The Diagnosis Confirmation Model includes a dual-pricing mechanism designed to support value-based pricing of novel antibiotics while improving the alignment of financial incentives with their optimal use in patients at high risk of drug-resistant infections. DCM is a market-based model and complementary to delinked models. Policymakers interested in stimulating antibiotic innovation could consider tailoring the DCM to their reimbursement systems and incorporating it into the suite of incentives to improve the economics of antibiotics.

In this paper I provide support for the view that at least some forms of adversariality in argumentation are legitimate. The support comes from Aristotle’s theory of illegitimate adversarial argumentation in dialectical contexts: his theory of eristic in his work On Sophistical Refutations. Here Aristotle develops non-epistemic standards for evaluating the legitimacy of dialectical procedures, standards which I propose can be understood in terms of the pragmatic notion of context as common ground. Put briefly, Aristotle makes the answerer’s meaning in (...) giving assent in dialectical contexts the basis for further moves in the game of dialectic. Moves which subvert the answerer’s meaning or do not solicit the answerer’s consent are marked as eristic, i.e. adversarial in a problematic sense. I conclude with remarks on what Aristotle’s theory may teach us about how semantic features relate to the normative evaluation of argumentation. (shrink)

This study investigates how dispute-mediators handle impasse in the re-negotiation of divorce decrees by divorced couples. Three sources of impasse and three strategies for handling impasse are identified based on analysis of mediation transcripts. The concern here lies not so much in the disputant's arguments but in the discussion procedures dispute-mediators use to craft the disputant's argumentation into a tool to solve conflict. Their moves are understood here as a practice of reconstructing argumentative discourse that is neither naïve nor critical (...) but reconstruction as design. Mediator's reconstruction reveals a type of communication work in contemporary societies involved in the crafting of forums and formats that mediate argumentative communication. This work is often invisible and strategic which makes its interpretation, judgment, and development a challenge for pragma-dialectical theory. How reconstruction as design can be understood is discussed by building on prior pragma-dialectical theory and research. (shrink)

This paper contributes to the principled construction of tableau-based decision procedures for hybrid logic with global, difference, and converse modalities. We also consider reflexive and transitive relations. For converse-free formulas we present a terminating control that does not rely on the usual chain-based blocking scheme. Our tableau systems are based on a new model existence theorem.

In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:Plato’s CratylusRosamond Kent SpragueDavid Sedley. Plato’s Cratylus. New York: Cambridge University Press, 2003. Pp. xi + 190. Cloth, $60.00Discussion of Plato's Cratylus, to which this book is a notable contribution, must straightway come to terms with the question of Plato's seriousness (or lack thereof) in the etymology sections of the dialogue. Professor Sedley is a strong advocate of the seriousness of the etymologies, a position which, he remarks, (...) will not surprise most classicists, although it "may cause apoplexy among many of Plato's philosophical admirers" (23). More colloquially he writes, "if Plato was joking, the joke flopped" (39).But need we assume that Plato was either serious or joking? His sense of humor was peculiar, and seems to me nicely characterized by Guthrie when, in commenting on the present dialogue, he speaks of Plato as "tumbling together with an equally straight face absurdities and deeply held convictions" (History V, 25). I also incline more than Sedley to the frequent topicality of Plato's work.Nevertheless, the Sedley thesis may be seen to pay rich rewards. Perhaps most notable is the perception that the etymologies constitute a philosophical curriculum, moving along a well-defined trace from cosmology to the consideration (a watershed here) of ethical terms. This progression is especially significant in marking the emancipation of Plato from his early association with Cratylus and his subsequent allegiance to Socrates.Another mandatory topic is, of course, chronology. The Cratylus is seen to be unusual here in that what we have is most probably a reedited version. (A substantive point is at issue because the earlier version fails to distinguish clearly between the lawmaker and the [End Page 490] dialectician.) Thus to the question, where does the Cratylus fit in the traditional chronology, Sedley's answer is, "not in any one place" (7). As to the projected time of the revision, proximity to the Sophist is most likely.Sedley's general approach to the etymologies is hierarchical (here he identifies two important principles, Uniformity and Groundedness) rather than one of mutual support. He writes that the "'imitation' relation between sounds and things will be found [at] not just the primary level, but all the way up the chain" (126). Similarly with Socrates' painting analogy: "the primary pigments which the painter uses already imitate the simplest objects of vision" (128). In both cases the principles of Uniformity and Groundedness "are to some extent permitted to merge" (127).The business of name-making is of course a techne, as is that of painting. That both of these arts are approximate in nature is not an "ad hoc postulate [but] lies at the heart of Platonic metaphysics," since "any craftsman's embodiment of a Form in matter is necessarily less than perfect" (45). (As Sedley tellingly points out, "it is the Sophist Thrasymachus, and not Socrates, who proposes that a craftsman, qua craftsman, never gets anything wrong" [44].) As for Socrates' final position, it is "not the reversion to conventionalism that it has so often been taken to be" (145). Convention does play some part in signification, but it is also the case that names are some kind of vocal imitations, "a thesis, massively documented in the etymological section, from which Socrates never retreats" (145).One point on which I would like to have had Sedley's comments is the following: what does he think of Diogenes Laertius's remark (III, 6) that not only did Plato, after the death of Socrates, "attach himself to Cratylus the Heraclitean," but also to Hermogenes "who professed the philosophy of Parmenides"? Now the only real Parmenideanism in the dialogue (the position that a name is either a true name or not a name at all) is attributed not to Hermogenes but to Cratylus! (Is Descartes an empiricist? Is Hume a rationalist?) Furthermore, even though Cratylus adopts this position on a variety of occasions (429d, 432a, 433c, 436c, and 438c), he is too flighty (or, one might say, too fluxy) to stick with it, and continually relapses (431a, 432d, 433b, 435e, for instance). At the risk of being categorized as a non-serious reader of the Cratylus (which I am not... (shrink)

