Complex diseases involve both a genetic component and a response to environmental factors or lifestyle changes. Recently, genome-wide association studies (GWAS) have succeeded in identifying hundreds of polymorphisms that are statistically associated with complex diseases. However, the association is usually weak and none of the associated allelic forms is either necessary or sufficient for the disease occurrence. We argue that this promotes a network view, centred on functional redundancy. We adapted reliability theory to the concerned sub-network, modelled as a parallel (...) array of functional modules. In our model, as long as one module remains active, the function correlated with the respective disease is ensured and disease does not occur. Genetic factors reduce the initial number of available modules while environment, contingent surroundings, personal history, epigenetics, and some intrinsic stochasticity influence their persistence time. This model reproduces age-specific incidence curves and explains the influence of environmental changes. It offers a new paradigm, according to which disease occurs due to a lack of functional elements, depending on many idiosyncratic factors. Genetic risk assessed from GWAS is only a statistical notion with no direct interpretation at the individual level. However, genomic profiling could be useful at population level in devising models to guide decisions in health care policy. (shrink)

This Element examines Kant's innovative account of labour in his political philosophy and develops an intersectional analysis of Kant. By demonstrating that Kant's analysis of slavery, citizenship, and sex developed in inter-linked ways over several decades, culminating in his development of a 'trichotomy' of Right, the author shows that Kant's normative account of independence is configured through his theory of labour, and is continuous with his anthropological accounts of race and gender, providing a systemic justification for the dependency of women (...) and non-whites embedded in his philosophy of right. By examining Kant's arguments about slavery as intertwined with his account of domestic labour, the author argues that his ultimate rejection of slavery may owe more to his changing conceptualization of labour than to his theory of race, and that his final arguments against slavery rehearse strategies for embedding intersectional patterns of domestic dependence in his account of the rightful state. (shrink)

This Element considers the relationship between the traditional view of God as all-powerful, all-knowing and wholly good on the one hand, and the idea of human free will on the other. It focuses on the potential threats to human free will arising from two divine attributes: God's exhaustive foreknowledge and God's providential control of creation.

This paper formulates a response to standard accounts of Kantian sexual morality, by first clarifying why sex should be understood as a case of using a person as a thing, rather than merely as a means. The author argues that Kant’s remedy to this problem is not sexual consent, but a model of setting and sharing sexual ends. Kant’s account of sexual morality, read in this way, is a critical framework for contemporary moves to think beyond consent, and to grapple (...) with concerns about sexual violation and “bad sex” that have gained uptake in the wake of the MeToo movement. The author defends an account of sex as a process of setting and sharing sexual ends in a Kantian key, which provides us with resources for thinking about the robust ongoing project of making our sexual selves in nonideal conditions, as well as for identifying the wrongs of both “bad” sex and sexual harassment. In doing so, they offer a critical middle ground between contemporary accounts of sexual morality that center questions of individual agency or autonomy, and those that foreground the intersubjective nature of sex. (shrink)

Pascoe, David The notion of stewardship is an emerging reality in the Catholic Church,1 albeit somewhat confined to some Western localities, particularly the USA, and also developing in the Australian context. While the notion is not new to the wider Christian Church, there remain questions as to the theological foundation for stewardship as a principle of Christian living in its Catholic context. There is, for example, a question of how stewardship is a lived reality for the people who are (...) the Catholic Church, when stewardship is understood as giving expression to the nature and mission of the church. If, as the Second Vatican Council teaches, the one sole purpose of the church is 'that the kingdom of God may come and the salvation of the human race may be accomplished' (GS 45), how does stewardship play a part in accomplishing this purpose? And, perhaps more importantly, there is the question what is it about stewardship in our time that presents the Church with a renewed impetus to take up its central purpose as noted in Gaudium et spes, with more deliberate vigour? (shrink)

