Rhodopsins are one of the most studied photoreceptor protein families, and ion‐translocating rhodopsins, both pumps and channels, have recently attracted broad attention because of the development of optogenetics. Recently, a new functional class of ion‐pumping rhodopsins, an outward Na+ pump, was discovered, and following structural and functional studies enable us to compare three functionally different ion‐pumping rhodopsins: outward proton pump, inward Cl− pump, and outward Na+ pump. Here, we review the current knowledge on structure‐function relationships in these three light‐driven pumps, (...) mainly focusing on Na+ pumps. A structural and functional comparison reveals both unique and conserved features of these ion pumps, and enhances our understanding about how the structurally similar microbial rhodopsins acquired such diverse functions. We also discuss some unresolved questions and future perspectives in research of ion‐pumping rhodopsins, including optogenetics application and engineering of novel rhodopsins. (shrink)

In this paper I investigate the possibility of a dictatorship in the context of Harsanyi's Social Aggregation Theorem. Preliminarily, some propositions about Harsanyi's Theorem are presented using an alternative principle that I name Quasi-strong Pareto, which is the latter part of Strong Pareto. Then I define dictatorship as a requirement that social preference agrees with a dictator's preference or those of members of dictatorial group even if their preferences strictly contradict those of all other people in the society. Conclusively, although (...) in each version of Harsanyi's Theorem with Pareto Indifference, Weak Preference Pareto or Weak Pareto the social utility function may have a form of dictatorship, however if individuals' vNM utility functions are all 'individualistic' and Quasi-strong Pareto is satisfied, then the dictatorship is excluded. (shrink)

This chapter traces the evolution of Japan's systems of household and land registration from c.1600 to the period of early Meiji reforms in the 1870s and 1880s, with due attention to the distinction between a system designed by the state and local forms of registration practice. In the section on the pre-Meiji period, one such local practice of having people ‘disowned’ and its consequence — registerlessness — is examined. The section on the Meiji reforms and the section that follows turn (...) to the issue of continuity and discontinuity, and the question of whether any progress was made by those reforms. In order to illustrate the actual changes that took place at the local level, the chapter begins with an eighteenth-century story about a peasant woman and ends with a case of a family dispute that another village woman brought before the court some 120 years later. (shrink)

This study investigates interpretations of the Japanese initial mora-based minimizer “X.Y...”-_no_ “X”-_no ji-mo_ ‘lit. even the letter “X” of “X.Y...”.’ Although initial mora-based minimizers have a literal interpretation of _ji_ ‘letter’, they have a non-literal interpretation as well. The non-literal interpretation has several distinctive features that are not present in ordinary minimizers. First, it is highly productive in that various expressions can appear in the form “X.Y...”-_no_ “X”-_no ji_. Second, non-literal minimizers typically co-occur with predicates that relate to knowledge, information, (...) concepts, thought, and habituality, as seen in the corpus data (Balanced Corpus of Contemporary Written Japanese [BCCWJ]). I argue that in the non-literal use, X refers to the minimum on the scale of the main predicate concerning “X.Y...”. I suggest that the non-literal use was developed as a result of the conventionalization of the pragmatic inference derived from the literal reading, and that the co-occurrence with predicates related to knowledge, information, knowledge, concepts, thought, or habituality is due to the interpretation of “X.Y...”, which were originally interpreted as letters as an abstract concept. The theoretical implication of this study is that, in addition to a non-compositional (lexically specified) minimizer whose scale is lexically fixed (e.g., _give a damn_, _lift a finger_), there also exists a compositional (lexically unspecified) minimizer in natural language, whose scale is specified via the predicate with which the minimizer co-occurs. The last section of this paper briefly discusses similar/related phenomena in Bosnian/Croatian/Serbian, Korean, and English from a cross-linguistic perspective. (shrink)

