There is a paucity of treatment options for cognitively normal individuals with drug resistant genetic generalized epilepsy. Centromedian nucleus of the thalamus deep brain stimulation may be a viable treatment for GGE. Here, we present the case of a 27-year-old cognitively normal woman with drug resistant GGE, with childhood onset. Seizure semiology are absence seizures and generalized onset tonic clonic seizures. At baseline she had 4–8 GTC seizures per month and weekly absence seizures despite three antiseizure medications and vagus nerve (...) stimulation. A multidisciplinary committee recommended off-label use of CM DBS in this patient. Over 12-months of CM DBS she had two GTC seizure days, which were in the setting of medication withdrawal and illness, and no GTC seizures in the last 6 months. There was no significant change in the burden of absence seizures. Presently, just two studies clearly document CM DBS in cognitively normal individuals with GGE or idiopathic generalized epilepsy [in contrast to studies of cognitively impaired individuals with developmental and epileptic encephalopathies ]. Our results suggest that CM DBS can be an effective treatment for cognitively normal individuals with GGE and underscore the need for prospective studies of CM DBS. (shrink)

To Wrestle With Demons offers a rare glimpse of a psychiatrist's innermost thoughts about how his work affects patients, deeply move him, and reflects the society in which we live. Describing the unconscious as music, "a silent and explosive score," Dr. Ablow recalls the process of helping patients ferret out the past from the deep recesses of their minds. In so doing, he becomes enchanted with "the subtlety and power of human interaction." He describes the lonely gentleman who, gaining a (...) sense of security from hearing voices, refuses the medication that would take them away...the depressed woman whose extreme dependence on others is rooted in a violent and abusive childhood...the doting husband whose obsessive devotion to his ill wife harks back to the tragic loss of a childhood friend. In delving into the minds of his patients, Dr. Ablow must also wrestle with his own demons. He speaks with unabashed candor about the guilt he feels exchanging empathy for money, his struggle to help a homeless veteran, and the embarrassment of warning a mother of her son's intent to kill her. Through his eyes, the reader confronts a patient's suicide and a close colleague's murder. While sharing these private revelations, Dr. Ablow provides to us all a looking glass to society. Discussed here, among many issues are poverty, the insanity defense, patients' rights, sexual malpractice, and changing medical economics. Captured is the critical moment which psychiatry now finds itself - attempting to integrate technology with spirituality, science with the soul, and economics with empathy. To Wrestle With Demons offers anyone who has ever wondered whether psychiatrists are touched by the lives of their patients a resounding yes. (shrink)

_Philosophy of Religion_ provides an account of the central issues and viewpoints in the philosophy of religion but also shows how such issues can be rationally assessed and in what ways competing views can be rationally assessed. It includes major philosophical figures in religious traditions as well as discussions by important contemporary philosophers. Keith Yandell deals lucidly and constructively with representative views from Judaism, Christianity, Islam, Hinduism, Buddhism, and Jainism. This book will appeal to students of both philosophy and (...) religion as well as to the general reader interested in the subject. Unique features of _Philosophy of Religion_: * key reading and new reading in the subject area * questions at the ends of chapters * a glossary of philosophical terms * annotated further reading. (shrink)

This book derives from a 1993 National Endowment for the Humanities Summer Institute on Knowledge, Teaching, and Wisdom. The Institute took place at the University of California, Berkeley, and was co-directed by Keith Lehrer and Nicholas D. Smith. The aims of the Institute were several: we sought to reintroduce wisdom as a topic of discussion among contemporary philosophers, to undertake an historical investigation of how and when and why it was that wisdom faded from philosophical view, and to ask (...) how contemporary epistemological theories might apply to the obviously related subjects of teaching and wisdom. In recruiting participants, Lehrer and Smith put the greatest emphasis on those with professional interests in epistemology and the history of philosophy, of the ancient Greeks especially ancient Greek philosophy (because in the writings all three subjects of the Institute were explicitly related and discussed). But in addition to these two groups, some effort was made also to include others, with academic specializations in a variety of fields other than epistemology and the history of philosophy, to ensure that a broad perspective could be achieved in our discussions. To an obvious extent, the papers in this book reflect the recruitment emphases and variety. They also testify to the extent that the Institute managed to bring life to our subjects, and to raise very old questions in a contemporary context. (shrink)

In Delusions and Other Irrational Beliefs , Lisa Bortolotti argues that the irrationality of delusions is no barrier to their being classified as beliefs. This comment asks how Bortolotti’s position may be affected if we accept that there are two distinct types of belief, belonging to different levels of mentality and subject to different ascriptive constraints. It addresses some worries Bortolotti has expressed about the proposed two-level framework and outlines some questions that arise for her if the framework is adopted. (...) It also suggests that, rather than being beliefs that fail to meet the relevant standards of rationality, delusions may be non-doxastic acceptances that were never meant to meet them. (shrink)

