Because of the misspecification of models and specificity of operationalizations, many studies produce claims of limited utility. We suggest a path forward that requires taking a few steps back. Researchers can retool large-scale replications to conduct the descriptive research which assesses the generalizability of constructs. Large-scale construct validation is feasible and a necessary next step in addressing the generalizability crisis.

Background The ethical governance of Artificial Intelligence (AI) in health care and public health continues to be an urgent issue for attention in policy, research, and practice. In this paper we report on central themes related to challenges and strategies for promoting ethics in research involving AI in global health, arising from the Global Forum on Bioethics in Research (GFBR), held in Cape Town, South Africa in November 2022. Methods The GFBR is an annual meeting organized by the World Health (...) Organization and supported by the Wellcome Trust, the US National Institutes of Health, the UK Medical Research Council (MRC) and the South African MRC. The forum aims to bring together ethicists, researchers, policymakers, research ethics committee members and other actors to engage with challenges and opportunities specifically related to research ethics. In 2022 the focus of the GFBR was “Ethics of AI in Global Health Research”. The forum consisted of 6 case study presentations, 16 governance presentations, and a series of small group and large group discussions. A total of 87 participants attended the forum from 31 countries around the world, representing disciplines of bioethics, AI, health policy, health professional practice, research funding, and bioinformatics. In this paper, we highlight central insights arising from GFBR 2022. Results We describe the significance of four thematic insights arising from the forum: (1) Appropriateness of building AI, (2) Transferability of AI systems, (3) Accountability for AI decision-making and outcomes, and (4) Individual consent. We then describe eight recommendations for governance leaders to enhance the ethical governance of AI in global health research, addressing issues such as AI impact assessments, environmental values, and fair partnerships. Conclusions The 2022 Global Forum on Bioethics in Research illustrated several innovations in ethical governance of AI for global health research, as well as several areas in need of urgent attention internationally. This summary is intended to inform international and domestic efforts to strengthen research ethics and support the evolution of governance leadership to meet the demands of AI in global health research. (shrink)

Desire satisfaction has not received detailed philosophical examination. Yet intuitive judgments about the satisfaction of desires have been used as data points guiding theories of desire, desire content, and the semantics of ‘desire’. This paper examines desire satisfaction and the standard propositional view of desire. Firstly, I argue that there are several distinct concepts of satisfaction. Secondly, I argue that separating them defuses a difficulty for the standard view in accommodating desires that Derek Parfit described as ‘implicitly conditional on their (...) own persistence’, a problem posed by Shieva Kleinschmidt, Kris McDaniel, and Ben Bradley. The solution undercuts a key motivation for rejecting the standard view in favour of more radical accounts proposed in the literature. (shrink)

Cryonic suspension is a relatively new technology that offers those who can afford it the chance to be 'frozen' for future revival when they reach the ends of their lives. This paper will examine the ethical status of this technology and whether its use can be justified. Among the arguments against using this technology are: it is 'against nature', and would change the very concept of death; no friends or family of the 'freezee' will be left alive when he is (...) revived; the considerable expense involved for the freezee and the future society that will revive him; the environmental cost of maintaining suspension; those who wish to use cryonics might not live life to the full because they would economize in order to afford suspension; and cryonics could lead to premature euthanasia in order to maximize chances of success. Furthermore, science might not advance enough to ever permit revival, and reanimation might not take place due to socio-political or catastrophic reasons. Arguments advanced by proponents of cryonics include: the potential benefit to society; the ability to cheat death for at least a few more years; the prospect of immortality if revival is successful; and all the associated benefits that delaying or avoiding dying would bring. It emerges that it might be imprudent not to use the technology, given the relatively minor expense involved and the potential payoff. An adapted and more persuasive version of Pascal's Wager is presented and offered as a conclusive argument in favour of utilizing cryonic suspension. (shrink)

