Phenotypic plasticity is a crucial feature of aggressive cancer, providing the means for cancer progression. Stochastic changes in tumor cell transcriptional programs increase the chances of survival under any condition. I hypothesize that unstable chromatin permits stochastic transitions between transcriptional programs in aggressive cancers and supports non‐genetic heterogeneity of tumor cells as a basis for their adaptability. I present a mechanistic model for unstable chromatin which includes destabilized nucleosomes, mobile chromatin fibers and random enhancer‐promoter contacts, resulting in stochastic transcription. I (...) suggest potential markers for “unsettled” chromatin in tumors associated with poor prognosis. Although many of the characteristics of unstable chromatin have been described, they were mostly used to explain changes in the transcription of individual genes. I discuss approaches to evaluate the role of unstable chromatin in non‐genetic tumor cell heterogeneity and suggest using the degree of chromatin instability and transcriptional noise in tumor cells to predict cancer aggressiveness. (shrink)

In this essay, I propose that DNA‐binding anti‐cancer drugs work more via chromatin disruption than DNA damage. Success of long‐awaited drugs targeting cancer‐specific drivers is limited by the heterogeneity of tumors. Therefore, chemotherapy acting via universal targets (e.g., DNA) is still the mainstream treatment for cancer. Nevertheless, the problem with targeting DNA is insufficient efficacy due to high toxicity. I propose that this problem stems from the presumption that DNA damage is critical for the anti‐cancer activity of these drugs. DNA (...) in cells exists as chromatin, and many DNA‐targeting drugs alter chromatin structure by destabilizing nucleosomes and inducing histone eviction from chromatin. This effect has been largely ignored because DNA damage is seen as the major reason for anti‐cancer activity. I discuss how DNA‐binding molecules destabilize chromatin, why this effect is more toxic to tumoral than normal cells, and why cells die as a result of chromatin destabilization. (shrink)

An incomplete truth -- Multiple truths -- Media practice or media bribery? conceptual and theoretical considerations and implications -- Dispelling the myths of the ethical significance and validity of the concept of cultural relativism and the need for cultural tolerance in combatting media bribery worldwide -- The global study of media transparency -- Professional communities against media bribery -- A normative theory of media bribery.

Despite its historical focus on aberrant behavior, sexology barely dealt with sexual deviants in 1950s Czechoslovakia. Rather, sexologists treated only isolated instances of deviance. The rare cases that went to court appeared mostly because they hindered work or harmed the national economy. Two decades later, however, the situation was markedly different. Hundreds of men were labeled as sexual delinquents and sentenced for treatment in special sexological wards at psychiatric hospitals. They endangered society, so it was claimed, by being unwilling or (...) unable to conform to the family norm. The mode of subjection shifted from work to family. I analyse this change by using the tools of Gil Eyal’s sociology of expertise (2013), which focuses on shifts in institutional matrices that bring forth new groups of agents creating new expert networks. I argue that sexology became profoundly institutionalized in the early 1970s, which brought the discipline closer to psychiatry and forensic science. New inpatient facilities were opened that could admit sentenced sexual deviants. Also, demographic changes accelerated in the 1960s, especially skyrocketing divorce rates and plummeting birth rates, which made it imperative for the government to focus on cementing the family. After the failed attempts of the Prague Spring in 1968, the new pro-Soviet government of communist Czechoslovakia did just that. During the time dubbed as ‘normalization’ by the new elites, anyone who strayed from the family norm was suspected of deviance. (shrink)

Sound-symbolism is the nonarbitrary link between the sound and meaning of a word. Japanese-speaking children performed better in a verb generalization task when they were taught novel sound-symbolic verbs, created based on existing Japanese sound-symbolic words, than novel nonsound-symbolic verbs (Imai, Kita, Nagumo, & Okada, 2008). A question remained as to whether the Japanese children had picked up regularities in the Japanese sound-symbolic lexicon or were sensitive to universal sound-symbolism. The present study aimed to provide support for the latter. In (...) a verb generalization task, English-speaking 3-year-olds were taught novel sound-symbolic verbs, created based on Japanese sound-symbolism, or novel nonsound-symbolic verbs. English-speaking children performed better with the sound-symbolic verbs, just like Japanese-speaking children. We concluded that children are sensitive to universal sound-symbolism and can utilize it in word learning and generalization, regardless of their native language. (shrink)