Rauszer and Sabalski proved in [2] that distributivity with respect to infi- nite joins and meets is a sucient and necessary condition making the RasiowaSikorski Lemma valid in distributive lattices. The main part of their proof is a direct construction of a required filter under distributivity. In this note we show that a generalization of the result can be obtained from the Rasiowa-Sikorski Lemma for Boolean algebras by using Gornemann’s result in [1] instead of a direct con- ¨ struction. Suppose (...) A is a distributive lattice and Q; R 2 A f;g. We call A complete if 8M 2 Q9 M 2 A and 8N 2 R9 F N 2 A. M 2 Q is -dis if 9 M 2 A and 8a 2 A a t M = m2M. N 2 R is F -dis if 9 F N 2 A and 8a 2 A a u F N = F n2N. is called distributive if every M 2 Q is -dis and every N 2 R is F -dis. Suppose A is complete and C; D A. By rC we mean the filter in A generated by C, in particular, let r; = ; = ;. is called complete if and , where 8M 2 Q 9m 2 MrC \ D[fmg = ;) 8N 2 R 9n 2 NrC[fng \ D = ;). (shrink)

This dialogue introduces type nihilism and token realism about the meaning of life.

We provide two alternative characterizations of the Nash bargaining solution. We introduce new simple axioms, strong undominatedness by the disagreement point, and egalitarian Pareto optimality. First, we prove that the Nash solution is characterized by symmetry, scale invariance, independence of irrelevant alternatives, and strong undominatedness by the disagreement point. Second, we replace the independence of irrelevant alternatives axiom with the sandwich axiom and egalitarian Pareto optimality. We then demonstrate that the Nash solution is characterized by symmetry, scale invariance, strong undominatedness (...) by the disagreement point, the sandwich axiom, and egalitarian Pareto optimality. (shrink)

現代人が直面する、安楽死、臓器移植、死刑といった倫理問題に、徳、善、良心、愛を基礎として、読者と共に考えぬく強靱な思索。.

The social and cultural causes behind the widespread use and acceptance of robots in Japan are not yet completely understood. This study compares humans and robots in images gathered through Google searches in Japanese and in English. Numerous pictures obtained by the search in Japanese were found to have a human and a robot looking together at something else (“third item”), whereas many of the images acquired by search in English show a human and a robot facing each other. This (...) is similar to the composition of mother and child in paintings: in _ukiyo-e_ that was painted mainly in the Edo period of Japan, the mother and child are often depicted together viewing something other than themselves, whereas this is not the case in Western paintings of mother and child. It has also been pointed out that, in modern Western paintings, the world inside the picture is separated from the outside world, forming an independent microcosmos, whereas the inside and outside are continuous in Japanese paintings. These may indicate that, in Japanese society, robots are to a certain extent regarded as fellow human beings who can share the third item. In Western society, on the other hand, no code is embedded that can fix robots’ superiority or inferiority to humans, which would easily trigger an antagonistic view toward artificial intelligence (AI)/robots as threatening entities, as shown in most of Western literature and movies. We suggest that such cultural characteristics of Japanese society can contribute to enhance coexistence with AI/robots. (shrink)

Cognitive science uses artificial intelligence to model the human mind. In this book, Yukio Pegio Gunji, a Japanese theoretical biologist, proposes the notion of “traumatic structure” to capture human creativity. He suggests that creativity is difficult to model with AI because it comes from “the outside.” According to Gunji, cognitive scientists like Boden (2004) view creativity merely as a manipulation of data, and fail to capture anything that comes from the outside. He compares the outside to what Wittgenstein (1922/1998) stated (...) “we cannot speak of.” The outside is also compared to what speculative realism (Brassier et al., 2007) posits lies outside the correlation between thinking and being. Gunji not only speaks of the outside but also proposes a notion that makes us accessible to it. The notion of traumatic structure is proposed to capture creativity that comes from the outside.... (shrink)

This paper investigates the semantics of measure phrases in Japanese. Based on new data, we argue that the interpretation of measure phrases in Japanese is sensitive to scale structure such that (i) measure phrases are introduced by a degree morpheme that selects only for gradable predicates whose scale contains a minimal element (i.e., a lower closed scale) and (ii) violations to this restriction are repaired via coercion, which forces a comparative interpretation with a contextually determined standard and hence a minimal (...) element. We compare the Japanese facts to data in other languages and argue that the requirement of having a minimal element is not specific to Japanese, but universal. We show that languages may vary in how they deal with potential violations of this universal constraint, including coercion of a contextually recoverable derived minimal element (Japanese), ungrammaticality (e.g., Spanish, Korean, Russian), and a hybrid system of ungrammaticality for some adjectives and allowed constraint violation for others (e.g., English, German, Italian). (shrink)

We prove the strong normalization theorem for the natural deduction system for the constructive arithmetic TRDB (the system with Definition by Transfinite Recursion and Bar induction), which was introduced by Yasugi and Hayashi. We also establish the consistency of this system, applying the strong normalization theorem.

