BackgroundThe ARRIVE (Animal Research: Reporting of In Vivo Experiments) guidelines are widely endorsed but compliance is limited. We sought to determine whether journal-requested completion of an ARRIVE checklist improves full compliance with the guidelines.MethodsIn a randomised controlled trial, manuscripts reporting in vivo animal research submitted to PLOS ONE (March–June 2015) were randomly allocated to either requested completion of an ARRIVE checklist or current standard practice. Authors, academic editors, and peer reviewers were blinded to group allocation. Trained reviewers performed outcome adjudication (...) in duplicate by assessing manuscripts against an operationalised version of the ARRIVE guidelines that consists 108 items. Our primary outcome was the between-group differences in the proportion of manuscripts meeting all ARRIVE guideline checklist subitems.ResultsWe randomised 1689 manuscripts (control: n = 844, intervention: n = 845), of which 1269 were sent for peer review and 762 (control: n = 340; intervention: n = 332) accepted for publication. No manuscript in either group achieved full compliance with the ARRIVE checklist. Details of animal husbandry (ARRIVE subitem 9b) was the only subitem to show improvements in reporting, with the proportion of compliant manuscripts rising from 52.1 to 74.1% (X2 = 34.0, df = 1, p = 2.1 × 10−7) in the control and intervention groups, respectively.ConclusionsThese results suggest that altering the editorial process to include requests for a completed ARRIVE checklist is not enough to improve compliance with the ARRIVE guidelines. Other approaches, such as more stringent editorial policies or a targeted approach on key quality items, may promote improvements in reporting. (shrink)

Wittgenstein was one of the most powerful influences on contemporary philosophy, yet he shunned publicity and was essentially a private man. This remarkable, vivid, personal memoir is written by one of his friends, the eminent philosopher Norman Malcolm. Reissued in paperback, this edition includes the complete text of fifty-seven letters which Wittgenstein wrote to Malcolm over a period of eleven years. Also included is a concise biographical sketch by another of Wittgenstein's philosopher friends, Georg Henrik von Wright. 'A (...) reader does not need to care about philosophy to be excited by Mr Malcolm's book; it is about Wittgenstein as a man, and its interest is human interest'. (shrink)

This unusually innovative book treats reflexivity, not as a philosophical conundrum, but as a practical issue that arises in the course of scholarly research and argument. In order to demonstrate the concrete and consequential nature of reflexivity, Malcolm Ashmore concentrates on an area in which reflexive "problems" are acute: the sociology of scientific knowledge. At the forefront of recent radical changes in our understanding of science, this increasingly influential mode of analysis specializes in rigorous deconstructions of the research practices (...) and textual products of the scientific enterprise. Through a series of detailed examinations of the practices and products of the sociology of scientific knowledge, Ashmore turns its own claims and findings back onto itself and opens up a whole new era of exploration beyond the common fear of reflexive self-destruction. (shrink)

The Stoic Idea of the City offers the first systematic analysis of the Stoic school, concentrating on Zeno's Republic . Renowned classical scholar Malcolm Schofield brings together scattered and underused textual evidence, examining the Stoic ideals that initiated the natural law tradition of Western political thought. A new foreword by Martha Nussbaum and a new epilogue written by the author further secure this text as the standard work on Presocratic Stoics. "The account emerges from a jigsaw-puzzle of items from (...) a wide range of authorities, painstakingly pieced together and then annotated in a series of appendixes, the whole executed with fine scholarship, clarity, and good humor."-- Times Literary Supplement. (shrink)

Plato is the best known and most widely studied of all the ancient Greek philosophers. Malcolm Schofield, a leading scholar of ancient philosophy, offers a lucid and accessible guide to Plato's political thought, enormously influential and much discussed in the modern world as well as the ancient. Schofield discusses Plato's ideas on education, democracy and its shortcomings, the role of knowledge in government, utopia and the idea of community, money and its grip on the psyche, and ideological uses of (...) religion. (shrink)

