Drosophila responds to a septic injury by the rapid synthesis of antimicrobial peptides. These molecules are predominantly produced by the fat body, a functional equivalent of mammalian liver, and are secreted into the hemolymph where their concentrations can reach up to 100 μM. Six distinct antibacterial peptides (plus isoforms) and one antifungal peptide have been characterized in Drosophila and their genes cloned. The induction of the gene encoding the antifungal peptide relies on the spätzle/Toll/cactus gene cassette, which is involved in (...) the control of dorsoventral patterning in the embryo, and shows interesting structural and functional similarities with cytokine‐induced activation of NF‐ϰB in mammalian cells. An additional pathway, dependent on the as yet unidentified imd (for immune‐deficiency) gene, is required for the full induction of the antibacterial peptide genes. Mutants deficient for the Toll and imd pathways exhibit a severely reduced survival to fungal and bacterial infections, respectively. Recent data on the molecular mechanisms underlying recognition of non‐self are also discussed in this review. (shrink)

I discuss Eckhart’s and Aquinas’ conception of human-divine union with reference to what I call the problem of intrinsic goods, a problem concerning how to reconcile the pursuit of actions which are prima facie sought for their own sake (e.g. pursuing justice for the marginalized, listening to a work of music) with the pursuit of God as the ultimate end of every action. I introduce the problem with the help of Germain Grisez’s critique of Aquinas’ account of union with God, (...) and I suggest that Eckhart’s alternative conception of union may be understood as an attempt to resolve (or dissolve) the problem. (shrink)

Artykuł jest prezentacją najważniejszych rysów teologii apofatycznej Mistrza Eckharta, która jest mocno zakorzeniona w myśli Pseudo-Dionizego Areopagity. Autor ukazuje swoistą dialektykę poznawalności i niepoznawalności Boga, ilustrując to obficie przykładami z Eckhartowych Kazań. W tekście został poruszony także inny, niezwykle istotny problem, a mianowicie relacji zakorzenionej w neoplatonizmie henologicznej wizji rzeczywistości Eckharta do chrześcijańskiej nauki o Trójcy Świętej. Autor przytacza tu opinię Marie-Anne Vannier, że Eckhart jest „wirtuozem teologii trynitarnej”, ale dodaje, że zawsze pozostawia on tu miejsce dla przeżywania Tajemnicy.

While researchers have examined the types of ethical issues that arise in long-term care, few studies have explored long-term care nurses’ experiences of moral distress and fewer still have examined responses to initial moral distress. Using an interpretive description approach, 15 nurses working in long-term care settings within one city in Canada were interviewed about their responses to experiences of initial moral distress, resources or supports they identified as helpful or potentially helpful in dealing with these situations, and factors that (...) hindered nurses in their responses. Using a thematic analysis process, three major themes were identified from the nurses’ experiences: (i) the context of the situation matters; (ii) the value of coming together as a team; and (iii) looking for outside direction. The work of responding to initial moral distress was more fruitful if opportunities existed to discuss conflicts with other team members and if managers supported nurses in moving their concerns forward through meetings or conversations with the team, physician, or family. Access to objective others and opportunities for education about ethics were also identified as important for dealing with value conflicts. (shrink)

La correspondance de Pline le Jeune, publiée au II e siècle de notre ère, regorge de références à la mission de l’avocat. Bien que l’activité d’avocat ne soit pas la seule exercée par l’auteur, elle occupe une partie très importante de son temps, comme il le reconnaît lui-même, et remplit une fonction essentielle au sein de la société romaine. En assurant la défense des droits des femmes et des hommes qui le sollicitent, l’avocat s’assure de placer la justice et le (...) droit au cœur de la société et participe ainsi au renforcement du lien social. Une telle mission ne peut, selon Pline le Jeune, être confiée qu’à des hommes dont les qualités humaines sont supérieures et qui appartiennent de facto à la noblesse romaine. L’avocat plinien s’illustre par une noblesse de rang et d’âme. (shrink)

This dissertation aims to construct a non-dogmatic defence of common sense. It tries to show why the absence of justification for the judgements of common sense, which the sceptic reveals, does not invalidate them.

