There is a paucity of treatment options for cognitively normal individuals with drug resistant genetic generalized epilepsy. Centromedian nucleus of the thalamus deep brain stimulation may be a viable treatment for GGE. Here, we present the case of a 27-year-old cognitively normal woman with drug resistant GGE, with childhood onset. Seizure semiology are absence seizures and generalized onset tonic clonic seizures. At baseline she had 4–8 GTC seizures per month and weekly absence seizures despite three antiseizure medications and vagus nerve (...) stimulation. A multidisciplinary committee recommended off-label use of CM DBS in this patient. Over 12-months of CM DBS she had two GTC seizure days, which were in the setting of medication withdrawal and illness, and no GTC seizures in the last 6 months. There was no significant change in the burden of absence seizures. Presently, just two studies clearly document CM DBS in cognitively normal individuals with GGE or idiopathic generalized epilepsy [in contrast to studies of cognitively impaired individuals with developmental and epileptic encephalopathies ]. Our results suggest that CM DBS can be an effective treatment for cognitively normal individuals with GGE and underscore the need for prospective studies of CM DBS. (shrink)

To Wrestle With Demons offers a rare glimpse of a psychiatrist's innermost thoughts about how his work affects patients, deeply move him, and reflects the society in which we live. Describing the unconscious as music, "a silent and explosive score," Dr. Ablow recalls the process of helping patients ferret out the past from the deep recesses of their minds. In so doing, he becomes enchanted with "the subtlety and power of human interaction." He describes the lonely gentleman who, gaining a (...) sense of security from hearing voices, refuses the medication that would take them away...the depressed woman whose extreme dependence on others is rooted in a violent and abusive childhood...the doting husband whose obsessive devotion to his ill wife harks back to the tragic loss of a childhood friend. In delving into the minds of his patients, Dr. Ablow must also wrestle with his own demons. He speaks with unabashed candor about the guilt he feels exchanging empathy for money, his struggle to help a homeless veteran, and the embarrassment of warning a mother of her son's intent to kill her. Through his eyes, the reader confronts a patient's suicide and a close colleague's murder. While sharing these private revelations, Dr. Ablow provides to us all a looking glass to society. Discussed here, among many issues are poverty, the insanity defense, patients' rights, sexual malpractice, and changing medical economics. Captured is the critical moment which psychiatry now finds itself - attempting to integrate technology with spirituality, science with the soul, and economics with empathy. To Wrestle With Demons offers anyone who has ever wondered whether psychiatrists are touched by the lives of their patients a resounding yes. (shrink)

Deepfakes and other forms of synthetic media are widely regarded as serious threats to our knowledge of the world. Various technological responses to these threats have been proposed. The reactive approach proposes to use artificial intelligence to identify synthetic media. The proactive approach proposes to use blockchain and related technologies to create immutable records of verified media content. I argue that both approaches, but especially the reactive approach, are vulnerable to a problem analogous to the ancient problem of the criterion—a (...) line of argument with skeptical implications. I argue that, while the proactive approach is relatively resistant to this objection, it faces its own serious challenges. In short, the proactive approach would place a heavy burden on users to verify their own content, a burden that is exacerbated by and is likely to exacerbate existing inequalities. (shrink)

Margaret Cavendish was a contemporary critic of the mechanistic theories of matter that came to dominate seventeenth-century thought and the proponent of a distinctive form of non-mechanistic materialism. Colour was a central issue both to the mechanistic theories of matter that Cavendish opposed and to the non-mechanistic alternative that she defended. This chapter considers the form of colour realism that Cavendish developed to complement her non-mechanistic materialism, and uses her criticisms of contemporary views of colour to try to better understand (...) the experimental approach to natural philosophy associated with writers like Hooke and Boyle. Allen argues that Cavendish’s discussion of colour in Observations upon Experimental Philosophy helps to show that there was a close connection between experimental philosophy and mechanistic theories of matter, and that, at least in the middle of the seventeenth century, experimental and speculative forms of mechanism were not mutually exclusive. (shrink)

Cognitive science is a cross-disciplinary enterprise devoted to understanding the nature of the mind. In recent years, investigators in philosophy, psychology, the neurosciences, artificial intelligence, and a host of other disciplines have come to appreciate how much they can learn from one another about the various dimensions of cognition. The result has been the emergence of one of the most exciting and fruitful areas of inter-disciplinary research in the history of science. This volume of original essays surveys foundational, theoretical, and (...) philosophical issues across the discipline, and introduces the foundations of cognitive science, the principal areas of research, and the major research programs. With a focus on broad philosophical themes rather than detailed technical issues, the volume will be valuable not only to cognitive scientists and philosophers of cognitive science, but also to those in other disciplines looking for an authoritative and up-to-date introduction to the field. (shrink)