Several states have recently adopted more restrictive abortion policies yet permit fertility clinics to create surplus IVF embryos. This essay examines this issue: Is it morally inconsistent to prohibit abortion yet permit surplus embryos to be used in fertility medicine? I consider various arguments that try to reconcile this tension. None succeed. Either one holds that embryos have full moral status, and opposes both abortion and surplus embryos, or one denies that embryos have full moral status, which would permit surplus (...) embryos to be used but would entail that some abortions should be permissible as well. (shrink)

There has been a resurgence between two closely related discussions concerning modern science funding policy. The first revolves around the coherence and usefulness of the distinction between basic and applied science and the second concerns whether science should be free to pursue research according to its own internal standards or pursue socially responsible research agendas that are held accountable to moral or political standards. In this paper, I argue that the distinction between basic and applied science, and the concomitant debate (...) about freedom and social responsibility, require revision. I contend that the distinction can only be maintained in cases of _urgent science_. I go on to elucidate the notion of urgent science using a case study from research of the climate refugee crisis. (shrink)

Virtues are habits of character that advance excellence in all of ones endeavors. In the Aristotelian formulation, training in the virtuesis driven by a sense of the “good,” that is, by a widely shared agreement on the components of a good society and on the roles (and appropriate virtues or excellencies) of the “social animals” that energize that society. In the modern era, however, a strong sense of community has been much diminished. Freedom from the restraints of the Church and (...) other social institutions and an emphasis on individual autonomy has fostered a different ethical perspective, a perspective in which the market enters importantly into one’s conception of the good. Does the market generate virtues which in turn sustain it? What guides the development of virtue in market economies that are entering the “information superhighway,” and a new millennium as well? (shrink)

This paper re-evaluates euthanasia and assisted suicide from the perspective of eudaimonia, the ancient Greek conception of happiness across one’s whole life. It is argued that one cannot be said to have fully flourished or had a truly happy life if one’s death is preceded by a period of unbearable pain or suffering that one cannot avoid without assistance in ending one’s life. While death is to be accepted as part of life, it should not be left to nature to (...) dictate the way we die, and it is fundamentally unjust to grant people liberal latitude in how they live their lives while granting them little control over the conclusion of their life narratives. Three objections to this position are considered and rejected; the paper also offers an explanation of why we think killing can be a benefit. Ultimately, euthanasia may be necessary in some cases in order to achieve eudaimonia. (shrink)

BackgroundFear of cancer recurrence is common amongst cancer survivors. There is rapidly growing research interest in FCR but a need to prioritize research to address the most pressing clinical issues and reduce duplication and fragmentation of effort. This study aimed to establish international consensus among clinical and academic FCR experts regarding priorities for FCR research.MethodsMembers of the International Psycho-oncology Society Fear of Cancer Recurrence Special Interest Group were invited to participate in an online Delphi study. Research domains identified in Round (...) 1 were presented and discussed at a focus group to consolidate the domains and items prior to presentation in further survey rounds aimed at gaining consensus on research priorities of international significance.ResultsThirty four research items were identified in Round 1 and 33 of the items were consolidated into six overarching themes through a focus group discussion with FCR experts. The 33 research items were presented in subsequent rounds of the delphi technique. Twenty one participants contributed to delphi round 1, 16 in round 2, and 25 and 29 participants for subsequent delphi rounds. Consensus was reached for 27 items in round 3.1. A further four research items were identified by panelists and included in round 3.2. After round 3.2, 35 individual research items were ratified by the panelists. Given the high levels of consensus and stability between rounds, no further rounds were conducted. Overall intervention research was considered the most important focus for FCR research. Panelists identified models of care that facilitate greater access to FCR treatment and evaluation of the effectiveness of FCR interventions in real world settings as the two research items of highest priority. Defining the mechanisms of action and active components across FCR/P interventions was the third highest priority identified.ConclusionThe findings of this study outline a research agenda for international FCR research. Intervention research to identify models of care that increase access to treatment are based on a flexible approach based on symptom severity and can be delivered within routine clinical care were identified as research areas to prioritize. Greater understanding of the active components and mechanisms of action of existing FCR interventions will facilitate increased tailoring of interventions to meet patient need. (shrink)

