Nanomedicine is yielding new and improved treatments and diagnostics for a range of diseases and disorders. Nanomedicine applications incorporate materials and components with nanoscale dimensions where novel physiochemical properties emerge as a result of size-dependent phenomena and high surface-to-mass ratio. Nanotherapeutics and in vivo nanodiagnostics are a subset of nanomedicine products that enter the human body. These include drugs, biological products, implantable medical devices, and combination products that are designed to function in the body in ways unachievable at larger scales. (...) Nanotherapeutics andin vivonanodiagnostics incorporate materials that are engineered at the nanoscale to express novel properties that are medicinally useful. These nanomedicine applications can also contain nanomaterials that are biologically active, producing interactions that depend on biological triggers. Examples include nanoscale formulations of insoluble drugs to improve bioavailability and pharmacokinetics, drugs encapsulated in hollow nanoparticles with the ability to target and cross cellular and tissue membranes and to release their payload at a specific time or location, imaging agents that demonstrate novel optical properties to aid in locating micrometastases, and antimicrobial and drug-eluting components or coatings of implantable medical devices such as stents. (shrink)

In a recent Inquiry article Louis Pascal argues that the problem of massive starvation in the modern world is the result of a genetically-based human propensity to produce as many offspring as possible, regardless of ecological conditions. In this paper biological and anthropological objections to Pascal's thesis are discussed as well as the conclusions he draws from it. It is suggested that natural selection has produced humans who are flexible in their reproductive behavior in order to cope with rapidly changing (...) environments. The implications of both arguments for the population movement and the attempt to eliminate starvation are discussed. (shrink)

This rejoinder to J. Patrick Gray's and Linda Wolfe's 'The Loving Parent Meets the Selfish Gene' (Inquiry, this issue), which in turn was in response to the author's 'Human Tragedy and Natural Selection' (Inquiry, Vol. 21, No. 4), briefly addresses their major objections and suggests that in many instances they have misunderstood the point of that paper. They argue that many of the traits referred to are more cultural than genetic. That this is not the central issue is (...) made clearer by stressing certain aspects of the view underlying the original article, chiefly concerning the extent of human irrationality and insensitivity. (shrink)

This book provides an accessible comprehensive exploration of phenomenological theory and research methods and is geared specifically to the needs of therapists ...

The category of ‘organism’ has an ambiguous status: is it scientific or is it philosophical? Or, if one looks at it from within the relatively recent field or sub-field of philosophy of biology, is it a central, or at least legitimate category therein, or should it be dispensed with? In any case, it has long served as a kind of scientific “bolstering” for a philosophical train of argument which seeks to refute the “mechanistic” or “reductionist” trend, which has been perceived (...) as dominant since the 17th century, whether in the case of Stahlian animism, Leibnizian monadology, the neo-vitalism of Hans Driesch, or, lastly, of the “phenomenology of organic life” in the 20th century, with authors such as Kurt Goldstein, Maurice Merleau-Ponty, and Georges Canguilhem. In this paper I try to reconstruct some of the main interpretive ‘stages’ or ‘layers’ of the concept of organism in order to critically evaluate it. How might ‘organism’ be a useful concept if one rules out the excesses of ‘organismic’ biology and metaphysics? Varieties of instrumentalism and what I call the ‘projective’ concept of organism are appealing, but perhaps ultimately unsatisfying. (shrink)

This paper explores ethical questions arising from the work of health practitioners in immigration detention centres in Australia. It raises questions about the roles of professional disciplines and the ways in which they confront dual loyalty issues. The exploration is guided by interviews conducted with health professionals who have worked in asylum seeker detention and an examination of the outsider advocacy role undertaken by the social work profession. The paper discusses the stance taken by individuals and professional associations on participation (...) in controlled settings, including as participant, bystander and advocate, and asks when the provision of care becomes collusion with oppression. (shrink)

Bringing these two emergent areas of thought into direct conversation in Before the Law, Cary Wolfe fosters a new discussion about the status of nonhuman animals and the shared plight of humans and animals under biopolitics.