Contributing to both ageing research and queer-feminist scholarship, this article introduces feminist philosopher Margrit Shildrick’s queer notion of the monstrous to the subject of ageing and the issue of dealing with frailty within ageing research. The monstrous, as a norm-critical notion, takes as its point of departure that we are always already monstrous, meaning that the western ideal of well-ordered, independent, unleaky, rational embodied subjects is impossible to achieve. From this starting point the normalizing and optimizing strategies of ageing research (...) – here exemplified through the concept of successful ageing and the treatment of Alzheimer’s disease – can be problematized. The notion of the monstrous instead suggests a view on ageing and ‘monstrous’ embodiment which provides room for other, different ways of being recognized as an embodied subject, and for dealing with difference, vulnerability and frailty. (shrink)

Motivation plays an important role in students’ school behavior, and research has established that students’ learning environment experiences such as teachers’ behavior toward them contribute to their motivation and behavior at school. Self-determination theory offers an interesting frame of reference in the study of the relationship between students’ learning experiences at school and their school behavior. Considering three basic psychological needs, the SDT points to the importance of nutriments and support in the social environment in order to allow growth in (...) motivation, engagement, and well-functioning. In addition, thwarting these needs is supposed to contribute to maladaptive functioning. Teachers can play an important role in the fulfillment of students’ basic psychological needs by delivering support ; however, controlling instructional behavior, chaos in the classroom, and teacher rejection and neglect are supposed to be a treat to the fulfillment of students’ basic psychological needs. In the current innovative longitudinal study, teachers’ need-supportive behavior as well as teachers’ thwarting of these needs are considered and their relationship with students’ academic engagement and procrastination behavior is studied. In addition, attention is paid to differential effects of teachers’ behavior with regard to boys and girls. Participants were 566 students belonging to 20 mathematics/English grade 1 secondary education classes in the Netherlands. Multilevel analyses revealed evidence for the importance of both teachers’ need-supportive and need-thwarting behaviors in relation to students’ academic engagement and procrastination behavior. In addition, the findings revealed that teachers’ need-supportive behavior is more important for students’ academic engagement, while teachers’ need-thwarting behavior has larger effects on students’ procrastination behavior. Furthermore, evidence was found that boys often seemed to be more sensitive to their teachers’ behavior than girls. The findings highlight the importance of both teachers’ need-supportive and need-thwarting behaviors in daily classrooms and contribute to deepen our insight into and understanding of factors leading to adaptive and maladaptive functioning of boys and girls in relation to learning tasks at school. (shrink)

This article examines how immigrant careworkers relate dynamically with the Norwegian gender regime. While the importation of careworkers contributes both to the practical maintenance and to the undermining on a more ideological level of the Norwegian gender regime, it also brings in new constellations and possibilities. In this article examples from two studies are discussed in the light of institutional and intersectional perspectives. It describes features of the Norwegian gender regime that are especially relevant to carework, and the highly gendered (...) distribution and sharing of carework across the public and private domains. One central Norwegian form of care institution, the nursing home, then comes into focus. Making use of empirical examples from fieldwork and interviews, the article discusses how, as immigrant careworkers increasingly staff these institutions, new light is thrown on existing power structures, while at the same time these structures may be challenged through the fluidity of situational and relational gendering processes. (shrink)

Within recent years, an increasing number of people and researchers in the Global North have become interested in psychedelic substances and their therapeutic application. While much of the current media attention and research effort mainly concentrate on the therapeutic potential and actions of the individual's acute psychedelic experience, this article explores the user-perceived, therapeutic dynamics of psychedelics in a more long-term perspective by charting the lived experiences and practices of ‘integration’ among psychedelic users in Denmark. Based on ethnographic fieldwork from (...) November 2020 to June 2021, I offer a dual typology of self-related integration as narrative and experiential-somatic. Combining the two, I argue that psychedelic integration in contemporary Denmark can be viewed as a processual self-transformation of the users' experiential orientation where understandings and/or modes of being from the acute psychedelic experience are woven into, prolonged, and/or embodied in their everyday existence. (shrink)

