In this article I argue that the method of normative reconstruction that is underlying Freedom’s Right undermines Critical Theory’s aspiration to be a force that is unreservedly critical and progressive. I start out by giving a brief account of the four premises of the method of normative reconstruction and unpack their implications for how Honneth conceptualizes social pathologies and misdevelopments, specifically that these notions are no longer linked to radical critique and normative revolution. In the second part, I demonstrate (...) that abandoning forms of radical critique and normative revolution is internally linked to adopting this method, before arguing that Freedom’s Right entails no resources to account for why abandoning them does not amount to a deficiency. In the final part, I point out two problematic implications of turning away from radical critique and normative revolution for the very project Honneth pursues in Freedom’s Right. I show that Honneth’s own view about the limited scope of application of the method of normative reconstruction and his account of the dangers associated with social misdevelopments give us reasons to consider this method to be incomplete. Finally, I contend that the explanatory power of Freedom’s Right is dubious because methodological premises that form part of normative reconstruction lead Honneth to ignore relevant alternative explanations of processes of deviation and disassociation from norms of social freedom, which he characterizes as social misdevelopments. (shrink)

The Pathology of Man is the first comprehensive study of the psychology and epistemology of human evil, long urged by leading psychiatrists and psychologists, including Freud, Jung, Menninger, Fromm, and Peck. The book breaks new ground by offering a clear, empirically based, and theoretically sound understanding of human evil as a widespread, real, non-metaphorical pathology. With deliberate and thorough scholarship the author proposes a new framework-relative theory of disease and justifies the provocative thesis that human evil should be classified as (...) a pathology which is not a deviation from an accepted norm, but rather is a normal state. This break with tradition provides the necessary psychological foundation for the familiar concept of the banality of human evil, a foundation which in the past it has lacked. (shrink)

An original study of late Enlightenment aesthetics, poetics, and environmental medicine as overlapping ways of comprehending the dislocations of historical existence lodged in the movements of bodies and minds This book studies later eighteenth-century medicine, aesthetics, and poetics as overlapping forms of knowledge increasingly concerned about the relationship between the geographical movements of persons displaced from home and the physiological or nervous "motions" within their bodies and minds. Looking beyond familiar narratives about medicine and art's shared therapeutic and harmonizing ideals, (...) this book explores Enlightenment and Romantic-era aesthetics and poetics in relation to a central but less well known area of eighteenth-century environmental medicine: pathology. No mere system of diagnosis or classification, philosophical pathology was an art of interpretation, offering sophisticated ways of reading the multiple conditions and causes of disease, however absent from perception, in their palpable, embodied effects. For medical, anthropological, environmental, and literary authors alike, it helped to locate the dislocations of modern mobility when a full view of their causes and conditions remained imperfectly understood or still unfolding. Goodman traces the surprising afterlife of the period's exemplary but unexplained pathology of motion, medical nostalgia, within aesthetic theory and poetics, arguing that nostalgia persisted there not as a named condition but as a set of formal principles and practices, perturbing claims about the harmony, freedom, and free play of the mind. (shrink)

Pathological morphogenesis on leaves of Fraxinus ornus (ash) and Solanum lycopersicum (tomato) under the influence of mites (Aceria fraxinivora and Eriophyes cladophthirus respectively) leads to a range of structures whose morphology and development cannot be reduced to the classical categories of plant morphology, but present a heterogeneous continuum which links fundamental structural categories. These findings support the pyramid model of plant construction.

This is a penetrating reinterpretation and defense of Hegel's social theory as an alternative to reigning liberal notions of social justice. The eminent German philosopher Axel Honneth rereads Hegel's Philosophy of Right to show how it diagnoses the pathologies of the overcommitment to individual freedom that Honneth says underlies the ideas of Rawls and Habermas alike. Honneth argues that Hegel's theory contains an account of the psychological damage caused by placing too much emphasis on personal and moral freedom. Although (...) these freedoms are crucial to the achievement of justice, they are insufficient and in themselves leave people vulnerable to loneliness, emptiness, and depression. Hegel argues that people must also find their freedom or "self-realization" through shared projects. Such projects involve the three institutions of ethical life--family, civil society, and the state--and provide the arena of a crucial third kind of freedom, which Honneth calls "communicative" freedom. A society is just only if it gives all of its members sufficient and equal opportunity to realize communicative freedom as well as personal and moral freedom. (shrink)