The author of handbooks that reflected the Victorian emphasis on bettering one's prospects, Charles Eyre Pascoe addressed the topic of female education in this work of 1879, at a time when the Cambridge colleges of Girton and Newnham were in their infancy. 'Chiefly designed for the use of persons of the upper middle class', the guide aims to assist parents in making informed choices about their daughters' education. The coverage extends from kindergarten through to university, before focusing on career (...) options for women in the late nineteenth century, in fields such as teaching, the arts and medicine. Throughout, Pascoe's recommendations are based on consideration of the breadth of the curriculum, the qualifications of the teaching staff and the results achieved in examinations. For higher education, details of entrance examinations are provided, together with information on the subjects and lectures that were open to women at that time. (shrink)

Maiese and Hanna (2019) argue that social institutions shape and transform our embodied minds, and that detrimental and harmful institutions can be reverted in order to promote mentally healthy, authentic, and fulfilling lives. This commentary aims to complement this proposal by understanding the role that narratives and narrative practices play in shaping our embodied minds, by highlighting narrativity’s (1) active, deliberative, and productive functions, and (2) its strong entanglement with embodiment. We will argue that this addition to Maiese and Hanna’s (...) account allows agents to assume a more active role within social institutions by engaging in conscious and deliberative self-narration. This is because, we contend, not only do we understand ourselves and others according to cultural narrative archetypes; we also, crucially, bring about concrete changes in our embodiment and behavior by narrative deliberation and intention formation. As such, self-narration is not only an intellectual endeavor, but can also have profound consequences for how we experience the world; in other words, narrative practices can purposefully alter our affective framing which, in Maiese and Hanna’s account, is fundamental in the process of changing detrimental institutions into constructive, enabling institutions. (shrink)

ABSTRACT. Public discourse about ethics in the COVID-19 pandemic has tended to focus on scarcity of resources and the protection of civil liberties. We show how these preoccupations reflect an established disaster imaginary that orients the ethics of response. In this paper, we argue that pandemic ethics should instead be oriented through a relational account of persons as vulnerable vectors embedded in existing networks of care. We argue for the creation of a new disaster imaginary to shape our own understandings (...) of the interrelated social, political, and economic hardships under conditions of social distancing. We develop a pandemic ethics framework rooted in uBuntu and care ethics that makes visible the underlying multidimensional structural inequities of the pandemic, attending to the problems of resource scarcity and inequities in mortality while insisting on a response that surges existing and emergent forms of solidarity. (shrink)

In this article, I compare Kant’s and Marx’s analysis of women and domestic labour in their mature political works, and argue that Kant offers more analytic tools for understanding the social and economic role of domestic labour than does Marx. While domestic labour becomes visible to Marx only as it is outsourced, Kant develops a clear account of the specific rules governing domestic labour in the emerging bourgeois household. Because of his commitment to the domestic realm as a core feature (...) of the just state, however, much of Kant’s account of domestic labour should be challenged by contemporary Kantian feminists. (shrink)

Trust is often an assumed outcome of participation in Alternative Food Networks (AFNs) as they directly connect producers with consumers. It is based on this potential for trust “between producers and consumers” that AFNs have emerged as a significant field of food studies analysis as it also suggests a capacity for AFNs to foster associated embedded qualities, like ‘morality’, ‘social justice’, ‘ecology’ and ‘equity’. These positive benefits of AFNs, however, cannot be taken for granted as trust is not necessarily an (...) outcome of AFN participation. Using Chinese case studies of AFNs, which are characterised by a distinct form of trust pressure—consumers who are particularly cynical about small scale farmers, food safety and the organic credentials of producers—this paper highlights how the dynamics of trust are in constant flux between producers and consumers. I suggest that it is the careful construction of the aesthetic and multi-sensory qualities of food, which is often celebrated via social media, that human centred relations in Chinese AFNs are mediated. This leads to two key conclusions: first, that the key variable for establishing trust is satisfying the consumer's desire for safe (i.e. "fresh") food; and second, the materiality of the food and the perception of foods materiality (especially through social media), must both be actively constructed by the farmer to fit the consumer's ideal of freshness. (shrink)

Laura and I met for this interview to review her book at the Philosophy of Education Society Australasia (PESA) Conference in Christchurch | Ōtautahi at Te Pae Convention Centre, December 2024.JP:...

