Asymmetric RNA localization is required for many developmental processes in a wide range of organisms. For example, wingless and pair‐rule transcripts are localized to the apical membrane of polarized cells. It has been unclear, however, if this localization is important for biological activity and, in addition, how the transcripts are transported. Two recent studies(1,2) have identified cis‐elements and trans‐acting factors that are required for the asymmetric localization of mRNAs. Correct localization is shown to be required for biological activity, and a (...) mechanism of RNA transport involving the microtubule motor dynein has been revealed. BioEssays 23:869–872, 2001. © 2001 John Wiley & Sons, Inc. (shrink)

Mark Eli Kalderon presents an original study of perception, taking as its starting point a puzzle in Empedocles' theory of vision: if perception is a mode of material assimilation, how can we perceive colors at a distance? Kalderon argues that the theory of perception offered by Aristotle in answer to the puzzle is both attractive and defensible.

In this paper, I describe some of what I take to be the more interesting features of friendship, then explore the extent to which other virtues can be reconstructed as sharing those features. I use trustworthiness as my example throughout, but I think that other virtues such as generosity & gratitude, pride & respect, and the producer’s & consumer’s sense of humor can also be analyzed with this model. The aim of the paper is not to demonstrate that all moral (...) virtues are exactly like friendship in all important respects, but rather to articulate a fruitful model in which to explore the virtues. Section 2 explores the relational nature of friendship, drawing on Aristotle’s discussion of friendship in the Nicomachean Ethics. Section 3 catalogues four motivations for taking seriously the friendship model of virtue. Section 4 applies the friendship model in depth to the virtue of trustworthiness. (shrink)

Geach's problem, the problem of accounting for the fact that judgements expressed using moral terms function logically like other judgements, stands in the way of most noncognitive analyses of moral judgements. The non-cognitivist must offer a plausible interpretation of such terms when they appear in conditionals that also explains their logical interaction with straightforward moral assertions. Blackburn and Gibbard have offered a series of accounts each of which interprets such conditionals as expressing higher order commitments. Each then invokes norms for (...) the coherent acceptance of attitudes to explain why we hold certain combinations inconsistent. Against these accounts the paper presses two related objections: (1) The norms needed to do the explanatory work cannot be strong enough to do that work without also ruling clearly consistent attitudes inconsistent. And (2), the norms of rational attitude acceptance do not neatly track the distinction between consistent and inconsistent attitudes. (shrink)

This book explores these differences and in particular considers various theoretical perspectives that might be useful for opening new interpretive strategies for critical social theory in relation to these differences.

I know that I could have been where you are right now and that you could have been where I am right now, but that neither of us could have been turnips or natural numbers. This knowledge of metaphysical modality stands in need of explanation. I will offer an account based on our knowledge of the natures, or essencess, of things. I will argue that essences need not be viewed as metaphysically bizarre entities; that we can conceptualise and refer to (...) essences; and that we can gain knowledge of them. We can know about which properties are, and which properties are not, essential to a given entity. This knowledge of essence offers a route to knowledge of the ways those entities must be or could be. (shrink)

This paper brings together two erstwhile distinct strands of philosophical inquiry: the extended mind hypothesis and the situationist challenge to virtue theory. According to proponents of the extended mind hypothesis, the vehicles of at least some mental states (beliefs, desires, emotions) are not located solely within the confines of the nervous system (central or peripheral) or even the skin of the agent whose states they are. When external props, tools, and other systems are suitably integrated into the functional apparatus of (...) the agent, they are partial bearers of her cognitions, motivations, memories, and so on. According to proponents of the situationist challenge to virtue theory, dispositions located solely within the confines of the nervous system (central or peripheral) or even the skin of the agent to whom they are attributed typically do not meet the normative standards associated with either virtue or vice (moral, epistemic, or otherwise) because they are too susceptible to moderating external variables, such as mood modulators, ambient sensibilia, and social expectation signaling. We here draw on both of these literatures to formulate two novel views – the embedded and extended character hypotheses – according to which the vehicles of not just mental states but longer-lasting, wider-ranging, and normatively-evaluable agentic dispositions are sometimes located partially beyond the confines of the agent’s skin. (shrink)

The concepts of placebos and placebo effects refer to extremely diverse phenomena. I recommend dissolving the concepts of placebos and placebo effects into loosely related groups of specific mechanisms, including (potentially among others) expectation-fulfillment, classical conditioning, and attentional-somatic feedback loops. If this approach is on the right track, it has three main implications for the ethics of informed consent. First, because of the expectation-fulfillment mechanism, the process of informing cannot be considered independently from the potential effects of treatment. Obtaining informed (...) consent influences the effects of treatment. This provides support for the authorized concealment and authorized deception paradigms, and perhaps even for outright deceptive placebo use. Second, doctors may easily fail to consider the potential benefits of conditioning, leading them to misjudge the trade-off between beneficence and autonomy. Third, how attentional-somatic feedback loops play out depends not only on the content of the informing process but also on its framing. This suggests a role for libertarian paternalism in clinical practice. (shrink)