This paper is an introduction to the special issue on Pathologies of Recognition. The first subsection briefly introduces the notion of recognition and trace its development from Fichte and Hegel to Honneth and his critics, and the second subsection turns to the concept of a social pathology. The third section provides a brief look at the individual papers. -/- The special issue focuses on two central concepts in contemporary critical social theory: namely ‘recognition’ and ‘social pathology’. For defenders of (...) a theory of recognition, adequate recognition is itself a key normative criterion for analysing social wrongs and pathologies which fall short of the ideal. For critics, the focus on recognition – even at its best – rather conceals social wrongs. While the contributors in this collection represent slightly different approaches, the general consensus amongst them is that recognition as such is a good ideal but like all good ideals it can go wrong in various ways and take pathological forms itself. In this introduction we focus first briefly on the concepts of recognition and social pathology, and finally present the papers of this special issue. (shrink)

This paper is a response to Christopher Boorse's recent defense of hisBiostatistical Theory (BST) of health and disease. Boorse maintains that hisconcept of theoretical health and disease reflects the ``consideredusage of pathologists.'' I argue that pathologists do not use ``disease'' inthe purely theoretical way that is required by the BST. Pathology does notdraw a sharp distinction between theoretical and practical aspects ofmedicine. Pathology does not even need a theoretical concept of disease. Itsfocus is not theoretical, but practical; pathology's goal is (...) to contribute tothe healing of patients. Pathology, even experimental pathology, is notvalue-free. Not only ``disease'' but also such terms as ``nerve'' and ``organ''are laden with conceptual values. (shrink)

Following the recent practice turn in privacy research, informational privacy is increasingly analyzed with regard to the “appropriate flow of information” within a given practice, which preserves the “contextual integrity” of that practice (Nissenbaum, 2010, p. 149; 2015). Such a practice-theoretical take on privacy emphasizes the normative structure of practices as well as its structural injustices and power asymmetries, rather than focusing on the intentions and moral considerations of individual or institutional actors. Since privacy norms are seen to be institutionalized (...) via the role obligations of the practice's participants, this approach can analyze structural and systematic privacy infringements in terms of “defective role performances and defective social relations” (Roessler & Mokrosinska, 2013, p. 780). -/- Unfortunately, it is still often somewhat unclear what this exactly means within the context of informational privacy, why these performances and relations are defective and for whom. This raises the common objection of a so-called “practice positivism” (Applbaum, 1999, p. 51), that is, the difficulty of practice–theoretical accounts to take a practice-independent standpoint, from which to normatively evaluate the existing practice norms themselves. For example, Nissenbaum herself initially argues for a “presumption in favor of the status quo” with respect to the appropriateness and flow of privacy norms within a practice (Nissenbaum, 2004, p. 127). Such a “practice conservatism” (Nissenbaum, 2010, p. 169) comes dangerously close to committing a naturalistic fallacy, if not undergirded by practice-external criteria (which is ultimately what she does). -/- Merely resorting to existing practice norms to assess what defective role performances amount to, only shifts the question from how to recognize an appropriate flow of information to the question of how to recognize those defective role performances and social relations. Against this backdrop, the central aim of this article is to shed light on this question without resorting to practice-independent first principles or far-reaching universalistic anthropological assumptions. For this, I will analyze the notion of “defective role performances and social relations” in terms of social pathologies.1 Doing so has two advantages: First of all, it can draw on already existing concepts and distinctions, which help to categorize the different levels of analysis that exist in informational privacy research and situate the notion of “defective role performances” within them (Section 1). Second, those concepts and distinctions can serve as a basis for establishing a typology of phenomena with regard to deficient practices of informational privacy (Section 4). (shrink)

Modern man's pathology of normalcy -- The concept of mental health -- Humanistic science of man -- Is man lazy by nature?.

Boyer & Lienard's (B&L's) biological model of ritual achieves a rather straightforward account of features shared by ritual pathology and the idiosyncratic rituals of children; but complexities accrue in extending it to human ritual culture generally. My commentary suggests that the ritual cultural traditions of animals such as songbirds share structural features, handicap-based origin, as well as the enabling neural mechanism of vocal learning with human ritual culture. (Published Online February 8 2007).