[About the book]: Neuroscience has long had an impact on the field of psychiatry, and over the last two decades, with the advent of cognitive neuroscience and functional neuroimaging, that influence has been most pronounced. However, many question whether psychopathology can be understood by relying on neuroscience alone, and highlight some of the perceived limits to the way in which neuroscience informs psychiatry. Psychiatry as Cognitive Neuroscience is a philosophical analysis of the role of neuroscience in the study of psychopathology. (...) The book examines numerous cognitive neuroscientific methods, such as neuroimaging and the use of neuropsychological models, in the context of a variety of psychiatric disorders, including depression, schizophrenia, dependence syndrome, and personality disorders. Psychiatry as Cognitive Neuroscience includes chapters on the nature of psychiatry as a science; the compatibility of the accounts of mental illness derived from neuroscience, information-processing, and folk psychology; the nature of mental illness; the impact of methods such as fMRI, neuropsychology, and neurochemistry, on psychiatry; the relationship between phenomenological accounts of mental illness and those provided by naturalistic explanations; the status of delusions and the continuity between delusions and ordinary beliefs; the interplay between clinical and empirical findings in psychopathology and issues in moral psychology and ethics. With contributions from world class experts in philosophy and cognitive science, this book will be essential reading for those who have an interest in the importance and the limitations of cognitive neuroscience as an aid to understanding mental illness. (shrink)

"[Goodbye, Descartes] is certain to attract attention and controversy..a fascinating journey to the edges of logical thinking and beyond." -Publishers Weekly Critical Acclaim for Keith Devlin's Previous Book Mathematics: The Science of Patterns "A book such as this belongs in the personal library of everyone interested in learning about some of the most subtle and profound works of the human spirit." -American Scientist "Devlin's very attractive book is a well-written attempt to explain mathematics to educated nonmathematicians. the basic ideas (...) are presented in a clear, concise, and easily understood manner. Highly recommended." -Choice "[Devlin] has found an interesting way of exhibiting how mathematics is unified. the author's presentation is a tour de force." -Mathematical Reviews A Selection of the Newbridge Library of Science and Reader's Subscription. (shrink)

Luck egalitarianism is the view that inequalities are justified when and only when a particular condition is met. Recent years have seen considerable debate about the exact nature of the risky choices thought by luck egalitarians to justify inequality. All positions in the debate emphasise the importance of choice, but they differ in the precise details of how choice features in the inequality-justifying condition. The present paper argues for a novel view about the conditions under which risky choices should justify (...) choice in a manner that uncovers ambiguity and flaws in existing positions. It rejects existing accounts and develops a new hypothetical choice based account of inequality-justifying risk. (shrink)

The discourses of agricultural extension reveal how actors represent their scientific activities and goals. The “transfer of technology” discourse developed with the professional U.S. extension service, reproducing its expert/lay power relations. Agroecology is emerging as a systems approach to preventing agricultural pollution. Its theoreticians argue that agroecology cannot be transferred like technology but must be extended through networks of participatory social learning. In California, hundreds of actors and dozens of institutions have cocreated agroecological partnerships using this alternative extension model. They (...) have developed three alternative extension discourses to represent and explain their activities. Bruno Latour's “circulatory system of science” model provides a superior theoretical framework for interpreting the participation and discourses of diverse actors in this extension practice. (shrink)

In this book, the author considers the doctrine of ultimate reality - God - within five world religions: Hinduism, Buddhism, Islam, Judaism and Christianity. By closely studying an orthodox writer in each tradition, the author builds up "pictures" of God and uncovers a common core of belief.

Sandel's book argues against genetic enhancement as an illegitimate expression of a drive to human mastery and a rejection of the proper appreciation of the gift of life. His view combines bad theology with bad virtue ethics, and exemplifies the problem of status quo bias in ethics.