Using rhetorical analysis as a bridge, the essay attempts to reconcile the scientific Locke with Locke the social philosopher of rights who worked a persuasion against the fruits of social passivity and the status quo; the latter are represented by ingrained institutions like legal nonage and monarchy. The consistency between the two Lockes is language as it forwards understanding in a legitimating consensus. Ironically, iteration and nominalisms bind Locke's social contract; yet the linguistic reduction inherent in nominalisms precludes the production (...) of a more complex public knowledge that might improve community problem solving. (shrink)

This article explores the early history of Roman exemplary literature through the case study of the elder Cato’s account of his imitation of the parsimony and self-sufficiency of M’. Curius Dentatus. I reconstruct from Cicero, Plutarch, and other sources a Catonian prose text that unified the exemplary narrative of Curius’ refusal of a bribe from Samnite emissaries with an evocative location at the hearth of a humble Sabine farmstead, an approving “audience” in Cato himself, and a model for the replication (...) of Curius’ virtue. The narrative itself served as the monumentum for the exemplum, and its details are often evoked in place of the exemplary deed itself. I argue that this narrative is both a very early instance of exemplary literature and a self-conscious reflection on the power of literature to transcend temporal and spatial limitations and to extend cultural models for the familial replication of elite virtues to a broader audience. (shrink)

In this essay, I draw on Kant’s legal philosophy in order to defend the right to voluntary motherhood by way of abortion at any stage of pregnancy as an essential feature of women’s basic rights. By developing the distinction between innate and acquired right in Kant’s legal philosophy, I argue that the viability standard in US law (as established in Planned Parenthood v. Casey) misunderstands the nature of embodied right. Our body is the site of innate right; it is the (...) means through which we can set and pursue ends in the world. The law, therefore, cannot adjudicate the relationship between the will and the body: it cannot require us to allow our bodies to be used against our will. By comparing unwanted pregnancy to sexual assault, I problematize the notion that consent to pregnancy, like consent to sex, can ever be conclusive. I examine Kant’s own account of unwanted pregnancy, in which he describes mother and child finding themselves “in a state of nature” in order to rethink the status of the fetus in law, and I argue that we should understand the fetus’s right to life as provisional, rather than as enforceable by law. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:100 Feminist Studies 45, no. 1. © 2019 by Feminist Studies, Inc. Carla Pascoe Leahy From the Little Wife to the Supermom? Maternographies of Feminism and Mothering in Australia since 1945 Men didn’t do anything.... The mother did for the child. The father went out to work.... I was a very determined, modern woman, but I didn’t mind being the little wife. —Marjorie, 1950s mother1 There were competing (...) narratives. One was a woman’s place is full time mothering in the home.... And then there was the feminist movement which said women can do it all.... There was level of unreality about both of them. I did feel really conflicted. —Sally, 1970s mother I read a headline today that said I send my kids to childcare and I refuse to feel guilty.... I feel the guilt a little bit but not enough to stop me from sending them, and I still know that in the long run... it’s far better for me to work and... I don’t want to be a stay at home mum for the rest of my life. —Ariana, 2010s mother 1. All interviewees are referred to by pseudonyms. Where permission is granted by the interviewee, interview material is preserved at Museums Victoria in Melbourne, Australia. All interviews are in the possession of the author. “Marjorie” was interviewed by the author on June 27, 2014; “Sally” was interviewed by the author on March 8, 2014; “Ariana” was interviewed by the author on April 5, 2017. Carla Pascoe Leahy 101 The daily lives and long-term aspirations of Australian mothers have undergone significant changes over the past seventy years, alongside shifting cultural and personal concepts of mothering, employment, and female identity. At face value, these quotes from three generations of Australian mothers imply a trajectory of shifting understandings of care, work, gender, and subjectivity, with women’s self-identity increasingly associated with paid work outside the home. Each of these women positions herself in relation to the dominant gender culture at the time she experienced matrescence.2 Marjorie, who had her children in the 1950s, characterizes herself as “the little wife” and recalls being contented with her role as a stay-at-home mother. Sally, who became a mother in the late 1970s, remembers wanting to believe that “women can do it all” without sacrificing family or career, but she experienced this radical ideal as conflicted at both a cultural and personal level. Ariana, a twenty-first-century mother, feels ambivalent about sending her children to childcare, but had always assumed that she would combine paid work with mothering. Despite this seemingly linear progression from a female identity centered on mothering to one focused on paid work, I argue that closer attention to these maternal narratives reveals that changing gender discourses were experienced as riven with internal contradictions by individual mothers. Drawing on a new collection of fifty-six oral history interviews co-created with Australian women about their experiences of becoming mothers, I will analyze the ways in which changing cultural understandings of selfhood, work, care, and gender have played out in the lives of mothers from 1945 to the present. When I started this project, I envisaged it partially as a history of my grandmother’s, my mother’s, and my own maternal generations. In this sense, it is a record of the living memory of Australian mothering; an archive of the maternal memories still circulating in contemporary Australia. But it is also a history of Australian mothering before, during, and after the women’s liberation movement of the 1970s. The women’s movement initiated fundamental shifts in the ways Australians thought about women’s role in society, 2. Matrescence is a term coined by Dana Raphael to describe the experience of becoming a mother for the first time. See Dana Raphael, “Matrescence, Becoming a Mother, a ‘New/Old’ Rite de Passage,” in Being Female: Reproduction, Power, and Change, ed. Dana Raphael (Berlin: De Gruyter, 1975). 102 Carla Pascoe Leahy their relationships to men and children, and their capabilities in relation to paid and unpaid work. My contention is that the women’s liberation movement unsettled and complicated Australian women’s relationships to... (shrink)

