In this essay, I propose that DNA‐binding anti‐cancer drugs work more via chromatin disruption than DNA damage. Success of long‐awaited drugs targeting cancer‐specific drivers is limited by the heterogeneity of tumors. Therefore, chemotherapy acting via universal targets (e.g., DNA) is still the mainstream treatment for cancer. Nevertheless, the problem with targeting DNA is insufficient efficacy due to high toxicity. I propose that this problem stems from the presumption that DNA damage is critical for the anti‐cancer activity of these drugs. DNA (...) in cells exists as chromatin, and many DNA‐targeting drugs alter chromatin structure by destabilizing nucleosomes and inducing histone eviction from chromatin. This effect has been largely ignored because DNA damage is seen as the major reason for anti‐cancer activity. I discuss how DNA‐binding molecules destabilize chromatin, why this effect is more toxic to tumoral than normal cells, and why cells die as a result of chromatin destabilization. (shrink)

The aim of this paper is to unravel Aristotle’s reasoning with regard to the ontological status of colours; also, to get a better understanding of his views on the production of the whole spectrum of colours; and finally, to evaluate the explanatory power of his theory of colours. The texts I mainly draw my evidence from is Aristotle’s De sensu 3 and the relevant passages from the De anima as well as from other Aristotelian treatises; in addition, I use for (...) my interpretation remarks made by Alexander of Aphrodisias in his commentary on the De sensu, in his Quaestiones and in the dubious treatise Mantissa. (shrink)

In his Foundations of a General Theory of Manifolds, Georg Cantor praised Bernard Bolzano as a clear defender of actual infinity who had the courage to work with infinite numbers. At the same time, he sharply criticized the way Bolzano dealt with them. Cantor’s concept was based on the existence of a one-to-one correspondence, while Bolzano insisted on Euclid’s Axiom of the whole being greater than a part. Cantor’s set theory has eventually prevailed, and became a formal basis of contemporary (...) mathematics, while Bolzano’s approach is generally considered a step in the wrong direction. In the present paper, we demonstrate that a fragment of Bolzano’s theory of infinite quantities retaining the part-whole principle can be extended to a consistent mathematical structure. It can be interpreted in several possible ways. We obtain either a linearly ordered ring of finite and infinitely great quantities, or a partially ordered ring containing infinitely small, finite and infinitely great quantities. These structures can be used as a basis of the infinitesimal calculus similarly as in non-standard analysis, whether in its full version employing ultrafilters due to Abraham Robinson, or in the recent “cheap version” avoiding ultrafilters due to Terence Tao. (shrink)

Regulations implemented by World Athletics (WA) require female athletes with differences of sexual development to suppress their blood testosterone levels in order to participate in certain women’s sporting competitions. These regulations have been justified by reference to fairness. In this paper, we reconstruct WA’s understanding of fairness, which requires a “level playing field” where no athlete should have a significant performance advantage based on factors other than talent, dedication, and hard work over an average athlete in their category. We demonstrate (...) that by placing regulations only on testosterone levels, while ignoring physical as well as socioeconomic advantages, WA consistently fails to meet its own definition of fairness. We then discuss several ways in which this definition could be met. Our analysis shows that a categorical system, in which athletes are divided into categories based on properties leading to significant performance advantages, is best suited for meeting WA’s definition of fairness. (shrink)

Katerina Deligiorgi offers a contemporary defence of autonomy which is Kantian but engages closely with recent arguments about agency, morality, and practical reasoning.

Cognitive and emotional processes are now known to be intertwined and thus the limbic system that underlies emotions is important for human brain evolution, including the evolution of circuits supporting language. The neural substrates of limbic functions, like motivation, attention, inhibition, evaluation, detection of emotional stimuli and others have changed over time. Even though no new, added structures are present in the human brain compared to nonhuman primates, evolution tweaks existing structural systems with possible functional implications. Empirical comparative neuroanatomical evidence (...) is presented here in support of such changes in the limbic system, including the amygdala and the orbitofrontal cortex. Given their possible functional significance, these alterations may further enable and enhance human interest and motivation to communicate beyond what is seen in other primates living in complex social groups. The argument here is that even though emotion processing is likely needed for increased social complexity independent of language, the reason why humans want to talk may be related in part to the enhancement of socioemotional processes resulting from the reorganization and rewiring of underlying neural systems some of which are interconnected to the language areas. Neurodevelopmental disorders in humans affecting both language and sociability fuel such arguments. (shrink)

