This chapter discusses Mina Bissell's pathbreaking research on cancer. Along with her colleagues and students, Bissell focused her attention on how the causal pathways regulating cell behavior were a two way street. Healthy cells’ and cancer cells’ behavior are both highly context-dependent. The pathway to this insight was not direct. Bissell’s work began with research into cellular metabolism. As a result of this early research, she found that cells can “change their fate” – revert to, or (...) activate, functions not typical of cells in the differentiated state. This had important implications for our understanding of cancer's etiology and treatment. Bissell - among others - emphasized in her research that it was not simply cell intrinsic properties – such as mutations to “oncogenes” and “tumor suppressor” genes – that determine the typical behaviors of cancer cells, but also a variety of extrinsic properties in the surrounding environment: metabolic and other signaling molecules, the extracellular matrix, and tissue architecture. (shrink)

Dismissing criticisms that Leonard Peikoff's book, The DIM Hypothesis, is unscientific, deterministic, or rationalistic, this essay focuses on problems with the logical framework of Peikoff's study of Western culture. In particular, Peikoff has conflated two different kinds of rationalists and empiricists and has completely overlooked combinations of the Platonist and so-called “Kantian” modes. As a result, his three pure integration “modes” actually produce not just two “mixtures” but a total of six. Furthermore, without absolving Kant of very serious philosophical errors, (...) the author marshals evidence that the real culprit responsible for the culturally disastrous “Disintegration” mode was one of Kant's predecessors. (shrink)

To rethink history from the perspective of an economy of affects as they are engendered by beings ousted from the definition of the human, I will draw on two Caribbean texts, Anim-Addo's Imoinda: Or She Mho will Lose Her Name and Philip's Zong!. This essay discusses how these two Caribbean texts counterwrite the history of the slave plantation by staging and embodying the work of what I call an affective memory drawn from the history of the black subject as a (...) history of absence and reconstellated in the present as a history of being and community. This affective memory represents the being of the ‘living corpse’ and her making of a community as the subject of a new polity, the polity of decolonised beings. By drawing on these texts to demonstrate how they write the history of spectres, ruins and other communities, I discuss affective memory not as the absolute possession of a body, but rather as the alienated property of the body that can be reclaimed only by a community that, precarious and tentative as it is for it is a community of slaves and subjected bodies, remains the only promise for the future. (shrink)

The author reiterates his thesis that the motivation for power lust in liberals, conservatives, and totalitarians cannot be explained by “metaphysical importance” of economic or noneconomic activity per se, but only by the metaphysical fear that voluntary action in one or both of these realms evokes in statists of whatever stripe. Rand actually made both of these arguments, but only the latter has psychological explanatory power and plausibility in terms of Rand's discussion of the benevolent and malevolent universe premises, and (...) thus is to be preferred over the former. (shrink)

At the beginning of the Italian Renaissance, Michelangelo lamented in a sonnet dedicated to his beloved Vittoria Colonna that in carving sculptures he could only create dead forms and was powerless to create a living thing:My pitiful geniusIn love can call forth only death.

This paper provides a stagewise overview of the important issues that play a role in technology adoption and use in organizations. In the current literature, there is a lack of consistency and clarity about the different stages of the technology adoption process, the important issues at each stage, and the differentiation between antecedents, after-effects, enablers, and barriers to technology adoption. This paper collected the relevant issues in technology adoption and use, mentioned dispersedly and under various terminologies, in the recent literature. (...) The qualitative literature review was followed by thematic analysis of the data. The resulting themes were organized into a thematic map depicting three stages of the technology adoption process: pre-change, change, and post-change. The relevant themes and subthemes at each stage were identified and their significance discussed. The themes at each stage are antecedents to the next stage. All the themes of the pre-change and change stages are neutral, but the way they are managed and executed makes them enablers or barriers in effect. The thematic map is a continuous cycle where every round of technology adoption provides input for the subsequent rounds. Based on how themes have been addressed and executed in practice, they can either enhance or impair the subsequent technology adoption. This thematic map can be used as a qualitative framework by academics and practitioners in the field to evaluate technological changes. (shrink)

Издание содержит: общая характеристика проблемы времени в науке; психофизиологический подход к изучению проблемы времени в психологии; саморегуляция профессиональной деятельности и т.д.

THE CONCEPT OF CONSCIOUSNESS CHAPTER I THE RENAISSANCE OF LOGIC WITHIN the last two decades the scholarly world has witnessed a revival of interest in logic ...

