There is a paucity of treatment options for cognitively normal individuals with drug resistant genetic generalized epilepsy. Centromedian nucleus of the thalamus deep brain stimulation may be a viable treatment for GGE. Here, we present the case of a 27-year-old cognitively normal woman with drug resistant GGE, with childhood onset. Seizure semiology are absence seizures and generalized onset tonic clonic seizures. At baseline she had 4–8 GTC seizures per month and weekly absence seizures despite three antiseizure medications and vagus nerve (...) stimulation. A multidisciplinary committee recommended off-label use of CM DBS in this patient. Over 12-months of CM DBS she had two GTC seizure days, which were in the setting of medication withdrawal and illness, and no GTC seizures in the last 6 months. There was no significant change in the burden of absence seizures. Presently, just two studies clearly document CM DBS in cognitively normal individuals with GGE or idiopathic generalized epilepsy [in contrast to studies of cognitively impaired individuals with developmental and epileptic encephalopathies ]. Our results suggest that CM DBS can be an effective treatment for cognitively normal individuals with GGE and underscore the need for prospective studies of CM DBS. (shrink)

To Wrestle With Demons offers a rare glimpse of a psychiatrist's innermost thoughts about how his work affects patients, deeply move him, and reflects the society in which we live. Describing the unconscious as music, "a silent and explosive score," Dr. Ablow recalls the process of helping patients ferret out the past from the deep recesses of their minds. In so doing, he becomes enchanted with "the subtlety and power of human interaction." He describes the lonely gentleman who, gaining a (...) sense of security from hearing voices, refuses the medication that would take them away...the depressed woman whose extreme dependence on others is rooted in a violent and abusive childhood...the doting husband whose obsessive devotion to his ill wife harks back to the tragic loss of a childhood friend. In delving into the minds of his patients, Dr. Ablow must also wrestle with his own demons. He speaks with unabashed candor about the guilt he feels exchanging empathy for money, his struggle to help a homeless veteran, and the embarrassment of warning a mother of her son's intent to kill her. Through his eyes, the reader confronts a patient's suicide and a close colleague's murder. While sharing these private revelations, Dr. Ablow provides to us all a looking glass to society. Discussed here, among many issues are poverty, the insanity defense, patients' rights, sexual malpractice, and changing medical economics. Captured is the critical moment which psychiatry now finds itself - attempting to integrate technology with spirituality, science with the soul, and economics with empathy. To Wrestle With Demons offers anyone who has ever wondered whether psychiatrists are touched by the lives of their patients a resounding yes. (shrink)

Philosophers who study conspiracy theories have increasingly addressed the questions of where conspiracy theories come from, what such theories do, and what to do about them. This essay serves as a commentary on the answers to these questions offered by contributors to this special issue.

Deepfakes and other forms of synthetic media are widely regarded as serious threats to our knowledge of the world. Various technological responses to these threats have been proposed. The reactive approach proposes to use artificial intelligence to identify synthetic media. The proactive approach proposes to use blockchain and related technologies to create immutable records of verified media content. I argue that both approaches, but especially the reactive approach, are vulnerable to a problem analogous to the ancient problem of the criterion—a (...) line of argument with skeptical implications. I argue that, while the proactive approach is relatively resistant to this objection, it faces its own serious challenges. In short, the proactive approach would place a heavy burden on users to verify their own content, a burden that is exacerbated by and is likely to exacerbate existing inequalities. (shrink)

_Philosophy of Religion_ provides an account of the central issues and viewpoints in the philosophy of religion but also shows how such issues can be rationally assessed and in what ways competing views can be rationally assessed. It includes major philosophical figures in religious traditions as well as discussions by important contemporary philosophers. Keith Yandell deals lucidly and constructively with representative views from Judaism, Christianity, Islam, Hinduism, Buddhism, and Jainism. This book will appeal to students of both philosophy and (...) religion as well as to the general reader interested in the subject. Unique features of _Philosophy of Religion_: * key reading and new reading in the subject area * questions at the ends of chapters * a glossary of philosophical terms * annotated further reading. (shrink)