Late Stoics and, in particular, Epictetus made ample use of the notion of attention, which they understood as the soul’s vigilant focus on sense impressions and on the Stoic principles. Attention, in their view, was meant to assist our self-examination and lead to ethical progress. It was thus regarded as a Stoic good and a constitutive part of eudaimonia. Early Stoics did not seem to have invoked such a notion, whereas the Neoplatonists appropriated it into their psychology by postulating the (...) soul’s attentive part, which they introduced to explain both perceptual and intellectual attention as well as self-awareness. (shrink)

Sound-symbolism is the nonarbitrary link between the sound and meaning of a word. Japanese-speaking children performed better in a verb generalization task when they were taught novel sound-symbolic verbs, created based on existing Japanese sound-symbolic words, than novel nonsound-symbolic verbs (Imai, Kita, Nagumo, & Okada, 2008). A question remained as to whether the Japanese children had picked up regularities in the Japanese sound-symbolic lexicon or were sensitive to universal sound-symbolism. The present study aimed to provide support for the latter. In (...) a verb generalization task, English-speaking 3-year-olds were taught novel sound-symbolic verbs, created based on Japanese sound-symbolism, or novel nonsound-symbolic verbs. English-speaking children performed better with the sound-symbolic verbs, just like Japanese-speaking children. We concluded that children are sensitive to universal sound-symbolism and can utilize it in word learning and generalization, regardless of their native language. (shrink)

The past decade has seen extensive research carried out on the systematic causes of research misconduct. Simultaneously, less attention has been paid to the variation in academic misconduct between research fields, as most empirical studies focus on one particular discipline. We propose that academic discipline is one of several systematic factors that might contribute to academic misbehavior. Drawing on a neo-institutional approach, we argue that in the developing countries, the norm of textual originality has not drawn equal support across different (...) research fields depending on its level of internationalization. Using plagiarism detection software, we analyzed 2,405 doctoral dissertations randomly selected from all dissertations defended in Russia between 2007 and 2015. We measured the globalization of each academic discipline by calculating the share of publications indexed in the global citation database in relation to overall output. Our results showed that, with an average share of detected borrowings of over 19%, the incidence of plagiarism in Russia is remarkably higher than in Western countries. Overall, disciplines closely follow the pattern of higher globalization associated with a lower percentage of borrowed text. We also found that plagiarism is less prevalent at research-oriented institutions supporting global ethical standards. Our findings suggest that it might be misleading to measure the prevalence of academic misconduct in developing countries without paying attention to variations at the disciplinary level. (shrink)

The aim of this paper is to show how concern with agency, expressed in the idea that history is the doing of agents, shapes both Kant’s and Hegel’s conceptions of history and, by extension, the roles they accord philosophical historiography.

Despite its historical focus on aberrant behavior, sexology barely dealt with sexual deviants in 1950s Czechoslovakia. Rather, sexologists treated only isolated instances of deviance. The rare cases that went to court appeared mostly because they hindered work or harmed the national economy. Two decades later, however, the situation was markedly different. Hundreds of men were labeled as sexual delinquents and sentenced for treatment in special sexological wards at psychiatric hospitals. They endangered society, so it was claimed, by being unwilling or (...) unable to conform to the family norm. The mode of subjection shifted from work to family. I analyse this change by using the tools of Gil Eyal’s sociology of expertise (2013), which focuses on shifts in institutional matrices that bring forth new groups of agents creating new expert networks. I argue that sexology became profoundly institutionalized in the early 1970s, which brought the discipline closer to psychiatry and forensic science. New inpatient facilities were opened that could admit sentenced sexual deviants. Also, demographic changes accelerated in the 1960s, especially skyrocketing divorce rates and plummeting birth rates, which made it imperative for the government to focus on cementing the family. After the failed attempts of the Prague Spring in 1968, the new pro-Soviet government of communist Czechoslovakia did just that. During the time dubbed as ‘normalization’ by the new elites, anyone who strayed from the family norm was suspected of deviance. (shrink)