Pluralists about coincident entities say that distinct entities may be spatially coincident throughout their entire existence. The most pressing issue they face is the grounding problem. They say that coincident entities may differ in their persistence conditions and in the sortals they fall under. But how can they differ in these ways, given that they share all their microphysical properties? What grounds those differences, if not their microphysical properties? Do those differences depend only on the way we conceptualise those objects? (...) Are they primitive facts about reality? Neither option is pleasant for the pluralist, but what else can she say? To respond to the grounding problem, the pluralist should first tell a story about what material objects are. If that story explains how the modal and sortal properties of objects are grounded, in a way that allows for differences between coincident objects, then she has a response to the problem. That is precisely my aim in this paper. (shrink)

I present an internal problem for David Lewis’s genuine modal realism. My aim is to show that his analysis of modality is inconsistent with his metaphysics. I consider several ways of modifying the Lewisian analysis of modality, but argue that none are successful. I argue that the problem also affects theories related to genuine modal realism, including the stage theory of persistence and modal fictionalism.

In this article I argue that two current accounts of scientific understanding are incorrect and I propose an alternative theory. My new account draws on recent research in cognitive psychology which reveals the importance of making causal and logical inferences on the basis of incoming information. To understand a phenomenon we need to make particular kinds of inferences concerning the explanations we are given. Specifically, we come to understand a phenomenon scientifically by developing mental models that incorporate the correct causal (...) and logical properties responsible for the causes or logical properties of the phenomenon being explained. (shrink)

Prehensity -- Intensity -- Potentiality -- Sensibility.

The speech act of bragging has never been subjected to conceptual analysis until now. We argue that a speaker brags just in case she makes an utterance that is an assertion and is intended to impress the addressee with something about the speaker via the belief produced by the speaker's assertion. We conclude by discussing why it is especially difficult to cancel a brag by prefacing it with, ‘I'm not trying to impress you, but…’ and connect this discussion with Moore's (...) paradox and the recent neologism ‘humblebrag’. (shrink)

This paper offers a new way to make sense of disagreement expansion from a polylogical perspective by incorporating various places in addition to players and positions into the analysis. The concepts build on prior implicit ideas about disagreement space by suggesting how to more fully account for argumentative context, and its construction, in large-scale complex controversies. As a basis for our polylogical analysis, we use a New York Times news story reporting on an oil train explosion—a significant point in the (...) broader controversy over producing oil and gas via hydraulic fracturing. (shrink)

Bundle theories identify material objects with bundles of properties. On the traditional approach, these are the properties possessed by that material object. That view faces a deep problem: it seems to say that all of an object’s properties are essential to it.Essential bundle theoryattempts to overcome this objection, by taking the bundle as a specification of the object’s essential properties only. In this paper, I show that essential bundle theory faces a variant of the objection. To avoid the problem, the (...) theory must accept the contingency of identity. I show how this can be achieved in a coherent and well-motivated way, a way that isn’t available to traditional bundle theories. (shrink)

Although Nietzsche accepted a distant cousin of Brian Leiter’s “Doctrine of Types,” according to which, “Each person has a fixed psycho-physical constitution, which defines him as a particular type of person,” the details of his actual view are quite different from the flat-footed position Leiter attributes to him. Leiter argues that Nietzsche thought that type-facts partially explain the beliefs and actions, including moral beliefs and actions, of the person whom those type-facts characterize. With this much, I agree. However, the Doctrine (...) of Types as formulated by Leiter, is manifestly unsupported both by Nietzsche’s texts and as an empirical hypothesis. Although Leiter has teamed up with Joshua Knobe to shore up the empirical credentials of his version of the Doctrine of Types, and although Knobe is one of the best experimental philosophers currently working in moral psychology, their account of the Doctrine is wrong both textually and empirically. That is to say, Nietzsche did not hold the version of the Doctrine they attribute to him, and it’s a good thing he didn’t, because the version that he actually did hold is better empirically supported than the version that they attribute to him. For Nietzsche – and in reality – types are not immutable or fixed. Although not everyone is endowed with the same type, which type someone belongs to can (though needn’t) evolve over the course of her lifetime. In particular, whereas I agree with Leiter that the neo-Aristotelian account of character development is empirically inadequate, I do so not because I think no character development occurs but because I think that character development occurs in a different way. In addition, for Nietzsche – and in reality – types on their own are not normative. Character, which is normatively evaluable, only arises through the refinement, calibration, and development of temperament. It might seem like I’ve just set myself an ambitious-enough goal, but I want to do more in this paper. The main point I want to argue is that Nietzsche held a person-type-relative unity of virtue thesis, according to which what’s intrinsically good for a particular person is to develop and act from particular character traits that “fit” her type. (shrink)