In “Global Knowledge Frameworks and the Tasks of Cross-Cultural Philosophy,” Leigh Jenco searches for the conception of knowledge that best justifies the judgment that one can learn from non-local traditions of philosophy. Jenco considers four conceptions of knowledge, namely, in catchwords, the esoteric, Enlightenment, hermeneutic, and self- transformative conceptions of knowledge, and she defends the latter as more plausible than the former three. In this critical discussion of Jenco’s article, I provide reason to doubt the self-transformative conception, and also (...) advance a fifth, pluralist conception of knowledge that I contend best explains the prospect of learning from traditions other than one’s own. (shrink)

Real-world economies are open-ended dynamic systems consisting of heterogeneous interacting participants. Human participants are decision-makers who strategically take into account the past actions and potential future actions of other participants. All participants are forced to be locally constructive, meaning their actions at any given time must be based on their local states; and participant actions at any given time affect future local states. Taken together, these essential properties imply real-world economies are locally-constructive sequential games. This paper discusses a modeling approach, (...) Agent-based Computational Economics, that permits researchers to study economic systems from this point of view. ACE modeling principles and objectives are first concisely presented and explained. The remainder of the paper then highlights challenging issues and edgier explorations that ACE researchers are currently pursuing. (shrink)

Polemicists and disciplinary puritans commonly make a sharp distinction between the normative, “prescriptive,” philosophical work of bioethicists and the empirical, “descriptive” work of anthropologists and sociologists studying medicine, healthcare, and illness. Though few contemporary medical anthropologists and sociologists of health and illness subscribe to positivism, the legacy of positivist thought persists in some areas of the social sciences. It is still quite common for social scientists to insist that their work does not contain explicit normative analysis, offers no practical recommendations (...) for social reform or policy making, and simply interprets social worlds. (shrink)