Pathologizing ugliness refers to the use of disease language and medical processes to foster and support the claim that undesirable features are pathological conditions requiring medical or surgical intervention. Primarily situated in cosmetic surgery, the practice appeals to the concept of “aesthetic pathology”, which is a medical designation for features that deviate from some designated aesthetic norms. This article offers a two-pronged conceptual analysis of aesthetic pathology. First, I argue that three sets of claims, derived from normativist and naturalistic accounts (...) of disease, inform the framing of ugliness as a disease. These claims concern: (1) aesthetic harms, (2) aesthetic dysfunction, and (3) aesthetic deviation. Second, I introduce the notion of a hybridization loop in medicine, which merges the naturalist and normative understanding of the disease that potentially enables pathologizing practices. In the context of cosmetic surgery, the loop simultaneously promotes the framing of beauty ideals as normal biological attributes and the framing of normal appearance as an aesthetic ideal to legitimize the need for cosmetic interventions. The article thus offers an original discussion of the conceptual problems arising from a specific practice in cosmetic surgery that depicts ugliness as the disease. (shrink)

In recent years, an array of critical emotion theorists have emerged who call for change with respect to how emotion theory is done, how emotions are understood, and how we do emotion. In this chapter, I draw on the work that some of these authors have produced to analyze how emotional marginalization of trans and disabled identities is experienced, considering in particular how this emotional marginalization results from the long history of pathologization of trans and disabled people. The past and (...) current pathologization of trans and disabled people is produced through normative assumptions, values, and beliefs that uphold systems of normalcy, including assumptions, values, and beliefs about how we feel and express emotions. In order to examine these issues, I identify three different stages at which emotional marginalization may take place: emotion experience, emotional display, and emotion recognition. In other words, emotional marginalization of trans and disabled people can occur at any of these stages. The central concern of my chapter is thus to show how emotional marginalization, at each of these stages, affects trans and disabled people. (shrink)

For denoting ill, abnormal, generally undesirable social phenomena the term social pathology is most often accepted. It embodies also the sanctioned forms of deviant behaviour and the study of the causal relations of their origin and existence. The difficulty with delimitating precisely what is pathological stems from the fact that we are not able to give a satisfactory definition of the normal. The normal cannot be identified with the mediocrity. The paper supports the view that the normality is opposite to (...) anomy. The analogy to pathologization is "medicinalization" stemming out from the principle that while a deviant person, e.g. an offender of a crime, is as a rule responsible for his deed, in other kinds of offences the offender is usually referred to as "ill" and while an ill person cannot be expected to be responsible for his/her deeds, he/she must be "cured" . In this way the person is not only disburdened of his/her deed, but also of his/her responsibility. A negative phenomenon accompanying the pathologization and medicinalization is d e p r i v i n g sociology, social pedagogy and social work of their competencies in favour of medicine or pathopsychology. As a result the remedy is reduced to "therapy" and "custody" with consequent labelling of the persons concerned. The author sees social pathology as a branch of sociology investigating negative phenomena which result from social deviation and which are to a decisive degree the subject matter of social work. (shrink)

In this post the author defends a pathology based approach to the philosophy of mind.

Girard’s attempts to present his main ideas have been numerous and, according to himself, never fully satisfying: many problems arise when looking for the best way to explain what Mimetic Theory is about, mainly because the order of the discourse and the logic of the underlying long argument, just as the micro level of the analysis and the macro one, are twisted with one another in a hermeneutical circle that can easily be misinterpreted as vicious. A thorough work of analysis (...) of the essential logical features of Mimetic Theory main hypotheses has been done by Jean–Pierre Dupuy. In what follows, we are going to use a few of his concepts in order to set the analysis of secularization and modernity and their consequences both at a micro level, dealing with modern pathologies, and at the macro one, investigating the displacement of the sacred. (shrink)

Pathological Altruism presents a number of new, thought-provoking theses that explore a range of hurtful effects of altruism and empathy.

Pathologies of agency affect both groups and individuals. I present a case study of agential pathology in a group, in which supposedly rogue members of a group act in light of what they take the group’s interests and attitudes to be, but in a way that goes against the group’s explicitly stated agential point of view. I consider several practical concerns brought out by rogue member action in the context of a group agent, focusing in particular on how it (...) undermines the agency of the group and whether or not the group agent itself may be responsible for it. (shrink)

