Platelets have important hemostatic functions in repairing blood vessels upon tissue injury. Cytokines, growth factors, and metabolites stored in platelet α‐granules and dense granules are released upon platelet activation and clotting. Emerging evidence indicates that such platelet‐derived signaling factors are instrumental in guiding tissue regeneration. Here, we discuss the important roles of platelet‐secreted signaling factors in skeletal muscle regeneration. Chemokines secreted by platelets in the early phase after injury are needed to recruit neutrophils to injured muscles, and impeding this early (...) step of muscle regeneration exacerbates inflammation at later stages, compromises neo‐angiogenesis and the growth of newly formed myofibers, and reduces post‐injury muscle force production. Platelets also contribute to the recruitment of pro‐regenerative stromal cells from the adipose tissue, and the platelet releasate may also regulate the metabolism and proliferation of muscle satellite cells, which sustain myogenesis. Therefore, harnessing the signaling functions of platelets and the platelet secretome may provide new avenues for promoting skeletal muscle regeneration in health and disease. (shrink)

The aim of this paper is to define a λ-calculus typed in aMixed (commutative and non-commutative) Intuitionistic Linear Logic. The terms of such a calculus are the labelling of proofs of a linear intuitionistic mixed natural deduction NILL, which is based on the non-commutative linear multiplicative sequent calculus MNL [RuetAbrusci 99]. This linear λ-calculus involves three linear arrows: two directional arrows and a nondirectional one (the usual linear arrow). Moreover, the -terms are provided with seriesparallel orders on free variables. We (...) prove a normalization theorem which explicitly gives the behaviour of the order during the normalization procedure. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:Trois récits utopiques classiques: Gabriel de Foigny, La Terre Australe connue; Denis Veiras, Histoire des Sévarambes; Bernard de Fontenelle, Histoire des Ajaoïens ed. by Jean-Michel RacaultAndrew CremerJean-Michel Racault, ed. Trois récits utopiques classiques: Gabriel de Foigny, La Terre Australe connue; Denis Veiras, Histoire des Sévarambes; Bernard de Fontenelle, Histoire des Ajaoïens. Saint-Denis (La Réunion): Presses Universitaires Indianocéaniques. 2020. 539 pp., illus. Paperback, €16. ISBN: 978 2 490596 24 (...) 9.M. Jean-Michel Racault, Emeritus Professor of the University of La Réunion and general editor of the Œuvres complètes of Bernardin de Saint-Pierre in progress under the Classiques Garnier imprint, is an acknowledged expert in utopian studies, and works edited and presented by him in this field will be justly welcomed with keen interest and appreciation. It inspires confidence [End Page 168] that this edition should be the fruit of many years’ study and find its origins in his two theses of 1981 and 1987 and articles of 1991, 2003, and 2010 (21 n. 21). The blurb announces this volume as bringing together “three major works of political thought of the end of the seventeenth century representative of ‘Louis XIV utopias,’” a label that could be supposed to imply an anti-absolutist outlook in the three writers. But Racault argues that the idea, as put forward by the late Myriam Yardeni in her 1980 study Utopie et révolte sous Louis XIV, that these classical utopias express revolt against the monarchy of Louis XIV should be treated in a nuanced way, even with serious reservations (7, 217–18).Racault writes with impressive depth and clarity and makes a superb guide, yet it by no means follows that these works are easy to interpret. Indeed, part of his achievement is to show they may not be so and to offer evidence to suggest that they may invite “multiple possible readings.” The blurb gives fair warning of irony, ambiguity, and contradictoriness, and states that the utopia of these experimental fictions can be inverted to become an “anti-utopia.” As Racault observes with admirable honesty in his preface, “Ambivalence, uncertainty, and a sense of complexity are in fact characteristics of these utopias, in which one sometimes has the impression that the author develops lines of thought that are ideologically incompatible and does not know himself on which side he stands” (19). Racault exemplifies this paradox by reference to Foigny’s hero, “a Pascalian libertin as well as a Christian deist” (19–20). One might be allowed to object that this is to offer the reader who seeks it no clear utopian vision, and that such ambiguity leads to confusion worse confounded; indeed, I am tempted to wonder if ambiguity here reveals subtlety of thought less than a mere lack of perspicuity. Racault makes the highly important point that a similar duality “penetrates the accounts of Veiras and Fontenelle and prevents one from seeing them as simple preludes to Enlightenment thought” (20). Two more vigorous quotations may suffice to convey the flavor of this argument of duality: “the deism of La Terre Australe connue can also be read as a critique of deism, the [...] democratic humanism of the Histoire des Ajaoïens includes a utilitarian system of colonial domination” (21). Again, “the ‘heliocratic’ Sevarambian system inspired by the empire of the Incas after Garcilaso de la Vega [?1501–36] is essentially a theocratic absolutism in the end not much different from the monarchy of Louis XIV. Ajao, on the other hand, has no monarchy, and no ministers” (460). As to this variety between the texts, another indication is that Foigny’s land is anarchical (but [End Page 169] well ordered!), whereas Veiras’s can be understood as embracing certain policies of Colbert (236 and n. 14, 292 and n. 46), to whose protégé Pierre-Paul Riquet, baron de Bonrepos (1609–80), Veiras’s account is dedicated (231–34, 306–7).This substantial but not overlong volume is tastefully adorned with attractive covers and five splendid and richly annotated plates of maps illustrating the subject of the “Imaginary Voyage” or “Extraordinary Voyage,” a term used in a... (shrink)

