Nanomedicine is yielding new and improved treatments and diagnostics for a range of diseases and disorders. Nanomedicine applications incorporate materials and components with nanoscale dimensions where novel physiochemical properties emerge as a result of size-dependent phenomena and high surface-to-mass ratio. Nanotherapeutics and in vivo nanodiagnostics are a subset of nanomedicine products that enter the human body. These include drugs, biological products, implantable medical devices, and combination products that are designed to function in the body in ways unachievable at larger scales. (...) Nanotherapeutics andin vivonanodiagnostics incorporate materials that are engineered at the nanoscale to express novel properties that are medicinally useful. These nanomedicine applications can also contain nanomaterials that are biologically active, producing interactions that depend on biological triggers. Examples include nanoscale formulations of insoluble drugs to improve bioavailability and pharmacokinetics, drugs encapsulated in hollow nanoparticles with the ability to target and cross cellular and tissue membranes and to release their payload at a specific time or location, imaging agents that demonstrate novel optical properties to aid in locating micrometastases, and antimicrobial and drug-eluting components or coatings of implantable medical devices such as stents. (shrink)

In a recent Inquiry article Louis Pascal argues that the problem of massive starvation in the modern world is the result of a genetically-based human propensity to produce as many offspring as possible, regardless of ecological conditions. In this paper biological and anthropological objections to Pascal's thesis are discussed as well as the conclusions he draws from it. It is suggested that natural selection has produced humans who are flexible in their reproductive behavior in order to cope with rapidly changing (...) environments. The implications of both arguments for the population movement and the attempt to eliminate starvation are discussed. (shrink)

This rejoinder to J. Patrick Gray's and Linda Wolfe's 'The Loving Parent Meets the Selfish Gene' (Inquiry, this issue), which in turn was in response to the author's 'Human Tragedy and Natural Selection' (Inquiry, Vol. 21, No. 4), briefly addresses their major objections and suggests that in many instances they have misunderstood the point of that paper. They argue that many of the traits referred to are more cultural than genetic. That this is not the central issue is (...) made clearer by stressing certain aspects of the view underlying the original article, chiefly concerning the extent of human irrationality and insensitivity. (shrink)

Bringing these two emergent areas of thought into direct conversation in Before the Law, Cary Wolfe fosters a new discussion about the status of nonhuman animals and the shared plight of humans and animals under biopolitics.

Whose Keeper? is a profound and creative treatise on modernity and its challenge to social science. Alan Wolfe argues that modern liberal democracies, such as the United States and Scandinavia, have broken with traditional sources of mortality and instead have relied upon economic and political frameworks to define their obligations to one another. Wolfe calls for reinvigorating a sense of community and thus a sense of obligation to the larger society.

The distinctiveness of political evil -- Widespread evil within -- Unrelenting evil without -- The misuses of appeasement -- Democracy's terrorism problem -- The case against dramatizing genocide -- Ethnic cleaning's seductive attractions -- The politics of counter-evil.

We argue for a conception of ‘philosophy of biology before biology’ which is neither internalist study of biological doctrines, nor a reconstruction of the role philosophical concepts might have played in the constitution of biology as science, but rather a kind of interplay between metaphysical and empirical issues. This should have an impact both on our present understanding of philosophy of biology, given that it is necessarily conditioned by a very specific history and historiography, and on our understanding of how (...) biology as a science of life became unified. (shrink)

Anthropologists have provided rich field descriptions of the norms and conventions governing behavior and interactions in small-scale societies. Here, we add a further dimension to this work by presenting hypothetical moral dilemmas involving harm, to a small-scale, agrarian Mayan population, with the specific goal of exploring the hypothesis that certain moral principles apply universally. We presented Mayan participants with moral dilemmas translated into their native language, Tseltal. Paralleling several studies carried out with educated subjects living in large-scale, developed nations, the (...) Mayan participants judged harms caused as the means to a greater good as more forbidden than harms caused as a side-effect (i.e., side-effect bias). However, unlike these other populations living in large-scale societies, as well as a more educated and less rural Mayan comparison group, the target rural Mayan participants did not judge actions causing harm as worse than omissions (i.e., omission bias). A series of probes targeting the action-omission distinction suggest that the absence of an omission bias among the rural Mayan participants was not due to difficulties comprehending the dilemmas, using the judgment scale, or in attributing a greater causal role for actions over omissions. Thus, while the moral distinction between means and side-effect may be more universal, the moral distinction between actions and omission appears to be open to greater cross-cultural variation. We discuss these results in light of issues concerning the role of biological constraints and cultural variation in moral decision-making, as well as the limitations of such experimental, cross-cultural research. (shrink)