This book derives from a 1993 National Endowment for the Humanities Summer Institute on Knowledge, Teaching, and Wisdom. The Institute took place at the University of California, Berkeley, and was co-directed by Keith Lehrer and Nicholas D. Smith. The aims of the Institute were several: we sought to reintroduce wisdom as a topic of discussion among contemporary philosophers, to undertake an historical investigation of how and when and why it was that wisdom faded from philosophical view, and to ask (...) how contemporary epistemological theories might apply to the obviously related subjects of teaching and wisdom. In recruiting participants, Lehrer and Smith put the greatest emphasis on those with professional interests in epistemology and the history of philosophy, of the ancient Greeks especially ancient Greek philosophy (because in the writings all three subjects of the Institute were explicitly related and discussed). But in addition to these two groups, some effort was made also to include others, with academic specializations in a variety of fields other than epistemology and the history of philosophy, to ensure that a broad perspective could be achieved in our discussions. To an obvious extent, the papers in this book reflect the recruitment emphases and variety. They also testify to the extent that the Institute managed to bring life to our subjects, and to raise very old questions in a contemporary context. (shrink)

Experts are sharply divided concerning the prevalence and influence of misinformation. Some have emphasized the severe epistemic and political threats posed by misinformation and have argued that some such threats have been realized in the real world. Others have argued that such concerns overstate the prevalence of misinformation and the gullibility of ordinary persons. Rather than taking a stand on this issue, I consider what would follow from the supposition that this latter perspective is correct. I argue that, if the (...) prevalence and influence of misinformation are indeed overstated, then many reports as to the prevalence and influence of misinformation constitute a kind of higher-order misinformation. I argue that higher-order misinformation presents its own challenges. In particular, higher-order misinformation, ironically, would lend credibility to the very misinformation whose influence it exaggerates. Additionally, higher-order misinformation would lead to underestimations of the reasons favoring opposing views. In short, higher-order misinformation constitutes misleading higher-order evidence concerning the quality of the evidence on which individuals form their beliefs. (shrink)

Social media misinformation is widely thought to pose a host of threats to the acquisition of knowledge. One response to these threats is to remove misleading information from social media and to de-platform those who spread it. While content moderation of this sort has been criticized on various grounds—including potential incompatibility with free expression—the epistemic case for the removal of misinformation from social media has received little scrutiny. Here, I provide an overview of some costs and benefits of the removal (...) of misinformation from social media. On the one hand, removing misinformation from social media can promote knowledge acquisition by removing misleading evidence from online social epistemic environments. On the other hand, such removals require the exercise of power over evidence by content moderators. As I argue, such exercises of power can encourage suspicions on the part of social media users and can compromise the force of the evidence possessed by such users. For these reasons, the removal of misinformation from social media poses its own threats to knowledge. (shrink)

"[Goodbye, Descartes] is certain to attract attention and controversy..a fascinating journey to the edges of logical thinking and beyond." -Publishers Weekly Critical Acclaim for Keith Devlin's Previous Book Mathematics: The Science of Patterns "A book such as this belongs in the personal library of everyone interested in learning about some of the most subtle and profound works of the human spirit." -American Scientist "Devlin's very attractive book is a well-written attempt to explain mathematics to educated nonmathematicians. the basic ideas (...) are presented in a clear, concise, and easily understood manner. Highly recommended." -Choice "[Devlin] has found an interesting way of exhibiting how mathematics is unified. the author's presentation is a tour de force." -Mathematical Reviews A Selection of the Newbridge Library of Science and Reader's Subscription. (shrink)

Luck egalitarianism is the view that inequalities are justified when and only when a particular condition is met. Recent years have seen considerable debate about the exact nature of the risky choices thought by luck egalitarians to justify inequality. All positions in the debate emphasise the importance of choice, but they differ in the precise details of how choice features in the inequality-justifying condition. The present paper argues for a novel view about the conditions under which risky choices should justify (...) choice in a manner that uncovers ambiguity and flaws in existing positions. It rejects existing accounts and develops a new hypothetical choice based account of inequality-justifying risk. (shrink)