Causal inference plays a central role in behavioral science. Historically, behavioral science methodologies have typically sought to infer a single causal relation. Each of the major approaches to causal inference in the behavioral sciences follows this pattern. Nonetheless, such approaches sometimes differ in the causal relation that they infer. Incremental causal inference offers an alternative to this conceptualization of causal inference that divides the inference into a series of incremental steps. Different steps infer different causal relations. Incremental causal inference is (...) consistent with both causal pluralism and anti-pluralism. However, anti-pluralism places greater constraints the possible topology of sequential inferences. Arguments against causal inference include questioning consistency with causation as an explanatory principle, charging undue complexity, and questioning the need for it. Arguments in favor of incremental inference include better explanation of diverse causal inferences in behavioral science, tailored causal inference, and more detailed and explicit description of causal inference. Incremental causal inference offers a viable and potentially fruitful alternative to approaches limited to a single causal relation. (shrink)

Drawing from a four-year study of US science institutions that support biological control of arthropods, this article examines the decline in biological control institutional capacity in California within the context of both declining public interest science and declining agricultural research activism. After explaining how debates over the public interest character of biological control science have shaped institutions in California, we use scientometric methods to assess the present status and trends in biological control programs within both the University of California Land (...) Grant System and the California Department of Food and Agriculture. We present available data on the number of scientific positions and the types of positions to discuss the impact on the amount of public interest research on biological control in California. We use sociograms to depict how biological control science networks have been reconfigured over time. Our quantitative and qualitative analyses indicate that the following factors contributed to the decline of biological control science in California over the 45-year period analyzed: (1) the institutional reconfiguration of university research priorities; (2) the fraying networks within and increasing specialization of biological control science; (3) the transformation of the social organization of the life science work, including privatization; and (4) the abandonment of this thematic area by civil society activist groups. This broad array of forces suggests that biological control, as a public interest science, will require a deliberate intervention, based on advocacy of clear public interest criteria. (shrink)

This article comprises a dialogue between two historians who have attempted, individually, to narrate the life of Lord George Gordon (1751 – 93), the Scottish prophet, revolutionary, and convert to Judaism. For modern cultural historians, Gordon's peregrinations between identities offer a kaleidoscopic view of Britain in the overlooked but crucial interstice between the upheavals of 1776 and 1789. Yet the partial nature of the evidence, the long omission of Gordon from the historiography of eighteenth-century Britain, and the complex, often furtive (...) nature of Gordon's activism create multiple ambiguities in his story. These ambiguities are compounded here by the authors' differing approaches. Marsha Keith Schuchard argues for a Gordon shaped by Scottish origins; Dominic Green, for a Gordon responding to English opportunities. They disagree over the likely date of Gordon's conversion to Judaism and, crucially, over whether he was a religious atavist or a Romantic pioneer. This dialogue is meant to illustrate the utility of a scholarship that acknowledges fuzziness rather than attempting to overclarify it. The article is also meant to show, however, that on the public stage fuzziness can be less benign: Gordon was a religious politician, who reworked his complexities and confusions into a violent, uncompromising critique of eighteenth-century British social order. (shrink)

The study of law and politics is one of the foundation stones of the discipline of political science, and it has been one of the productive areas of cross-fertilization between the various subfields of political science and between political science and other cognate disciplines. This Handbook provides a comprehensive survey of the field of law and politics in all its diversity, ranging from such traditional subjects as theories of jurisprudence, constitutionalism, judicial politics and law-and-society to such re-emerging subjects as comparative (...) judicial politics, international law, and democratization. The Oxford Handbook of Law and Politics gathers together leading scholars in the field to assess key literatures shaping the discipline today and to help set the direction of research in the decade ahead. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:Global Justice, Christology and Christian Ethics by Lisa Sowle CahillKeith SokoGlobal Justice, Christology and Christian Ethics Lisa Sowle Cahill NEW YORK: CAMBRIDGE UNIVERSITY PRESS, 2013. 328 pp. £62.00 / £20.99Given this book's title and its cover photo of Catholic Relief Services workers in Kenya, I was expecting an examination of global issues with case studies. But chapter titles such as "Creation and Evil," "Kingdom of God," "Christ," "Spirit," (...) and "Cross" tipped me off that my original expectations were incorrect.Perhaps this is Cahill's summa, an attempt to bring together current understandings of major themes in Christian systematic theology and to show how those are tied to Christian ethics. As the series editor, Robin Gill, notes, as opposed to specific moral issues, Cahill's "aim now is to supply a sustained theological basis for global justice" (xi). Cahill herself explains that she hopes "to give biblical and theological reasons for Christian commitment to justice, to show why just action is necessarily a criterion of authentic Christian theology, and to give grounds for Christian hope that change in violent structures is really possible" (1). This is a bold attempt that I feel works on some levels. Cahill draws from key historical and current theologians, including feminist thinkers and marginalized groups.As an ethicist, much of this was a fascinating read in current systematic theology, while some seemed like an overview. I found the chapter on creation and evil somewhat of a plodding summary, yet the chapters on the Kingdom of God, Christ, and the Cross are interesting reads on current discussions in Christology. I would recommend this book for academics and graduate students. Selected sections might work well for undergrads. Sections such as "Historical Research on Jesus" could be great current summaries for undergraduates. [End Page 190]The chapter on the Spirit was interesting but problematic because Cahill's overall approach could err too strongly on the presence of the Spirit primarily in the church itself rather than the world. The chapter on the Cross illustrates interesting historical and current discussion on the necessity of Jesus' death. At this point (246), I feel we primarily have a summary of Christian systematic theology. She acknowledges this as well: "The chapters thus far have been primarily biblical and theological in orientation, but ethical ideals and standards have played a key part in readings of scripture, doctrines, and theologies" (247).Then the book seems to abruptly shift to traditional ethics. With the chapter title of "Nature," I was expecting an examination of environmental ethics but instead got a helpful read on the natural law and virtue ethics approach of Thomas Aquinas. This chapter includes examples of "War as a Test Case" and "Ecology." The final chapter, "Hope," speaks of the need for hope in working toward just and peaceful societies. It includes the longest and only real case study in the book, describing how "Liberian peace activist Leymah Gbowee won the Nobel Prize for spearheading a grassroots women's movement against the civil war" there (295). This is a fascinating account of women using their power and perseverance to overcome an unjust regime, noting that "women had become the 'toy of war'" (298). Finally, observing that "peacebuilding practices reflect the vision of Christian politics that has shaped the previous chapters of this project" (302), she offers seven key points that tie previous chapter topics to current Christian ethics. It seems like an abrupt ending, finishing on point seven and not offering an overall reflection on the book itself.Given this structure, I wish that it had been written as a text for undergrads because the systematic topics covered, and their tie to and conclusion on Christian ethics, would be a nice format for an introductory course. But Cahill's work has always been current, progressive, and concerned with global ethics and the common good. This book is no different, and it is a welcome part of the New Studies in Christian Ethics series.Keith SokoSaint Ambrose UniversityCopyright © 2018 Society of Christian Ethics... (shrink)

