Cancer chemotherapy has been the most common cancer treatment. However, it has side effects that kill both tumor cells and immune cells, which can ravage the patient’s immune system. Chemotherapy should be administered depending on the patient’s immunity as well as the level of cancer cells. Thus, we need to design an efficient treatment protocol. In this work, we study a feedback control problem of tumor-immune system to design an optimal chemotherapy strategy. For this, we first propose a mathematical model (...) of tumor-immune interactions and conduct stability analysis of two equilibria. Next, the feedback control is found by solving the Hamilton–Jacobi–Bellman equation. Here, we use an upwind finite-difference method for a numerical approximate solution of the HJB equation. Numerical simulations show that the feedback control can help determine the treatment protocol of chemotherapy for tumor and immune cells depending on the side effects. (shrink)

미래 한국의 기초는 신뢰, 도덕적 원칙, 개인적 자율, 상호주의, 공평성이라는 도덕적 패러다임을 중심으로 구축되어야 한다고 이야기 한다. 이를 위해서 이 책에 참여한 사회학자들은 일상생활에서 우리가 규범을 따르는 이류하는 아주 간단한 원리에서부터 기업경영의 성패, 패륜적 범죄, 여성문제에서의 도덕, 과학윤리, 시민문화, 시장경제에서의 도덕성까지 사회 전반의 문제를 매우 현실적 사례와 함께 다루고 있다. 그리고 사회를 이해하는 핵심 코드가 바로 도덕이며, 미래 한국사회의 경쟁력도 도덕이 제공할 수 있다고 역설한다.

The notions of a hyper MV-deductive system, a -hyper MV-deductive system, a - hyper MV-deductive system, a -hyper MV-deductive system, a -hyper MV-deductive system and a -hyper MV-deductive system are introduced, and then their relations are investigated.

This paper examines Alfred Schutz’s insights on types and typification. Beginning with a brief overview of the history and meaning of typification in interpretive sociology, the paper further addresses both the ubiquity and the necessity of typification in social life and scientific method. Schutz’s contribution itself is lacking in empirical application and grounding, but examples are provided of ongoing empirical research which advances the understanding of types and typification. As is suggested by illustrations from scholarship in the social studies of (...) social science, studies of social identity associated with membership categorization analysis, and constructionist social problems theory, typification can be found to be central to social research whether it is taken up as a largely unacknowledged resource or whether it is addressed by different names. The overview and illustrations suggest the continuing, widespread, and indeed foundational relevance of Schutz’s insights into types and typification. (shrink)

An incoherent feed‐forward loop (FFL) is one of the most‐frequently observed motifs in biomolecular regulatory networks. It has been thought that the incoherent FFL is designed simply to induce a transient response shaped by a ‘fast activation and delayed inhibition’. We find that the dynamics of various incoherent FFLs can be further classified into two types: time‐dependent biphasic responses and dose‐dependent biphasic responses. Why do the structurally identical incoherent FFLs play such different dynamical roles? Through computational studies, we show that (...) the dynamics of the two types of incoherent FFLs are mutually exclusive. Following from further computational results and experimental observations, we hypothesize that incoherent FFLs have been optimally designed to achieve distinct biological function arising from different cellular contexts. Additional Supporting Information may be found in the online version of the article. BioEssays 30:1204–1211, 2008. © 2008 Wiley Periodicals, Inc. (shrink)

The cognitive model for social anxiety disorder highlights the role of safety behaviors and post-event processing. We identify the serial mediating effect of state and trait PEP between three types of safety behaviors and social anxiety. Given that the associations between the three subtypes of safety behaviors and two perspectives of PEP have not yet been examined, we aimed to investigate these relationships according to the level of social anxiety. A total of 487 participants participated in an online survey. Participants (...) were classified into two groups, high and low, based on their social anxiety scores. We used Social Behavior Questionnaire to distinguish three types of safety behaviors and the State and Trait versions of the Post-Event Processing Inventory to identify two perspectives of PEP. We used descriptive statistics and an independent t-test to compare the high and low social anxiety groups. Mediation effects were examined using mediation analysis and bootstrapping with 5,000 replications. The results showed that the three safety behaviors had different effects on social anxiety via PEP. In the high social anxiety group, avoidance behavior and anxiety-symptom control predicted social anxiety positively, whereas impression management did not. However, with state PEP and trait PEP as mediators, impression management and avoidance behavior positively predicted social anxiety but not anxiety-symptom control. In the low social anxiety group, only avoidance behavior was significantly related to social anxiety, but when the state and trait PEP were mediated, the effect disappeared. These results indicated that impression management could affect social anxiety only when mediated by PEP in people with high social anxiety. A better understanding of the content and processes underpinning safety behavior and PEPs might have important implications for the prevention and treatment of social anxiety disorder. (shrink)

Cover Photograph: Resolving developmental genetics in the fourth dimension: an illustration (by Kwang‐Hyun Cho himself) of the principle of dynamic network motifs in Drosophila development. Hitherto largely considered in terms of time‐invariant networks, drosophila development is viewed in the article by Man‐Sun Kim, Jeong‐Rae Kim, and Kwang‐Hyun Cho as the result of networks of gene interactions that change during the course of development. Using this paradigm, pivotal developmental events can be correlated with particular changes from one constellation of (...) gene interactions to a different one, and the method allows the identification of certain network motifs that are not identifiable using static approaches. Features article: “Dynamic network rewiring determines temporal regulatory functions in the Drosophila melanogaster development processes”, see pages 505 – 513. (shrink)