The concept of professionalism is embedded into all aspects of nursing education and practice yet is rarely critically interrogated in nursing scholarship. This paper describes how professionalism in nursing is based on whiteness. When actualized, this oppressive construct homogenizes individuals' identities to assist nurses in building and wielding power against each other and against patients, and results in dehumanization and disconnection. Foregrounding an ethic of authenticity as a practice of resistance against white professionalism offers an alternative possibility for how nursing (...) could be taught, practiced and theorized. As such a practice must begin with oneself, the authors outline a reflexive process from which to begin this work. (shrink)

The main objective of this article is to provide an alternative understanding of the treatise on will and freedom in Aquinas’s Prima Secundae (q. 6–17). I explore these questions in their close relation to the preceding treatise on beatitude. The paper shows similarities between the “hierarchy of beings” and “hierarchy of the powers of the soul”. This similitude helps us to understand Aquinas’s notion of the final end. Special attention is given to the question On deliberation/ counsel. The conclusion suggests (...) that the passage, commonly understood as two separate treatises, is in fact one treatise on the general pattern of spiritual life. (shrink)

Text seznamuje čtenáře s výukovou metodou nastavení problému, jeho řešení pomocí zavedení a aplikování teoretických pojmů, konceptovou analýzou vybraného díla a důslednou oporou o kontext a ko-text díla. Příklady vybírá ze soudobé scény výtvarného umění a jeho cílem je zdůvodněná interpretace díla. Opírá se o Goodmanovské termíny denotace, exemplifikace a exprese. Metaforickou exemplifikaci, expresi člení průhledem poznávacími perspektivami 1. a 3. osoby na prožitkovou a empatickou komponentu, opírá se tak o teorii artefiletiky. Otevírá a řeší tak problém vztahu relativních objektivních (...) daností díla, jeho intersubjektivně kotvené interpretace a subjektivně vnímaného prožitku z díla. Tvorbu chápe jako způsob poznání. (shrink)

In a series of recent publications Jerry Fodor has attacked what many believe is the core of Darwinian theory of evolution – the theory of natural selection. Not surprisingly, Fodor’s attack has provoked a strong negative reaction. Fodor’s critics have insisted both that his main argument is unsound and that his central claim that the theory of natural selection “can’t explain the distribution of phenotypic traits in biological populations” is untenable. I can generally agree with the first part of the (...) launched criticism: Fodor’s “putative argument” does rely on controversial premises which make it unsound. However, I don’t think that Fodor’s critics have succeeded in their attempts to refute his central claim. The refutation strategy that most of them have undertaken is to show examples of successful evolutionary explanations by natural selection. In what follows, two of these examples are put into scrutiny. The analysis reveals that: (1) The theory of natural selection should be only partially credited with the explanatory success of evolutionary explanations by natural selection because these explanations rely on additional empirical hypotheses which might be true or false. That means that the selectionist explanations are fallible statements the truth value of which depends crucially on the truth value of the empirical assumptions which have been premised. (2) In both cases alternative non-selectionist explanations can be found that fit the same empirical data and no reason has been given (or could be given) why these alternative explanations should be ignored a priori as inferior. The observations (1) and (2) stand against the claim that theory of natural selection is the only legitimate explanance for the distribution of phenotypic traits. This does not mean, of course, that natural selection does not play any explanatory role or that the theory of natural selection is a false theory (as Fodor is inclined to argue for). This only means that there is indeed a problem of understanding the proper explanatory role of natural selection and that this problem is not only Fodor’s problem. The paper ends with a suggestion of what should be admitted in order to get to a better understanding of the proper role that the theory of natural selection plays in evolutionary explanations. (shrink)

Inferentialism as a theory of meaning builds on the idea that what a linguistic expression means depends exclusively on the inferential rules that govern its use. Following different strategies and exploring various case studies, the authors of this collection of essays discuss under what circumstances and to what extent the central tenets of inferentialism are tenable. The essays in this volume present the results of a three-year research project "Representation and Inference" which was conducted from the beginning of 2008 to (...) the end 2010. The aim of the project was to assess the research program of inferentialism as it has been pursued recently by Robert Brandom, Mark Lance, and Jaroslav Peregrin. Earlier versions of these texts were presented at the conference "Inference, Consequence, and Meaning" held in Sofia on the 3rd and 4th of December, 2008. (shrink)

This paper examines the concept of hope in the epistemology and psychology of Immanuel Kant and Johann Christoph Hoffbauer (1766-1827). The decisive question is how according to Kant hope can impair the objectivity of judgements about future and what are the positive and negative effects of this impairment. While for Kant hope is not essentially considered as an affect, he admits that it could transform into an affect and in this way it can impair the mood and its cognitive faculties (...) negatively. In my paper I examine this argumentations of Kant and their reception in the psychology and psychopathology of Hoffbauer, where hope as affect is even considered as a cause of madness and where Hoffbauer seems to suggest that the clinical state of madness can be effect of inappropriate use of the cognitive faculties of the soul. (shrink)