In 'Benefit, Disability and the Non-Identity Problem', Hallvard Lillehammer uses the case of a couple who chose to have deaf children to argue against the view that impartial perspectives can provide an exhaustive account of the rightness and wrongness of particular reproductive choices. His conclusion is that the traditional approach to the non-identity problem leads to erroneous conclusions about the morality of creating disabled children. This paper will show that Lillehammer underestimates the power of impartial perspectives and exaggerates the ethical (...) force of partial perspectives, which in turn commits him to providing weak justifications for the choice made by the couple in his example case. (shrink)

This introduction provides brief outlines of the articles collected in this special issue of the International Journal of Philosophical Studies on the topic of Ethics and Emotions. It also announces the winners of the 2021 Robert Papazian and PERITIA prizes.

It is clearly unethical for the NHS to tell people that they will die sooner unless they pay for private treatment, and then to tell them that if they pay for private treatment they will have to pay the NHS for its insufficient service. This is all the more true if people in other parts of the country are receiving all the drugs they need for the same condition on the NHS. Patients who discover that the NHS care that they (...) have paid for will not keep them alive should be able to supplement their care privately if they can afford it, without the added burden and insult of being told their independently inadequate NHS care will cease unless they pay for it too. Mired in self-contradiction as it is, the NHS’ "anti-two-tier" policy must change. (shrink)

In this chapter I consider the narrow and wider benefits of permitting assisted dying in the specific context of organ donation and transplantation. In addition to the commonly used arguments, there are two other neglected reasons for permitting assisted suicide and/or euthanasia: assisted dying enables those who do not wish to remain alive to prolong the lives of those who do, and also allows many more people to fulfill their wish to donate organs after death. In the first part of (...) this chapter I explore the possibility of allowing those who die with assistance to donate their organs and the potential benefits of doing so in countries where some form of assisted dying is legal; in the second part I consider the added force that organ donation considerations bring to the argument in favour of legalizing assisted dying in countries where such practices remain forbidden. (shrink)

In this article, we will identify two issues that deserve greater attention from those researching lay people’s attitudes to moral responsibility and determinism. The first issue concerns whether people interpret the term “moral responsibility” in a retributive way and whether they are motivated to hold offenders responsible for pre-determined behaviour by considerations other than retributivism, e.g. the desires to condemn the action and to protect society. The second issue concerns whether explicitly rejecting moral responsibility and retributivism, after reading about determinism, (...) would have any impact on “implicit” retributivism when recommending a sentence for a hypothetical offender. We will report the results of an exploratory study that investigated these questions. Our preliminary findings raise the possibility that a significant proportion of participants either i) may not interpret “moral responsibility” in the basic, retributive sense of the term, which is at issue in the determinism debate, or ii) may be unconsciously motivated by non-retributive considerations to judge that the offender is morally responsible, in the basic, retributive sense. If this is confirmed by future research, a wider implication would be that theorists’ arguments against retributivism are more likely to affect public attitudes to punishment when non-retributive ways of achieving important punishment goals are emphasised. Our preliminary findings also suggested that explicit retributivism did not correlate with implicit retributivism. If this is confirmed in future research, it would imply that free will theorists who wish to affect public attitudes toward punishment should, when communicating their research to the public, give detailed consideration to the implications for sentencing. (shrink)

Alcohol use and abuse play a major role in both crime and negative health outcomes in Scotland. This paper provides a description and ethical and legal analyses of a novel remote alcohol monitoring scheme for offenders which seeks to reduce alcohol-related harm to both the criminal and the public. It emerges that the prospective benefits of this scheme to health and public order vastly outweigh any potential harms.