This essay rethinks the meaning of ecopoetics by exploring poems about birds’ song – one of the most canonical themes in all of poetry – and how their poetics may be understood in relation to our growing ornithological knowledge about birds and how, why, and what they sing. While ecocriticism has traditionally thought such questions in terms of the experience – and the representation of the experience – of an auditor who, in her rapt attention, establishes the well-known bird/bard matrix (...) familiar from the poetic tradition, this essay argues for a non-representationalist ecopoetics in which poem and birds’ song share a common infrastructure of iterability. This helps us locate the ecological dimension of poetics rather differently, and it also opens onto the non-representationalist understanding of our experience of “world” in both deconstruction and systems theory, which long ago replaced the concept of “nature” with “environment.”. (shrink)

This paper reports a study focusing on the transition of women who changed their sexual orientation during the mid‐life period. It is my premise that these midlife women, by changing their sexual identity to lesbian, also changed cultural systems from heterosexual to lesbian. One finding of the study is the development of an expanding consciousness of and about women by the women who later made a sexual preference transition.

Philosophy of biology before biology -/- Edited by Cécilia Bognon-Küss & Charles T. Wolfe -/- Table of contents -/- Cécilia Bognon-Küss & Charles T. Wolfe. Introduction -/- 1. Cécilia Bognon-Küss & Charles T. Wolfe. The idea of “philosophy of biology before biology”: a methodological provocation -/- Part I. FORM AND DEVELOPMENT -/- 2. Stéphane Schmitt. Buffon’s theories of generation and the changing dialectics of molds and molecules 3. Phillip Sloan. Metaphysics and “Vital” Materialism: The Gabrielle Du Châtelet (...) Circle and French Vitalism 4. John Zammito. The Philosophical Reception of C. F. Wolff’s Epigenesis in Germany, 1770-1790: Herder, Tetens and Kant -/- Part II. ORGANISM & ORGANIZATION 5. François Duchesneau. Senebier and the Advent of General Physiology 6. Tobias Cheung. Organization and Process. Living Systems Between Inner and Outer Worlds: Cuvier, Hufeland, Cabanis. -/- Part III. SYSTEMS 7. Georg Toepfer. Philosophy of Ecology Long Before Ecology: Kant’s Idea of an Organized System of Organized Beings 8. Ina Goy. "All is leaf". Goethe's plant philosophy and poetry 9. Snait Gissis. ‘Biology’, Lamarck, Lamarckisms -/- POSTSCRIPTS 1. Lynn Nyhart. A Historical Proposal Around Prepositions -/- 2. Philippe Huneman. Philosophy after Philosophy of Biology before Biology -/- Cécilia Bognon-Küss and Charles T. Wolfe. Conclusion . (shrink)

The social scientific study of ethical-unethical behavior in work organizations is in an early stage of development. This paper discusses some of the problems of conducting social scientific research in this area and explores the potential contribution of experimental research approaches. Both laboratory and field experimentation allow the investigator to test theory-based hypotheses and to study causal relations. Examples are provided of investigations that have applied these methods to the study of business ethics.

