some way but not entirely alike. Partial resemblance, then, involves similarity in a respect. It has been observed that talk of “respects” appears to be thinly‐veiled talk of properties. So some theorists take similarity in a respect to require property realism. I will go a step further and argue that similarity in intrinsic respects (partial intrinsic resemblance) requires properties to be immanent in objects. For a property to be immanent in an object (...) is roughly for it to be wholly present in that object. (So understood, immanence does not imply repeatability, and thus tropes count as immanent.) If two objects are intrinsically similar in one way but not another, there must be a difference between the two ways. And if the similarity is between the objects as they are in themselves, then this difference, too, must be within the objects. Partial intrinsic resemblance thus requires internal structure. Without it, there can be no distinctions between ways in which things are intrinsically alike and ways in which they aren't. I will argue, further, that distinctions between properties that transcend objects fail to account for the possibility of partial intrinsic resemblance. (shrink)

_ Source: _Volume 31, Issue 1, pp 75 - 92 The aim of this article is to explore some of what Hobbes says in _Leviathan_ about what the Leviathan is. I propose that Hobbes is not finally clear on this score. Nonetheless, such indeterminacy might be revealing, insofar as it points us in different directions regarding how the state can be conceptualized, and what it is thought able to do. The paper is thus deliberately open ended: it does not aim (...) to definitively settle interpretative issues, but rather to use Hobbes as a way of thinking about the differing potentials of state theory. (shrink)

Climate scientists and activists face the disturbing truths of climate change every day. How do they manage this psychologically? In-depth qualitative interviews with a small sample from these two groups suggest that scientists often take refuge in conventional understandings of scientific rationality in their attempts to defend themselves against anxieties generated by the politicisation of climate change. By contrast, activists seem more emotionally literate, building psychological support into their practice. We trace some of the dysfunctional effects of the social defences (...) adopted by the scientific community, and demonstrate how a different approach has led to the development of what might be called ‘sustainable activism’. (shrink)

Aristotelian ideas are presented in a favorable light in Duhem's historical works surveying the history of the notion of chemical combination (1902) and the development of mechanics (1903). The importance Duhem was later to ascribe to Aristotelian ideas as reflected in the weight he attached to medieval science is well known. But the Aristotelian influence on his own mature philosophical perspective, and more particularly on his concern for logical coherence and the development of his ontological views, is not generally acknowledged. (...) There are, however, clear pointers in this direction in these two earlier books on the history of science, which are unashamedly written in such a way as to project the author's own view of what is important in the relevant areas. Thermodynamics was the pinnacle of Duhemian science, and its interpretation requires the reinstatement, in Duhem's view, of Aristotelian conceptions which have been unfashionable since the rise of certain ideas with the scientific revolution of the seventeenth century. The present paper is not primarily an exposition of these Aristotelian views of Duhem's, but an attempt to pursue the interpretation of a macroscopic, thermodynamical perspective on chemical substances from an elementary viewpoint in the spirit of Duhem (1902), sometimes being more definite than Duhem seems to be, and occasionally taking issue with him on certain points. Some of his leading ideas will determine the general approach, but views and problems will also be taken from modern textbooks in an attempt to lay down the general lines along which an explicit ontology--in Quine's sense--of macroscopic theory might be developed. (shrink)

The emergence of large-scale social media systems, such as Wikipedia, Facebook, and Twitter, has given rise to a new multi-disciplinary effort based around the concept of social machines. For the most part, this research effort has limited its attention to the study of Web-based systems. It has also, perhaps unsurprisingly, tended to highlight the social scientific relevance of such systems. The present paper seeks to expand the scope of the social machine research effort to encompass the Internet of Things. One (...) advantage of this expansion is that it helps to reveal some of the links between the science of social machines and the sciences of the mind. A second advantage is that it furthers our conceptual understanding of social machines and supports the quest to derive a philosophically-robust definition of the term “social machine.” The results of the present analysis suggest that social machines are best conceived as systems in which a combination of social and technological elements play a role in the mechanistic realization of system-level phenomena. The analysis also highlights the relevance of cognitive science and the philosophy of mind to our general understanding of systems that transcend the cyber, physical, and social domains. (shrink)

In his famous Wager, Blaise Pascal offers the reader an argument that it is rational to strive to believe in God. Philosophical debates about this classic argument have continued until our own times. This volume provides a comprehensive examination of Pascal's Wager, including its theological framework, its place in the history of philosophy, and its importance to contemporary decision theory. The volume starts with a valuable primer on infinity and decision theory for students and non-specialists. A sequence of chapters then (...) examines topics including the Wager's underlying theology, its influence on later philosophical figures, and contemporary analyses of the Wager including Alan Hájek's challenge to its validity, the many gods objection, and the ethics of belief. The final five chapters explore various ways in which the Wager has inspired contemporary decision theory, including questions related to infinite utility, imprecise probabilities, and infinitesimals. (shrink)

For Kant, we cannot understand how to approach moral education without confronting the radical evil of humanity. But if we start out, as Kant thinks we do, from a morally corrupt state, how...