It has often been claimed by philosophical theologians that the concept of God functions as an ‘ultimate explanation’ of the nature of the universe. In recent years, various theologians have regarded this notion of ‘ultimate explanation’ as one which has a central place in religious belief; and they construe the concept of God, at least in part, and sometimes mainly, as a concept which provides such an explanation. On the other hand, from the time of David Hume there has been (...) a long line of eminent philosophers who have found the whole idea of an ultimate explanation—something which completely explains absolutely everything—an incoherent one, analogous to the idea of the square of a circle. I think it worth trying to explore the possibilities and limits of the notion, and attempting to assess its importance for religious belief. First, I will briefly sketch the notion as it is found in recent work, and then offer an analysis of the notion of ‘explanation’ in general. Finally, I will try to ascertain the nature and limits of the notion in religion. (shrink)

I begin by querying whether ‘post-axial’ religions are cosmically optimistic, though what John Hick has in mind is forms of religious beliefs that affirm that there is life after physical death, and the possibility of final fulfilment for all. Hick accepts that ideas of this fulfilment, the ultimate goal of human striving, conflict. I query whether diverse traditions would accept that ‘the Real’ is wholly beyond their conceptions of it, and that their conception is no more authentic than the conceptions (...) held by other traditions. I reject soteriology as a criterion of choice between religions, as the criterion is either presently unverifiable or fails to pick out religions in a distinctive way. I suggest that ethics depends on ontology, or on basic views of human nature, and that Hick actually agrees with this, and in fact holds a personalist view of the metaphysical ground of ethics. This view allows various religions to apprehend aspects of ‘the Real’, but does not allow that all are more or less equally authentic. It is thus pluralistic but not totally egalitarian, though it is also not committed to the view that one tradition is wholly correct. (shrink)

THIS ESSAY SEEKS TO REDRESS THE SHORTCOMINGS OF CHRISTIAN ENVIronmental ethics by proposing Franciscan environmental ethics drawn from the affective and embodied experience of Francis of Assisi plus the Franciscan theological tradition that he inspired, as exemplified by Bonaventure and John Duns Scotus. Drawing its inspiration from the love Francis of Assisi had for nature, the Franciscan tradition holds that creation bursts with religious significance. This tradition interprets Francis' affective and direct sensory experience of the natural world with theological concepts (...) creatively reworked from scripture and patristic sources, especially the Incarnation and theTrinity.The Franciscan understanding of the Incarnation emphasizes continuity between humanity, creatures, and elements. The Franciscan vision of Trinity as community-ofpersons, inspired by Francis's Canticle of Creatures, supports a more inclusive vision of the moral community. Franciscan environmental ethics can inspire an enhanced moral imagination and the praxis of an ethic of care. (shrink)