Several social metaphysicians have argued that groups are constituted by, but not identical to, their members. While the constitution view is promising, there are significant difficulties with existing versions of that view. Fortunately, lessons may be extracted from more traditional metaphysics and applied to the case of group agents. Drawing on such lessons, I present a novel account of the constitution relation holding between individuals and group agents. According to the resulting structural-constitution view, when individuals constitute a group of a (...) certain kind, they do so in virtue of exhibiting the structure characteristic of groups of that kind. (shrink)

Luck egalitarianism is the view that inequalities are justified when and only when a particular condition is met. Recent years have seen considerable debate about the exact nature of the risky choices thought by luck egalitarians to justify inequality. All positions in the debate emphasise the importance of choice, but they differ in the precise details of how choice features in the inequality-justifying condition. The present paper argues for a novel view about the conditions under which risky choices should justify (...) choice in a manner that uncovers ambiguity and flaws in existing positions. It rejects existing accounts and develops a new hypothetical choice based account of inequality-justifying risk. (shrink)

I argue for an account of semantic paradox that requires minimal logical revision. I first consider a phenomenon that is common to the paradoxes of definability, Russell’s paradox and the Liar. The phenomenon—which I call Repetition—is this: given a paradoxical expression, we can go on to produce a semantically unproblematic expression composed of the very same words. I argue that Kripke’s and Field’s theories of truth make heavy weather of Repetition, and suggest a simpler contextual account. I go on to (...) outline a ‘singularity’ theory of semantical predicates in the spirit of remarks of Gödel. According to this theory, ‘denotes’, ‘extension’ and ‘true’ are context-sensitive expression that apply almost everywhere on a given occasion of use, except for certain singular points. I then turn to revenge paradoxes, and argue that even the dialetheist is subject to revenge. I then examine how the singularity theory responds to revenge. (shrink)

Sandel's book argues against genetic enhancement as an illegitimate expression of a drive to human mastery and a rejection of the proper appreciation of the gift of life. His view combines bad theology with bad virtue ethics, and exemplifies the problem of status quo bias in ethics.

Some texts appear more than once across the corpus of Zygmunt Bauman’s work. This has led to accusations of self-plagiarism and a lack of scholarly rigour. This paper is an explanation of why texts reappear. It pays attention to a number of frequently overlooked texts from the 1970s which are of fundamental importance for any understanding of Bauman’s work. It is contended that if: (a) there is an understanding of the stakes and purpose of sociology as it is framed in (...) Bauman’s work; and (b) attention is paid to the argument of Hermeneutics and Social Science; then (c) the repetition of texts across the work becomes explicable and unproblematic. The paper argues that dealings with Bauman’s work need to be more aware of the less well-known texts. They also need to be alert to different – and incommensurable – ways of practising sociology. (shrink)

Causal inference plays a central role in behavioral science. Historically, behavioral science methodologies have typically sought to infer a single causal relation. Each of the major approaches to causal inference in the behavioral sciences follows this pattern. Nonetheless, such approaches sometimes differ in the causal relation that they infer. Incremental causal inference offers an alternative to this conceptualization of causal inference that divides the inference into a series of incremental steps. Different steps infer different causal relations. Incremental causal inference is (...) consistent with both causal pluralism and anti-pluralism. However, anti-pluralism places greater constraints the possible topology of sequential inferences. Arguments against causal inference include questioning consistency with causation as an explanatory principle, charging undue complexity, and questioning the need for it. Arguments in favor of incremental inference include better explanation of diverse causal inferences in behavioral science, tailored causal inference, and more detailed and explicit description of causal inference. Incremental causal inference offers a viable and potentially fruitful alternative to approaches limited to a single causal relation. (shrink)

In this paper, I examine Spinoza’s account of envy (invidia) with specific attention to his consistent remarks about envy in the context of “superstition”—how “superstition” amplifies envy as an affect, that along with fear and ambition, motivates intolerance. Spinoza counterposes his methodological commitment to view the affects, on a “geometric” model, to Aristotelian and scholastic accounts, and to Descartes’ Passions of the Soul. But they inform his account of the relationship between envy, esteem (gloria), pride (superbia), self-depreciation (abjection), and ambition (...) (ambitio). Spinoza argues that that envy just is a form of hate, it encompasses both sadness at another’s good, but joy at others’ misfortune, and he regards it as evil, even though he refuses to describe it as a vice. Within his methodological framework, it is a consciousness of weakness with an idea of others’ good as the cause. This accounts for its amplification by “superstition”, and its role in motivating ambition and intolerance. I focus, in particular, on the implications of Spinoza’s discussion for tolerance of moral disagreement and difference. (shrink)