Anthropologists and sociologists offer numerous critiques of bioethics. Social scientists criticize bioethicists for their arm-chair philosophizing and socially ungrounded pontificating, offering philosophical abstractions in response to particular instances of suffering, making all-encompassing universalistic claims that fail to acknowledge cultural differences, fostering individualism and neglecting the importance of families and communities, and insinuating themselves within the “belly” of biomedicine. Although numerous aspects of bioethics warrant critique and reform, all too frequently social scientists offer ungrounded, exaggerated criticisms of bioethics. Anthropological and sociological (...) critiques of bioethics are hampered by the tendency to equate bioethics with clinical ethics and moral theory in bioethics with principlist bioethics. Also, social scientists neglect the role of bioethicists in addressing organizational ethics and other “macro-social” concerns. If anthropologists and sociologists want to provide informed critiques of bioethics they need to draw upon research methods from their own fields and develop richer, more informed analyses of what bioethicists say and do in particular social settings. (shrink)

There is no doubt that Immanuel Kant has a woman problem. His anthropo-logical studies of women are full of cutting remarks, and despite a generation offeminist Kantian scholarship, it is an open question whether he meant to include women as full, equal agents in either his moral or political philosophy. Those who engage this question within Kant’s political philosophy ask whether or not women can “work their way up” to full, active citizenship. If women can achieve equality in this way, (...) the argument goes, then we can solve Kant’s woman problem. But this approach, I argue, asks the wrong question. It focuses on the status of wives rather than on the structure of the domestic sphere as a whole, and therefore obscures the ways in which the valuation of domestic space and reproductive labor shape access to rights and equality in Kant’s political philosophy. I will argue that this approach misses the deeper structural and gendered inequalities built into Kant’s conception of the state. Re-examining Kant’s “woman problem” points us toward a larger problem with labor and inequality in the Kantian state: Kant’s map of the rightful institutional order normatively requires that someone do the dependency work that makes independence possible. (shrink)

Contemporary liberal democracies contain multiple cultural, religious, and philosophical traditions. Within these societies, different interpretive communities provide divergent models for understanding health, illness, and moral obligations. Bioethicists commonly draw upon models of moral reasoning that presume the existence of shared moral intuitions. Principlist bioethics, case-based models of moral deliberation, intuitionist frameworks, and cost-benefit analyses all emphasise the uniformity of moral reasoning. However, religious and cultural differences challenge assumptions about common modes of moral deliberation. Too often, bioethicists minimize or ignore the (...) existence of multiple traditions of moral inquiry. Careful consideration of the presence of multiple horizons for moral deliberation generates challenging questions about the capacity of bioethicists to effectively resolve complex cases and social policy disputes. (shrink)

J.-J. Rousseau is the most original, most profound and most controversial of all the great eighteenth-century writers. The problems he raised have since become even more acute and the search for a solution increasingly desirable. His voice was a dissonant one in an age which found satisfaction in material progress, correlates the well-being of humanity with the advancement of knowledge, and displayed a form of complacency which Rousseau sets out to shatter. His message falls uneasily on the ears of the (...) acquisitive society. This volume contains the proceedings of a colloquium held in 1978 in Trinity College, Cambridge, to commemorate the bicentenary of Rousseau's death. It contains the complete text of the fourteen papers given before an invited audience by leading specialists, covering politics, sociology, language, literature and music. It also contains a slightly abridged version of the discussions to which these papers gave rise. (shrink)

The demand from society for organizations to be ethical and responsible is growing, and the cost of irresponsible behavior is often huge. Unethical action can dramatically affect the future of a company or destroy it all together.Ethical Leadership shines a light on the role of both culture and ethics in organizations by making the issues more transparent, accessible and above all, connected. Business leaders are now accountable for showing that they have the correct ethical policies and culture in place. Cultural (...) and behavioral change consultant Andrew Leigh focuses on the fact that ethical culture is manifest in the actual behavior and attitudes of all staff, rather than in policy documents.While there are very few absolutes when it comes to ethics, there are clear ways to be a responsible leader, and Ethical Leadership is full of practical strategies, case studies and action points which will help leaders to improve and manage ethical culture in their organizations. (shrink)