Music is a stimulus capable of triggering an array of basic and complex emotions. We investigated whether and how individuals employ music to induce specific emotional states in everyday situations for the purpose of emotion regulation. Furthermore, we wanted to examine whether specific emotion-regulation styles influence music selection in specific situations. Participants indicated how likely it would be that they would want to listen to various pieces of music (which are known to elicit specific emotions) in various emotional situations. Data (...) analyses by means of non-metric multidimensional scaling revealed a clear preference for pieces of music that were emotionally congruent with an emotional situation. In addition, we found that specific emotion-regulation styles might influence the selection of pieces of music characterised by specific emotions. Our findings demonstrate emotion-congruent music selection and highlight the important role of specific emotion-regulation styles in the selection of music in everyday situations. (shrink)

Focusing on the interactions between people suffering from neuromuscular diseases and their wheelchairs, the author raises the question of action: how is action made possible for people suffering from neuromuscular diseases? Starting with actor-network theory, the author shows that action not only results from distribution and delegation to heterogeneous entities but emerges from hard and lengthy work that makes the relation between them possible and transforms the entities involved. The author describes this work, called the process of adjustment, as work (...) on the links making a person, his or her body, and his or her world. Through this work, new possibilities of action emerge for the person, but also new abilities; the person’s identity is transformed and shaped. This analysis leads to a particular conception of the person as made up through his or her relations to other entities. (shrink)

L'Essai sur l'être, traduit ci-dessous pour la première fois en français, fut rédigé par Herder en 1763-1764, pendant ses années d'études à Königsberg, à l'écoute de Kant. Reprenant et discutant certains des arguments développés par Kant dans ses conférences et écrits précritiques consacrés à la métaphysique, Herder pose les bases philosophiques de son œuvre future. L'étude du texte permet de réévaluer la thèse, jadis avancée par Dilthey, selon laquelle le futur protagoniste de Jacobi dans le débat sur le spinozisme infléchit (...) alors la pensée vers un « panthéisme esthétique » dont Hölderlin, Schelling et Hegel se feront plus tard les hérauts: le chemin suivi par la philosophie en Allemagne, après Kant, fut d'abord, effectivement, celui de l'esthétique — mais seulement parce que et dans la mesure où cette discipline fut comprise comme la « science du mode de connaissance et d'exposition sensible » (A. G. Baumgarten). Der Versuch über das Sein, hier erstmals in französischer Übersetzung vorgelegt, wurde von Herder in den Jahren 1763-1764 verfaßt, also während seiner Königsberger Studienjahre, als er regelmäßig die Vorlesungen Kants hörte. In der Aufnahme und in der Auseinandersetzung mit bestimmten Argumenten, die Kant in denjenigen seiner vorkritischen Vorlesungen und Schriften entwickelte, die der Metaphysik gewidmet sind, schuf Herder die philosophischen Grundlagen seines zukünftigen Werkes. Die vorliegende Deutung des herderschen Textes führt zu einer Neubewertung der seinerzeit von Dilthey vorgetragenen These, derzufolge dieser (neben Jacobi) zukünftige Hauptakteur im Pantheismusstreit das philosophische Denken in Richtung auf einen « ästhetischen Pantheismus » gebeugt habe, dessen Herolde später Hölderlin, Schelling und Hegel geworden wären. Der Weg der deutschen Philosophie nach Kant war tatsächlich derjenige der Ästhetik — allerdings nur dann, wenn diese Disziplin als die Wissenschaft, die das Sinnliche wahrnimmt und darstellt (A. G. Baumgarten), verstanden wird. (shrink)