This article discusses findings of a qualitative study on strategies of othering observed in anti-immigrant discourse, by analysing selected examples from the UK and Polish media, together with data collected from interviews with migrants. The purpose is to identify discursive strategies of othering, which aim to categorise, denigrate, oppress and ultimately reject the stigmatised or racialised ‘other’. We do not offer a systematic comparison of the data from the UK and Poland; instead, we are interested in what is common in (...) the discursive practices of these two countries/contexts. In using newspaper together with interview data, we are combining representation and experience in identifying not only strategies of othering, but also how these are perceived by and affect the othered individuals. The paper uses the following data: 40 newspaper articles – 20 from the UK and 20 from Poland, and 19 interviews – 12 from Poland and 7 from the UK. The analysis that follows identifies five shared strategies of othering: a) Stereotyping; b) Whiteness as the norm; c) Racialisation; d) Objectification; e) Wrongly Ascribed Ethnicity. We conclude with the research limitations and outlining possible next stages, such as working with a larger corpus, investigating frequency, or including other media genres. (shrink)

Hutto and Satne, Philosophia propose to redefine the problem of naturalizing semantic content as searching for the origin of content instead of attempting to reduce it to some natural phenomenon. The search is to proceed within the framework of Relaxed Naturalism and under the banner of teleosemiotics which places Ur-intentionality at the source of content. We support the proposed redefinition of the problem but object to the proposed solution. In particular, we call for adherence to Strict Naturalism and replace teleosemiotics (...) with autopoietic theory of living beings. Our argument for these adjustments stems from our analysis of the flagship properties of Ur-intentionality: specificity and directedness. We attempt to show that the first property is not unique to living systems and therefore poses a problem of where to place a demarcation line for the origin of content. We then argue that the second property is a feature ascribed to living systems, not their intrinsic part and therefore does not form a good foundation for the game of naturalizing content. In conclusion we suggest that autopoietic theory can not only provide a competitive explanation of the basic responding of pre-contentful organisms but also clarify why Ur-intentionality is attributed to them in such an intuitive manner. (shrink)

Following François Laruelle's nonstandard philosophy and the work of Judith Butler, Drucilla Cornell, Luce Irigaray, and Rosi Braidotti, Katerina Kolozova reclaims the relevance of categories traditionally rendered "unthinkable" by postmodern feminist philosophies, such as "the real," "the one," "the limit," and "finality," thus critically repositioning poststructuralist feminist philosophy and gender/queer studies. Poststructuralist (feminist) theory sees the subject as a purely linguistic category, as _always alread_y multiple, as _always already_ nonfixed and fluctuating, as limitless discursivity, and as constitutively detached from (...) the instance of the real. This reconceptualization is based on the exclusion of and dichotomous opposition to notions of the real, the one (unity and continuity), and the stable. The non-philosophical reading of postructuralist philosophy engenders new forms of universalisms for global debate and action, expressed in a language the world can understand. It also liberates theory from ideological paralysis, recasting the real as an immediately experienced human condition determined by gender, race, and social and economic circumstance. (shrink)

Text seznamuje čtenáře s výukovou metodou nastavení problému, jeho řešení pomocí zavedení a aplikování teoretických pojmů, konceptovou analýzou vybraného díla a důslednou oporou o kontext a ko-text díla. Příklady vybírá ze soudobé scény výtvarného umění a jeho cílem je zdůvodněná interpretace díla. Opírá se o Goodmanovské termíny denotace, exemplifikace a exprese. Metaforickou exemplifikaci, expresi člení průhledem poznávacími perspektivami 1. a 3. osoby na prožitkovou a empatickou komponentu, opírá se tak o teorii artefiletiky. Otevírá a řeší tak problém vztahu relativních objektivních (...) daností díla, jeho intersubjektivně kotvené interpretace a subjektivně vnímaného prožitku z díla. Tvorbu chápe jako způsob poznání. (shrink)

This paper considers the systematic relationship between faith and reason in Kant’s grounding and limiting of moral faith in the Canon of Pure Reason in the Critique of Pure Reason. The first section addresses the interrelationship between Kant’s critique of knowledge and his critique of faith. The second section defines the complex interplay of theoretical and practical issues in Kant’s critical question of what a morally acting agent may hope for regarding the overall outcome of his actions. The third section (...) investigates Kant’s positioning of faith in relation to the epistemic modi of opining and knowing, and defines the specific status of moral faith in Kant. The textually based systematic analyses focus on the complementary relationship in Kant’s work between the way rational critique limits theoretical knowledge in favor of moral faith and the way this critique limits religious faith through moral consciousness. (shrink)