This paper critically examines Christopher Zurn’s suggestion mentioned above that various social pathologies (pathologies of ideological recognition, maldistribution, invisibilization, rationality distortions, reification and institutionally forced self-realization) share the structure of being ‘second-order disorders’: that is, that they each entail ‘constitutive disconnects between first-order contents and secondorder reflexive comprehension of those contents, where those disconnects are pervasive and socially caused’ (Zurn, 2011, 345-346). The paper argues that the cases even as discussed by Zurn do not actually match that characterization, (...) but that it would be premature to conclude that they are not thereby social pathologies, or that they do not have a structure in common. It is just that the structure is more complex than originally described, covering pervasive socially caused evils (i) in the social reality, (ii) in the first order experiences and understandings, (iii) in the second order reflection as discussed by Zurn, and also (iv) in the ‘third order’ phenomenon concerning the pre-emptive silencing or nullification of social criticism even before it takes Place. -/- Research Interests: Critical Theory, Social Theory, Political Theory, Recognition - Social Pathologies, Axel Honneth, Mutual recognition and Dani Zubair . (shrink)

Axel Honneth has been instrumental in advancing the work of the Frankfurt School of critical theorists, rebuilding their effort to combine radical social and political analysis with rigorous philosophical inquiry. These eleven essays published over the past five years reclaim the relevant themes of the Frankfurt School, which counted Theodor W. Adorno, Max Horkheimer, Walter Benjamin, Jürgen Habermas, Franz Neumann, and Albrecht Wellmer as members. They also engage with Kant, Freud, Alexander Mitscherlich, and Michael Walzer, whose work on morality, history, (...) democracy, and individuality intersects with the Frankfurt School's core concerns. Collected here for the first time in English, Honneth's essays pursue the unifying themes and theses that support the methodologies and thematics of critical social theory, and they address the possibilities of continuing this tradition through radically changed theoretical and social conditions. According to Honneth, there is a unity that underlies critical theory's multiple approaches: the way in which reason is both distorted and furthered in contemporary capitalist society. And while much is dead in the social and psychological doctrines of critical social theory, its central inquiries remain vitally relevant. Is social progress still possible after the horrors of the twentieth century? Does capitalism deform reason and, if so, in what respects? Can we justify the relationship between law and violence in secular terms, or is it inextricably bound to divine justice? How can we be free when we're subject to socialization in a highly complex and in many respects unfree society? For Honneth, suffering and moral struggle are departure points for a new "reconstructive" form of social criticism, one that is based solidly in the empirically grounded, interdisciplinary approach of the Frankfurt School. (shrink)

Immanuel Kant’s aesthetics invites us to think the intensity of aesthetic contemplation as freeing the mind of its “pathological” subordination to desires and other empirical interests. For Kant, what is at stake in contemplation can never be understood as merely sensory: it involves a special disposition (Stimmung) that directs the mind to the supersensible, which he determines as the idea that transcends all sensibility. Beyond interpreting the domain of the ideal as an immaterial, self-sufficient realm, this collection of essays opens (...) up the question of its ‘life’, suggesting an interrelation with the pathological that is more intimate than Kant himself seems to have surmised. (shrink)

Pericytes, like vascular smooth muscle cells, are perivascular cells closely associated with blood vessels throughout the body. Pericytes are necessary for vascular development and homeostasis, with particularly critical roles in the brain, where they are involved in regulating cerebral blood flow and establishing the blood-brain barrier. A role for pericytes during neurovascular disease pathogenesis is less clear—while some studies associate decreased pericyte coverage with select neurovascular diseases, others suggest increased pericyte infiltration in response to hypoxia or traumatic brain injury. Here, (...) we used an endothelial loss-of-function Recombination signal binding protein for immunoglobulin kappa J region (Rbpj)/Notch mediated mouse model of brain arteriovenous malformation (AVM) to investigate effects on pericytes during neurovascular disease pathogenesis. We tested the hypothesis that pericyte expansion, via morphological changes, and Platelet-derived growth factor B/Platelet-derived growth factor receptor β (Pdgf-B/Pdgfrβ)-dependent endothelial cell-pericyte communication are affected, during the pathogenesis of Rbpj mediated brain AVM in mice. Our data show that pericyte coverage of vascular endothelium expanded pathologically, to maintain coverage of vascular abnormalities in brain and retina, following endothelial deletion of Rbpj. In Rbpj-mutant brain, pericyte expansion was likely attributed to cytoplasmic process extension and not to increased pericyte proliferation. Despite expanding overall area of vessel coverage, pericytes from Rbpj-mutant brains showed decreased expression of Pdgfrβ, Neural (N)-cadherin, and cluster of differentiation (CD)146, as compared to controls, which likely affected Pdgf-B/Pdgfrβ-dependent communication and appositional associations between endothelial cells and pericytes in Rbpj-mutant brain microvessels. By contrast, and perhaps by compensatory mechanism, endothelial cells showed increased expression of N-cadherin. Our data identify cellular and molecular effects on brain pericytes, following endothelial deletion of Rbpj, and suggest pericytes as potential therapeutic targets for Rbpj/Notch related brain AVM. (shrink)

