Ageing causes progressive decline in metabolic, behavioural, and physiological functions, leading to a reduced health span. The extracellular matrix (ECM) is the three‐dimensional network of macromolecules that provides our tissues with structure and biomechanical resilience. Imbalance between damage and repair/regeneration causes the ECM to undergo structural deterioration with age, contributing to age‐associated pathology. The ECM ‘Ageing Across the Life Course’ interdisciplinary research network (ECMage) was established to bring together researchers in the United Kingdom, and internationally, working on the emerging field (...) of ECM ageing. Here we report on a consultation at a joint meeting of ECMage and the Medical Research Council / Versus Arthritis Centre for Integrated Research into Musculoskeletal Ageing, held in January 2023, in which delegates analysed the key questions and research opportunities in the field of ECM ageing. We examine fundamental biological questions, enabling technologies, systems of study and emerging in vitro and in silico models, alongside consideration of the broader challenges facing the field. (shrink)

Highly portable and accessible MRI technology will allow researchers to conduct field-based MRI research in community settings. Previous guidance for researchers working with fixed MRI does not address the novel ethical, legal, and societal issues (ELSI) of portable MRI (pMRI). Our interdisciplinary Working Group (WG) previously identified 15 core ELSI challenges associated with pMRI research and recommended solutions. In this article, we distill those detailed recommendations into a Portable MRI Research ELSI Checklist that offers practical operational guidance for researchers contemplating (...) using this technology. (shrink)

Neural correlates of consciousness (for brevity NCC) are foundational to the scientific study of consciousness. Chalmers (2000) has provided the most informative and influential definition of NCC, according to which neural correlates are minimally sufficient for consciousness. However, the sense of sufficiency needs further clarification since there are several relevant senses with different entailments. In section one of this article, we give an overview of the desiderata for a good definition of NCC and Chalmers’s definition. The second section analyses the (...) merit of understanding the sufficiency of neural correlates for corresponding consciousness according to three relevant types of sufficiency: logical, metaphysical, and physical. In section three, a theoretical approach to consciousness studies is suggested in light of the sense in which NCC are sufficient for consciousness. Section four addresses a concern some might have about this approach. By the end, it will become apparent that our conception of NCC has important implications for research methodology, neuroethics, and the vitality of the search for NCC. (shrink)

This book explores how ancient philosophers, particularly Plato, Aristotle, the Stoics, and Sextus Empiricus, understood relativity and how their theories of the phenomenon affected, and were affected by, their broader philosophical outlooks.

Sport Philosophy Now examines the current sports philosophy available and updates it in the “post-Lance Armstrong” age. While many sports philosophers have turned a blind eye to the reality of sport by focusing on ideologically-driven abstract ideals, this book offers an engaging alternative. Examining the field primarily through the competitive world of cycling, Matthew James McNees explores such issues as authenticity in sport, our tendency to create superficial high-minded meaning from the actions of athletes, and American capitalism in sports.

In this book, Matthew P. Meyer analyzes the archer and the bow as a metaphor for the human condition in Lacan, Nietzsche, and Greek literature. The bow is a model of the tension at the heart of the human condition, while the archer is a symbol of control.

Yuval Steinitz has argued that, since it is logically possible that there are logically necessary beings, it follows that there is at least one logically necessary being. Steinitz switches the Leibnitzean ontological argument's concern from perfect beings to logically necessary beings. My paper has two primary aims. First, I argue that Steinitz's quick treatment is insufficient to establish the validity of his argument. Secondly, I argue that the correct approach to logical necessity must account for those possible situations in which (...) the meanings of some of the terms in our language might have been different; on such an approach, the premise of Steinitz's argument is false. My remarks here are intended to add to the prima facie plausibility of Hume's claim that logic has no existential implications. (shrink)