Agonistic Democracy explores how theoretical concepts from agonistic democracy can inform institutional design in order to mediate conflict in multicultural, pluralist societies. Drawing on the work of Foucault, Nietzsche, Schmitt, and Arendt, Marie Paxton outlines the importance of their themes of public contestation, contingency and necessary interdependency for contemporary agonistic thinkers. Paxton delineates three distinct approaches to agonistic democracy: David Owen's perfectionist agonism, Mouffe's adversarial agonism, and William Connolly and James Tully's inclusive agonism. Paxton demonstrates how each is fundamental (...) to enabling citizens to cultivate better virtues for themselves and society (Owen), motivating democratic engagement (Mouffe) and enhancing relations of respect and understanding between conflicting citizens (Connolly and Tully). Situated within the context of a deeply polarised post-Trump America and post-Brexit Britain, this book reveals the need to rethink our approach to conflict mediation through democratic institutions. Pulling together insights from experimental research with deliberative democratic innovations, Paxton explores how agonistic theory might be institutionalised further. Through discussing ways in which agonistic institutions might be developed to render democracy more virtuous, more engaging, and more inclusive, Agonistic Democracy provides a unique resource for students of contemporary political theory. (shrink)

Measuring the rate at which the universe expands at a given time–the ‘Hubble constant’– has been a topic of controversy since the first measure of its expansion by Edwin Hubble in the 1920s. As early as the 1970s, Sandage and de Vaucouleurs have been arguing about the adequate methodology for such a measurement. Should astronomers focus only on their best indicators, e.g., the Cepheids, and improve the precision of this measurement based on a unique object to the best possible? Or (...) should they “spread the risks”, i.e., multiply the indicators and methodologies before averaging over their results? Is a robust agreement across several uncertain measures, as is currently argued to defend the existence of a ‘Hubble crisis’ more telling than a single 1% precision measurement? This controversy, I argue, stems from a misconception of what managing the uncertainties associated with such experimental measurements require. Astrophysical measurements, such as the measure of the Hubble constant, require a methodology that permits both to reduce the known uncertainties and to track the unknown unknowns. Based on the lessons drawn from the so-called Hubble crisis, I sketch a methodological guide for identifying, quantifying and reducing uncertainties in astrophysical measurements, hoping that such a guide can not only help to re-frame the current Hubble tension, but serve as a starting point for future fruitful discussions between astrophysicists, astronomers and philosophers. (shrink)

First Published in 1995. Routledge is an imprint of Taylor & Francis, an informa company.

Discussion of Wittgenstein's Tractatus is currently dominated by two opposing interpretations of the work: a metaphysical or realist reading and the 'resolute' reading of Diamond and Conant. Marie McGinn's principal aim in this book is to develop an alternative interpretative line, which rejects the idea, central to the metaphysical reading, that Wittgenstein sets out to ground the logic of our language in features of an independently constituted reality, but which allows that he aims to provide positive philosophical insights into (...) how language functions. McGinn takes as a guiding principle the idea that we should see Wittgenstein's early work as an attempt to eschew philosophical theory and to allow language itself to reveal how it functions. By this account, the aim of the work is to elucidate what language itself makes clear, namely, what is essential to its capacity to express thoughts that are true or false. However, the early Wittgenstein undertakes this descriptive project in the grip of a set of preconceptions concerning the essence of language that determine both how he conceives the problem and the approach he takes to the task of clarification. Nevertheless, the Tractatus contains philosophical insights, achieved despite his early preconceptions, that form the foundation of his later philosophy. -/- The anti-metaphysical interpretation that is presented includes a novel reading of the problematic opening sections of the Tractatus, in which the apparently metaphysical status of Wittgenstein's remarks is shown to be an illusion. The book includes a discussion of the philosophical background to the Tractatus, a comprehensive interpretation of Wittgenstein's early views of logic and language, and an interpretation of the remarks on solipsism. The final chapter is a discussion of the relation between the early and the later philosophy that articulates the fundamental shift in Wittgenstein's approach to the task of understanding how language functions and reveal the still more fundamental continuity in his conception of his philosophical task. (shrink)