'Justice' and 'democracy' have alternated as dominant themes in political philosophy over the last fifty years. Since its revival in the middle of the twentieth century, political philosophy has focused on first one and then the other of these two themes. Rarely, however, has it succeeded in holding them in joint focus. This volume brings together leading authors who consider the relationship between democracy and justice in a set of specially written chapters. The intrinsic justness of democracy is challenged, the (...) relationship between justice, democracy and impartiality queried and the relationship between justice, democracy and the common good examined. Further chapters explore the problem of social exclusion and issues surrounding sub-national groups in the context of democracy and justice. Authors include Keith Dowding, Richard Arneson, Norman Schofield, Albert Weale, Robert E. Goodin, Jon Elster, David Miller, Phillip Pettit, Julian LeGrand and Russell Hardin. (shrink)

Sandel's book argues against genetic enhancement as an illegitimate expression of a drive to human mastery and a rejection of the proper appreciation of the gift of life. His view combines bad theology with bad virtue ethics, and exemplifies the problem of status quo bias in ethics.

In this article, I shed new light on a misunderstood aspect of Heraclitus’ style. The opposites employed by Heraclitus are often of equal status except that one member of each pair may also appear as a designation for the encompassing whole. I begin by discussing two interpretations of this phenomenon, which were put forward by Roman Dilcher and Alexander Mourelatos. The phenomenon is, I suggest, better understood as being an example of what is known as markedness neutralisation. I argue that (...) this phenomenon should be interpreted as further undermining what Mourelatos identified as a naïve paratactic metaphysics of mere things (NMT), to which Heraclitus was reacting by beginning to develop a hypotactic metaphysics of hierarchies and dependencies as part of a view of the world as being logos-textured. Further, I consider a series of three problems that were put forward by Dilcher, which he thinks must be addressed by anyone who claims that Heraclitus held a unity of opposites thesis. I also consider some related issues, and provide some responses. (shrink)

The United Nations’ Sustainable Development Goals (UN-SDGs) offer a comprehensive framework for global sustainable development, embraced by both UN member states and multinational enterprises (MNEs). The SDGs take a holistic approach and emphasize the need to align public- and private-sector actions. However, understanding the effectiveness of the SDG framework in coordinating stakeholder actions remains a challenge. This study explores how MNEs engage with the SDGs as a function of their home countries’ SDG profiles. Leveraging institutional theory, we test competing mechanisms (...) by analyzing sustainability reports from 150 MNEs across 23 countries. Our results suggest that MNEs’ engagement with the SDGs aligns most closely with a “liability of origin” explanation, with firms showing greater SDG engagement when their home countries have lower progress on the SDGs. However, at the individual SDG level, the engagement patterns are more nuanced. Our findings have important implications for both theory and practice, providing insights into the complex dynamics that shape MNEs’ engagement with the SDGs and offering guidance for policymakers and businesses seeking to enhance their contributions to sustainable development. (shrink)

Causal inference plays a central role in behavioral science. Historically, behavioral science methodologies have typically sought to infer a single causal relation. Each of the major approaches to causal inference in the behavioral sciences follows this pattern. Nonetheless, such approaches sometimes differ in the causal relation that they infer. Incremental causal inference offers an alternative to this conceptualization of causal inference that divides the inference into a series of incremental steps. Different steps infer different causal relations. Incremental causal inference is (...) consistent with both causal pluralism and anti-pluralism. However, anti-pluralism places greater constraints the possible topology of sequential inferences. Arguments against causal inference include questioning consistency with causation as an explanatory principle, charging undue complexity, and questioning the need for it. Arguments in favor of incremental inference include better explanation of diverse causal inferences in behavioral science, tailored causal inference, and more detailed and explicit description of causal inference. Incremental causal inference offers a viable and potentially fruitful alternative to approaches limited to a single causal relation. (shrink)