This volume unites established authors and rising young voices in philosophical theology and philosophy of religion to offer the single most wide-ranging examination of theological determinism-in terms of both authors represented and issues investigated-published to date. Fifteen contributors present discussions about theological determinism, the view that God determines everything that occurs in the world. Some authors provide arguments in favor of this position, while others provide considerations against it. Many contributors investigate the relationship between theological determinism and other philosophical issues, (...) theological doctrines, or moral attitudes and practices. This book is essential reading for all those interested in the relationship between theological determinism and philosophical thought. (shrink)

Elvira Basevich, Martin Sticker, and Helga Varden offered generative criticism of my monograph, Kant’s Theory of Labour. In this response, I explore how the resources they offer for thinking about gender, labour, and the state’s responsibility to ensure the material conditions of freedom can deepen both our attentiveness to patterns of systemic injustice in Kant’s political philosophy, and the resources Kant offers for addressing contemporary patterns of intersectional and material injustice.

In “Rethinking Race and Gender in Kant: Toward a Non-Ideal, Intersectional Kant,” Jordan Pascoe argues that Kant’s moral philosophy is productively read through the “non-ideal” lens of the sociopolitical concerns he faced and espoused. This lens in turn offers possibilities for thinking differently about the particular articulation that his formal principles take. She defends a non-ideal, modified methodological approach in which Kant’s problematic conception of race and gender are opportunities for expanding our reflection on Kant’s moral philosophy as a (...) whole. (shrink)

In this paper I argue for the superiority of a critical realist understanding of interdisciplinarity over a mainstream understanding of it. I begin by exploring the reasons for the failure of mainstream researchers to achieve interdisciplinarity. My main argument is that mainstream interdisciplinary researchers tend to hypostatize facts, fetishize constant conjunctions of events and apply to open systems an epistemology designed for closed systems. I also explain how mainstream interdisciplinarity supports oppression and gross inequality. I argue that mainstream interdisciplinarity is (...) not true interdisciplinarity and refer to it accordingly as ‘condisciplinarity’. By way of example, I examine the condisciplinarity of the World Health Organization’s ecological model applied to the issue of men’s violence against women. Specifically, I argue that critical realist interdisciplinarity is preferable because it acknowledges inter alia the empirical, actual and real layers of reality, which allows it to develop depth-explanations of phenomena. In practice, this means that critical realist interdisciplinarity can potentially provide explanations that, compared to condisciplinarity, are broader (include more of the human and non-human context) and deeper (include for example individuals’ conscious and unconscious psychological motivations). In the World Health Organization’s example of the causes of men’s violence against women, condisciplinarity resulted in the absence of historical, global and unconscious aspects of the problem. It is also restricted the analysis to reductive, constant-conjunction based theories of the causes of the problem, specifically ‘risk factors’, thereby providing a relatively shallow explanation for the problem. (shrink)

This study examined the effects of an issue-based science teaching strategy on middle school students in a rural Idaho school. Two eighth-grade classes investigated an issue of local significance—the use of the Bear River. Using the Jurisprudential Inquiry Model of Science, Technology and Society (STS) as a guide, students researched and debated the issue. They attempted to create a Worldwide Web site to share the information collected and ideas generated with other students and interested adults. This article describes the challenges (...) encountered in attempting to integrate the use of technology as part of this project as well as the resulting positive outcomes for students. (shrink)

Theological Determinism Theological determinism is the view that God determines every event that occurs in the history of the world. While there is much debate about which prominent historical figures were theological determinists, St. Augustine, Thomas Aquinas, John Calvin, and Gottfried Leibniz all seemed to espouse the view at least at certain points in their … Continue reading Theological Determinism →.