Locke and Leibniz deny that there are any such beings as ‘monsters’ (anomalies, natural curiosities, wonders, and marvels), for two very different reasons. For Locke, monsters are not ‘natural kinds’: the word ‘monster’ does not individuate any specific class of beings ‘out there’ in the natural world. Monsters depend on our subjective viewpoint. For Leibniz, there are no monsters because we are all parts of the Great Chain of Being. Everything that happens, happens for a reason, including a monstrous birth. (...) But what about materialism? Well, beginning with the anatomical interest into ‘monstrous births’ in the French Académie des Sciences in the first three decades of the eighteenth century, there is a shift away from ‘imaginationist’ claims such as those of Malebranche, that if a woman gives birth to a monstrous child it is a consequence of something she imagined. Anatomists such as Lemery and Winslow try to formulate a strictly mechanical explanation for such events, rejecting moral and metaphysical explanations. Picking up on this work, materialist thinkers like Diderot are compelled to reject the very idea of monsters. We are all material beings produced according to the same mechanisms or laws, some of us are more ‘successful’ products than others, i.e. some live longer than others. In his late Eléments de physiologie he says “L’homme est un effet commun, le monstre un effet rare.” Ultimately he arrives at a materialist version of Leibniz’s position: there are no monsters, we are all monsters in each other’s eyes, at one time or another. This conclusion is a pregnant one in light of twentieth century interest in the problem of ‘the normal and the pathological’ (Canguilhem), and the broader question of how materialism relates to the biological world. (shrink)

Whose Keeper? is a profound and creative treatise on modernity and its challenge to social science. Alan Wolfe argues that modern liberal democracies, such as the United States and Scandinavia, have broken with traditional sources of mortality and instead have relied upon economic and political frameworks to define their obligations to one another. Wolfe calls for reinvigorating a sense of community and thus a sense of obligation to the larger society.

The distinctiveness of political evil -- Widespread evil within -- Unrelenting evil without -- The misuses of appeasement -- Democracy's terrorism problem -- The case against dramatizing genocide -- Ethnic cleaning's seductive attractions -- The politics of counter-evil.

We argue for a conception of ‘philosophy of biology before biology’ which is neither internalist study of biological doctrines, nor a reconstruction of the role philosophical concepts might have played in the constitution of biology as science, but rather a kind of interplay between metaphysical and empirical issues. This should have an impact both on our present understanding of philosophy of biology, given that it is necessarily conditioned by a very specific history and historiography, and on our understanding of how (...) biology as a science of life became unified. (shrink)

Well prior to the invention of the term ‘biology’ in the early 1800s by Lamarck and Treviranus, and also prior to the appearance of terms such as ‘organism’ under the pen of Leibniz in the early 1700s, the question of ‘Life’, that is, the status of living organisms within the broader physico-mechanical universe, agitated different corners of the European intellectual scene. From modern Epicureanism to medical Newtonianism, from Stahlian animism to the discourse on the ‘animal economy’ in vitalist medicine, models (...) of living being were constructed in opposition to ‘merely anatomical’, structural, mechanical models. It is therefore curious to turn to the ‘passion play’ of the Scientific Revolution – whether in its early, canonical definitions or its more recent, hybridized, reconstructed and expanded versions: from Koyré to Biagioli, from Merton to Shapin – and find there a conspicuous absence of worry over what status to grant living beings in a newly physicalized universe. Neither Harvey, nor Boyle, nor Locke (to name some likely candidates, the latter having studied with Willis and collaborated with Sydenham) ever ask what makes organisms unique, or conversely, what does not. In this paper I seek to establish how ‘Life’ became a source of contention in early modern thought, and how the Scientific Revolution missed the controversy. (shrink)