Recent approaches to causal modelling rely upon the causal Markov condition, which specifies which probability distributions are compatible with a directed acyclic graph. Further principles are required in order to choose among the large number of DAGs compatible with a given probability distribution. Here we present a principle that we call frugality. This principle tells one to choose the DAG with the fewest causal arrows. We argue that frugality has several desirable properties compared to the other principles that have been (...) suggested, including the well-known causal faithfulness condition. _1_ Introduction _2_ The Causal Markov Condition _3_ Faithfulness _4_ Frugality _4.1_ Basic independences and frugality _4.2_ General properties of directed acyclic graphs satisfying frugality _4.3_ Connection to minimality assumptions _5_ Frugality as a Parsimony Principle _6_ Conclusion Appendix. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Hume, Shaftesbury, and the Peirce-James Controversy EDMUND G. HOWELLS I. ACCORDING TO HUME, the "religious hypothesis" is "a particular method of accounting for the visible phenomena of the universe''1 that is "mere conjecture and hypothesis," (Enquiry, 145) and "both uncertain and useless" (Enquiry, 142). But there was one version of this hypothesis that seemed to pose particular difficulties for him in making these claims convincing. This was Shaftesbury (...) 's view of the world as the object of "divine passion." Besides Shaftesbury's massive influence at the time, Hume was wrestling with the peculiar disadvantage of having agreed with him on so many points, particularly in the attempt to solve the problem of personal identity. He attempted to discredit Shaftesbury's "particular method" on several levels: viz., it cannot be rationally justified, deductively or inductively ; it is not really a belief, so afortiori it is not a natural belief; to the extent it is confused with a genuine belief, its effects are very rare and transitory unless it degenerates into superstition or enthusiasm, which are demonstrably pernicious. 2 These attacks were frequently reinforced with arguments ad hominem. Shaftesbury's theism is extremely ambiguous. In the Essay Concerning Virtue or Merit he pronounced, "to believe therefore that everything is governed, ordered, or regulated for the best, by a designing principle or mind, necessarily good or permanent, is to be a perfect theist" (CH I:240). This is merely the least common denominator of what all eighteenth-century natural theologians agreed could be inferred a posteriori from some form of design argument. Shaftesbury used several analogies to support this view, each based upon a comparison of a part of the universe to the whole:(l) an artifact, for example, a watch (CH I: 190), a ship (CH i Enquiry Concerning Human Understanding, ed. L. A. Selby-Bigge,2nd ed. (Oxford: Clarendon Press, 1902),p. 139;hereafter cited as Enquiry. The quotes in my opening statement are technically not from Hume himself but from his "sceptical friend who lovesparadoxes." But the closest Hume comes to a single refutation of all forms of the "religious hypothesis," comparable to Cleanthes' "entirely decisive" refutation of Demea's version of the ontological argument (Dialogues, 189),is stated by Hume in his own person in the final paragraph of this section (Enquiry, XI). Other abbreviations used in this paper are: Treatisefor.4 Treatiseof Human Nature, ed. L. A. SelbyBigge {Oxford: Clarendon Press, 1949);Abstract for An Abstract of a Treatiseof Human Nature, 1740, ed. J. M. Keynesand P. Sraffa (Cambridge: Cambridge University Press, 1938);G&G for David Hume: The Philosophical Works, ed. T. H. Green and T. H. Grose, 4 vols. (London, 1886); Dialogues for Dialogues ConcerningNatural Religion, ed. Norman Kemp Smith, 2nd ed. (Indianapolis: Bobbs-Merrill, 1947); Letters for The Letters of David Hume, ed. J. Y. T. Grieg, 2 vols. (Oxford: Clarendon Press, 1932); CH for Characteristics of Men, Manners, Opinions, Times, ed. J. M. Robertson, 2 vols. (Indianapolis : Bobbs-Merrill, 1964). A roman numeral followed by a colon denotes volume; other roman numerals denote parts or sections; arabic numbers denote pages. 2For a striking exampleof one of their many points of agreement cf. Hume's essay(G&G 111: 144-150) with CH 11: 178-180. [4491 450 HISTORY OF PHILOSOPHY II:66), "a pile of regular architecture" (CH II:66-67), is to the artisan as the universe is to God. (2) A work of art, for example, a symphony (CH II :66), is to the artist as the universe is to God. (3) An organ is to the organism as the organism or species is to the teleologically structured and intelligent whole (CH I:243ff.) 3 (4) Microcosm (man) to Macrocosm (God), that is, man's mind is the governing principle over the other parts of his nature as God's mind is to the universe: though "all else may be only dream and shadow. All which even sense suggests may be deceitful.... Reason subsists." We are "in a manner conscious" that our reason is part of the pervasive world soul which inhabits our own, and "all nature's wonders serve to excite and perfect this idea of their author" (CH II : 112). In keeping with... (shrink)

