Membrane proteins possess certain features that make them susceptible to the electric fields generated at the level of the plasma membrane. A reappraisal of cell signalling, taking into account the protein interactions with the membrane electrostatic profile, suggests that an electrical dimension is deeply involved in this fundamental aspect of cell biology. At least three types of potentials can contribute to this dimension: (1) the potential across the compact layer of water adherent to membrane surfaces; this potential is affected by (...) classical inducers of cell differentiation, like dimethylsulfoxide and hexamethylenebisacetamide; (2) the potential across the Gouy‐Chapman double layer, which accounts for the effects of extracellular cations in the modulation of differentiation; and (3) the resting potential. This last potential and its governing ion currents can be exploited in localised mechanisms of cell signalling centred on the functional association of integrin receptors with ion channels. (shrink)

For the past two decades, Einstein's Hole Argument (which deals with the apparent indeterminateness of general relativity due to the general covariance of the field equations) and its resolution in terms of "Leibniz equivalence" (the statement that pseudo-Riemannian geometries related by active diffeomorphisms represent the same physical solution) have been the starting point for a lively philosophical debate on the objectivity of the point-events of space-time. It seems that Leibniz equivalence makes it impossible to consider the points of the space-time (...) manifold as physically individuated without recourse to dynamical individuating fields. Various authors have posited that the metric field itself can be used in this way , but nobody so far has considered the problem of explicitly distilling the "metrical fingerprint" of point-events from the gauge-dependent elements of the metric field. Working in the Hamiltonian formulation of general relativity, and building on the results of Lusanna and Pauri (2002), we show how Bergmann and Komar's "intrinsic pseudo-coordinates" (based on the value of curvature invariants) can be used to provide a physical individuation of point-events in terms of the true degrees of freedom (the "Dirac observables") of the gravitational field, and we suggest how this conceptual individuation could in principle be implemented with a well-defined empirical procedure. We argue from these results that point-events retain a significant kind of physical objectivity. (shrink)

This article examines some of the most relevant issues concerning P2P systems so as to take sides in today's strongly polarized debate. The idea is to integrate a context-based perspective with an ontological representation of informational norms; thanks to a procedural outlook which is presented in terms of burden of proof More particularly, we examine three ''roads." First, the topological approach to complex social networks allows us to comprehend the laws according to which information is distributed through P2P systems and (...) how a "short route" has joined, and sometimes replaced, the traditional "long route" between creator, business, and the public. The second road is the context-based perspective elaborated by Helen Nissenbaum, and developed by Francis Grodzinsky and Herman Tavani: The goal is to determine the norms that govern such an informational flow as norms of appropriateness and distribution. The final road is the informational viewpoint on ethics proposed by Luciano Floridi with the idea that standard ethical theories cannot easily be adapted to deal with the new informational issues emerging with digital technology. While empirical evidence on the impact of P2P systems is still quite controversial, it is crucial to determine on whom the burden of proof falls in a given context, on censors or advocates, by singling out both the default norms and exceptions in the use and development of P2P software. (shrink)

Due to the current availability of the English translation of almost all of Lesniewski's works it is now possible to give a clear and detailed picture of his ideas. Lesniewski's system of the foundation of mathematics is discussed. In abrief ouüine of his three systems Mereology, Ontology and Protothetics his positions conceming the problems of the forms of expression, proper names, synonymity, analytic and synthetic propositions, existential propositions, the concept of logic, and his views of theory of science and metaphysics (...) are sketched. The influence of Mill, Lukasiewicz, Austrian philosophy and especially Petrazycki on his thinking is evaluated and an interpretation is suggested setting him squarely in a tradition of classical Aristotelian logic. (shrink)

Musings and observations of a scientist turned philosopher.

The articles in this issue reflect the results of the 25th Altenberg Workshop in Theoretical Biology on ‘‘The Meaning of ‘Theory’ in Biology’’ held at the Konrad Lorenz Institute for Evolution and Cognition Research, Altenberg, Austria, 30 June–3 July, 2011.

Will the scientific quest ever end? Will it be with a bang or with a whisper?