Emmanuel Levinas’ aesthetics has been critically discussed much less than other components of his philosophy. In one way, this is not surprising, given Levinas’ wider post-war project. Nevertheless, in the late 1940s, the very time his influential later philosophy was taking shape, Levinas published a series of papers on literary criticism, and on the nature of art. istents and Existence, the text where Levinas first announces his project of “leaving the climate” of Heidegger’s thought, contains in its heart a remarkable (...) discussion of modernist painting. 2 Levinas’ aesthetics, moreover, represents a provocative standpoint within modern aesthetic theory in its own right. As such, it stands as a partial corrective to the comparative and surely surprising – dearth of phenomenological analyses of art, which at the same time contrasts markedly with Heidegger’s renowned position in “The Origin of the Work of Art.” From a critical perspective, however, an examination of Levinas’ aesthetics is interesting in another, and perhaps deeper way. As critics have intimated, 3 Levinas’ aesthetics arguably marks what could be called a “supplement” within his texts. As is well known, Levinas’ post-war works defend his own post-Husserlian version of what Kant called “the primacy of practical reason” which he calls – in a more classical vein – “ethics as first philosophy.” 4 In this light, Levinas’ texts feature an axiological devaluation of aesthetics in comparison with the ethical encounter with the Other. What this paper will argue – in line with but beyond Derrida’s masterful “Violence and Metaphysics” 5 – is that aesthetic experience as analysed by Levinas has an uncanny structural proximity to his analyses of “ethics.” And recognition of this primacy might well cause us to reconsider Levinas’ classically “Greek” as much as Judaic devaluation of aesthetics as one dimension of human experience. Part I takes a poem as the basis to construct Levinas’ account of the aesthetical or art-quality of artworks. Part II examines what Levinas takes his analysis of the work of art to point towards in terms of a more general [de]ontology, wherein the reality given in phenomenological perception is doubled by its own “shadow.” Part III questions not Levinas’ aesthetics but how it signifies in terms of his avowed project of elevating ethics as “first philosophy.” –. (shrink)

We are happy to announce that Libertarian Papers has been chosen for inclusion in the web archives of the Library of Congress. This means that, once archived, the complete journal will be available indefinitely both to researchers at Library facilities and by special arrangement. Of course, because Libertarian Papers uses an open-access format, the use of ….

I offer an account of truth that combines elements of deflationism and traditional correspondence theories. We need such an intermediary account, I argue, in order to adequately answer two kinds of questions: "Why do we find it obvious that 'p' is true iff p?" and "Why is it contingent that 'p' is true iff p?" If what it is for 'p' to be true is explained by simply saying that p, as the deflationist claims, it is hard to see how (...) it could be contingent that 'p' is true iff p. But if it is claimed instead that what it is for a sentence to be true is for it to correspond to a fact, we still need some explanation of why 'p's correspondence with reality insure that p, and vice versa. What we need, I claim, is to recognize a structure to truth: truth for sentences, utterances, and other non-propositional entities depends on, and is analyzable in terms of, the expression of true propositions. Propositional truth can then be treated as insubstantial, as deflationary, and truth for other entities as substantial, consisting of correspondence to a fact . ;This account of truth, which I call Weak Deflationism, anchors the dissertation. In an introductory chapter, I give a partial defense of realism about propositions and properties, later defending Platonism against attacks by David Lewis. After formulating Weak Deflationism, I examine its implications for such matters as the "absurd comparison" objection, the truthmaker project in ontology, and non-factualist theories in metaethics. In a final chapter, I provide a Kripke-inspired modification of Weak Deflationism aimed to avoid liar-like paradox. Premised on a distinction between propositions that predicatively involve truth, i.e., truth-dependent propositions, and those that do not, truth-independent propositions, I argue that truth for the latter is deflationary and that truth for the former consists in being determined by the totality of truth-independent fact. Falsity is understood as truth of the negation. Liars are then counted neither true nor false, and paradox is averted. (shrink)

