There is a paucity of treatment options for cognitively normal individuals with drug resistant genetic generalized epilepsy. Centromedian nucleus of the thalamus deep brain stimulation may be a viable treatment for GGE. Here, we present the case of a 27-year-old cognitively normal woman with drug resistant GGE, with childhood onset. Seizure semiology are absence seizures and generalized onset tonic clonic seizures. At baseline she had 4–8 GTC seizures per month and weekly absence seizures despite three antiseizure medications and vagus nerve (...) stimulation. A multidisciplinary committee recommended off-label use of CM DBS in this patient. Over 12-months of CM DBS she had two GTC seizure days, which were in the setting of medication withdrawal and illness, and no GTC seizures in the last 6 months. There was no significant change in the burden of absence seizures. Presently, just two studies clearly document CM DBS in cognitively normal individuals with GGE or idiopathic generalized epilepsy [in contrast to studies of cognitively impaired individuals with developmental and epileptic encephalopathies ]. Our results suggest that CM DBS can be an effective treatment for cognitively normal individuals with GGE and underscore the need for prospective studies of CM DBS. (shrink)

To Wrestle With Demons offers a rare glimpse of a psychiatrist's innermost thoughts about how his work affects patients, deeply move him, and reflects the society in which we live. Describing the unconscious as music, "a silent and explosive score," Dr. Ablow recalls the process of helping patients ferret out the past from the deep recesses of their minds. In so doing, he becomes enchanted with "the subtlety and power of human interaction." He describes the lonely gentleman who, gaining a (...) sense of security from hearing voices, refuses the medication that would take them away...the depressed woman whose extreme dependence on others is rooted in a violent and abusive childhood...the doting husband whose obsessive devotion to his ill wife harks back to the tragic loss of a childhood friend. In delving into the minds of his patients, Dr. Ablow must also wrestle with his own demons. He speaks with unabashed candor about the guilt he feels exchanging empathy for money, his struggle to help a homeless veteran, and the embarrassment of warning a mother of her son's intent to kill her. Through his eyes, the reader confronts a patient's suicide and a close colleague's murder. While sharing these private revelations, Dr. Ablow provides to us all a looking glass to society. Discussed here, among many issues are poverty, the insanity defense, patients' rights, sexual malpractice, and changing medical economics. Captured is the critical moment which psychiatry now finds itself - attempting to integrate technology with spirituality, science with the soul, and economics with empathy. To Wrestle With Demons offers anyone who has ever wondered whether psychiatrists are touched by the lives of their patients a resounding yes. (shrink)

Several social metaphysicians have argued that groups are constituted by, but not identical to, their members. While the constitution view is promising, there are significant difficulties with existing versions of that view. Fortunately, lessons may be extracted from more traditional metaphysics and applied to the case of group agents. Drawing on such lessons, I present a novel account of the constitution relation holding between individuals and group agents. According to the resulting structural-constitution view, when individuals constitute a group of a (...) certain kind, they do so in virtue of exhibiting the structure characteristic of groups of that kind. (shrink)

Luck egalitarianism is the view that inequalities are justified when and only when a particular condition is met. Recent years have seen considerable debate about the exact nature of the risky choices thought by luck egalitarians to justify inequality. All positions in the debate emphasise the importance of choice, but they differ in the precise details of how choice features in the inequality-justifying condition. The present paper argues for a novel view about the conditions under which risky choices should justify (...) choice in a manner that uncovers ambiguity and flaws in existing positions. It rejects existing accounts and develops a new hypothetical choice based account of inequality-justifying risk. (shrink)

Sandel's book argues against genetic enhancement as an illegitimate expression of a drive to human mastery and a rejection of the proper appreciation of the gift of life. His view combines bad theology with bad virtue ethics, and exemplifies the problem of status quo bias in ethics.

Some texts appear more than once across the corpus of Zygmunt Bauman’s work. This has led to accusations of self-plagiarism and a lack of scholarly rigour. This paper is an explanation of why texts reappear. It pays attention to a number of frequently overlooked texts from the 1970s which are of fundamental importance for any understanding of Bauman’s work. It is contended that if: (a) there is an understanding of the stakes and purpose of sociology as it is framed in (...) Bauman’s work; and (b) attention is paid to the argument of Hermeneutics and Social Science; then (c) the repetition of texts across the work becomes explicable and unproblematic. The paper argues that dealings with Bauman’s work need to be more aware of the less well-known texts. They also need to be alert to different – and incommensurable – ways of practising sociology. (shrink)