Historically the focus of moral decision-making in games has been narrow, mostly confined to challenges of moral judgement (deciding right and wrong). In this paper, we look to moral psychology to get a broader view of the skills involved in ethical behaviour and how these skills can be employed in games. Following the Four Component Model of Rest and colleagues, we identify four “lenses” – perspectives for considering moral gameplay in terms of focus, sensitivity, judgement and action – and describe (...) the design problems raised by each. To conclude, we analyse two recent games, The Walking Dead and Papers, Please, and show how the lenses give us insight into important design differences between these games. (shrink)

Historically the focus of moral decision-making in games has been narrow, mostly confined to challenges of moral judgement (deciding right and wrong). In this paper, we look to moral psychology to get a broader view of the skills involved in ethical behaviour and how they may be employed in games. Following the Four Component Model of Rest and colleagues, we identify four “lenses” – perspectives for considering moral gameplay in terms of focus, sensitivity, judgement and action – and describe the (...) design problems raised by each. To conclude, we analyse two recent games, The Walking Dead and Papers, Please, and show how the lenses give us insight into important design differences between them. (shrink)

What is extremism, and how can it be countered? According to a recent account by (Cassam, 2021), there are three kinds of extremism: ideological, methodological, and psychological. The psychological kind – what Cassam calls ‘mindset extremism’ – is used by Cassam to explain what leads individuals to resort to extreme methods. From there we can say that methods extremism can be countered by preventing people from becoming mindset extremists. This paper outlines Cassam’s overall theory, and challenges it in two respects. (...) First, it is argued that whilst mindset extremism does account for some individuals, it applies more readily to groups in a way analogous to the contrast between individual and group belief. This creates space for an account of group mindset extremism. Second, I propose that Cassam’s account of the role mindset extremism occupies in predicting an individual’s turn to extreme methods underplays the social aspects that lead the individual to form the mindset. By acknowledging these social and group properties, we can begin to develop a social epistemology of extremism. (shrink)

Is social science really a science at all, and if so in what sense? This is the first real question that any course on the philosophy of the social sciences must tackle. In this brief introduction, Malcolm Williams gives the students the grounding that will enable them to discuss the issues involved with confidence.

Roger Scruton's extraordinarily rich and impressive book The Aesthetics of Music has not received the attention it deserves. In this paper I take issue with one of its most striking claims, namely that the basic perceptions of music are informed by spatial concepts understood metaphorically. To evaluate this claim it is necessary to grasp Scruton's theory of metaphor, which has largely been neglected. I sketch his theory and derive from it the essence of his claim about the fundamental role of (...) spatial metaphors in musical experience. With the issue clarified in this way, I attempt to show that the claim is not plausible. (shrink)

Résumé: Dans ce dialogue, deux personnages principaux, Philopolis et Éleuthérios, proposent la position communautarienne et la position contractualiste libérale comme fondements de la théorie politique. Le débat se déroule, comme tout bon débat devrait le faire, autour d’une bouteille de Chardonnay.

Transitive inference is claimed to be “deductive”. Yet every group/species ever reported apparently uses it. We asked 58 adults to solve five-term transitive tasks, requiring neither training nor premise learning. A computer-based procedure ensured all premises were continually visible. Response accuracy and RT (non-discriminative nRT ) were measured as is typically done. We also measured RT confined to correct responses ( cRT ). Overall, very few typical transitive phenomena emerged. The symbolic distance effect never extended to premise recall and was (...) not at all evident for nRT ; suggesting the use of non-deductive end-anchor strategies. For overall performance, and particularly the critical B ? D inference, our findings indicate that deductive transitive inference is far more intellectually challenging than previously thought. Contrasts of our present findings against previous findings suggest at least two distinct transitive inference modes, with most research and most computational models to date targeting an associative mode rather than their desired deductive mode. This conclusion fits well with the growing number of theories embracing a “dual process” conception of reasoning. Finally, our differing findings for nRT versus cRT suggest that researchers should give closer consideration to matching the RT measure they use to the particular conception of transitive inference they pre-held. (shrink)