It’s generally assumed that a compositional semantic theory will have to recognise a semantic category of expressions which serve simply to pick out some one object: e-type expressions. Kripke’s views about names, Kaplan’s about indexicals and demonstratives, the standard Tarskian semantics for bound variables, Heim and Kratzer’s Strawsonian view about definites, even an analysis of indefinites, assume as much. In this thesis, I argue that recent advances in the semantics of names and of quotation, and in metaphysics, give good reason (...) to doubt there is such a category. I do so in two parts. In the first part, comprising about two thirds of the thesis, I combine two recent views, one from semantics and one from metaphysics. From semantics, I take over predicativism about names, the view, as one might have guessed, that names are predicates. From metaphysics, I take over the doctrine that there are temporal parts. Putting them together, I hold that the semantic contribution of the name ’Joan’, in a sentence like ’Joan is a barrister’, is a predicate, and in particular a predicate the extension of which is Joan’s temporal parts. Names are not, as is commonly thought, e-type expressions. In the second part, building on the first, I further undermine the existence of a semantically important category of e-type expressions by arguing that a construction which might be thought to mandate such a category, namely de re attitude ascriptions, in fact, when properly analysed, does not do so. I argue this by considering the nature of transparent occurrences of expressions in opaque contexts in general, and in particular by considering the phenomenon of mixed quotation. I present a new theory of it, and show how it can be parlayed into a new Fregean theory of de re attitude ascriptions. The thesis overall, then, will provide strong evidence against the semantic importance of e-type expressions either in language, or in thought. (shrink)

The general issue addressed in this dissertation is: what do the models of formal model-theoretic semantics represent? In chapter 2, I argue that those of first-order classical logic represent meaning assignments in possible worlds. This motivates an inquiry into what the interpretations of first-order quantified model logic represent, and in Chapter 3 I argue that they represent meaning assignments in possible universes of possible worlds. A possible universe is unpacked as one way model reality might be. The problem arises here (...) as to how we are to understand the distinction between the actual and the possible as it relates to modal reality. ;Along with the development of the main arguments in Chapters 2 and 3, the dissertation assesses the status of semantic accounts or logical properties and relations. Specifically, what does the model-theoretic account of a logically possible situation add to the syntactic account ? ;Proofs of invalidity in terms of the models of formal semantics do not establish that it is possible for the premises to be true and the conclusion false, since a formal model is merely given by a consistent set of sentences. Unless there is some way to generate a non-formal model from a formal one, such proofs do not really go beyond syntactic notions. The dissertation ends by concluding that there is no way to generate a non-formal model from a formal one without relying on logical intuitions that are syntactical. ;Hence efforts to construct a semantic basis for model logic independent of syntactic commitments are misguided. However, in classical logic the independence of the semantic account from the syntactic one is grounded on the intuition that it is metaphysically possible for there to be a denumerably infinite totality of objects. (shrink)

According to Vasubandhu’s Trisvabhāvanirdeśa or Treatise on the Three Natures, experiential phenomena can be understood in terms of three natures: the constructed, the dependent, and the consummate. This paper will examine internalist and anti-internalist or non-dualist interpretations of the Yogācāra theory of the three natures of experience. The internalist interpretation is based on representationalist theory of experience wherein the contents of experience are logically independent of their cause and various interconnected cognitive processes continually create an integrated internal world-model that is (...) transparent to the cognitive system that creates and uses it. In contrast, the anti-internalist interpretation begins, not from the constructed nature of experiential objects, but from the perfected nature of mind-world non-duality. This interpretation treats the distinctions between inside and outside, subject and object, mind and world as distinctions drawn within experience rather than between experience and something else. And experience here refers to the continuous dynamic interplay of factors constituting our sentient embodied existence. Having examined each interpretation, the paper will suggest some reasons to favor the non-dualist view. (shrink)

This classroom edition includes _On the Social Contract_, the _Discourse on the Sciences and the Arts_, the _Discourse on the Origins of Inequality_, and the Preface to _Narcissus_. Each text has been newly translated and includes a full complement of explanatory notes. The editors’ introduction offers students diverse points of entry into some of the distinctive possibilities and challenges of each of these fundamental texts, as well as an introduction to Rousseau’s life and historical situation. The volume also includes annotated (...) appendices that help students to explore the origins and influences of Rousseau’s work, including excerpts from Hobbes, Pascal, Descartes, Mandeville, Diderot, Voltaire, Madame de Staël, Benjamin Constant, Joseph de Maistre, Kant, Hegel, and Engels. (shrink)

In the face of the Brexit vote and the election of Trump, there is serious worry about whether the liberal, democratic, and cosmopolitan values thought to underlie progressive immigration policies are in fact widely shared. In this article, I examine these worries and provide suggestions about how those who do favor just progressive immigration policies might best respond to the problems we currently face.