This study investigates how Human Factors is applied when designing and developing Immersive Visual Technologies, including Augmented Reality, Mixed Reality, and Virtual Reality. We interviewed fourteen people working at different organizations, that develop IVT applications in the Nordic region. We used thematic analysis to derive themes from the interviews. The results showed an insufficient knowledge and application of HF in IVT development, due to the lack of awareness of both scope and significance of HF, resource allocation strategy, market inertia, stakeholder's (...) involvement, standardization of HF application and IVT uses, and technology maturity. This situation could be improved by allocating experts, adjusting organizational strategy to balance resource allocation, training developers and user organizations to raise awareness and to encourage co-creative design and knowledge sharing, create a sense of ownership amongst stakeholders, and ensure the usefulness of the technology to the user's work. (shrink)

The author compares two very different guides to Atlas Shrugged. The first, by Curry and Trifiletti, is a more straightforward though thoughtful examination, in sequence, of the novel's thirty chapters, while the second, by Tracinski, is a collection of mostly freestanding, insightful, and inspirational essays. Special focus is given to the treatment in each book of the length and literary merit of Galt's speech.

The goal of this study is to reveal which contextual factors can shape ethical behaviour and decision-making in family firms (FFs), with the aim to uncover emerging themes that help set the stage for future work on FF ethics. To do so, we conducted an integrative literature review. By systematically collecting, reviewing 90 studies and synthesizing their key findings with prior theoretical foundations in the FF field, we demonstrate how personal and family values, preservation of socioemotional wealth, generation succession and (...) structural factors (e.g. FF size, FF life cycle) can affect ethical decision-making in FFs. We also provide propositions and research pathways to orient future studies. (shrink)

This scarce antiquarian book is a facsimile reprint of the original. Due to its age, it may contain imperfections such as marks, notations, marginalia and flawed pages. Because we believe this work is culturally important, we have made it available as part of our commitment for protecting, preserving, and promoting the world's literature in affordable, high quality, modern editions that are true to the original work.

The author assures readers that Chris Matthew Sciabarra has met all Aristotelian requirements in full, providing not one but two definitions of “dialectics,” which, as the art of context-keeping, is indeed an essential part of Ayn Rand's philosophical method. He shows how Sciabarra's definitional process compares quite favorably in terms of timeliness, transparency, and benevolence to that of Rand and other Objectivists, and notes that Sciabarra's overriding concern, notwithstanding his obvious great respect for Rand's substantive philosophical achievements, has been to (...) identify and clarify the methods she and other thinkers have used to profound benefit. (shrink)

In contrast to Pietraszewski's account, latent structure learning neither requires conflict nor relies on observation of explicit coalitional behavior to support group inference. This alternative addresses how even non-conflict-based groups may be defined and is supported by experimental evidence in human behavior.

Features essays that invoke Said and Derrida's rigorous examination of humanism in their works. This title addresses social change and political questions and analyze humanism from the perspectives of literature, theory, history, gender studies, and art in view of the intellectual impact of Said and Derrida on contemporary philosophy.

The core of Australia’s response to asylum seekers who arrive in an unauthorised manner has been to detain them in immigration detention centres until they are judged to engage Australia’s protection obligations or, if they do not, until they are returned to their country of origin. For a number of asylum seekers this has resulted in very prolonged detention. This policy has aroused a storm of controversy with very polarised positions being taken by participants in the debate. In particular, the (...) claim has frequently been made (including by this author) that the circumstances and duration of immigration detention cause substantial harm to the mental health of a significant number of detained asylum seekers. A rational debate on the effects of detention has been hampered by the fact that the Australian government has not allowed researchers access to the detention centres in spite of persistent requests for access by professional bodies. This paper is written in response to the following questions posed by the Journal: Is there a case to be made for individuals agreeing to participate in research studies and for the wider population of current and future detainees to be involved in research without informing either the detention provider or the host nation? Is it legitimate for a researcher to engage in potentially deceptive actions in order to obtain access to such detention facilities to undertake research? What ethical framework should underpin such research? Although there is very little guidance in the literature on the ethical conduct of research in settings such as immigration detention centres, a consideration of the ethical implications of carrying out research in the manner raised by these questions leads this author to conclude that such research cannot be ethically justified. Governments must be persuaded to allow, and to provide substantial support for, ethically conducted research on all aspects of detention. There is also a need for the development of an explicit ethical framework for the conduct of research in settings characterised by a very problematic human rights context. (shrink)

In this third installment of his series on key, underappreciated ideas in Ayn Rand's epistemology, the author discusses the nature of differentiation and integration as the functional essence of consciousness and applies that insight to various cognitive and noncognitive processes of awareness, with a special emphasis on logic and illogic. He offers an extended analysis of the fallacies of “Frozen Abstraction” and “False Alternative,” as well as critiques of a long-standing Objectivist conflation of falsity and contradiction and a relatively more (...) recent Objectivist error, the fallacy of “genuine awareness.”. (shrink)

The author examines the canonical Objectivist model of free will and finds it wanting, amounting to a form of Agency—Indeterminism. Employing an Aristotelian Four Cause analysis, he explores the complementary roles of determinism and free will, as well as the conditional nature of necessity and contingency, in understanding how causality operates in the human realm. He proposes an integration of what he calls “value-determinism” and “conditional free will,” arguing that it amounts to a basic axiom of human choice and action, (...) and urges its acceptance in place of the Orthodox Objectivist view of free will. (shrink)

Name der Zeitschrift: Semiotica Jahrgang: 2018 Heft: 225 Seiten: 141-165.