The recent literature surrounding the realist/anti-realist debates in the philosophy of science has focused its attention towards the role that history plays in explaining why science is successful and thus approximately true. This has been caused, in large part, by the Pessimistic Meta-Induction (PMI), which has challenged attempted explanations by turning our attention towards the large amount of scientific theories that have been abandoned but were still empirically successful. There will be two primary goals of this paper. The first will (...) be to explore the PMI more deeply than it traditionally has been. This will involve demonstrating how the PMI is more malleable than it is normally given credit for as well as how meta-inductions can and have been used in practice. The second goal will be to discuss the implications of this more robust form of the PMI for explanationist realism, or the thesis that scientific realism provides the best answer as to why science is successful. I will argue that explanationist realism, after being cornered by the malleability of the PMI, turns out to be either a trivial or false thesis. Given this demise of explanationist realism as a substantive thesis, I will argue that the strength of scientific realism truly lies in its critical abilities or its ability to normatively assess scientific theories and the way we ought to practice science. (shrink)

Cumming (2008) uses a puzzle about belief ascription to argue against a Millian semantics, and in favor of a semantics on which names are assigned denotations relative to a shiftable variable assignment. I use Cumming's puzzle to showcase the virtues of a rival, broadly Stalnakerian, treatment of attitude ascriptions that safeguards Millianism. I begin by arguing that Cumming's solution seems unable to account for substitutivity data that helps constitute the very puzzle he uses to motivate his account. Once the substitutivity (...) data is acknowledged, the puzzle actually seems to strengthen, rather than weaken, the Millian position. I then argue that the real force of the puzzle is to place special constraints on our accounts of de re belief ascription. To help bring out the nature of those constraints, I connect aspects of Cumming's puzzle to more familiar problems about belief ascription raised by Quine. I then defend three theses making up a skeletal account of de re belief ascription that promises to cope naturally with the variants of Cumming's puzzle, and integrate them into a broader theory of de re intensionality. (shrink)

This paper is an elaboration of Paul de Man’s critique, in “Heidegger’s Exegeses of Hölderlin,” of Martin Heidegger’s commentary on Friedrich Hölderlin’s poem, “As when on a holiday…” I show that de Man’s critique can be expanded into a critique of a type of testimony that Heidegger ascribes to Hölderlin’s poem. Heidegger ascribes to Hölderlin’s poem what I call “infinite testimony,” but, thereby, suppresses in the poem another type of testimony—what I call “finite testimony. This suppression is most in evidence (...) in Heidegger’s interpretation of Hölderlin’s reference to the myth of Semele, as well as in Heidegger’s excision, in the version of the poem that he printed in the commentary, of the concluding lines of the poem. Additionally, I discuss the political implications of Heidegger’s suppression of the finite testimony depicted in “As when on a holiday...”. (shrink)

Chemotaxis in bacteria is an excellent model for signal transduction processes. In Agrobacterium tumefaciens, the causative agent of crown gall tumour on wounded plants, it is a vital part of the organism's biology. A chromosomally‐determined chemotaxis system causes the bacterium to be attracted into the rhizosphere by chemoattractants in plant exudates. By interfacing with this system, the multifunctional products of two Tiplasmid encoded genes, virA and virG, allow the sensing of specific wound phenolics such as acetosyringone. This attracts Ti‐plasmid harbouring (...) A. tumefaciens to wound sites, where the higher acetosyringone concentrations lead to virA and virG‐mediated induction of the vir‐genes. The products of the induced genes, act in concert to effect transfer of the T‐DNA to the plant cell. (shrink)

