BackgroundFinancial interactions between pharmaceutical companies and physicians lead to conflicts of interest. This study examines the extent and trends of non-research payments made by pharmaceutical companies to board-certified allergists in Japan between 2016 and 2020.MethodsA retrospective analysis of disclosed payment data from pharmaceutical companies affiliated with the Japanese Pharmaceutical Manufacturers Association was conducted. The study focused on non-research payments for lecturing, consulting, and manuscript drafting made to board-certified allergists from 2016 to 2020. We performed descriptive analyses on payment data. Trends (...) were analyzed using generalized estimating equation models.ResultsOf the 3,943 board-certified allergists, 2,398 (60.8%) received non-research payments totaling $43.4 million over five years. Lecturing fees comprised 85.7% ($37.2 million) of the total payment amounts. For allergists who received at least one payment, the median amount per allergist was $3,106 (interquartile range: $966 – $12,124), in contrast to a mean of $18,092 (standard deviation: $49,233) over the five-year span. The top 1% and 10% of these allergists accounted for 20.8% and 68.8% of all non-research payments, respectively. The annual payment amounts significantly increased by 7.2% annual increase (95% CI: 4.4 – 10.0%, p < 0.001) each year until 2019, but saw a significant decrease in 2020 amid the COVID-19 pandemic.ConclusionThe majority of allergists received non-research payments, with a notable concentration among a small group. Payments increased annually until the pandemic’s onset, which coincided with a substantial decrease. Further research is needed to explore the implications of these financial interactions on clinical practice and patient care in Japan. (shrink)

Fuzzy logic has become an important tool for a number of different applications ranging from the control of engineering systems to artificial intelligence. In this concise introduction, the author presents a succinct guide to the basic ideas of fuzzy logic, fuzzy sets, fuzzy relations, and fuzzy reasoning, and shows how they may be applied. The book culminates in a chapter which describes fuzzy logic control: the design of intelligent control systems using fuzzy if-then rules which make use of human knowledge (...) and experience to behave in a manner similar to a human controller. Throughout, the level of mathematical knowledge required is kept basic and the concepts are illustrated with numerous diagrams to aid in comprehension. As a result, all those curious to know more about fuzzy concepts and their real-world application will find this a good place to start. (shrink)

本書は、生活者のハピネス(豊かさや幸せ)の視点から科学技術や社会の変革を考える『因果関係から相関へ、個別技術からシステムへ』と題した『武田シンポジウム2018』の内容をまとめたものです。昨今最も注目を 浴びている科学技術である「AI」、「免疫システム研究」、「民間宇宙ロケット開発」の3つと異なる切り口から、ビッグデータと言われる時代の科学の方法論、個の集積以上の意味をもつシステムとしてのアプローチに ついて立体的に考察します。.

We consider a spatial bargaining model where players collectively choose a facility location on a two-dimensional rectilinear distance space through bargaining using the unanimity rule. We show that as players become infinitely patient, their stationary subgame perfect equilibrium utilities converge to the utilities that satisfy the lexicographic maximin utility criterion introduced by Sen.

The Christian philosopher Muto Kazuo contributed substantially to the predominantly Buddhist “Kyoto School of Philosophy.” Through critical exchange with its representatives, he opened up new perceptions of Christian faith, enabled mutual understanding between Buddhism and Christianity, and challenged the Western dialectical method.