Generic generalisations like ‘Opioids are highly addictive’ are very useful in scientific communication, but they can often be interpreted in many different ways. Although this is not a problem when all interpretations provide the same answer to the question under discussion, a problem arises when a generic generalisation is used to answer a question other than that originally intended. In such cases, some interpretations of the generalisation might answer the question in a way that the original speaker would not endorse. (...) Rather than excising generic generalisations from scientific communication, I recommend that scientific communicators carefully consider the kinds of questions their words might be taken to answer and try to avoid phrasing that might be taken to provide unintended answers. (shrink)

Many people have been enraged lately by the enormous increases in certain generic prescription drugs. But free marketeers defend these prices by arguing that they simply represent what the market will bear, and in a capitalist society there is accordingly nothing wrong with charging them. This paper argues that such a defense is actually contrary to the very principles that free marketeers claim to embrace. These prices are not only unjust and exploitative, but government interference with them would not render (...) the market less free, at least if what it means for a market to be “free” is properly understood. Everyone, even free marketeers with a libertarian or neoliberal bent, should accordingly be against this kind of profiteering. (shrink)

Pragmatism has enjoyed a major resurgence in Anglo-American philosophy over the course of the last decade or two, and Robert Brandom’s work – particularly his 1994 tome Making it Explicit (MIE) – has been at the vanguard of this resurgence (Brandom 1994).2 But pragmatism comes in several surprisingly distinct flavours. Authors such as Hubert Dreyfus find their roots in certain parts of Heidegger and in phenomenologists such as Merleau-Ponty, and they privilege embodied, preconceptual skills as opposed to discursive practices as (...) the basic sites of meaning and agency (Dreyfus 1991; Dreyfus 1992; Todes 2001). With strong inheritances from Dewey and Wittgenstein, Richard Rorty has championed a pragmatism whose core emphasis is on the rejection of transcendental truth and high metaphysical theorizing (Rorty 1982), and this anti-theoretical banner has been taken up by several prominent ethicists, among others. For his part, Brandom, who purports to offer a systematic theory of language and meaning grounded on a foundation of pragmatic normative relationships between speakers, looks back instead to Sellars and Quine for his stripe of pragmatism. Near the start of MIE, he writes: The explanatory strategy pursued here is to begin with an account of social practices, identify the particular structure they must exhibit in order to qualify as specifically linguistic practices, and then consider what different sorts of semantic contents those practices can confer on states, performances, and expressions caught up in them in suitable ways. (Brandom 1994, xiii) Despite his professed pragmatism, Brandom is no foe of high theory or metanarratives, and he is vastly more interested in language and theoretical reason than in the rest of human bodily activity. For Brandom, inferentially articulated discourse forms an autonomous domain of normativity, while our bodily encounters with the world in perception and in action serve as language entry and exit points respectively.. (shrink)

Non-human animals (henceforth, “animals”) are typically regarded as moral patients rather than moral agents. Let us define these terms as follows: 1) X is a moral patient if and only if X is a legitimate object of moral concern: that is, roughly, X is something whose interests should be taken into account when decisions are made concerning it or which otherwise impact on it. 2) X is a moral agent if and only if X can be morally evaluated–praised or blamed (...) (broadly understood)–for its motives and actions. Nothing in (1) and (2), of course, rules out one and the same individual being both a moral agent and a patient. Most humans are both. The notion of a moral agent is typically run together with that of a moral subject: 3) X is a moral subject if and only if X is, at least sometimes, motivated to act by moral considerations. However, (2) and (3) are not equivalent: the motivation for an action is one thing, the evaluation of the action quite another; indeed evaluation is often of motivation. As a matter of practice these are, for obvious reasons, run together. But motivation and evaluation are conceptually distinct. This is a claim that many will regard with surprise. In effect, the bulk of this paper can be regarded as an attempt to defend this claim as it applies to the case of animals. In this section, I merely offer some preliminary remarks in its defense. Suppose that my wife, worn down by the domestic squalor that goes with two young boys, a very large dog, and a slovenly husband, has me (unknowingly) hypnotized. Now, whenever she utters the word ‘Rosebud’, I experience an uncontrollable desire to mop the floor. This desire is, it seems, a motivational state, one that when combined with relevant cognitive states (the belief that this is a mop, the belief that this is a floor, and so on) will, ceteris paribus, result in a certain sort of behavior on my part. This floor-mopping, however, is not something for which I can be praised or blamed. Ex hypothesi, it is the result of a motivational state that is outside my control.. (shrink)