This article provides a historical perspective on how both American and European psychiatrists have conceptualized and categorized sexual deviance throughout the past 150 years. During this time, quite a number of sexual preferences, desires, and behaviors have been pathologized and depathologized at will, thus revealing psychiatry's constant struggle to distinguish mental disorder--in other words, the "perversions," "sexual deviations," or "paraphilias"--from immoral, unethical, or illegal behavior. This struggle is apparent in the works of 19th- and early-20th-century psychiatrists and sexologists, but it (...) is also present in the more recent psychiatric textbooks and diagnostic manuals, such as the consecutive editions of the Diagnostic and Statistical Manual of Mental Disorders. While much of the historical literature revolves around the controversy over homosexuality, this article also reviews the recent medicohistorical and sociohistorical work on other forms of sexual deviance, including the diagnostic categories listed in the latest edition, the DSM-IV-TR: exhibitionism, voyeurism, fetishism, frotteurism, pedophilia, sexual masochism, sexual sadism, and transvestic fetishism. (shrink)

Benenson et al. provide a compelling case for treating greater investment into self-protection among females as an adaptive strategy. Here, we wish to expand their proposed adaptive explanation by placing it squarely in modern state-based and behavioural life-history theory, drawing on Veit'spathological complexityframework. This allows us to make sense of alternative “lifestyle” strategies, rather than pathologizing them.

Over the last two decades, Axel Honneth has written extensively on the notion of social pathology, presenting it as a distinctive critical resource of Frankfurt School Critical Theory, in which tradition he places himself, and as an alternative to the mainstream liberal approaches in political philosophy. In this paper, I review the developments of Honneth's writing on this notion and offer an immanent critique, with a particular focus on his recent major work "Freedom's Right". Tracing the use of, and problems (...) internal to, Honneth's concept of social pathology serves to demonstrate his increasing reformism. It also serves to catalogue some of the dead ends that Critical Theory should avoid in taking up the idea of social pathology. The implication is not that this idea should be dropped. Rather, the paper is undertaking the necessary step of clearing the ground for further progress to take place on the question of what role the idea of social pathology can and should play in Critical Theory. The paper is critical in nature (and relentlessly so), but ultimately serves a constructive purpose. (shrink)

Pathologizing ugliness refers to the framing of unattractive features as a type of disease or deformity. By framing ugliness as pathology, cosmetic procedures are reframed as therapy rather than enhancement, thereby potentially avoiding ethical critiques regularly levelled against cosmetic surgery. As such, the practice of pathologizing ugliness and the ensuing therapeuticalization of cosmetic procedures require an ethical analysis that goes beyond that offered by current enhancement critiques. In this article, I propose using a thick description of the goals of medicine (...) as an ethical framework for evaluating problematic medical practices. I first describe the goals of medicine based on Daniel Callahan's account. I then propose that the goals work best in conjunction with ancillary ethical concepts, namely medical knowledge and skills, standards of practice and medical duties and virtues. Next, I apply the thick description of the goals of medicine in critiquing the practice of framing ugliness as disease. Here, I demonstrate ethical conflicts between aesthetic judgments that underpin the practice of pathologizing ugliness and medical judgments that inform ethical medical practices. In particular, the thick description of the goals of medicine helps reveal ethical conflicts in at least three key domains common to clinical practices, which include (a) disease determination, (b) diagnostic evaluation and (c) establishing clinical indications. My analysis offers a novel way of critiquing the practice of pathologizing ugliness in cosmetic surgery, which tends to be neglected by enhancement critiques. (shrink)

Axel Honneth has been instrumental in advancing the work of the Frankfurt School of critical theorists, rebuilding their effort to combine radical social and political analysis with rigorous philosophical inquiry. These eleven essays published over the past five years reclaim the relevant themes of the Frankfurt School, which counted Theodor W. Adorno, Max Horkheimer, Walter Benjamin, Jürgen Habermas, Franz Neumann, and Albrecht Wellmer as members. They also engage with Kant, Freud, Alexander Mitscherlich, and Michael Walzer, whose work on morality, history, (...) democracy, and individuality intersects with the Frankfurt School's core concerns. Collected here for the first time in English, Honneth's essays pursue the unifying themes and theses that support the methodologies and thematics of critical social theory, and they address the possibilities of continuing this tradition through radically changed theoretical and social conditions. According to Honneth, there is a unity that underlies critical theory's multiple approaches: the way in which reason is both distorted and furthered in contemporary capitalist society. And while much is dead in the social and psychological doctrines of critical social theory, its central inquiries remain vitally relevant. Is social progress still possible after the horrors of the twentieth century? Does capitalism deform reason and, if so, in what respects? Can we justify the relationship between law and violence in secular terms, or is it inextricably bound to divine justice? How can we be free when we're subject to socialization in a highly complex and in many respects unfree society? For Honneth, suffering and moral struggle are departure points for a new "reconstructive" form of social criticism, one that is based solidly in the empirically grounded, interdisciplinary approach of the Frankfurt School. (shrink)