In this paper, I examine Spinoza’s account of envy (invidia) with specific attention to his consistent remarks about envy in the context of “superstition”—how “superstition” amplifies envy as an affect, that along with fear and ambition, motivates intolerance. Spinoza counterposes his methodological commitment to view the affects, on a “geometric” model, to Aristotelian and scholastic accounts, and to Descartes’ Passions of the Soul. But they inform his account of the relationship between envy, esteem (gloria), pride (superbia), self-depreciation (abjection), and ambition (...) (ambitio). Spinoza argues that that envy just is a form of hate, it encompasses both sadness at another’s good, but joy at others’ misfortune, and he regards it as evil, even though he refuses to describe it as a vice. Within his methodological framework, it is a consciousness of weakness with an idea of others’ good as the cause. This accounts for its amplification by “superstition”, and its role in motivating ambition and intolerance. I focus, in particular, on the implications of Spinoza’s discussion for tolerance of moral disagreement and difference. (shrink)

Causal inference plays a central role in behavioral science. Historically, behavioral science methodologies have typically sought to infer a single causal relation. Each of the major approaches to causal inference in the behavioral sciences follows this pattern. Nonetheless, such approaches sometimes differ in the causal relation that they infer. Incremental causal inference offers an alternative to this conceptualization of causal inference that divides the inference into a series of incremental steps. Different steps infer different causal relations. Incremental causal inference is (...) consistent with both causal pluralism and anti-pluralism. However, anti-pluralism places greater constraints the possible topology of sequential inferences. Arguments against causal inference include questioning consistency with causation as an explanatory principle, charging undue complexity, and questioning the need for it. Arguments in favor of incremental inference include better explanation of diverse causal inferences in behavioral science, tailored causal inference, and more detailed and explicit description of causal inference. Incremental causal inference offers a viable and potentially fruitful alternative to approaches limited to a single causal relation. (shrink)

This article explores the pros and cons of teaching moral development and moral psychology theories and principles in media ethics courses. Five theorists are introduced: Kohlberg, Gilligan, Rest, Kierkegaard, and Perry. Debates over the descriptive-prescriptive nature of the models are discussed, and a number of suggestions about how to implement the models in the classroom are offered.

A theory of probabilities of probabilities is articulated and defended. Hume's argument against higher probabiHties is critically evaluated. Conflicting probability assignments for a hypothetis or theory may result from the appHcation of different methods or perspectives, for example, those of consensual authority and individual ratiocination. When we have conflicting probabilities we may assign probabilities to the diverse probabilities initially obtained. These second level probabilities may also conflict as a result of applying diverse methods or perspectives, and the same is true (...) of higher order probabilities. However, when higher order probabilities are normalized to obtain weights that are used to average the probabilities of the next lower level, the averaging process will yield convergence towards a single first order probability condensing higher order information. An infinite averaging process can be finitely calculated to obtain a coherent assignment. Hence there is no vicious regress of probabilities. Memory beliefs illustrate the convergence of an infinite hierarchy. (shrink)

My discussion in this paper is divided into three parts. In section I, I discuss some fairly familiar lines of approach to the question how moral considerations may be shown to have rational appeal. In section II, I suggest how our existence as constituents in collective entities might also influence our practical thinking. In section III, I entertain the idea that identification with collectives might displace moral thinking to some degree, and I offer Marx's class theory as a sample of (...) collective identification for the purposes of practical deliberation. (shrink)

This article comprises a dialogue between two historians who have attempted, individually, to narrate the life of Lord George Gordon (1751 – 93), the Scottish prophet, revolutionary, and convert to Judaism. For modern cultural historians, Gordon's peregrinations between identities offer a kaleidoscopic view of Britain in the overlooked but crucial interstice between the upheavals of 1776 and 1789. Yet the partial nature of the evidence, the long omission of Gordon from the historiography of eighteenth-century Britain, and the complex, often furtive (...) nature of Gordon's activism create multiple ambiguities in his story. These ambiguities are compounded here by the authors' differing approaches. Marsha Keith Schuchard argues for a Gordon shaped by Scottish origins; Dominic Green, for a Gordon responding to English opportunities. They disagree over the likely date of Gordon's conversion to Judaism and, crucially, over whether he was a religious atavist or a Romantic pioneer. This dialogue is meant to illustrate the utility of a scholarship that acknowledges fuzziness rather than attempting to overclarify it. The article is also meant to show, however, that on the public stage fuzziness can be less benign: Gordon was a religious politician, who reworked his complexities and confusions into a violent, uncompromising critique of eighteenth-century British social order. (shrink)

Nicolai Hartmann contributed significantly to the revitalization of the discipline of ontology in the early twentieth century. Developing a systematic, post-Kantian critical ontology ‘this side’ of idealism and realism, he subverted the widespread impression that philosophy must either exhaust itself in foundationalist epistemology or engage in system-building metaphysical excess. This essay provides an introduction to Hartmann’s approach in light of the recent translation of his early essay ‘How is Critical Ontology Possible?’ ( 1923 ) In it Hartmann criticizes both the (...) pretensions of epistemology as well as the principal errors of classical ontology, and he proposes a series of correctives that lead to his development of a highly original and elaborate stratified categorial ontology. This introduction explains the most important errors of the ‘old’ ontology, his correctives to them, and further fleshes out these correctives with reference to his mature ontological work. (shrink)