It has been argued in the conservation literature that giving conservation absolute priority over competing interests would best protect the environment. Attributing infinite value to the environment or claiming it is ‘priceless’ are two ways of ensuring this priority (e.g. Hargrove 1989; Bulte and van Kooten 2000; Ackerman and Heinzerling 2002; McCauley 2006; Halsing and Moore 2008). But such proposals would paralyse conservation efforts. We describe the serious problems with these proposals and what they mean for practical applications, and we (...) diagnose and resolve some conceptual confusions permeating the literature on this topic. (shrink)

The first film adaptation of the story of the unmasking of the insatiable Transylvanian vampire, Count Dracula. The tale unfolds with an awesome eeriness unequalled in later versions.

From his earliest work on personal identity to his last on the value of truthfulness, the ideas and arguments of Bernard Williams - in the metaphysics of personhood, in the history of philosophy, but especially in ethics and moral psychology - have proved sometimes controversial, often influential, and always worth studying. This book provides a comprehensive account of Williams's many significant contributions to contemporary philosophy. Topics include personal identity, various critiques of moral theory, practical reasoning and moral motivation, truth and (...) objectivity, and the relevance of ancient Greece to modern life. It not only positions Williams among these important philosophical topics, but also with regard to the views of other philosophers, including prominent forerunners such as Hume and Nietzsche and contemporary thinkers such as, Nagel, McDowell, MacIntyre and Taylor. The fragmentary nature of Williams's work is addressed and recurring themes and connections within his work are brought to light. (shrink)

This book is a philosophical study of the relations between hearing and thinking about music. The central problem it addresses is as follows: how is it possible to talk about what a listener perceives in terms that the listener does not recognize? By applying the concepts and techniques of analytic philosophy the author explores the ways in which musical hearing may be described as nonconceptual, and how such mental representation contrasts with conceptual thought. The author is both philosopher and musicologist (...) and uniquely combines the perspectives of both disciplines. Exploring the philosophical questions of mental representation in the relatively neglected, nonverbal domain of music, this study is a major contribution to the philosophical understanding of music perception and cognitive theory. (shrink)

Why do people stay together in monogamous relationships? Love? Fear? Habit? Ethics? Integrity? Desperation? In this paper I will consider a rather surprising answer that comes from mathematics. It turns out that cooperative behaviour, such as mutually-faithful marriages, can be given a firm basis in a mathematical theory known as game theory. I will suggest that faithfulness in relationships is fully accounted for by narrow self interest in the appropriate game theory setting. This is a surprising answer because faithful behaviour (...) is usually thought to involve love, ethics, and caring about the well being of your partner. It seems that the game-theory account of faithfulness has no need for such romantic notions. I will consider the philosophical upshot of the game-theoretic answer and see if it really does deliver what is required. Does the game-theoretic answer miss what is important about faithful relationships or does it help us get to the heart of the matter? Before we start looking at lasting, faithful relationships, though, let’s get a feel for how mathematics might be employed to help in matters of the heart. Let’s first consider how mathematics might shed light on dating to find a suitable partner. (shrink)

In a recent article, Dawn Wilson (2021) has argued against single-stage accounts of photography by arguing against the latent photographic images upon which those accounts depend. Concomitantly, she argues that the only viable account of photography is multi-stage. Unlike single-stage accounts, multi-stage accounts do not postulate the existence of photographic images of any kind prior to development. Rather, according to multi-stage accounts, photographs are produced from “photographic registers.” In this Discussion Piece, I defend single-stage accounts by arguing that Wilson’s rejection (...) of latent photographic images is premised on an implausible view of what a latent photographic image is. Given a reasonable interpretation, the latent images described in single-stage accounts just are the photographic registers described in multi-stage accounts. (shrink)

Physicist Perakh critically reviews recent trends towards harmonizing religion and science, and shows that all such approaches are little more than tailoring evidence to fit the desired theory.

As the average age of the population increases, so too do the number of people living with chronic illnesses. With limited resources available, the development of dialogue-based e-health systems that provide justified general health advice offers a cost-effective solution to the management of chronic conditions. It is however imperative that such systems are responsible in their approach. We present in this paper two main challenges for the deployment of e-health systems, that have a particular relevance to dialogue and argumentation: collecting (...) and handling health data, and trust. For both challenges, we look at specific issues therein, outlining their importance in general, and describing their relevance to dialogue and argumentation. Finally, we go on to propose six recommendations for handling these issues, towards addressing the main challenges themselves, that act both as general advice for dialogue and argumentation research in the e-health domain, and as a foundation for future work on this topic. (shrink)