A framework for “improvisational” social acts and communication is introduced by referring to the idea of “relationalism” such as natural farming, permaculture and deep ecology. Based on this conception, the notion of Existential Graph by C. S. Peirce is introduced. The notion of extended self in deep ecology is substantiated based on the Roy Adaptation Model in Nursing Theory and Narrative approaches. By focusing on Leibnizian notions of space and time and by introducing Petri net, a spatio-temporal model of improvisation (...) is constructed. This model is expected to substantiate the interesting notion of “Ba” proposed by H. Shimizu reflecting Japanese culture. (shrink)

Naturalistic teleological accounts of mental content rely on an etiological theory of function. Nanay has raised a new objection to an etiological theory, and proposed an alternative theory of function that attributes modal force to claims about function. The aim of this paper is both to defend and to cast a new light on an etiological theory of function. I argue against Nanay’s “trait type individuation objection,” suggesting that an etiological theory also attributes modal force to claims about function. An (...) etiological theory of function can be thought to analyze claims about function with modal force, not relying on any theory of counterfactuals. (shrink)

BackgroundThis essay provides an ethical and conceptual argument for the use of informed consent prior to the diagnosis of brain death. It is meant to enable the family to make critical end-of-life decisions, particularly withdrawal of life support system and organ donation, before brain death is diagnosed, as opposed to the current practice of making such decisions after the diagnosis of death. The recent tragic case of a 13-year-old brain-dead patient in California who was maintained on a ventilator for over (...) 2 years illustrates how such a consent would have made a crucial difference.MethodsConceptual, philosophical, and ethical analysis.ResultsI first consider a conceptual justification for the use of consent for certain non-beneficial and unwanted medical diagnoses. I suggest that the diagnosis of brain death falls into this category for some patients. Because the diagnostic process of brain death lacks the transparency of traditional death determination, has a unique epistemic structure and a complex risk-benefit profile which differs markedly from case to case, and presents conflicts of interest for physicians and society, I argue that pre-diagnostic counseling and informed consent should be part of the diagnostic process. This approach can be termed as “allow cardiac death”, whose parallel logic with “allow natural death” is discussed. I also discuss potential negative impacts on organ donation and health care cost from this proposal and offer possible mitigation. I show that the pre-diagnostic counseling can improve the possibility for well-thought-out decisions regarding organ donation and terminating life-support system in cases of hopeless prognosis. This approach differs conceptually from the pluralism of the definition of death, such as those in New Jersey and Japan, and it upholds the Uniform Determination of Death Act.ConclusionsMy intention is not to provide an instant panacea for the ongoing impasse of the brain death debate, but to point to a novel conceptual ground for a more pragmatic, and more patient- and family-centered approach. By enabling the family to consent to or decline the diagnostic process of brain death, but not to choose the definition of death, it upholds the current legal definition of death. (shrink)