Le tragique n'est pas uniquement à l'Age classique une catégorie théâtrale ; il est également un concept philosophique, et si pour des auteurs comme Corneille ou Racine, il est une donnée littéraire reçue de l'Antiquité, il est chez des philosophes comme Descartes, Pascal ou Spinoza, un concept à construire ou à élaborer. Cette relation idéale entre hommes de théâtre et philosophes a un enjeu important : quelles solutions apporter au tragique?

Résumé La littérature hétérolingue serait-elle susceptible de contribuer à une poétique du traduire? Notre investigation, qui nous fera quitter la linguistique pour les théories de l’énonciation puis aborder l’analyse rhétorique en termes d’ ethos, s’achèvera sur l’étude d’une phrase extraite d’ Hijo de hombre, roman guarani-hispanophone du Paraguayen Augusto Roa Bastos (1917-2005). Les trois versions françaises étayeront l’hypothèse selon laquelle chaque traduction est un acte de ré-énonciation où se rejoue le rapport à l’altérité linguistique.

La sexualité préoccupe le Moyen Âge occidental : miroir de la nature peccamineuse de l’homme, elle en révèle le meilleur (tempérance, renoncement) et le pire (appétit, violence). Envisagée dans le seul mariage chrétien, elle est hors de ce cadre adultère, condamnée (juridiquement, judiciairement) et expose les individus à la vindicte populaire. Les lettres de rémission (grâce royale des crimes) des xiv e et xv e siècles témoignent de façon originale de l’impact que le type de conjugalité vécu peut avoir sur (...) les violences sexuelles faites aux femmes. Si les sources sont muettes et absentes sur les violences matrimoniales, isolement, célibat laïc, séparation et adultère exposent les femmes médiévales au viol. Mariée, la femme est appropriée, son corps territorialisé, gardé ; seule ou concubine, elle est mal famée et son corps à prendre. C’est dans ce paradigme que la question du couple et des violences sexuelles se pose alors. (shrink)

Dass sich Hegel und Hermann Cohen trotz scheinbarer Gegensatze miteinander versohnen lassen, ist eine Grunduberzeugung des Werkes von Myriam Bienenstock, welches sich stets durch die doppelte Ausrichtung auf Hegel und das judische Denken auszeichnete. Mit diesem Band wird Myriam Bienenstock, seit 1997 Professorin fur Philosophie an der Universitat Francois Rabelais in Tours, anlasslich ihres 70. Geburtstages geehrt. Mit Beitragen von Dominque Bourel, Bernard Bourgeois, Christophe Bouton, Pierfrancesco Fiorato, Jean-Francois Goubet, Dana Hollander, Helmut Holzhey, Gerhard Kurz, Claudia Melica, Wolfdietrich (...) Schmied-Kowarzik, Ludwig Siep, Guy Stroumsa und Norbert Waszek. (shrink)

PURPOSE/OBJECTIVES: To examine differences in nursing care received by patients with breast cancer enrolled in clinical trials and those not enrolled in clinical trials. DESIGN: Retrospective review of clinic charts. SETTING: Oncology outpatient department of a tertiary-care hospital. SAMPLE: 90 women with early stage breast cancer. The mean age of the women was 53 years. More than half of the women (51 of 90) were treated in a clinical trial. METHODS: Retrospective chart review of all the nurse-patient clinic encounters for (...) a six-month period from date of cancer diagnosis. The content of each encounter was coded using a modified version of the Nursing Action Classification System. MAIN RESEARCH VARIABLES: Nursing interventions (i.e., assessment, medical scheduling, psychosocial scheduling, reassurance, and teaching) and phone calls. FINDINGS: Women enrolled in clinical trials had more phone interactions with nursing staff (p = 0.003) and received teaching (p < 0.001) and reassurance (p = 0.005) from nursing staff more often than women not enrolled in clinical trials. Controlling for age and stage of disease, teaching (p < 0.001), and reassurance (p = 0.10) were the primary differences in nursing care between the patients enrolled in clinical trials and those not enrolled. CONCLUSION: Differences in nursing care received exist between patients with breast cancer enrolled in clinical trials and those not enrolled. IMPLICATIONS FOR NURSING PRACTICE: Both teaching and reassurance are important components of caring for patients with cancer and are associated with treatment compliance. If the results of this study are confirmed, measures must be employed to ensure that all patients receive optimal care. (shrink)