My discussion in this paper is divided into three parts. In section I, I discuss some fairly familiar lines of approach to the question how moral considerations may be shown to have rational appeal. In section II, I suggest how our existence as constituents in collective entities might also influence our practical thinking. In section III, I entertain the idea that identification with collectives might displace moral thinking to some degree, and I offer Marx's class theory as a sample of (...) collective identification for the purposes of practical deliberation. (shrink)

This article comprises a dialogue between two historians who have attempted, individually, to narrate the life of Lord George Gordon (1751 – 93), the Scottish prophet, revolutionary, and convert to Judaism. For modern cultural historians, Gordon's peregrinations between identities offer a kaleidoscopic view of Britain in the overlooked but crucial interstice between the upheavals of 1776 and 1789. Yet the partial nature of the evidence, the long omission of Gordon from the historiography of eighteenth-century Britain, and the complex, often furtive (...) nature of Gordon's activism create multiple ambiguities in his story. These ambiguities are compounded here by the authors' differing approaches. Marsha Keith Schuchard argues for a Gordon shaped by Scottish origins; Dominic Green, for a Gordon responding to English opportunities. They disagree over the likely date of Gordon's conversion to Judaism and, crucially, over whether he was a religious atavist or a Romantic pioneer. This dialogue is meant to illustrate the utility of a scholarship that acknowledges fuzziness rather than attempting to overclarify it. The article is also meant to show, however, that on the public stage fuzziness can be less benign: Gordon was a religious politician, who reworked his complexities and confusions into a violent, uncompromising critique of eighteenth-century British social order. (shrink)

This chapter begins by defining natural theology in analytical philosophy, and next considers analytical philosophers's rejection of natural theology and the rise of analytical theism. The focus then turns to one of the most prominent arguments debated in recent discussions of natural theology, the so-called fine-tuning argument. The FTA is a sophisticated version of the traditional argument to design, one that appeals to the apparent ‘fine tuning’ of the fundamental constants of nature, such as the gravitational constant, such that even (...) a minute variation in these values would not have permitted the development in our universe of complex forms of life or, a fortiori, intelligent and sentient creatures. The chapter first presents a statement of the argument by two of its defenders – William Lane Craig and Robin Collins – and then looks at criticisms by such philosophers as Robin Le Poidevin and Graham Oppy. It concludes by asking whether the recent debates among analytic philosophers of religion have really advanced the case for natural theology. (shrink)

Contexts and connexions -- Language and the world -- Language and the mind -- Language and linguistic theory -- 'These fragments I have shored against my ruins' : Russell and modernism.

The study of law and politics is one of the foundation stones of the discipline of political science, and it has been one of the productive areas of cross-fertilization between the various subfields of political science and between political science and other cognate disciplines. This Handbook provides a comprehensive survey of the field of law and politics in all its diversity, ranging from such traditional subjects as theories of jurisprudence, constitutionalism, judicial politics and law-and-society to such re-emerging subjects as comparative (...) judicial politics, international law, and democratization. The Oxford Handbook of Law and Politics gathers together leading scholars in the field to assess key literatures shaping the discipline today and to help set the direction of research in the decade ahead. (shrink)

Nicolai Hartmann contributed significantly to the revitalization of the discipline of ontology in the early twentieth century. Developing a systematic, post-Kantian critical ontology ‘this side’ of idealism and realism, he subverted the widespread impression that philosophy must either exhaust itself in foundationalist epistemology or engage in system-building metaphysical excess. This essay provides an introduction to Hartmann’s approach in light of the recent translation of his early essay ‘How is Critical Ontology Possible?’ ( 1923 ) In it Hartmann criticizes both the (...) pretensions of epistemology as well as the principal errors of classical ontology, and he proposes a series of correctives that lead to his development of a highly original and elaborate stratified categorial ontology. This introduction explains the most important errors of the ‘old’ ontology, his correctives to them, and further fleshes out these correctives with reference to his mature ontological work. (shrink)

Shors & Matzel's conclusion that LTP is not related to learning is similar to one we reached several years ago. We discuss some methodological advances that have relevance to the issue and applaud the authors for challenging existing dogma.