: This paper examines a claim defended by an unlikely pair: Friedrich Nietzsche and Iris Murdoch. The claim is that perceptual experience itself—as distinct from perceptually based judgments and beliefs—can be morally significant. In particular, Nietzsche and Murdoch hold that two agents in the same circumstances attending to the same objects can have experiences with different contents, depending on the concepts that they possess and employ. Moreover, they maintain that this renders perception an object of moral concern. This paper explicates (...) these claims, examines the way in which we might distinguish between better and worse perceptual experiences, and argues that if some version of the Murdochian/Nietzschean claim is accepted, then certain influential accounts of moral epistemology and agency must be rejected. (shrink)

Paul Ricoeur was one of the most important philosophers of the twentieth century. In this short and accessible book, he turns to a topic at the heart of much of his work: What is translation and why is it so important? Reminding us that The Bible, the Koran, the Torah and the works of the great philosophers are often only ever read in translation, Ricoeur reminds us that translation not only spreads knowledge but can change its very meaning. In (...) spite of these risk, he argues that in a climate of ethnic and religious conflict, the art and ethics of translation are invaluable. Drawing on interesting examples such as the translation of early Greek philosophy during the Renaissance, the poetry of Paul Celan and the work of Hannah Arendt, he reflects not only on the challenges of translating one language into another but how one community speaks to another. Throughout, Ricoeur shows how to move through life is to navigate a world that requires translation itself. Paul Ricoeur died in 2005. He was one of the great contemporary French philosophers and a leading figure in hermeneutics, psychoanalytic thought, literary theory and religion. His many books include Freud and Philosophy and Time and Narrative. (shrink)

(2002). Clarifying the Ethics of Clinical Research: A Path toward Avoiding the Therapeutic Misconception. The American Journal of Bioethics: Vol. 2, No. 2, pp. 22-23.

Journal Name: Apeiron Issue: Ahead of print.

One often hears a version of the following: “A poem is never finished, just abandoned.” I have always found this proposition irksome. The fact that Paul Valéry seems to be the source of it, in something like the above form, makes me feel a certain trepidation in writing this. But I do find myself thinking, when I hear people say that their poems are never finished, only abandoned: why don’t you just finish them? I want a poem to be (...) finished. But is this the same as demanding it be perfect? This article is resolutely opposed to perfection, whether it comes in poetry or any other art. I start by citing a passage from Kant, as a way of offering an initial sketch of that opposition. I then turn to two brief... (shrink)

This essay explores the mutual reinforcements between socioeconomic precarity and right-wing populism, and then envisions a politics that contests Trumpism through workers’ organizations that create alternatives to predominant patterns of subject formation through work. I first revisit my recent critique of precarity, which initiates a new method of critical theory informed by Paulo Freire’s political pedagogy of popular education. Reading migrant day laborers’ commentaries on their work experiences alongside critical accounts of today’s general work culture, this “critical-popular” procedure yields a (...) conception of precarity with two defining characteristics. First, precarity is socially bivalent: it singles out specific groups for especially harsh treatment even as it pervades society. Second, precarity constitutes subjects through contradictory experiences of time in everyday work-life, exacerbated by insoluble dilemmas of moral responsibility. Antonio Vásquez-Arroyo’s conception of “political literacy” and Bridget Anderson’s notion of “migrantizing the citizen,” in turn, help us understand how precaritization blocks workers from developing the critical dispositions toward time needed for democratic citizenship. This analysis then makes it possible to elucidate, in dialogue with Daniel Martinez-HoSang and Joseph Lowndes, how precaritized worker-citizenship facilitates the cross-class and multiracial appeal of Trumpism’s white supremacist discourse of national economic decline and resurgence, while normalizing the temporal affects of shock and violence characteristic of Trumpism, as theorized by Lia Haro and Romand Coles. Day laborers’ worker centers, I argue, refunction precaritized time, regenerate political literacy, and migrantize the citizen. A large-scale alternative to right-wing populism thus could emerge if the worker center network were expanded throughout the economy. (shrink)

From a modern point of view, compounds are contrasted with elements of which they are composed, and the two categories combine to give the category of substances. Mixtures, on the other hand, might be understood to contrast with pure substances (substances in isolation), so that mixtures are quantities of matter containing several substances (be they compounds or uncombined elements) whereas pure substances are understood to be quantities of matter exhausting the material contents of a region of space which contain only (...) one substance, and might be either a compound or an element. But heterogeneous quantities of matter (comprising several phases) might also be understood to be mixtures. Thus, it is common to speak of a mixture of ice, liquid water and water vapour in equilibrium at the triple point of water, although there is only a single substance present. The general concept of mixture as treated by Gibbs’ phase rule is a quantity of matter comprising either several substances or several phases, “or” being used in the inclusive sense. Gibbs’ phase rule is a relatively recent development in the history of the concept of chemical substance, dating from the latter half of the nineteenth century. The concepts and distinctions it presupposes have not always been apparent. I trace some of the important conceptual developments underlying the important distinctions at issue here from Aristotle, who didn’t distinguish either substance and phase, or what are now called compounds and solutions. (shrink)

Genomic research—including whole genome sequencing and whole exome sequencing—has a growing presence in contemporary biomedical investigation. The capacity of sequencing techniques to generate results that go beyond the primary aims of the research—historically referred to as “incidental findings”—has generated considerable discussion as to how this information should be handled—that is, whether incidental results should be returned, and if so, which ones.Federal regulations governing most human subjects research in the United States require the disclosure of “the procedures to be followed” in (...) the research as part of the informed consent process. It seems reasonable to assume—and indeed, many commentators have concluded—that genomic investigators will be expected to inform participants about, among other procedures, the prospect that incidental findings will become available and the mechanisms for dealing with them. Investigators, most of whom will not have dealt with these issues before, will face considerable challenges in framing meaningful disclosures for research participants.To help in this task, we undertook to identify the elements that should be included in the informed consent process related to incidental findings. We did this by surveying a large number of genomic researchers (n = 241) and by conducting in‐depth interviews with a smaller number of researchers (n = 28) and genomic research participants (n = 20). Based on these findings, it seems clear to us that routine approaches to informed consent are not likely to be effective in genomic research in which the prospect of incidental findings exists. Ensuring that participants’ decisions are informed and meaningful will require innovative approaches to dealing with the consent issue. We have identified four prototypical models of a consent process for return of incidental findings. (shrink)