In this article I compare and contrast various elements of the work of George Santayana and Arthur Schopenhauer. Though others have acknowledged the relation between these thinkers, they have failed to consider whether and to what extent Santayana fits within the American tradition via this relation. I consider this by first identifying three areas of kinship in their philosophies, each of which I claim distinguish Santayana from the American tradition. Finally, I identify a significant point on which Santayana's philosophy departs (...) from Schopenhauer's, a point which I claim ultimately identifies Santayana with the American tradition. (shrink)

In this paper I argue that anyone who accepts a Rawlsian account of justice should favor granting family-based immigration benefit to same-sex couples. I first provide a brief over-view of the most relevant aspects of Rawls's position, Justice as Fairness. I then explain why family-based immigration benefits are an important topic and one that everyone interested in immigration and justice must consider. I then show how same-sex couples are currently systematically excluded from the benefits that flow from family-based immigration rights. (...) Next I argue that people in the constitutional and legislative stages of Rawls's original position would act to protect family-based immigration rights for themselves and show how these rights are rights of the current citizens of a state to bring in certain outsiders and not rights of outsiders seeking to enter. Importantly, this argument takes place entirely within the bounds of Rawls's domestic theory of justice and does not make reference to his more controversial views found in his account of international justice. I then show that there is no acceptable reason to restrict these rights to opposite-sex couples and good reason to extend them to same-sex couples. Finally I consider two objections to my account and show why they do not threaten my conclusion. (shrink)

Temporary labor migration programs have been among the most controversial topics in discussions of immigration reform. They have been opposed by many, perhaps most, academics writing on immigration, by immigration reform activists, and by organized labor. This opposition has not been without some good reasons, as many historical temporary labor migration programs have led to significant injustice and abuse. However, in this paper I argue that a well-crafted temporary labor migration program is both compatible with liberal principles of justice and (...) likely to be an important part of a sensible immigration policy for the near future, at least. I show how the many injustices and high potential for abuse of earlier programs may be avoided. I also show good reason to favor a well-crafted temporary labor migration program over either the more likely alternative outcome of officially tight borders (which would almost certainly maintain our current dependence on large-scale unauthorized immigration) and the much less likely option of nearly open borders. As increased labor migration of all sorts is an intrinsic part of increased economic globalization, it is especially important to craft guidelines for just temporary labor migration programs if we are to both gain the advantages of globalization and protect the rights of workers. (shrink)

Ultimate reality is often characterized in terms of a variety of what are thought to be incompatible concepts, like God, Dao, Brahman, etc. This book examines the plausibility of a genuine religious pluralism, arguing against relativism but in favor of the authenticity of a plurality of the world's major religious traditions.

We are happy to announce that Volume 8 of Libertarian Papers is now available in a print edition. This volume contains all Libertarian Papers articles for 2016, including contributions by scholars like Jan Narveson, Billy Christmas, Peter Lewin, Ryan Murphy, Aiden P. Gregg, and many others. It also covers a wide range of the most pressing and controversial topics in ….

Joe Campbell has identified an apparent flaw in van Inwagen’s Consequence Argument. It apparently derives a metaphysically necessary conclusion from what Campbell argues is a contingent premise: that the past is in some sense necessary. I criticise Campbell’s examples attempting to show that this is not the case (in the requisite sense) and suggest some directions along which an incompatibilist could reconstruct her argument so as to remain immune to Campbell’s worries.

We present evidence for the existence of 'responsibility voids' in committee decision-making, that is, the existence of situations where no member of a committee can individually be held morally responsible for the outcome. We analyse three types of reasons (causal, normative and epistemic) for the emergence of responsibility voids, and show that each of them can occur in committees. But the conditions for these voids are so restrictive as to reduce the philosophical or institutional significance they might be thought to (...) possess. (shrink)