In lieu of an abstract, here is a brief excerpt of the content:NOTES AND DISCUSSIONS 69 in pre-Socratic scholarship. But he does not do justice to the religious mood which pervades the whole poem (a mood which is set by the prologue which casts the whole work into the form of some kind of religious revelation). The prologue is considerably more than a mere literary device, and the poem is more than logic. Generally, Jaeger9 and Guthrie are surely correct (...) in their judgment that any adequate interpretation of Parmenides' work (as well as that of the other early Greek thinkers) must be willing to take into account its essentially theological character and religious inspirationl~ not always grasped through strict analysis and exegesis. g Theolooy of the Early C-reekPhilosophers, trans. Edward S. Robinson (Oxford, 1947), p. lff, 90ft. agCf. Guthrie's excellent statement: "...Parmenides was at one with Heraclitus in claiming a prophetic or apocalyptic authority for his teaching." And again, the Greeks believed in "an inspiration whereby-the poet is granted deeper insight into the truth than other men" (p. 6). ED. L. MILLER University of Colorado AN UNKNOWN SEVENTEENTH-CENTURY FRENCH TRANSLATION OF SEXTUS EMPIRICUS* I. Introduction Included in a collection of manuscripts and early printed books recently acquired by the Library of the University of California, Los Angeles, from the Paris bookdealer Paul Jammes ~ are three manuscripts attributed to a certain Nicolas de la Toison, Baron de Bussy. Two of the three volumes contain extensive Latin commentaries on the major writings of Aristotle.2 The third is a miscellaneous volume written in three different hands, which contains, among other things, a complete French translation of the extant writings of Sextus Empiricus (c. A.D. 160-210).3 I * I would like to express my thanks to Mr. Richard O'Brien, Western European Bibliographer of the UCLA Library, for his help in numerous ways, who made it possible for me to consult this material during my sojourn in Los Angeles, even before it had been officially catalogued by the Library. I would also like to thank Professors Donald Kalish and Robert Yost of the UCLA Department of Philosophy for their support in making it possible for the collection to be purchased. 1For a brief description of the collection as a whole see Charles B. Schmitt, "Acquisition of Early French Books and Manuscripts", UCLA Librarian, XIX (1966)~25. 2These two manuscripts are bound m red leather with gold tooling. Thear present shelf mark is Collection 968, Box 2. On the spines is written: (1) PHILOSOPHIA.TO.I, and (2) METAPHYSIC ET PHYSICA TO.2. They measure approximately 10 X 14 cm. and each contains about 600fois. At the beginning of Vol. I, in a later hand (19th century?), we read: "Nicolas de la Thoison, baron de Bussy, qui 6crivit ces m6moires, 6tait conseiller laic au Parlement de Bourgogne. Il fur pourru par la r6signation de Pierre Catherine le IV Ddcembre M.DC.XLV et regu le XXIX janvier M.DC.XLVI. I1portait: de queueles dune bands d'or charges en coeur d'une quints feuiUe d'azur--ainsi qu'on le volt dans le Parlement de Bourgogne [Dijon, 1649]de Pierre PaiUot, p. 326." There is also a drawing of the coat-of-arms which has been described. That the de la Toison coat-of-arms is a quintefeuille is verified by Theodore de Renesse, Dictionnaire des figures h$raldiques (Brussels, 1894-1903) III, 461. The passage cited above from the manuscript is directly quoted from Pierre Paillot, Le Parlement de Bouroongne [I], son origins, son $tablissemerit, et son progr~s (Dijon, 1649), p. 326. s A description of this manuscript will be found in the Appendix. 70 HISTORY OF PHILOSOPHY shall here only give a preliminary survey of this third manuscript, pointing out some of the more interesting features and mentioning some problems connected with it which should be investigated further in more detail. As is now well-known the writings of Sextus Empiricus, which form the major extant compendium of ancient skeptical philosophy, had quite a significant impact on sixteenth and seventeenth-eentury thought, after their reintroduction in the sixteenth century. ~ Sextus' works were available in printed Latin editions after 15695 and the Greek text was printed in... (shrink)