Ob “nicht etwa eine vernünftigere Anordnung von Kreisen zu finden sei, von welchen alle erscheinende Ungleichmäßigkeit abhinge”, ist die Frage, die Copernicus umtreibt. Eine einheitliche, eine systematische Berechnung aller Planetenbewegungen – auch der der sogenannten irrenden Sterne – sucht Copernicus durch die Einführung einer Hypothese, die über eine bloß mathematische Annahme hinausgeht, zu begründen. Die Erkenntnis der einheitlichen Weltgestalt und des festen Ebenmaßes ihrer Teile hat die Annahme eines die systematische Einheit konstituierenden Prinzips zur Voraussetzung. Als dieses Prinzip versteht Copernicus (...) die Erdbewegung. So schließt Copernicus, daß entweder die Erde nicht ruhe oder eine vernünftige Ordnung der Planeten nicht zu begründen sei. Für Bruno und Schelling ist das Prinzip zur Ordnung des Universums keine mathematische Hypothese, sondern ein naturphilosophisches Prinzip. Schelling schließt sich Bruno in der Behauptung an, daß eine Ordnung nur unter der Voraussetzung möglich sei, daß das Subjekt wie das Objekt der Ordnung sich auf ein Prinzip zurückführen ließen. Damit droht die Kopernikanische Wende auf den Kopf gestellt zu werden. (shrink)

More and more frequently, the organisation of design fits into a project organisation where different designers have to cooperate with flexibility and reactivity. In order to help these cooperative design processes, we have to respond to new types of needs: a relatively unformalised coordination that requires permanent mutual adjustment, the fact that members of the team are geographically distant, the difficulty of building a shared reference via design documents and technical and organisational decisions that structure the project. In order to (...) provide computer support for these needs, asynchronous Group Ware is often recommended. However, the efficiency of these tools depends on the models that structure the work processes and the knowledge exchanged. In this paper, we present ABRICo, a new Design Rationale formalism that permits the recording of cooperative decision-making processes in complex design situations. We describe the formalism and explain how we intend to use it to specify cooperative design tools usable via an Intranet for computing projects. (shrink)

Why should Gordon Kaufman's mid-career theological method be of renewed interest to contemporary theists? Two distinguishing characteristics of the West today are its increasing religious pluralism and the growing numbers of theists who rely on hybrid approaches to construct concepts of God. Kaufman's method is well suited to this current state of affairs because it is open to diverse religious and theological perspectives and to perspectives from science and secular humanism. It also militates against the weaknesses inherent to hybrid approaches—ad (...) hoc constructs of God unable to motivate their holders to overcome human self-centeredness and so to contribute to the well-being and fulfillment of others. It achieves this by providing checks to reduce the risk of producing human-writ-large God-constructs. Lastly, Kaufman's method provides criteria to help theists identify humane and humanizing experiences, relationships, concepts, images, and texts (i.e., the basic material from which God-constructs are fashioned) from the plethora of options available, whether religious, cultural, or secular. (shrink)

This study investigates the engagement of family firms in corporate social responsibility. We first compare their corporate social performance to non-family firms. Then, following recent evidence on the heterogeneity of family firms, we examine two factors that may influence CSP within family firms: the level of family control and the governance orientation of the country in which they operate. This research is based on a theoretical framework which considers both agency and socioemotional wealth influences on family firms CSR engagements. Overall, (...) we find that family firms exhibit lower CSP than non-family firms. But when focusing on family firms, our analyses show a curvilinear relationship between family control and CSP. At lower levels of control, family owners invest more in social initiatives to protect their SEW. Beyond a threshold level of control that we estimate at 36 % in our sample, economic considerations prevail over SEW and social performance starts decreasing. We also find that family firms operating in stakeholder-oriented countries are more attentive to social concerns than those operating in more shareholder-oriented countries. (shrink)