An Introduction to the Philosophy of Mind provides a lively and accessible introduction to all the main themes and arguments currently being debated in this area. The book examines and criticizes four major theories of mind: Dualism, Mind/Brain Identity, Behaviourism and Functionalism. It argues that while consciousness and our mental lives depend upon physical processes in the brain, they are not reducible to those processes. The differences between mental and physical states, mind/body causality, the problem of other minds, and personal (...) identity are also explored in full. The second edition of this well respected text has been revised to include a new chapter which explores Aristotle’s philosophy of psychology and mind. It also includes new material on the Turing test and has been expanded and updated throughout. The book is designed to help students think for themselves about all the issues identified above, and contains exercises throughout the text to stimulate and challenge the reader. Objectives are clearly set out at the start of every chapter to enable students to check their understanding as they proceed, and each chapter ends with questions to consider. There are discussions of the most cited contemporary writers in the field, so that the reader can gain a rounded perspective of the debates. (shrink)

Drawing from a four-year study of US science institutions that support biological control of arthropods, this article examines the decline in biological control institutional capacity in California within the context of both declining public interest science and declining agricultural research activism. After explaining how debates over the public interest character of biological control science have shaped institutions in California, we use scientometric methods to assess the present status and trends in biological control programs within both the University of California Land (...) Grant System and the California Department of Food and Agriculture. We present available data on the number of scientific positions and the types of positions to discuss the impact on the amount of public interest research on biological control in California. We use sociograms to depict how biological control science networks have been reconfigured over time. Our quantitative and qualitative analyses indicate that the following factors contributed to the decline of biological control science in California over the 45-year period analyzed: (1) the institutional reconfiguration of university research priorities; (2) the fraying networks within and increasing specialization of biological control science; (3) the transformation of the social organization of the life science work, including privatization; and (4) the abandonment of this thematic area by civil society activist groups. This broad array of forces suggests that biological control, as a public interest science, will require a deliberate intervention, based on advocacy of clear public interest criteria. (shrink)

In this paper, I examine Spinoza’s account of envy (invidia) with specific attention to his consistent remarks about envy in the context of “superstition”—how “superstition” amplifies envy as an affect, that along with fear and ambition, motivates intolerance. Spinoza counterposes his methodological commitment to view the affects, on a “geometric” model, to Aristotelian and scholastic accounts, and to Descartes’ Passions of the Soul. But they inform his account of the relationship between envy, esteem (gloria), pride (superbia), self-depreciation (abjection), and ambition (...) (ambitio). Spinoza argues that that envy just is a form of hate, it encompasses both sadness at another’s good, but joy at others’ misfortune, and he regards it as evil, even though he refuses to describe it as a vice. Within his methodological framework, it is a consciousness of weakness with an idea of others’ good as the cause. This accounts for its amplification by “superstition”, and its role in motivating ambition and intolerance. I focus, in particular, on the implications of Spinoza’s discussion for tolerance of moral disagreement and difference. (shrink)

This article comprises a dialogue between two historians who have attempted, individually, to narrate the life of Lord George Gordon (1751 – 93), the Scottish prophet, revolutionary, and convert to Judaism. For modern cultural historians, Gordon's peregrinations between identities offer a kaleidoscopic view of Britain in the overlooked but crucial interstice between the upheavals of 1776 and 1789. Yet the partial nature of the evidence, the long omission of Gordon from the historiography of eighteenth-century Britain, and the complex, often furtive (...) nature of Gordon's activism create multiple ambiguities in his story. These ambiguities are compounded here by the authors' differing approaches. Marsha Keith Schuchard argues for a Gordon shaped by Scottish origins; Dominic Green, for a Gordon responding to English opportunities. They disagree over the likely date of Gordon's conversion to Judaism and, crucially, over whether he was a religious atavist or a Romantic pioneer. This dialogue is meant to illustrate the utility of a scholarship that acknowledges fuzziness rather than attempting to overclarify it. The article is also meant to show, however, that on the public stage fuzziness can be less benign: Gordon was a religious politician, who reworked his complexities and confusions into a violent, uncompromising critique of eighteenth-century British social order. (shrink)

Contexts and connexions -- Language and the world -- Language and the mind -- Language and linguistic theory -- 'These fragments I have shored against my ruins' : Russell and modernism.