Yes, Aristotle was named ‘Aristotle’. I want to show that since ‘Aristotle’ is a proper name, this is true by definition. My theory of proper names is a version of Russell's, a theory that a name is equivalent in meaning to definite description which single out the individual, if there is one, to which the name refers. Braithwaite at one time said that the proper name ‘Aristotle’ meant the description ‘the individual named “Aristotle” ’. This theory, which makes it contradictory (...) to suppose that Aristotle was not named ‘Aristotle’ I will argue is the correct one. This will involve some explanation of what naming is, which I will carry out in the first two sections. My contention is that naming is an activity that can be done either explicitly or non-explicitly. And names can be conferred either on the basis of acquaintance or by associating the name with descriptions. (shrink)

The author discusses how Rand’s largely underdeveloped concept of the “dual-aspect objective,” first introduced in the 1960s, is vital for understanding how knowledge is grounded in reality. He defines it, then applies it to perception and introspection, and to concepts, propositions, and syllogisms. The author also defines content of awareness, carefully distinguishing it from both object and form of awareness, and applies those distinctions throughout. In addition, he discusses how truth is both dual-aspect and contextual, and he extends his discussion (...) in Part 1 of Rand’s “unit-perspective,” showing how units, too, have a dual-aspect, even on the level of syllogisms. (shrink)

Research Ethics, Volume 18, Issue 2, Page 163-168, April 2022. Citation is an essential practice in scientific publishing. However, it is mandatory that citing the sources in a scientific work is performed in a proper manner. Manipulating citations in research articles is one form of academic research misconduct that violates publication ethics. Citation manipulation simply occurs for the purpose of increasing the number of citations of a researcher or a journal. Unfortunately, there has been a growing trend for this type (...) of misconduct recently and this has not received much attention from the science community. The most effective solution to prevent the growth of such unethical practices is for reputable journals to impose stricter rules on reference evaluation criteria in order to emphasize on the appropriateness of the citations. (shrink)

The author provides another metaphysical argument to bolster his thesis of the logical harmony of determinism and volition. He shows how the typical mainstream and Objectivist doctrine of “libertarian” free will commits the same logical error as the Sophist attacks on the Law of Non-Contradiction—namely, an out-of-context interpretation of, respectively, the Law of Causality and the Law of Identity as being unconditional absolutes, which they are not and cannot be.

The author contends that the Objectivist epistemology has lacked a viable model of propositional knowledge for nearly fifty years, due to neglect of Rand's unit-perspective view of concepts. This pioneering insight, he says, not only is an essential building block of her concept theory, but also welds together the three levels of logical theory and provides the clearest X-ray picture of our multilayered conceptual knowledge. Using the unit-perspective to expand Rand's theory of concepts, the author then devises a theory of (...) the proposition, giving considerable attention to axioms and statements about nonexistent subjects. (shrink)

The author argues that Rand’s ethical theory is much closer in essence to the eudaimonist, self-perfectionist perspectives of Aristotle and the neo-Aristotelians, Douglas Den Uyl and Douglas Rasmussen, than to the “selfish,” egoistic ethics many assume to be her basic position. He discusses Rand’s anti-hedonist and pro-rational selfishness positions as corollaries of man’s life as the standard of moral value, as well as Rand’s point that treating either happiness or personal benefit as the standard of moral value is a reversal (...) of cause and effect. He also identifies the oppressive negativism in Rand’s discussion of the seven canonical Objectivist virtues. (shrink)

ABSTRACT The author continues his challenge to the “official” Objectivist view of free will by addressing the implications of his value-determinism/conditional-volition model for various Objectivist moral concepts including value, sacrifice, virtue, obligation, and moral and legal responsibility and accountability. He argues that based on Rand’s definitions, the conventional understandings of sacrifice or betrayal of values, lapses in virtue, and breaches in morality need considerable reconceptualizing. The author gives special attention to Rand and Kant with regard to lying, use of force, (...) and acts of generosity, finding not nearly as much difference between them as is commonly believed. (shrink)