Den Begriff ‚Anerkennung‘ hat der deutsch-jüdische Denker Franz Rosenzweig benutzt, um sein Verlangen nach einem gegenseitigen Verhältnis zwischen Christentum und Judentum auszudrücken, das auch die theoretische Anerkennung des Judentums seitens der Christen beinhalten würde. Auf den Terminus ‚Anerkennung‘ griff Rosenzweig aber weder in seinen frühen Hegelstudien zurück noch in der Dialogphilosophie, die er stiftete. Sein dialogisches Denken erarbeitete er eher als eine Offenbarungsphilosophie, in welcher ein ‚Ich‘ erst mittels der Antwort auf den Anruf eines ‚Andern‘ entstehen würde.

Throughout his life, Franz Rosenzweig (1886–1929) wondered at the role fulfilled by myth in the course of history. He also questioned the relationship of myth to religion. His masterpiece, The Star of Redemption (1921), purported to give an answer to his questioning. This article endeavours to shed light upon Rosenzweig’s answer by focussing upon the Star, and also by recurring to one of his earlier articles, “Atheistic Theology” (1914).

Consacré à la section de L’Étoile intitulée « Le nom propre », cet article fait aussi ressortir l’influence sur Rosenzweig, à côté de Luther, de Samson Rafael Hirsch, dans sa traduction et son commentaire du Pentateuque. « L’appel du nom propre » de Rosenzweig sert ensuite de base à une réflexion sur la notion de « devoir de mémoire » : toujours adressé à quelqu’un, jamais abstraitement universel, ce devoir est également de nature éthique, c’est-à-dire politique.Un devoir de mémoire : (...) les nomsCentered upon the section of The Star... entitled « The proper name », this paper also brings out the influence upon Rosenzweig of Samson Rafael Hirsch, in his translation and commentary of the Pentateuch. Rosenzweig’s « Call of the proper name » is then used as a point of departure for reflecting upon the « duty to remember » : this duty, which is always turned towards a singularity and never abstractly universal, also is ethical in nature, i.e., political. (shrink)

The aim of this paper is to extend the classical sequent calculusLC to the second order. This task is realized by a semantical approach mixing the correlation spaces semantics ofLC on the one hand, and the analogy with the interpretation of systemF in coherent spaces on the other hand. This relies on the introduction of a new semantical object:noetherian correlation spaces.From the semantics we deduce the syntax of the second order classical sequent calculusLC2.

Background In June 2016, the Parliament of Canada passed federal legislation allowing eligible adults to request Medical Assistance in Dying (MAID). Since its implementation, there likely exists a degree of hesitancy among some healthcare providers due to the law being inconsistent with personal beliefs and values. It is imperative to explore how nurses in Quebec experience the shift from accompanying palliative clients through “a natural death” to participating in “a premeditated death.” Research question/aim/objectives This study aims to explore how Quebec (...) nurses personally and professionally face the new practice of MAID and their role evolution. Research design A grounded theory design was used. Participants and research context We recruited 37 nurses who participated in or coordinated at least one MAID. Semi-structured interviews and focus groups were conducted and audiotaped. Data collection and analysis followed Strauss and Corbin steps. Ethical considerations Ethics approval was received from the investigator’s affiliated University. Participants were informed regarding the research goal, signed a written consent, and were assigned pseudonyms. Findings/results Results show that nurses experienced the wide range of paradoxe during MAID centering around the following eight elements: 1) confrontation abouth death, 2) choice, 3) time of death, 4) emotional load, 5) new Bill, 6) relationship with the person, 7) communication skills, and 8) healthcare setting. The shifting of views and values in this new role is presented by the contradiction of opposites. Conclusions A better understanding of the paradox experienced by nurses involved with MAID paves the way for the development of interventions. (shrink)