This book . . . is an invitation to all Christians to begin constructing a food ethics; to the academic Christian ethicist, it presents an opportunity to join a discussion on a topic relevant in so many ways to the life of every American; to the Christian for whom the spark of the divine is detectable in the everyday life, it is a chance to begin making ethical sense out of something done every day for the entirety of one's natural (...) life-participating in agriculture. -from the Introduction In Sustainable Agriculture, Mark Graham joins the vibrant, substantive discussion about the moral issues in American agriculture by revealing what is going on in current agricultural practices and analyzing them in light of morality and sustainability. Graham's constructive proposal for change is based on a moral vision that identifies a group of core values around which our agricultural system should be developed, including: a) a consistent, safe food supply; b) vital, sustainable communities; and c) personal and environmental health. (shrink)

Most recent discussions of phenomenal consciousness are predicated on two deeply entrenched assumptions. The first is objectualism, the claim that what it is like to undergo an experience is something of which we are or can be aware in the having of that experience. The second is internalism, the claim that what it is like to undergo an experience is constituted by states, events and processes that are located inside the skins of experiencing subjects. This paper argues that both assumptions (...) should be rejected. What it is like to undergo an experience is not an object of consciousness but something that exists in the directing of consciousness towards objects. What it is like to undergo an experience is not something of which we are aware, but something in virtue of which we are aware. And there is little reason for supposing that the directing of consciousness towards its objects is something that occurs exclusively inside the skins of experiencing subjects. On the contrary, directing of consciousness towards its objects is often extended, involving acts of worldly probing and exploration. (shrink)

In his essay, “Affording our Culture: “Smart” Technology and the Prospects for Creative Democracy,” Tibor Solymosi addresses my challenge for neuropragmatism to counter what I have elsewhere called dopamine democracy. Although I believe that Solymosi has begun to provide an explanation for how neuropragmatism may counter dopamine democracy, especially with his conceptions Œ and cultural affordances, I respond with a helpful addition to his approach by returning to the theory of inquiry as put forth by John Dewey. In particular, I (...) focus on the phases of inquiry as colored by Dewey’s concept of humility. Solymosi does not pay adequate attention to the function of inquiry necessary for combatting dopamine democracy. His account of cultural affordances and education is strengthened by using Dewey’s concept of humility as a guiding disposition for neuropragmatic inquiry. Recognizing humility as an instrument of neuropragmatic inquiry provides us with a tool to better address the pitfalls of dopamine democracy, especially misinformation and incentive salience. My argument proceeds by first articulating dopamine democracy as a problem and Solymosi’s concept of cultural affordances and how he understands these as neuropragmatic tools to address the problem through education. I present humility as an instrumental concept derived from Dewey’s work on inquiry. I then suggest how humility may serve neuropragmatic inquiry to assist in combatting the problems of dopamine democracy. (shrink)

For forty years, Harvey Mansfield has been worth reading. Whether plumbing the depths of MachiavelliOs Discourses or explaining what was at stake in Bill ClintonOs impeachment, MansfieldOs work in political philosophy and political science has set the standard. In Educating the Prince, twenty-one of his students, themselves distinguished scholars, try to live up to that standard. Their essays offer penetrating analyses of Machiavellianism, liberalism, and America., all of them informed by MansfieldOs own work. The volume also includes a bibliography of (...) MansfieldOs writings. (shrink)

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Statistical topic models provide a general data - driven framework for automated discovery of high-level knowledge from large collections of text documents. Although topic models can potentially discover a broad range of themes in a data set, the interpretability of the learned topics is not always ideal. Human-defined concepts, however, tend to be semantically richer due to careful selection of words that define the concepts, but they may not span the themes in a data set exhaustively. In this study, we (...) review a new probabilistic framework for combining a hierarchy of human-defined semantic concepts with a statistical topic model to seek the best of both worlds. Results indicate that this combination leads to systematic improvements in generalization performance as well as enabling new techniques for inferring and visualizing the content of a document. (shrink)

Dynamically transforming the elements of any performing artist’s craft, this practical guide is a must-have for musicians, dancers, and actors. The handbook shows how artistic performance is embodied in the unification of three critical elements—motion, emotion, and love—demonstrating how it offers experiences and opportunities distinct from the nonperforming arts. Step-by-step guidelines are provided for building intentional and inspirational practice time, thereby enhancing the relationships between the source, the performer, and the audience. Illustrating how intentional movement invokes emotions from both the (...) performer and the audience and how the concept of love gives a performance humanity and life, this eye-opening exploration creates pathways for achieving true artistry. (shrink)

Every 4 years, for the past three decades, the world of argumentation research has gathered in Amsterdam at the International Society for the Study of Argumentation conferences to explore advances in understanding argumentation and how argumentation advances our understanding of the human condition. While comprehensive proceedings of selected papers are produced to document what has transpired in the world of argumentation over the preceding 4 years, there remains the important matter of taking the intellectual pulse of the world’s argumentation scholars, (...) to detect the beating heart of the community of scholars and the health and wellness of argumentation scholarship. One of the great services Frans van Eemeren, and his colleagues, have provided this community is a diagnosis that helps identify the assets upon which the health and wellness of the community can further build. This service has come in the form of several edited volumes, the most recent of which, Topical Themes in Argumen .. (shrink)