For a long time, Parmenides has been considered the first real metaphysician in history, a theorist of a disembodied being, unreachable by the scientific knowledge of the world. In his Eleatic Lectures, Giovanni Cerri goes back to his renown interpretation of Parmenides as a scientist fully aware of the epistemological foundations of knowledge, and capable of foreshadowing the ultimate outcome of the evolution of science, that is, the discovery of being as a single homogeneous body. Cerri also shows that the (...) works of two other thinkers who were trained in the heart of the school of Elea itself support his interpretation: on the one hand Zeno, with his arguments against plurality; on the other hand Leucippus, the inventor of atomism. Ten scholars have been called to discuss this broad interpretation of a crucial page in the history of thought. Cerri replies to each of them in the final pages of the volume, engaging in a dense dialogue. (shrink)

In introducing the present issue, we make clear that the concept of the other is susceptible to so multifarious declinations that it actually forms a conceptual galaxy. It is precisely this galaxy that the ten essays in the issue aim to shed light on. We then account for the basic ideas of each essay, and we stress the remarkable fact that they help to clarify how the concept of the other represents a useful means to undermine the purported divide between (...) continental and analytic philosophy. (shrink)

This paper is about the development of a face-to-face collaborative technology to support shifting attitudes of participants in conflict via a narration task. The work is based on two cultural elements: conflict resolution theory and the design of a collaboration enforcing interface designed specifically for the task. The general claim is that participants may achieve a greater understanding of and appreciation for the other’s viewpoint under conditions that support partaking in a tangible joint task and creating a shared narration. Specifically, (...) a co-located interface for producing a joint narration as a tool for favoring reconciliation is presented and discussed. The process based on this technology implicitly includes classical steps in conflict resolution approaches, such as escalation and de-escalation. Our goal is to show that this interface is effective and constitutes an alternative to a typical face-to-face moderated discussion. (shrink)

This paper is about the development of a face-to-face collaborative technology to support shifting attitudes of participants in conflict via a narration task. The work is based on two cultural elements: conflict resolution theory and the design of a collaboration enforcing interface designed specifically for the task. The general claim is that participants may achieve a greater understanding of and appreciation for the other’s viewpoint under conditions that support partaking in a tangible joint task and creating a shared narration. Specifically, (...) a co-located interface for producing a joint narration as a tool for favoring reconciliation is presented and discussed. The process based on this technology implicitly includes classical steps in conflict resolution approaches, such as escalation and de-escalation. Our goal is to show that this interface is effective and constitutes an alternative to a typical face-to-face moderated discussion. (shrink)

A vast literature exists on the concept of “linguistic ideology.” Scholars generally agree on defining it as a set of ideas that the members of a community hold about the role of language in the community. Nevertheless, scholars generally disagree on whether these ideas are explicit or implicit. Different views on this point imply different methodologies: the analysis of explicit considerations on language in the first case, that of a more multifarious material in the second one. However, excluding implicit ideas (...) from the analysis is too restrictive. A better option is to distinguish between explicit beliefs and implicit assumptions. Whereas the first ones must be studied through socio- or ethno-logical methods, the second ones must be studied through semiotics: the discourses that are produced in a community are considered as signs of implicit assumptions that such community holds about language. The paper deals with a case-study: the semiotic ideology behind denegation in the contemporary Italian political discourse. (shrink)

Il concetto di democrazia ed i progetti di costituzione elaborati da Rousseau vengono posti a confronto con la teoria del governo rappresentativo di Guizot: in particolare vengono esaminate le prospettive olistiche e individualistiche nel processo di individuazione della volontà generale attraverso il suffragio. Il ruolo della volontà prevale nella teoria rappresentativa di Rosseau, mentre per Guizot la ragione deve essere predominante sulla volontà. La libertà viene considerata irrinunciabile da Rousseau, che però non accetta una libertà di fede, preferendo l'istituzione di (...) una religione civile obbligatoria. Guizot riprende il concetto di cittadinanza esposto da Kant e lo pone come condizione necessaria per l'elettorato attivo, contro una visione democratica rivoluzionaria. Il concetto di corpo politico, nella prospettiva di Gonzague de Reynold Cressier, presenta notevoli affinità con la teoria del governo rappresentativo di Guizot, che si fonda sulla concezione di una società divisa in classi che devono permanere ben distinte, ma unite nel perseguimento dell'interesse generale. A tal fine, l'etimologia dell'espressione “democrazia” viene ricondotta ai demi (le tribù attiche) ed alle loro capacità censuarie e non al popolo, né come totalità, né come insieme di individui. (shrink)