One of the first philosophers to relate Indian philosophical thought to Western analytic philosophy, Jaysankar Lal Shaw has been reflecting on analytic themes from Indian philosophy for over 40 years. This collection of his most important writings, introduces his work and presents new ways of using Indian classical thought to approach and understand Western philosophy. By expanding, reinterpreting and reclassifying concepts and views of Indian philosophers, Shaw applies them to the main issues and theories discussed in contemporary philosophy (...) of language and epistemology. Carefully constructed, this volume of his collected writings, shows the parallels Shaw draws between core topics in both traditions, such as proper names, definite descriptions, meaning of a sentence, knowledge, doubt, inference and testimony. It captures how Shaw uses the techniques and concepts of Indian philosophers, especially the followers of the Navya-Nyaya, to address global problems like false belief, higher order knowledge and extraordinary perception. Exploring timeless ideas from Indian thought alongside major issues in contemporary philosophy, Shaw reveals how the two traditions can interact and throw light on each other, providing better solutions to philosophical problems. He has also reflected on modern issues such as freedom, morality and harmony from the classical Indian thought. Featuring a glossary and updates to his writings,The Collected Writings of Jaysankar Lal Shaw: Indian Analytic and Anglophone Philosophy also includes new work by Shaw on the relationship between Indian and analytic philosophy today. (shrink)

Peter Knox-Shaw, “The Dry Salvages: T. S. Eliot in Wordsworthian Waters” -/- Since Wordsworth was seen by T. S. Eliot both as a fellow revolutionary and as a cultural adversary, he supplies a particularly rich illustration of Eliot’s contention that the significance of a poem depends on an appreciation of its relation to the great poetry of the past. The Dry Salvages is the poem through which Eliot engages most fully with Romanticism, and it represents, as has long been (...) recognized, his closest approach to the loco-descriptive poem of that movement. Comparison of the many specific motifs that the poem shares with The Prelude allows for a close textured account of the immediate poetic implications of the two writers’ diverging views on the role of the poet, on primitivism, on the rival metaphysics of immanence and transcendence, and on the relative importance of individual and collective identity. The two poems abound in passages sufficiently affined to reveal the differing aims and achievements of each. (shrink)

This paper examines Irish campaigns for condom access in the early 1990s. Against the backdrop of the AIDS crisis, activists campaigned against a law which would not allow condoms to be sold from ordinary commercial spaces or vending machines, and restricted sale to young people. Advancing a conception of ‘transformative illegality’, we show that illegal action was fundamental to the eventual legalisation of commercial condom sale. However, rather than foregrounding illegal condom sale as a mode of spectacular direct action, we (...) show that tactics of illegal sale in the 1990s built on 20 years of everyday illegal sale within the Irish family planning movement. Everyday illegal sale was a long-term world-making practice, which gradually transformed condoms’ legal meanings, eventually enabling new forms of provocative and irreverent protest. Condoms ‘became legal’ when the state recognised modes of condom sale, gradually built up over many years and publicised in direct action and in the courts. (shrink)

Hélène Cixous has written a substantial body of writings about art. This article borrows Derrida's conception of the countersignature to explore the relationship she envisages in them between the plastic arts and writing. It argues that the works to which Cixous is drawn, many of which involve copying words, are driven by the desire to capture what is essentially uncapturable in the artist's idiom. Recognizing in them a displacement of her own concerns, Cixous suggests in these texts that all art (...) speaks a common language in so far as it represents the same attempt to pass beyond its own limits, visual or verbal. Writing and painting are thus as much translations of each other as one language is of another. In particular, their status as translations or copies profoundly troubles the possibility of determining the signatory of the text. (shrink)

Hélène Cixous and Jacques Derrida position themselves very differently in relation to literature. This article analyses that difference in the light of their relation to the symptom, the fundamentally unanalysable form through which the unconscious manifests itself. While Derrida dwells more on the impossibility of ever accessing the original secret wound to whose existence the symptom opaquely attests, Cixous tends to focus more on the effect, the symptom itself. For both, the ‘chance’ of literature lies in the fact that neither (...) the source nor the destination of letters can be determined. I argue that the difference between Derrida's relative resignation to this condition and Cixous's celebration of it helps to explain the contrast between his position at the margins of literature and her unequivocal embrace of it. (shrink)