This study investigates the meanings of the Japanese low-degree modifiers _kasukani_ ‘faintly’ and _honokani_ ‘approx. faintly’ and the English low-degree modifier _faintly_. I argue that, unlike typical low-degree modifiers such as _sukoshi_ ‘a bit’ in Japanese and _a bit_ in English, they are sense-based in that they not only semantically denote a small degree but also convey that the judge (typically the speaker) measures the degree of predicates based on their own sense (the senses of sight, smell, taste, etc.) at (...) the level of conventional implicature (CI) (e.g., Grice (in: Cole, Morgan (Eds.), Syntax and semantics iii: speech acts, Academic Press, New York, 1975), Potts (The logic of conventional implicatures, Oxford University Press, Oxford, 2005), McCready (Semant Pragmat 3:1–57, 2010. https://doi.org/10.3765/sp.3.8, Sawada (Pragmatic aspects of scalar modifiers. Ph.D. Dissertation, University of Chicago, 2010), Gutzmann (Empir Issues Syntax Semant 8:123–141, 2011)). I will also show that there are variations among the sense-based low-degree modifiers with regard to (i) the kind of sense, (ii) the presence/absence of positive evaluativity, and (iii) the possibility of direct measurement of emotion and will explain the variations in relation to the CI component. A unique feature of sense-based low-degree modifiers is that they can indirectly measure the degree of non-sense-based predicates (e.g., emotion) through sense (e.g., perception). I show that the proposed analysis can also explain the indirect measurement in a unified way. This paper shows that like predicates of personal taste such as _tasty_ (e.g., Pearson (J Semant 30(1):103–154, 2013. https://doi.org/10.1093/jos/ffs001 ), Ninan (Proc Semant Linguist Theory, 24:290–304, 2014. https://doi.org/10.3765/salt.v24i0.2413 ), Willer & Kennedy (Inquiry, 1–37, 2020. https://doi.org/10.1080/0020174X.2020.1850338 )), sense-based low-degree modifiers trigger acquaintance inference. The difference between them is that, unlike predicates of personal taste, sense-based low-degree modifiers co-occur with gradable predicates and their experiential components signal the manner/way in which the degree of the predicate in question is measured. (shrink)

Through the ratification and implementation of the Convention on the Rights of Persons with Disabilities, Japan’s policy towards people with disabilities and their rights has moved away from its traditional focus on economic and socio-cultural rights (known as “social rights”) to encompass civil and political rights (or “liberty rights”). Several factors have contributed to this development: firstly, the efforts of the Japanese disability rights movement, which benefited in 2009 from a favorable change of government when the coalition comprising the Liberal (...) Democratic Party and the New Kōmeitō was defeated in the elections by the Democratic Party of Japan; and secondly, the judicial developments surrounding the Law on Election to Public Office, as well as the support given to the victims of the former Eugenic Protection Law. As the first findings of the 2022 survey of Japan by the Committee on the Rights of Persons with Disabilities suggest, a better balance in the approach to social and liberty rights will be essential if Japan is to meet the main challenges posed by its disability policy. (shrink)

Nakamura proposed two three-valued temporal logics. We present two extended Gentzen-type formulations of these logics. Then we prove the soundness as well as the completeness theorem.

This book, written by one of the leading Japanese scholars in the philosophy of agricultural science, examines the relationship between human life, the natural environment, and agriculture.

The aim of this essay is to elaborate philosophical and ethical underpinnings of posthumous diagnosis of famous historical figures based on literary and artistic products, or commonly called retrospective diagnosis. It discusses ontological and epistemic challenges raised in the humanities and social sciences, and attempts to systematically reply to their criticisms from the viewpoint of clinical medicine, philosophy of medicine, particularly the ontology of disease and the epistemology of diagnosis, and medical ethics. The ontological challenge focuses on the doubt about (...) the persistence of a disease over historical time, whereas the epistemic challenge disputes the inaccessibility of scientific verification of a diagnosis in the past. I argue that the critics are in error in conflating the taxonomy of disease and the act of diagnosing a patient. Medical diagnosis is fundamentally a hypothesis-construction and an explanatory device that can be generated under various degrees of uncertainty and limited amount of information. It is not an apodictic judgment as the critics presuppose, but a probabilistic judgment with varying degrees of plausibility under uncertainty. In order to avoid this confusion, I propose that retrospective diagnosis of a historical figure be syndromic without identifying underlying disease, unless there is justifiable reason for such specification. Moreover it should be evaluated not only from the viewpoint of medical science but also in a larger context of the scholarship of the humanities and social sciences by its overall plausibility and consistency. On the other hand, I will endorse their concerns regarding the ethics and professionalism of retrospective diagnosis, and call for the need for situating such a diagnosis in an interdisciplinary scope and the context of the scholarship of the historical figure. I will then enumerate several important caveats for interdisciplinary retrospective diagnosis using an example of the retrospective diagnosis of Socrates for his life-long intermittent neurologic symptoms. Finally, I will situate the present argument in a larger context of the major debate among the historians of medicine and paleopathologists, and discuss the similarities and differences. (shrink)

『昭和前期の科学思想史』、『昭和後期の科学思想史』に続き、明治以降の我が国の科学思想史を通覧するシリーズ三部作最終巻。.