Cet article propose d’envisager un type particulier de texte, le texte tabulaire, qui s’oppose au texte linéaire, du double point de vue du texte et du corpus. Le texte tabulaire est un texte composé de plusieurs modules, ayant chacun une autonomie relative mais étant interdépendants les uns des autres, regroupés sur un espace matériel borné. L’objectif est double : il s’agit d’une part de décrire, dans une perspective croisée d’analyse du discours et de linguistique textuelle, le fonctionnement de ce type (...) de texte particulier, loin d’être marginal, et par ailleurs d’appliquer ces perspectives au fonctionnement des corpus, qui restent aujourd’hui calqués sur le modèle du texte linéaire. (shrink)

Lo spettro di un paradosso si aggira nella Galassia Lumière, attraversando tenacemente i sette lemmi chiave (rilocazione, reliquie e icone, assemblage, espansione, ipertopia, display, performance) che scandiscono la struttura interna dell’ultimo libro di Francesco Casetti: come può mantenersi un’identità nel cambiamento? Come può il cinema pur deformandosi nel corso del tempo rimanere sempre lo stesso? Da questo paradossale interrogativo, che innerva il volume dal principio alla fine, sorge s...

Cet article est une tentative pour mesurer les conséquences démographiques, pour l�Empire, de la perte des provinces orientales du fait de la conquête musulmane. Les sources, surtout les sources grecques, sont rares et donnent seulement quelques informations ponctuelles sur les transferts forcés de population, sur quelques individus quittant le califat et rejoignant l�Empire à dessein et enfin sur la destinée de quelques renégats. Comme d�habitude à cette époque, en raison du quasi monopole des sources ecclésiastiques, les renseignements sont plus nombreux (...) sur le clergé et le flot ininterrompu d�exilés depuis l�Anastasis à Jérusalem jusqu�à Constantinople et Sainte-Sophie. (shrink)

The method of metaphysics of scientific practice consists in developing metaphysical claims on the basis of empirical information from and about scientific practice. This method stands in the tradition of naturalistic or scientific metaphysics on the one hand, and philosophy of science in practice on the other. In this chapter we draw on some of our own research to specify the method at work. We argue that the method is typically carried out in four steps: identifying the available empirical information (...) that might be relevant to the metaphysical topic of interest; selecting the relevant empirical information; developing a preliminary metaphysical claim that the relevant empirical information supports; mutually adjusting empirical information and metaphysics. We reveal some major methodological challenges and present ways to overcome them. We conclude that when drawing metaphysical claims from scientific practicewe need to: first, make sure that our previous metaphysical views do not influence the empirical information or its selection in problematic ways; second, explain in what sense we are doing metaphysics, countering for instance the idea that metaphysical claims must be highly general and transdisciplinary. We end the chapter by pointing to the advantages of the method of metaphysics of scientific practice. (shrink)

La relation à l'autre est perçue comme une question éthique et politique, alors qu'elle est, chez Emmanuel Levinas, avant tout une question métaphysique. Cette relation est en effet constitutive de la personne. Le philosophe la décrit comme située au tout commencement, c'est-à-dire au principe, au fondement. Il y a bien une relation au point de départ de tout. Cette perception métaphysique change radicalement le regard sur l'éthique, sur la vie politique, sur le dialogue interreligieux. Ce petit ouvrage bref, dense, offre (...) une lecture originale de l'éthique d'Emmanuel Levinas, qui se veut philosophie première. Il donne des clés de lecture pour entrer dans des questionnements humains très contemporains. Qu'est-ce que l'altérité? (shrink)

Les auteurs cherchent à rendre compte d’un résultat particulier obtenu dans le cadre d’une recherche sur l’implication subjective des magistrats dans la construction de leur intime conviction. Comment comprendre la relation entre l’intime conviction de culpabilité et la prise en compte des liens familiaux et intersubjectifs? La méthode de recherche est centrée sur l’étude de la narrativité. La situation judiciaire proposée aux magistrats est une plainte pour inceste. L’intime conviction abordée dans ses fondements juridiques est envisagée du point de vue (...) du travail psychique qu’elle est susceptible de mobiliser. L’analyse des identités narratives permet de distinguer trois rapports au « conflit psychique induit ». Les magistrats qui prennent en compte les liens intersubjectifs seraient ceux qui appliquent le travail du doute d’une part, qui cherchent à penser la subjectivité de l’auteur et la relation entre cet homme et sa fille d’autre part. (shrink)