Bradley Armour-Garb and James A. Woodbridge, in Pretense and Pathology, make an ambitious and far-ranging case that philosophical fictionalism (particularly the pretence variety that they favour) illuminates several long-standing philosophical puzzles posed by words in ordinary language, such as ‘exist’, ‘true’ and ‘means that’, as well as the more technical, ‘refers to’, ‘proposition’ and ‘satisfies’. Along the way, Armour-Garb and Woodbridge discuss topics in the philosophy of language, philosophical logic, ontology, epistemology and more. An important aspect of their project is (...) its nominalist aspiration: by showing (if they do) that pretence is involved when we use the foregoing terms, they hope to show that it’s false that these uses induce ontological commitments (to, e.g., propositions or properties). In this respect, their pretence approach is yet another attempt to undercut the family of indispensability arguments (pioneered by W.V.O. Quine) that prima facie force ontological commitments by means of indispensable language usage. (shrink)

Aside from the systematic theory of recognition, Honneth’s work in the last decade has also centered around a less commented-upon theme: the critical social theoretic diagnosis of social pathologies. This paper claims first that his diverse diagnoses of specific social pathologies can be productively united through the conceptual structure evinced by second-order disorders, where there are substantial disconnects, of various kinds, between first-order contents and second-order reflexive understandings of those contents. The second major claim of the paper is (...) that once we understand social pathologies as second-order disorders, it becomes apparent that critical social theory must do more than accurately identify and explicate these disorders at the phenomenological and action-theoretic levels. It must further engage in insightful sociological explanations of the social causes of those pathologies in order to further the prognostic and therapeutic tasks implied by the aim of developing a social theory with emancipatory intent. The paper argues that the identificatory and explicative components of diagnostic social theory have been fulfilled by Honneth to a much greater degree than the latter components of explanation, prognosis and therapy. (shrink)

In Vagueness and Contradiction (2001), Roy Sorensen defends and extends his epistemic account of vagueness. In the process, he appeals to connections between vagueness and semantic paradox. These appeals come mainly in Chapter 11, where Sorensen offers a solution to what he calls the no-no paradox—a “neglected cousin” of the more famous liar—and attempts to use this solution as a precedent for an epistemic account of the sorites paradox. This strategy is problematic for Sorensen’s project, however, since, as we establish, (...) he fails to resolve the semantic pathology of the no-no paradox. (shrink)

The outbreak of a new, potentially fatal virus, SARS‐COV‐2, which started in December 2019 in Wuhan, China, and since developed into a pandemic has stimulated research for an effective treatment and vaccine. For this research to be successful, it is necessary to understand the pathology of the virus. So far, we know that this virus can harm different organs of the body. Although the exact mechanisms are still unknown, this phenomenon may result from the body's secretion of prostaglandin E2 (PGE2), (...) which is involved in several inflammation and immunity pathways. Noticeably, the expression of this molecule can lead to a cytokine storm causing a variety of side effects. In this paper, we discuss those side effects in SARS‐COV‐2 infection separately to determine whether PGE2 is, indeed, an important causative factor. Lastly, we propose a mechanism by which PGE2 production increases in response to COVID‐19 disease and suggest the possible direct relation between PGE2 levels and the severity of this disease. Also see the video abstract here: https://youtu.be/SnPFAcjxxKw. (shrink)

In their pursuit of adaptively biased misbelief-making systems, McKay & Dennett (M&D) describe a putative doxastic shear-pin system which enables misbeliefs to form in situations of extreme psychological stress. Rather than discussing their argument, I consider how this shear-pin system might combine with both pathological belief-making ( breakdowns caused by neuropathy) and normal belief-making to explain a spectrum of delusions.