The ethics of policing currently neglects to provide a framework for analysing the morality of deliberate inactions to prevent harm, even though these are often adopted tactically by police as a means of preventing greater harms. In this paper we argue (a) that police have special moral obligations to prevent harm, grounded both in a contractarian account of police legitimacy and in the interpersonal morality of associations and (b) that police are morally culpable for failures to fulfil these special obligations (...) when these are neither proportionate nor necessary to the prevention of greater crime-related harms. Our claims have implications both for the morality of policing and for its regulation and governance under human rights legislation, which we argue should be reformed so as to recognise police culpability not only for inflictions of harm, but also for failures to prevent it. (shrink)

The aim of the article is to examine and evaluate the social ethics aspects of the pamphlet Pro vindiciis contra tyrannos oratio by the scholar and rector of Prague University Jan Jesenský - Jessenius ; first published in Frankfurt in 1614 and for the second time in Prague in 1620 during the Czech Estate Revolt. Therefore, the broader intellectual context of the time is introduced, specifically the conflict between two theories of ruling power correlating with that between the ruler and (...) the Estates after the ideas of the Protestant reformation started to spread. The first theory supported the idea of a sovereign ruler whose authority would stand above the estates to be able to keep the kingdom under control. On the contrary, the so-called resistance theory strived to limit the monarch’s power and to justify a possible intervention against a malevolent ruler - the tyrant. I intend to show that Jessenius´ social ethics which refers to the latter resistance theory was of a premodern nature since its conception of State and its reign remained in a denominationally limited framework. Nevertheless; Jessenius’ polemics with the supporters of ruling sovereignty, which seem to be his original contribution, makes his writing a unique political work in Central Europe. Moreover, the second edition of Jessenius’ text, which for a long time had disappeared from public view, can rightly be considered a remarkable projection of resistance theory toward actual political struggle at the very beginning of the Thirty Years War. (shrink)

Alternative set theory was created by the Czech mathematician Petr Vopěnka in 1979 as an alternative to Cantor’s set theory. Vopěnka criticised Cantor’s approach for its loss of correspondence with the real world. Alternative set theory can be partially axiomatised and regarded as a nonstandard theory of natural numbers. However, its intention is much wider. It attempts to retain a correspondence between mathematical notions and phenomena of the natural world. Through infinity, Vopěnka grasps the phenomena of vagueness. Infinite sets are (...) defined as sets containing proper semisets, i.e. vague parts of sets limited by the horizon. The new interpretation extends the field of applicability of mathematics and simultaneously indicates its limits. Compared to strict finitism and other attempts at a reduction of the infinite to the finite Vopěnka’s theory reverses the process: he models the finite in the infinite. (shrink)

Phenotypic plasticity is a crucial feature of aggressive cancer, providing the means for cancer progression. Stochastic changes in tumor cell transcriptional programs increase the chances of survival under any condition. I hypothesize that unstable chromatin permits stochastic transitions between transcriptional programs in aggressive cancers and supports non‐genetic heterogeneity of tumor cells as a basis for their adaptability. I present a mechanistic model for unstable chromatin which includes destabilized nucleosomes, mobile chromatin fibers and random enhancer‐promoter contacts, resulting in stochastic transcription. I (...) suggest potential markers for “unsettled” chromatin in tumors associated with poor prognosis. Although many of the characteristics of unstable chromatin have been described, they were mostly used to explain changes in the transcription of individual genes. I discuss approaches to evaluate the role of unstable chromatin in non‐genetic tumor cell heterogeneity and suggest using the degree of chromatin instability and transcriptional noise in tumor cells to predict cancer aggressiveness. (shrink)

The article focuses on a method for collecting qualitative data. The method is the asynchronous email interview. The authors assess the advantages, challenges and best practices of the asynchronous email interview method. They base their assessment on the academic literature and their own experiences using this data collection method in qualitative research on women who had experienced perinatal loss. The asynchronous email interview will never fully replace traditional face-to-face interviews, but it could gain a solid position as a qualitative research (...) method thanks to its unique benefits. (shrink)