In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:Global Justice, Christology and Christian Ethics by Lisa Sowle CahillKeith SokoGlobal Justice, Christology and Christian Ethics Lisa Sowle Cahill NEW YORK: CAMBRIDGE UNIVERSITY PRESS, 2013. 328 pp. £62.00 / £20.99Given this book's title and its cover photo of Catholic Relief Services workers in Kenya, I was expecting an examination of global issues with case studies. But chapter titles such as "Creation and Evil," "Kingdom of God," "Christ," "Spirit," (...) and "Cross" tipped me off that my original expectations were incorrect.Perhaps this is Cahill's summa, an attempt to bring together current understandings of major themes in Christian systematic theology and to show how those are tied to Christian ethics. As the series editor, Robin Gill, notes, as opposed to specific moral issues, Cahill's "aim now is to supply a sustained theological basis for global justice" (xi). Cahill herself explains that she hopes "to give biblical and theological reasons for Christian commitment to justice, to show why just action is necessarily a criterion of authentic Christian theology, and to give grounds for Christian hope that change in violent structures is really possible" (1). This is a bold attempt that I feel works on some levels. Cahill draws from key historical and current theologians, including feminist thinkers and marginalized groups.As an ethicist, much of this was a fascinating read in current systematic theology, while some seemed like an overview. I found the chapter on creation and evil somewhat of a plodding summary, yet the chapters on the Kingdom of God, Christ, and the Cross are interesting reads on current discussions in Christology. I would recommend this book for academics and graduate students. Selected sections might work well for undergrads. Sections such as "Historical Research on Jesus" could be great current summaries for undergraduates. [End Page 190]The chapter on the Spirit was interesting but problematic because Cahill's overall approach could err too strongly on the presence of the Spirit primarily in the church itself rather than the world. The chapter on the Cross illustrates interesting historical and current discussion on the necessity of Jesus' death. At this point (246), I feel we primarily have a summary of Christian systematic theology. She acknowledges this as well: "The chapters thus far have been primarily biblical and theological in orientation, but ethical ideals and standards have played a key part in readings of scripture, doctrines, and theologies" (247).Then the book seems to abruptly shift to traditional ethics. With the chapter title of "Nature," I was expecting an examination of environmental ethics but instead got a helpful read on the natural law and virtue ethics approach of Thomas Aquinas. This chapter includes examples of "War as a Test Case" and "Ecology." The final chapter, "Hope," speaks of the need for hope in working toward just and peaceful societies. It includes the longest and only real case study in the book, describing how "Liberian peace activist Leymah Gbowee won the Nobel Prize for spearheading a grassroots women's movement against the civil war" there (295). This is a fascinating account of women using their power and perseverance to overcome an unjust regime, noting that "women had become the 'toy of war'" (298). Finally, observing that "peacebuilding practices reflect the vision of Christian politics that has shaped the previous chapters of this project" (302), she offers seven key points that tie previous chapter topics to current Christian ethics. It seems like an abrupt ending, finishing on point seven and not offering an overall reflection on the book itself.Given this structure, I wish that it had been written as a text for undergrads because the systematic topics covered, and their tie to and conclusion on Christian ethics, would be a nice format for an introductory course. But Cahill's work has always been current, progressive, and concerned with global ethics and the common good. This book is no different, and it is a welcome part of the New Studies in Christian Ethics series.Keith SokoSaint Ambrose UniversityCopyright © 2018 Society of Christian Ethics... (shrink)

A Curry paradox about truth is generated by the following sentence, written on the board in room 101:If the sentence on the board in room 101 is true then 1 ≠ 1.A Curry paradox about validity is generated by the following argument, written on the board in room 102:The argument on the board in room 102 is valid. Therefore, 1 ≠ 1.Though the sentence and the argument generate Curry paradoxes, they also generate more basic paradoxes, in a sense to be (...) made clear. I argue that if we solve these more basic paradoxes, we have solutions to both kinds of Curry paradox. The positive proposal is in part inspired by a brief remark of Gödel’s, that the paradoxes might appear “as something analogous to dividing by zero”—so that the concepts of truth and validity, for example, are everywhere applicable except for certain singular points or singularities. A second central claim is that 'true' and 'valid' are context-sensitive predicates. This contextual-singularity approach to the Curry paradoxes applies also to other paradoxes of truth, validity, denotation, and predicate-extension. So a more general aim of the paper is to provide a unified response to semantic paradox. (shrink)

A problem arises, both for philosophy and for argumentation theory, in a pluralist world where people hold widely different beliefs about what to do. Some responses to this problem, including relativism, might settle but do not provide any criteria for resolving such differences. Alternative responses seek a means of resolution in universalist, culture-neutral criteria which must be invoked in assessing all human action. A philosophically adequate account of universalism would contribute to an ideal of critical rationality, as well as to (...) the ideas of field-invariance and of convincing, as opposed to persuasive, argumentation. The account's adequacy would require universality both in form and in content. Universality in form is secured by seeking universal preconditions for practical reasoning in general, rather than specifically for morality. Universality in content is harder, and candidates such as freedom, autonomy and health are problematic. An alternative content is provided by the proposition that the satisfaction of material preconditions is necessary for the performance of any action whatever. Neglect of these preconditions may constitute a fallacy in the extended sense found in argumentation theory, and assumptions about them should form part of the point of departure for any practical deliberation. (shrink)