The topic of disease mechanisms is of clinical importance, as our understanding of such mechanisms plays an important role in how we approach devising treatments for disease. In this paper, I critique an argument made by Mauro Nervi, in which he asserts that pathology is often better viewed in the context of distinct theoretical mechanisms. I use this critique as a starting point to argue that viewing pathology as a broken-normal, malfunctioning mechanism is more therapeutically practical and more relevant to (...) clinical drug design, than creating a theoretical separation of pathology from physiology. (shrink)

Pathological gaming among adolescents has been reported to hamper the achievement of a balanced life and to threaten the development of social competencies. Despite the increasing social concerns on the adolescent users, however, the mechanism of gaming behavior of adolescents has not been sufficiently examined. This study explored the mechanism of pathological gaming among adolescents from 3-year longitudinal data of 778 Korean adolescent gamers, by analyzing the effects of negative affects on the degree of pathological gaming through the mediation variables (...) based on the stimulus-organism-response framework. Latent class analysis was used to uncover potential risk groups, and through partial least squares-structural equation modeling analysis, the mediation pathways to pathological gaming were compared between the risk group and the non-risk group. The results highlighted the key role of academic stress on the degree of pathological gaming. In the entire group, academic stress primarily increased pathological gaming through self-control. The mediation path of self-control was the most influential result in the risk group. Aggression was the key mediator between loneliness and pathological gaming in the non-risk group. The theoretical and practical implications of the results were discussed. (shrink)

For generations, critical social theorists have turned to the framing of ‘pathology’ to provide a theoretical infrastructure for their critique. Such an approach famously undergirds much of the Frankfurt School’s canonical work. Axel Honneth, current chair of the Institute of Social Research, continues this tradition. While Frankfurt School approaches have largely tied pathology diagnosis to a critique of historically mediated reason, a plurality of alternate conceptions exist. With the ascendancy of an intersubjective approach to critical social theory, the pathologies (...) of the social have increasingly been comprehended as ‘pathologies of recognition’. Advocates of such a framing point to the ease of establishing an immanent basis to their critique, and of the empirical evidence supporting the need for recognition. Yet, today’s academy is increasingly spilt between those who embrace a ‘pathologies of recognition’ framework, and those who consider the development a ‘domestication’ of the Critical Theoretical tradition. This special issue brings together contributors from both sides of this divide. While the optimal framing of social pathology remains contested, the contributors to this collection are committed to furthering forms of social critique which transcend the limited liberal framings of injustice and illegitimacy. (shrink)

The phenomenological method has been fruitfully used to study the experience of illness in recent years. However, the role of illness is not merely that of a passive object for phenomenological scrutiny. I propose that illness, and pathology more generally, can be developed into a phenomenological method in their own right. I claim that studying cases of pathology, breakdown, and illness offer illumination not only of these experiences, but also of normal function and the tacit background that underpins it. In (...) particular, I claim that the study of embodiment can be greatly enhanced, and indeed would be incomplete, without attending to bodily breakdown and what I term bodily doubt. I offer an analogy between illness and Husserl’s epoché, suggesting that both are a source of distancing, and therefore motivate a reflective stance. (shrink)

This chapter aims to distinguish between pathologies of agency in the strict sense and mere sources of impediments or distortion. Expanding on a recent notion of necessarily less-than-successful agency, it complements a mainstream approach to mental disorders and anomalous psychological conditions in the philosophy of mind and action. According this approach, the interest of such clinical case studies is heuristic, to differentiate between facets of agency that are functionally and conceptually separate even though they typically come together. Yet, in (...) the absence of independent criterion for a pathology of as opposed to inner obstacle to agency, this heuristic is at risk of becoming circular or uninformative, falling back on a clinical diagnosis it is meant to take as a starting point only. The chapter develops such a criterion and shows how it could work tracking agential achievement across two core dimensions of agency: planning and responsiveness to reasons. The discussion concludes with some implications on assessing decisional capacity and safeguarding agent autonomy in psychiatric settings. (shrink)

Insofar as psychiatrists and neurologists tend to the cognitive well-being of others, their work is interwoven with philosophical concerns and theoretical assumptions about the nature of the mind, its myriad functions, and the conditions governing its multiform pathologies. That the mind figures so prominently in their ordinary language attests to the wealth of insights that stands to be gained through a dialogue with philosophy. In one of the earliest efforts to taxonomize psychiatric medicine, Allgemeine Psychopathologie, Jaspers incisively remarks that (...) "the exclusion of philosophy would be disastrous for psychiatry…if any psychopathologist thinks he can disregard philosophy and leave it aside as useless he will... (shrink)