Introduction: Globally, vitamin D deficiency is one of the most common deficiencies, affecting nearly half the world's population. The objective of this survey was to assess and compare the knowledge about vitamin D and the perceived state of health in Emirati and international tourist female students in Dubai, UAE. Methods: This is a cross-sectional study that took place in universities in Dubai, UAE. This survey consisted of 17 multiple choice questions. The first part of the survey assessed levels of supplementation, (...) diet and UV exposure. Another section evaluated the participants’ self-assessed state of health regarding vitamin D testing, symptoms related to vitamin D deficiency and general welbeing. The collected data were statistically analyzed using SPSS statistics for windows version 26.0 (SPSS Inc., Chicago, IL). Statistical significance was set at P<0.05. Results: 105 respondents were Emiratis and 65 were international students. The average age was 21, with an average BMI 23.3. Almost one-third of each group reported using Vitamin D supplements once weekly. The majority of both groups reported rarely getting tanned. Almost all participants reported regular consumption of Vitamin-D rich foods. In both groups, more than half reported consuming milk and cheese regularly and up to one-third reported consuming fish in a regular manner. Although more than half of the students rated their health as good; more than two-thirds reported experiencing muscle pain; only half reported having their blood Vitamin D levels measured once; half reported experiencing problems with concentration and more than three-quarters reported experiencing bad mood in the past month. The prevalence of these symptoms was almost similar across different categories of vitamin D supplementation, tanning habits, dietary intake, or nationality. No statistically significant differences were noted between the 2 groups. Conclusion: more Emirati students were aware of the association between vitamin D and osteoporosis than International tourist students (40% vs. 21.9%, respectively; p<0.05). On the other hand, both groups had lower knowledge about the relationship between vitamin D deficiency and depression, Rheumatoid Arthritis and Hypertension, and the optimal vitamin D level; however, no statistically significant differences were noted regarding this knowledge of Emiratis and international students. (shrink)

À partir de cas cliniques, l’auteure analyse des situations de séparation précoce et met en évidence les conditions pour que cette séparation ne soit pas traumatique.

Resumen: El presente artículo pretende exponer algunos elementos fundamentales de la filosofía del pensador francés Michel Henry sobre el cuerpo, que él identifica con la subjetividad. Los conceptos fundamentales considerados son el esfuerzo, el movimiento, el hábito y la memoria, que permiten definir el cuerpo como un saber y una experiencia trascendental. La mayoría de estos conceptos se derivan de los estudios de Henry sobre Maine de Biran, pero luego son enlazados con su propio desarrollo filosófico en torno al cuerpo (...) como pathos de la carne viviente. El trabajo de Henry sobre el cuerpo puede contribuir con elementos cruciales a las discusiones actuales en las ciencias sociales, en áreas como el género, el trabajo, la violencia, la construcción de la autoimagen y los estereotipos sociales, el cuidado de la salud, entre otros.: This article aims to expose some fundamental elements of the French philosopher Michel Henry’s thinking about the body, which he identifies with subjectivity. The fundamental concepts considered are effort, movement, habit, and memory, which permits to define the body as a transcendental knowledge and experience. Most of these concepts derived from Henry’s studies on Maine de Biran but with a particular emphasis, relating them with his notion of the body as the pathos of living flesh. Henry’s concept of the body can contribute with crucial elements to the actual discussions in social sciences, in areas such as gender, work, violence, the construction of self-image and social stereotypes, health care, among others. (shrink)

L'Inopos, qui constitue le principal cours d'eau de Délos, prend sa source au Sud-Ouest du Cynthe. Il coule d'abord vers le Nord puis il s'oriente vers l'Ouest pour déboucher à l'emplacement de l'Agora des Hermaïstes. Un barrage associé à un vaste bassin de retenue a été construit à l'endroit où il change d'orientation. La paroi d'amont du mur qui barre le vallon est constituée de blocs de poros dont les joints verticaux ont été remplis de plomb et dont les assises (...) successives ont été associées par des barres métalliques se développant sur toute la longueur de l'ouvrage. Des drains ménagés dans l'épaisseur du mur conduisaient vers l'aval les eaux d'infiltration. Cette construction, qui atteste une remarquable connaissance des problèmes de stabilité des barrages, est sans doute une œuvre des Athéniens réalisée vers la fin du Ve ou le début du IVe s. Le barrage et son bassin furent réaménagés au début de l'Indépendance. A l'époque impériale, le barrage fut percé en sous-œuvre et associé à un aqueduc. (shrink)