This essay begins by noting that “the question of the animal” has been abandoned prematurely in the current theoretical landscape in favor of the Plant, the Stone, the Object, and a more general rush toward Materialism and Realism (in their various permutations). The latest iteration of this economy of knowledge production (and planned obsolescence) may be found in the ubiquitous discourse of “the Anthropocene.” While it is a large and diverse body of thought and writing, I will focus here on (...) Bruno Latour’s influential rendition in Facing Gaia: Eight Lectures on the New Climatic Regime. I share Latour’s reservations about the concept of the Anthropocene, and I also share his desire for a more complex understanding of Gaia as an “outlaw” whose alterity pushes back against traditional concepts of nature as a totalized and homeostatic order. As I will show, however, Latour’s Actor Network Theory is far too blunt a theoretical instrument to account for the radical difference between qualitatively different orders of complexity and causation that obtain in biological vs. physical systems, which is crucial, of course, for understanding the role of the biological in the larger domain of Gaia and climate change. As I will show – drawing principally on the work of Stuart Kauffman and his proposition that the evolution of the biosphere is neither non-ergodic nor governed by entailing laws – the real “outlaw” (to use Latour’s language), when it comes to the evolution of the earth and its climate system, is the contingency and recursivity of autopoietic biological systems, which enable a form of downward and distributed causality, and a “decoupling” between micro- and macro-levels (to borrow Alicia Juarrero’s phrase), in which the alterity and negativity of temporality (hence my emphasis on “dynamic”) is irreducible and “creative.” We see this both ontogenetically and phylogenetically (as in the example of niche formation in ecosystems). In short, biology is not (only) physics – far from it. Why is this important? Because, after decades of hegemony by the neo-Darwinian reductionist paradigm, with its infatuation with the genome as the “book of life” and its subsequent engineering paradigm for biological existence, it is crucial to formulate an anti-reductionist, interdisciplinary framework for understanding the real complexity of life on the planet and its evolution. Here, however – as I argued in What is Posthumanism? – the issue isn’t just what you are thinking (the decentering of the human and humanism that Latour and I both share) but how you are thinking it. Here, Latour’s work has a desire, but no theory, for the alterity we both seek. At this crucial epistemic moment, we need, in short, an anti-reductionist anti-reductionism – not flat ontologies, but ever more “jagged” ones. (shrink)

Vitalism was long viewed as the most grotesque view in biological theory: appeals to a mysterious life-force, Romantic insistence on the autonomy of life, or worse, a metaphysics of an entirely living universe. In the early twentieth century, attempts were made to present a revised, lighter version that was not weighted down by revisionary metaphysics: " organicism ". And philosophers since the Vienna Circle (Schlick, Frank and later Nagel) criticized Driesch and Bergson's " neovitalism " as a too-strong ontological commitment (...) to the existence of certain entities or " forces ", over and above the system of causal relations studied by mechanistic science, rejecting the weaker form, organicism, as well. But there has been some significant scholarly " push-back " against this orthodox attitude, notably pointing to the 18th-century Montpellier vitalists to show that there are different historical forms of vitalism, including how they relate to mainstream scientific practice (Wolfe and Normandin, eds. 2013). Additionally, some trends in recent biology that run counter to genetic reductionism and the informational model of the gene present themselves as organicist (Gilbert and Sarkar 2000, Moreno and Mossio 2015). Here, we examine some cases of vitalism in the twentieth century and today, not just as a historical form but as a significant metaphysical and scientific model. We argue for vitalism's conceptual originality without either reducing it to mainstream models of science or presenting it as an alternate model of science, by focusing on historical forms of vitalism, logical empiricist critiques thereof and the impact of synthetic biology on current (re-)theorizing of vitalism. (shrink)

Natural Law Today gives a strong voice to classical natural law theory as the best answers to the fundamental questions of ethics and as the best framework for political and social life. It explains various aspects of that theory and defends it against common misperceptions and criticisms.

This chapter argues that the objection that Socrates makes against diviners, poets, and rhapsodies having knowledge is an example of what has come to be known as an opacity objection: that is, some aspect of what would be required for them to know is unrecognised by them. This chapter contends that the opacity is of a different kind than what contemporary epistemologists have considered, and claims that Socrates’ specific version should have a place in contemporary theory of knowledge.

This Handbook considers Christian thought in the long nineteenth century, encompassing not only doctrine and theology, but also Christianity's mutual influence on literature and the arts, political and economic thought, and the natural and social sciences.

Religious faith may manifest itself, among other things, as a mode of seeing the ordinary world, which invests that world imaginatively (or inspiredly) with an unseen depth of divine intention and spiritual significance. While such seeing may well be truthful, it is also unavoidably constructive, involving the imagination in its philosophical sense of the capacity to organize underdetermined or ambiguous sense date into a whole or gestalt. One of the characteristic ways in which biblical narratives inspire and teach is by (...) renewing their characters’ and readers’ imagination. The texts do so not inexorably but in a similar way as (other) works of art. This paper therefore investigates the ways in which works of art engage and develop the imagination, and thereby enable renewed perceptual and cognitive engagement with the world. The paper introduces predictive processing as a helpful psychological theory for analyzing this dynamic, and outlines questions for further research. (shrink)