This essay argues that modern demagogy can be understood as a symptom of a kind of social pathology, combining Wendy Brown's account of neoliberal subjectivity with elements of Robert Pippin's interpretation of Hegel to do so. I begin by focussing on Brown's contention that neoliberal society has bred forms of individual subjectivity that are inherently attuned to right-wing rhetoric. Drawing on Pippin's reading of Hegel, the essay casts these modes of individual subjectivity as aspects of a flawed mode of collective (...) subjectivity; the contemporary rise of demagogic politics is thereby presented as a symptom of a pathological failure of collective self-determinacy, caused by inadequacies within the normative structures that articulate social activity. (shrink)

Does a diagnosis of brain dysfunction matter for ascriptions of moral responsibility? This chapter argues that, while knowledge of brain pathology can inform judgments of moral responsibility, its evidential value is currently limited for a number of practical and theoretical reasons. These include the problem of establishing causation from correlational data, drawing inferences about individuals from group data, and the reliance of the interpretation of brain findings on well-established psychological findings. Brain disorders sometimes matter for moral responsibility, however, because they (...) change an individual’s moral psychology in a way that is beyond their control. While control over psychological changes is not an excusing factor, brain disorders can mitigate moral responsibility because they confront individuals with new psychological deficits or urges for which their previous moral education and existing external and internal moral resources have not prepared them. (shrink)

This article addresses the precarious place of transgender and gender non-cis persons in relation to their discrimination-protections in recent legal, medical, and ethical policies in the United States. At present, there exists a contradiction such that trans persons are considered "pathological" enough that they are included in the latest iteration of the American Psychiatric Association's Diagnostic and Statistical Manual (DSM-V) as "gender dysphoric," but they are not included in the category of "disabled" under the Americans with Disabilities Act (ADA). As (...) such, trans persons in America are subject to the stigma of pathology (albeit with medical treatment) without the full protections of the ADA. By contrast, transgender and non-cis-gender Americans find their queer cohorts who are HIV-positive to be fully protected by the ADA. We ask whether transgender and non-cis-gender persons should embrace their (already pathologized) personhood as a disability. Sometimes "choosing disability" affords more rights than it deploys stigma. (shrink)

The taxonomy proposed by Pessoa et al. should be extended to include “pathological” completion phenomena in patients with unilateral brain damage. Patients with visual field defects (hemianopias) may “complete” whole figures, while patients with parietal lobe damage may “complete” partial figures. We argue that the former may be consistent with the brain “filling-in” information, and the latter may be consistent with the brain ignoring the absence of information.

In this paper, I explore the implications of adopting one model of self rather than another in respect to one particular feature of our mental life. The need to explain synchronic unity in normal subjectivity, and also to explain the apparent and puzzling absence of synchronic unity in certain symptoms of severe mental disorder, I show, becomes more pressing with one particular model. But in the process of developing that explanation we learn something about subjectivity and perhaps also something about (...) brain functioning. (shrink)

This essay provides an account of how to distinguish between health and pathology of trait tokens in medical theory. It proposes to distinguish between two health/pathology concepts—health/pathology pertaining to survival and health/pathology pertaining to reproduction. It defines measures for survival-efficiency and reproduction-efficiency of performances of physiological functions. It provides an account of how, using the efficiency measures, to draw the line between health and pathology. The account draws, but seeks to improve, on Christopher Boorse’s biostatistical theory. In relation to that (...) theory, the suggested account has the advantages that it defines efficiency and that it harmonizes with judgments in medical theory in cases of common diseases and “normal aging.” Furthermore, the essay argues against a competing idea of how to improve on the biostatistical theory, advocated by Peter Schwartz and Daniel Hausman. (shrink)

In the twenty-second series of The Logic of Sense, Gilles Deleuze references a remarkable essay by Günther (Stern) Anders. Anders’ essay, translated here as ‘The Pathology of Freedom’, addresses the sickness and health of our negotiation with the negative anthropological condition of ‘not being cut out for the world’.

Certain mathematical objects bear the name “pathological”. They either occur as unexpected and unwilling in mathematical research practice, or are constructed deliberately, for instance in order to delimit the scope of application of a theorem. I discuss examples of mathematical pathologies and the circumstances of their emergence. I focus my attention on the creative role of pathologies in the development of mathematics. Finally, I propose a few reflections concerning the degree of cognitive accessibility of mathematical objects. I believe (...) that the problems discussed in the paper may attract the attention of philosophers interested in concept formation and the development of mathematical ideas. (shrink)