“History is the most dangerous compound yet contrived by the chemistry of intellect”: it was in response to these words by Paul Valéry that Marc Bloch, professor of economic history at the Sorbonne, after the defeat of 1940, began writing a book on “how and why history is studied.” He gave it the provisional title Apologie pour l'Histoire ou Métier d'historien translated into English as The Historian's Craft. In the spring of 1944, he was killed by a German firing squad (...) for his clandestine activity in the Resistance. The manuscript of his book remained incomplete. Having entered the world at the same time as the research organization of Annales in 1949, Bloch's book on history, posthumously published by Lucien Febvre, was read and used as a product of that organization, which did not yet exist, even as a project, at the time the book was written. The Historian's Craft was read mostly by historians, history professors, and history students. Despite its readership, Bloch had written it for a different public: persons of culture and action, that same audience that Annales had tried in vain to conquer in the thirties—Paul Valéry's public. The study of the genesis of the interrupted manuscript reveals the richness of the content of Bloch's book, so far underrated. This example of the two pages missing from the 1949 edition, can today be the start of a deeper meditation on history, historians, and philology (and on the documents that refer to them). (shrink)

At death's door, Leibniz firmly refused to see a priest. This seems to be in strong contrast with the central role that he attributes to God in his philosophy and with his explicit acceptance of the Christian religion. Thus, the circumstances surrounding Leibniz's death, as related by some direct and indirect witnesses, provide an opportunity to examine the sincerity of Leibniz's position on religion. The final conclusion is that Leibniz believed in a religion broadly inspired by Christian principles but that (...) he was not a particularly pious believer, which is fully in line with his own kind of ante litteram deism. (shrink)

What Jerry Fodor and Massimo Piattelli-Palmarini got wrong about Darwin and evolution.

Di Massimo di Tiro si conoscono pochi dettagli biografici. Le fonti antiche, concordi nel ritenerlo ‘filosofo’ e ‘filosofo platonico’, affermano che le sue dissertazioni o indagini filosofiche sono da ricondursi al suo primo soggiorno a Roma, al tempo dell’imperatore Commodo. Le quarantuno dissertazioni filosofiche di Massimo di Tiro offrono una visione privilegiata della cultura imperiale del secondo secolo, epoca in cui, dominante l’eleganza stilistica, anche la filosofia non disdegnava di dispiegare i propri contenuti mediante il bello stilo dello (...) strumento retorico. Nello svolgimento dei temi, perlopiù platonici nell’ispirazione e orientati ad argomenti presenti al dibattito coevo, ma comunque non escludenti altre influenze filosofiche, Massimo di Tiro si mostra pensatore dalla non banale semplicità. Muovendosi fra filosofia e letteratura, fra Platone e Omero, egli calibra l’erudizione sul filtro di un’esigenza educativa di ampio respiro. Nel volume si presenta la prima traduzione italiana completa dal greco. Il commento critico, aggiornato al dibattito accademico internazionale, mira a mostrare come l’opera del pensatore meriti una rinnovata attenzione nell’ambito degli studi classici letterari e filosofici, giacché nel delineare il quadro culturale del tempo essa consente di meglio precisare alcuni non marginali aspetti del platonismo del secondo secolo. (shrink)

Biological research on race has often been seen as motivated by or lending credence to underlying racist attitudes; in part for this reason, recently philosophers and biologists have gone through great pains to essentially deny the existence of biological human races. We argue that human races, in the biological sense of local populations adapted to particular environments, do in fact exist; such races are best understood through the common ecological concept of ecotypes. However, human ecotypic races do not in general (...) correspond with 'folk' racial categories, largely because many similar ecotypes have multiple independent origins. Consequently, while human natural races exist, they have little or nothing in common with 'folk' races. (shrink)