My discussion in this paper is divided into three parts. In section I, I discuss some fairly familiar lines of approach to the question how moral considerations may be shown to have rational appeal. In section II, I suggest how our existence as constituents in collective entities might also influence our practical thinking. In section III, I entertain the idea that identification with collectives might displace moral thinking to some degree, and I offer Marx's class theory as a sample of (...) collective identification for the purposes of practical deliberation. (shrink)

The study of law and politics is one of the foundation stones of the discipline of political science, and it has been one of the productive areas of cross-fertilization between the various subfields of political science and between political science and other cognate disciplines. This Handbook provides a comprehensive survey of the field of law and politics in all its diversity, ranging from such traditional subjects as theories of jurisprudence, constitutionalism, judicial politics and law-and-society to such re-emerging subjects as comparative (...) judicial politics, international law, and democratization. The Oxford Handbook of Law and Politics gathers together leading scholars in the field to assess key literatures shaping the discipline today and to help set the direction of research in the decade ahead. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:Global Justice, Christology and Christian Ethics by Lisa Sowle CahillKeith SokoGlobal Justice, Christology and Christian Ethics Lisa Sowle Cahill NEW YORK: CAMBRIDGE UNIVERSITY PRESS, 2013. 328 pp. £62.00 / £20.99Given this book's title and its cover photo of Catholic Relief Services workers in Kenya, I was expecting an examination of global issues with case studies. But chapter titles such as "Creation and Evil," "Kingdom of God," "Christ," "Spirit," (...) and "Cross" tipped me off that my original expectations were incorrect.Perhaps this is Cahill's summa, an attempt to bring together current understandings of major themes in Christian systematic theology and to show how those are tied to Christian ethics. As the series editor, Robin Gill, notes, as opposed to specific moral issues, Cahill's "aim now is to supply a sustained theological basis for global justice" (xi). Cahill herself explains that she hopes "to give biblical and theological reasons for Christian commitment to justice, to show why just action is necessarily a criterion of authentic Christian theology, and to give grounds for Christian hope that change in violent structures is really possible" (1). This is a bold attempt that I feel works on some levels. Cahill draws from key historical and current theologians, including feminist thinkers and marginalized groups.As an ethicist, much of this was a fascinating read in current systematic theology, while some seemed like an overview. I found the chapter on creation and evil somewhat of a plodding summary, yet the chapters on the Kingdom of God, Christ, and the Cross are interesting reads on current discussions in Christology. I would recommend this book for academics and graduate students. Selected sections might work well for undergrads. Sections such as "Historical Research on Jesus" could be great current summaries for undergraduates. [End Page 190]The chapter on the Spirit was interesting but problematic because Cahill's overall approach could err too strongly on the presence of the Spirit primarily in the church itself rather than the world. The chapter on the Cross illustrates interesting historical and current discussion on the necessity of Jesus' death. At this point (246), I feel we primarily have a summary of Christian systematic theology. She acknowledges this as well: "The chapters thus far have been primarily biblical and theological in orientation, but ethical ideals and standards have played a key part in readings of scripture, doctrines, and theologies" (247).Then the book seems to abruptly shift to traditional ethics. With the chapter title of "Nature," I was expecting an examination of environmental ethics but instead got a helpful read on the natural law and virtue ethics approach of Thomas Aquinas. This chapter includes examples of "War as a Test Case" and "Ecology." The final chapter, "Hope," speaks of the need for hope in working toward just and peaceful societies. It includes the longest and only real case study in the book, describing how "Liberian peace activist Leymah Gbowee won the Nobel Prize for spearheading a grassroots women's movement against the civil war" there (295). This is a fascinating account of women using their power and perseverance to overcome an unjust regime, noting that "women had become the 'toy of war'" (298). Finally, observing that "peacebuilding practices reflect the vision of Christian politics that has shaped the previous chapters of this project" (302), she offers seven key points that tie previous chapter topics to current Christian ethics. It seems like an abrupt ending, finishing on point seven and not offering an overall reflection on the book itself.Given this structure, I wish that it had been written as a text for undergrads because the systematic topics covered, and their tie to and conclusion on Christian ethics, would be a nice format for an introductory course. But Cahill's work has always been current, progressive, and concerned with global ethics and the common good. This book is no different, and it is a welcome part of the New Studies in Christian Ethics series.Keith SokoSaint Ambrose UniversityCopyright © 2018 Society of Christian Ethics... (shrink)