Weismann's famous test of inheritance assumes that inherited traits will persist in the absence of the environment that first produced them; while, on the other hand, environmental traits are more transitory. The purpose of this paper is to show that this Weismannian criterion is inconsistent and equivocal, and should, therefore, be recognized as one of the obsolete dogmas of heredity. Equivocal interpretation of relevant experiments is possible. Failure to distinguish active from passive environmental changes has been responsible for much confusion (...) in genetic thinking. It is argued that the Lamarckian problem is a spurious problem—the illegitimate offspring of an equivocal distinction between inherited and acquired characteristics. Also considered are: homeostasis and heredity, the chemical theory of development, inadequacies in germinal theories, and genetic relationship between life levels. 26 references. (PsycINFO Database Record (c) 2016 APA, all rights reserved). (shrink)

This essay represents an initial attempt to understand the interrelationship of mortality and subjectivity, passion and death, as they are explored in the works of Sartre, Derrida and Jean-Luc Nancy. From the very first discussions of the passions by Greek philosophers such as Aristotle, passion has held a liminal position: manifested in both body and soul, it transgresses the boundaries of psyche and soma and is especially difficult to categorize. It is not possible to work on passion without exploring the (...) mind/body relationship; and the question of human mortality is the paradigmatic locus where this relationship is most intensely exposed. In this essay, I examine these questions through a few selected texts, and in particular Nancy's Corpus and ‘L'Intrus’. (shrink)

This paper discusses Rancière’s attitude to Sartre through an examination of the two philosophers’ analyses of Flaubert, and especially of Madame Bovary. It argues that Rancière simplifies Sartre’s conception of literary commitment and seriously downplays the subtlety of his understanding of the relationship between literature and politics. Furthermore, by limiting his sources to Sartre’s Qu’est-ce que la littérature?, and not considering L’Idiot de la famille, Rancière fails to recognise the similarities between Sartre’s account and his own, with respect to both (...) aesthetic theory and stylistic analysis. (shrink)

This essay explores the relationship between Sartre and Sloterdijk in the domain of ethics. The major Sloterdijkian imperative, “You must change your life,” is considered in its multiple aspects as an “unconditional instruction,” “the absolute imperative” and shown to exceed the Kantian options of hypothetical and categorical. Sloterdijk’s relations to Sartre are examined in the domains of human freedom, commitment, self-creation, practice, and habit. Ultimately, I conclude that Sloterdijk’s understanding of subjectivation and self-transcendence is, despite initial apparent similarities, profoundly at (...) odds with the Sartrean philosophical vision insofar as it can be seen as, at least partially, alienated, prescriptive, and mystified. (shrink)

This article combines critical, visual and aesthetic theory to argue that the very act of design is a Utopian process. Crucially, the Utopian dimension is not simply a matter of subject matter or utility. Rather, it lies in the act of formal arrangement and composition, and therefore can apply to visual texts with no apparent subject matter at all. The argument is grounded in Ernst Bloch’s critical theory of Utopia, which sees Utopia as a process rather than a destination. It (...) is illustrated with a case study of Navajo weaving, in tandem with an analysis of Navajo creation mythology. It concludes by arguing that we need to go beyond creation theory to a critical theory of creativity. Utopia is not something that we can delegate either to nature or to the supernatural because, as Bloch declares in The Spirit of Utopia, ‘Life has been put into our hands’. (shrink)

IntroductionIntensive care units are places where technologically advanced and aggressive treatment is the norm. End-of-life decision making for children in pediatric intensive care units (PICUs) i...

If you are interested in art, you engage in artistic evaluation, thinking of one work as being better than another; one artist as being better than another; some works and some artists as being great, mediocre, or poor; and, perhaps, thinking of some forms or genres of art as being superior to others in that works within the favored form or genre have achieved or can aspire to a higher artistic value than is possible for those less favored. The greatest (...) philosophical challenge to this practice—a challenge that, if successful, would have wide-ranging consequences outside philosophy, in particular in undermining the status of the practice of art criticism—would maintain that it is, all of it, taken at face value.. (shrink)

In this paper I argue that the stretch of dialogue from 385 b 2–d 1 in the Cratylus does not belong where it is found in the MSS. , but fits rather between 387 c 5 and 387 c 6. I suggest further that at any rate my negative thesis receives some measure of support from the fragments of Proclus' commentary on the dialogue.