Anthropologists have provided rich field descriptions of the norms and conventions governing behavior and interactions in small-scale societies. Here, we add a further dimension to this work by presenting hypothetical moral dilemmas involving harm, to a small-scale, agrarian Mayan population, with the specific goal of exploring the hypothesis that certain moral principles apply universally. We presented Mayan participants with moral dilemmas translated into their native language, Tseltal. Paralleling several studies carried out with educated subjects living in large-scale, developed nations, the (...) Mayan participants judged harms caused as the means to a greater good as more forbidden than harms caused as a side-effect (i.e., side-effect bias). However, unlike these other populations living in large-scale societies, as well as a more educated and less rural Mayan comparison group, the target rural Mayan participants did not judge actions causing harm as worse than omissions (i.e., omission bias). A series of probes targeting the action-omission distinction suggest that the absence of an omission bias among the rural Mayan participants was not due to difficulties comprehending the dilemmas, using the judgment scale, or in attributing a greater causal role for actions over omissions. Thus, while the moral distinction between means and side-effect may be more universal, the moral distinction between actions and omission appears to be open to greater cross-cultural variation. We discuss these results in light of issues concerning the role of biological constraints and cultural variation in moral decision-making, as well as the limitations of such experimental, cross-cultural research. (shrink)

If God knows everything he must know the future, and if he knows the future he must know the future acts of his creatures. But then his creatures must act as he knows they will act. How then can they be free? This dilemma has a long history in Christian philosophy and is now as hotly disputed as ever. The medieval scholastics were virtually unanimous in claiming both that God is omniscient and that humans have free will, though they disagreed (...) in their accounts of how the two are compatible. With the Reformation the debate became even more lively since there were Protestant philosophers who denied both claims, and many philosophers ever since have either thought it impossible to reconcile them or have thought it possible only because they weaken one or the other. (shrink)

This volume focuses on the development of empiricism as an interest in the body - as both the object of research and the subject of experience.

This essay rethinks the meaning of ecopoetics by exploring poems about birds’ song – one of the most canonical themes in all of poetry – and how their poetics may be understood in relation to our growing ornithological knowledge about birds and how, why, and what they sing. While ecocriticism has traditionally thought such questions in terms of the experience – and the representation of the experience – of an auditor who, in her rapt attention, establishes the well-known bird/bard matrix (...) familiar from the poetic tradition, this essay argues for a non-representationalist ecopoetics in which poem and birds’ song share a common infrastructure of iterability. This helps us locate the ecological dimension of poetics rather differently, and it also opens onto the non-representationalist understanding of our experience of “world” in both deconstruction and systems theory, which long ago replaced the concept of “nature” with “environment.”. (shrink)

This paper reports a study focusing on the transition of women who changed their sexual orientation during the mid‐life period. It is my premise that these midlife women, by changing their sexual identity to lesbian, also changed cultural systems from heterosexual to lesbian. One finding of the study is the development of an expanding consciousness of and about women by the women who later made a sexual preference transition.

Philosophy of biology before biology -/- Edited by Cécilia Bognon-Küss & Charles T. Wolfe -/- Table of contents -/- Cécilia Bognon-Küss & Charles T. Wolfe. Introduction -/- 1. Cécilia Bognon-Küss & Charles T. Wolfe. The idea of “philosophy of biology before biology”: a methodological provocation -/- Part I. FORM AND DEVELOPMENT -/- 2. Stéphane Schmitt. Buffon’s theories of generation and the changing dialectics of molds and molecules 3. Phillip Sloan. Metaphysics and “Vital” Materialism: The Gabrielle Du Châtelet (...) Circle and French Vitalism 4. John Zammito. The Philosophical Reception of C. F. Wolff’s Epigenesis in Germany, 1770-1790: Herder, Tetens and Kant -/- Part II. ORGANISM & ORGANIZATION 5. François Duchesneau. Senebier and the Advent of General Physiology 6. Tobias Cheung. Organization and Process. Living Systems Between Inner and Outer Worlds: Cuvier, Hufeland, Cabanis. -/- Part III. SYSTEMS 7. Georg Toepfer. Philosophy of Ecology Long Before Ecology: Kant’s Idea of an Organized System of Organized Beings 8. Ina Goy. "All is leaf". Goethe's plant philosophy and poetry 9. Snait Gissis. ‘Biology’, Lamarck, Lamarckisms -/- POSTSCRIPTS 1. Lynn Nyhart. A Historical Proposal Around Prepositions -/- 2. Philippe Huneman. Philosophy after Philosophy of Biology before Biology -/- Cécilia Bognon-Küss and Charles T. Wolfe. Conclusion . (shrink)

The social scientific study of ethical-unethical behavior in work organizations is in an early stage of development. This paper discusses some of the problems of conducting social scientific research in this area and explores the potential contribution of experimental research approaches. Both laboratory and field experimentation allow the investigator to test theory-based hypotheses and to study causal relations. Examples are provided of investigations that have applied these methods to the study of business ethics.

