Increased knowledge of the gene–disease associations contributing to common cancer development raises the prospect of population stratification by genotype and other risk factors. Individual risk assessments could be used to target interventions such as screening, treatment and health education. Genotyping neonates, infants or young children as part of a systematic programme would improve coverage and uptake, and facilitate a screening package that maximises potential benefits and minimises harms including overdiagnosis. This paper explores the potential justifications and risks of genotyping children (...) for genetic variants associated with common cancer development within a personalised screening programme. It identifies the ethical and legal principles that might guide population genotyping where the predictive value of the testing is modest and associated risks might arise in the future, and considers the standards required by population screening programme validity measures . These are distinguished from the normative principles underpinning predictive genetic testing of children for adult-onset diseases—namely, to make best-interests judgements and to preserve autonomy. While the case for population-based genotyping of neonates or young children has not yet been made, the justifications for this approach are likely to become increasingly compelling. A modified evaluative and normative framework should be developed, capturing elements from individualistic and population-based approaches. This should emphasise proper communication and genuine parental consent or informed choice, while recognising the challenges associated with making unsolicited approaches to an asymptomatic group. Such a framework would be strengthened by complementary empirical research. (shrink)

I discuss the social dimension of musical experience. I focus on the question of whether there is joint musical listening. One reason for this focus is that Adorno and those in his tradition give us little in the way of an understanding of what the social dimension of musical experience might be. We need a proper clear conception of the issue, which the issue of joint experience yields. I defend a radically individualistic view, while conceding that such a view, inspired (...) by Hanslick, may have political ramifications. I have two arguments. The first is a principled argument against joint musical listening from the impossibility of perceiving the aesthetic properties of music. I connect this with the privacy of our grounds for aesthetic judgements about music. The second argument accepts that joint listening could in principle span different sense modalities, but draws attention to the fact that the experiences on which aesthetic judgements are based cannot be willed in a way they would have to be if there was joint listening. Lastly, I consider two phenomena, of making music together and dancing together, which seem to involve joint listening, but in fact do not. I end by drawing an individualist conclusion about the nature of musical experience. (shrink)

The article summarizes and critically analyzes the encyclical letter of Pope Benedict XVI “Deus Caritas est.” This document discusses “diaconia” in the Roman Catholic Church in view of its biblical and theological foundations, its characteristics, and the position of works of mercy within the general self-understanding of the church. In going beyond the text, the author emphasizes the political dimension of church-based charity, the need to respond to the challenge of the principle of solidarity by contemporary neoliberal tendencies, and the (...) relationship of the church to those employed in the service of her diaconia. (shrink)

The theory of branching space-times, put forward by Belnap, considers indeterminism as local in space and time. In the axiomatic foundations of that theory, so-called choice points mark the points at which the possible future can turn out in different ways. Working under the assumption of choice points is suitable for many applications, but has an unwelcome topological consequence that makes it difficult to employ branching space-times to represent a range of possible physical space-times. Therefore it is interesting to develop (...) a branching space-times theory without choice points. This is what we set out to do in this paper, providing new foundations for branching space-times in terms of choice sets rather than choice points. After motivating and developing the resulting theory in formal detail, we show that it is possible to translate structures of one style into structures of the other style and vice versa. This result shows that the underlying idea of indeterminism as the branching of spatio-temporal histories is robust with respect to different implementations, making a choice between them a matter of expediency rather than of principle. (shrink)

CHAPTER I Introduction The history of mankind can boast not only of its times of fame and glory but also of quieter times with a different kind of heroism. ...

Book Information Hegel and Aristotle. By A. Ferrarin. Cambridge University Press. New York. 2001. Pp. xxii + 442. Hardback, US$65.00.

Historical essays on Lingayat philosophy.

En la historia de la filosofía es imprescindible, además de conocer los hechos (contenidos) reflexionar sobre lo que ha significado históricamente la filosofía: lo que pasó después. Es necesario, por tanto, para todos aquellos que hemos transitado por ella, y también para los que se acercan por primera vez, continuar filosofando sobre los asuntos humanos. Filosofía para después. Para aplicarla en la vida diaria después de haberla estudiado. Para arrojar la escalera después de haber subido. Para lo que venga despues... (...) Filosofía para después es precisamente esto: un libro de filosofía inversa para leer filosofía. Pensada para el joven estudiante que fuimos y al que tanto hemos deseado explicar lo que entonces no nos explicaron o no comprendiéramos, aunque aunque fuera después. (shrink)