Johann Heinrich Tieftrunk has a place among the early Kantians in Halle as both a theologian and a philosophical thinker. After situating Tieftrunk within this intellectual history and determining his theological and philosophical position, this paper provides a chronological account of the concept of hope—which lies at the basis of Kant’s moral philosophy—in Tieftrunk’s writings on philosophy of religion. In particular, the discussion centers on the relationship between the foundation of hope in the moral law and the exclusion of a (...) legalistic fulfilment of hope. The “love of the law,” which emerges especially in Tieftrunk’s work, takes a prominent position in the interpretation. The investigation is accompanied by an evaluation of Tieftrunk’s role in the early reception of Kant. (shrink)

Byzantine philosophy is an almost unexplored field. Being regarded either as mere scholars or as primarily religious thinkers, Byzantine philosophers have not been studied on their own philosophical merit. The eleven contributions in this volume, which cover most periods of Byzantine culture from the 4th to the 15th century, for the first time systematically investigate the attitude the Byzantines took towards the views of ancient philosophers, to uncover the distinctive character of Byzantine thought.

Physics is the most fundamental of the sciences and its main purpose is to explain how the world works on the smallest as well as the largest scales. This book outlines the most important discoveries and technical development in the field of physics during the past two decades. The reader will learn the basics of the major theories that form the backbone of the current understanding of the universe through descriptions of the latest findings in particle physics, quantum optics, structure (...) of matter or astrophysics. The book also explains how devices such as lasers or particle accelerators work. (shrink)

Moral judgements usually concern the moral responsibility of an acting person. Someone is considered praiseworthy or blameworthy for an action based on whether this action is according to or against moral norms. According to a Kantian account, the essential issue is the motivation of the acting person since this is a measure for being a moral cause of the action i.e. for intending it. Only moral causation allows the moral imputation of the action to the acting person. And moral motivation (...) always implies the use of practical reason, as the capacity of acting in accordance to rules, while there are two kinds of rules (categorical and hypothetical). To give priority to one of these would lead to moral merit or to moral guilt. The latter considers the acting person as treating himself or others merely as a means instead to respecting himself or others as persons i.e. as individuals able to act according to their own aims and to be responsible for that. We find such an account in Johann Christoph Hoffbauer’s interpretation of Kant’s theory of free will. While Kant is occasionally accused of inconsistency in claiming evil actions are real and imputable while claiming only good actions are free (and therefore imputable), Hoffbauer offers a consistent version of Kant’s theory of free will. In this paper, I analyze his interpretation, sketching first its pre-Kantian theoretical context, and second discussing Hoffbauer’s Kantian interpretation of the concepts of will and the faculty of choice, and using the case of a lie as an illustration. (shrink)

The concept of professionalism is embedded into all aspects of nursing education and practice yet is rarely critically interrogated in nursing scholarship. This paper describes how professionalism in nursing is based on whiteness. When actualized, this oppressive construct homogenizes individuals' identities to assist nurses in building and wielding power against each other and against patients, and results in dehumanization and disconnection. Foregrounding an ethic of authenticity as a practice of resistance against white professionalism offers an alternative possibility for how nursing (...) could be taught, practiced and theorized. As such a practice must begin with oneself, the authors outline a reflexive process from which to begin this work. (shrink)

Stoicism is one of the richest and most influential intellectual traditions of antiquity. Leading scholars here contribute new studies of a set of topics which are the focus of current research in this area. They combine careful analytical attention to the original texts with historical sensitivity and philosophical acuity, to provide the basis for a better understanding of Stoic ethics, political theory, logic, and physics.

The focus of this paper is on E. H. Gombrich's claim that pictorial perception is a case of illusion. My aim is to point out that, on the one hand, the interpretation of this claim that is widely accepted in pictorial theory is not supported by Gombrich's analysis of pictorial perception; and, on the other hand, that the interpretation of the claim that I see as more compatible with Gombrich's analysis is not consistent with relevant facts about our relation to (...) pictures. However, I will argue, Gombrich's elaboration of the claim of illusion is significant to the extent that it highlights important aspects of the system of pictorial representation. (shrink)