A theory of probabilities of probabilities is articulated and defended. Hume's argument against higher probabiHties is critically evaluated. Conflicting probability assignments for a hypothetis or theory may result from the appHcation of different methods or perspectives, for example, those of consensual authority and individual ratiocination. When we have conflicting probabilities we may assign probabilities to the diverse probabilities initially obtained. These second level probabilities may also conflict as a result of applying diverse methods or perspectives, and the same is true (...) of higher order probabilities. However, when higher order probabilities are normalized to obtain weights that are used to average the probabilities of the next lower level, the averaging process will yield convergence towards a single first order probability condensing higher order information. An infinite averaging process can be finitely calculated to obtain a coherent assignment. Hence there is no vicious regress of probabilities. Memory beliefs illustrate the convergence of an infinite hierarchy. (shrink)

The study of law and politics is one of the foundation stones of the discipline of political science, and it has been one of the productive areas of cross-fertilization between the various subfields of political science and between political science and other cognate disciplines. This Handbook provides a comprehensive survey of the field of law and politics in all its diversity, ranging from such traditional subjects as theories of jurisprudence, constitutionalism, judicial politics and law-and-society to such re-emerging subjects as comparative (...) judicial politics, international law, and democratization. The Oxford Handbook of Law and Politics gathers together leading scholars in the field to assess key literatures shaping the discipline today and to help set the direction of research in the decade ahead. (shrink)

A problem arises, both for philosophy and for argumentation theory, in a pluralist world where people hold widely different beliefs about what to do. Some responses to this problem, including relativism, might settle but do not provide any criteria for resolving such differences. Alternative responses seek a means of resolution in universalist, culture-neutral criteria which must be invoked in assessing all human action. A philosophically adequate account of universalism would contribute to an ideal of critical rationality, as well as to (...) the ideas of field-invariance and of convincing, as opposed to persuasive, argumentation. The account's adequacy would require universality both in form and in content. Universality in form is secured by seeking universal preconditions for practical reasoning in general, rather than specifically for morality. Universality in content is harder, and candidates such as freedom, autonomy and health are problematic. An alternative content is provided by the proposition that the satisfaction of material preconditions is necessary for the performance of any action whatever. Neglect of these preconditions may constitute a fallacy in the extended sense found in argumentation theory, and assumptions about them should form part of the point of departure for any practical deliberation. (shrink)

In this paper we reach back to an earlier generation of discussions about both linguistic meaning and moral language to answer the still-current question as to whether and in what way some special non-descriptive feature comprises part of the semantics of identifiably ethical terms. Taking off from the failure of familiar meta-ethical theories, restricted as they are to the Fregean categories of Sense and Force (whether singly or in combination), we propose that one particular variety belonging to Frege’s humble semantic (...) category of Farbung –– what Dummett calls Tone –– holds the key. Specifically, the kinds of expressions that Dummett dubs “expressives”, when properly understood as representing a speaker’s sentiment, solve the mystery not only of moral discourse, but of evaluative language, broadly construed. On this basis we account for moral language’s special relation to action motivation in ways that avoid Moore’s paradox and honor, in unasserted contexts, what Geach calls ‘the Frege point’. Commitments to the public and social character of natural language are also respected. (shrink)

It is asked to what extent answers to such questions as ?Can machines think??, ?Could robots have feelings?? might be expected to yield insight into traditional mind?body questions. It has sometimes been assumed that answering the first set of questions would be the same as answering the second. Against this approach other philosophers have argued that answering the first set of questions would not help us to answer the second. It is argued that both of these assessments are mistaken. It (...) is then claimed, although not argued in detail, that the following three approaches to the first set of questions are mistaken: (1) machines (and robots) obviously cannot think, feel, create, etc., since they do only what they are programmed to do; (2) on the basis of ah analysis of the meaning of the words ?machine? ('robot?, ?think?, ?feel?, etc.) we can see that in principle it would be impossible for machines (or robots) to think, feel, create, etc.; (3) machines (and robots) obviously can (or could) think, feel, etc., since they do certain things which, if we were to do them, would require thought, feeling, etc. It is argued that, once it is seen why approach (2) is mistaken, it becomes desirable to decline ?in principle? approaches to the first set of questions and to favor ?piecemeal investigations? where attention is centered upon what is actually taking place in machine technology, the development of new programming techniques, etc. Some suggestions are made concerning the relevance of current computer simulation studies to traditional mind?body questions. A new set of questions is proposed as a substitute for the first set of questions. It is hoped that attempts to answer these may provide us with new and detailed portraits of the mind?body relationship. (shrink)

Gunderson allows that internally propelled programmed devices (Hauser Robots) do act full-bloodedly under aspects but denies this evidences that they really have the mental properties such acts seem to indicate. Rather, given our intuitive conviction that these machines lack consciousness, such performances evidence the dementalizability (contrary to Searle and Hauser both) of full-blooded acts of detecting, calculating, etc., such machines really do (contrary to Searle) perform.