This essay begins by noting that “the question of the animal” has been abandoned prematurely in the current theoretical landscape in favor of the Plant, the Stone, the Object, and a more general rush toward Materialism and Realism (in their various permutations). The latest iteration of this economy of knowledge production (and planned obsolescence) may be found in the ubiquitous discourse of “the Anthropocene.” While it is a large and diverse body of thought and writing, I will focus here on (...) Bruno Latour’s influential rendition in Facing Gaia: Eight Lectures on the New Climatic Regime. I share Latour’s reservations about the concept of the Anthropocene, and I also share his desire for a more complex understanding of Gaia as an “outlaw” whose alterity pushes back against traditional concepts of nature as a totalized and homeostatic order. As I will show, however, Latour’s Actor Network Theory is far too blunt a theoretical instrument to account for the radical difference between qualitatively different orders of complexity and causation that obtain in biological vs. physical systems, which is crucial, of course, for understanding the role of the biological in the larger domain of Gaia and climate change. As I will show – drawing principally on the work of Stuart Kauffman and his proposition that the evolution of the biosphere is neither non-ergodic nor governed by entailing laws – the real “outlaw” (to use Latour’s language), when it comes to the evolution of the earth and its climate system, is the contingency and recursivity of autopoietic biological systems, which enable a form of downward and distributed causality, and a “decoupling” between micro- and macro-levels (to borrow Alicia Juarrero’s phrase), in which the alterity and negativity of temporality (hence my emphasis on “dynamic”) is irreducible and “creative.” We see this both ontogenetically and phylogenetically (as in the example of niche formation in ecosystems). In short, biology is not (only) physics – far from it. Why is this important? Because, after decades of hegemony by the neo-Darwinian reductionist paradigm, with its infatuation with the genome as the “book of life” and its subsequent engineering paradigm for biological existence, it is crucial to formulate an anti-reductionist, interdisciplinary framework for understanding the real complexity of life on the planet and its evolution. Here, however – as I argued in What is Posthumanism? – the issue isn’t just what you are thinking (the decentering of the human and humanism that Latour and I both share) but how you are thinking it. Here, Latour’s work has a desire, but no theory, for the alterity we both seek. At this crucial epistemic moment, we need, in short, an anti-reductionist anti-reductionism – not flat ontologies, but ever more “jagged” ones. (shrink)

Vitalism was long viewed as the most grotesque view in biological theory: appeals to a mysterious life-force, Romantic insistence on the autonomy of life, or worse, a metaphysics of an entirely living universe. In the early twentieth century, attempts were made to present a revised, lighter version that was not weighted down by revisionary metaphysics: " organicism ". And philosophers since the Vienna Circle (Schlick, Frank and later Nagel) criticized Driesch and Bergson's " neovitalism " as a too-strong ontological commitment (...) to the existence of certain entities or " forces ", over and above the system of causal relations studied by mechanistic science, rejecting the weaker form, organicism, as well. But there has been some significant scholarly " push-back " against this orthodox attitude, notably pointing to the 18th-century Montpellier vitalists to show that there are different historical forms of vitalism, including how they relate to mainstream scientific practice (Wolfe and Normandin, eds. 2013). Additionally, some trends in recent biology that run counter to genetic reductionism and the informational model of the gene present themselves as organicist (Gilbert and Sarkar 2000, Moreno and Mossio 2015). Here, we examine some cases of vitalism in the twentieth century and today, not just as a historical form but as a significant metaphysical and scientific model. We argue for vitalism's conceptual originality without either reducing it to mainstream models of science or presenting it as an alternate model of science, by focusing on historical forms of vitalism, logical empiricist critiques thereof and the impact of synthetic biology on current (re-)theorizing of vitalism. (shrink)