De nouvelles données enfantines pour l’étude du français : réflexions autour de leur collecte et de leur étiquetage.Cet article propose une réflexion autour d’un certain nombre de questions importantes auxquelles un chercheur doit répondre lorsqu’il construit son corpus en vue de recherches sur l’acquisition du langage. Dans ce cadre, deux étapes sont notamment discutées : la collecte des données (choix des informateurs, nombre, représentativité, etc.) et l’étiquetage de ces données, le but étant pour le chercheur de proposer une base de (...) données fiable et efficace à la communauté scientifique. (shrink)

The article focuses on the methodological specifics of qualitative sociological studies commissioned by public administration authorities (“the client”) which aim to provide solutions to specific problems defined by the client. In conducting this kind of study, the researcher is expected not only to describe and understand the existing state of affairs but also to provide a set of recommendations for amending it. The research terrain is not defined by the sociologist herself but basically by the client. This situation reveals a (...) series of methodological and epistemological issues. The article discusses some of them and proposes that the research strategy of heuristic investigation may be an answer to the associated dilemmas. The author argues that the correct use of reflexive methodology can help the researcher to overcome the limits imposed on the research by the client’s presence and even make the apparent disadvantages work for her. (shrink)

Following François Laruelle's nonstandard philosophy and the work of Judith Butler, Drucilla Cornell, Luce Irigaray, and Rosi Braidotti, Katerina Kolozova reclaims the relevance of categories traditionally rendered "unthinkable" by postmodern feminist philosophies, such as "the real," "the one," "the limit," and "finality," thus critically repositioning poststructuralist feminist philosophy and gender/queer studies. Poststructuralist (feminist) theory sees the subject as a purely linguistic category, as _always alread_y multiple, as _always already_ nonfixed and fluctuating, as limitless discursivity, and as constitutively detached from (...) the instance of the real. This reconceptualization is based on the exclusion of and dichotomous opposition to notions of the real, the one (unity and continuity), and the stable. The non-philosophical reading of postructuralist philosophy engenders new forms of universalisms for global debate and action, expressed in a language the world can understand. It also liberates theory from ideological paralysis, recasting the real as an immediately experienced human condition determined by gender, race, and social and economic circumstance. (shrink)

L’article examine trois types de temporalités patrimoniales. Le premier définit l’unité d’une salle muséale comme espace d’exposition cohérent et interroge la coexistence des objets dans son enceinte, en prenant comme exemple la salle 501 du Louvre. En se focalisant sur les objets-palimpsestes et l’art composite, il laisse ainsi entrevoir le mélange entre art latin et art byzantin, les remplois et les circulations de styles, que cette salle met en avant. Le second type évoque les interactions entre exposition permanente et exposition (...) temporaire et, plus particulièrement, la manière dont deux mosaïques byzantines rares, qui sont exposées dans la salle 501 de manière inadéquate, retrouvent une certaine visibilité grâce à un événement inattendu : la guerre en Ukraine et une opération d’urgence. Le troisième type concerne les manières évolutives d’exposer l’art byzantin au sein du musée du Louvre. Le but est de mieux situer le projet de la création d’un nouveau département patrimonial a... (shrink)

Cognitive and emotional processes are now known to be intertwined and thus the limbic system that underlies emotions is important for human brain evolution, including the evolution of circuits supporting language. The neural substrates of limbic functions, like motivation, attention, inhibition, evaluation, detection of emotional stimuli and others have changed over time. Even though no new, added structures are present in the human brain compared to nonhuman primates, evolution tweaks existing structural systems with possible functional implications. Empirical comparative neuroanatomical evidence (...) is presented here in support of such changes in the limbic system, including the amygdala and the orbitofrontal cortex. Given their possible functional significance, these alterations may further enable and enhance human interest and motivation to communicate beyond what is seen in other primates living in complex social groups. The argument here is that even though emotion processing is likely needed for increased social complexity independent of language, the reason why humans want to talk may be related in part to the enhancement of socioemotional processes resulting from the reorganization and rewiring of underlying neural systems some of which are interconnected to the language areas. Neurodevelopmental disorders in humans affecting both language and sociability fuel such arguments. (shrink)

Byzantine philosophy is an almost unexplored field. Being regarded either as mere scholars or as primarily religious thinkers, Byzantine philosophers have not been studied on their own philosophical merit. The eleven contributions in this volume, which cover most periods of Byzantine culture from the 4th to the 15th century, for the first time systematically investigate the attitude the Byzantines took towards the views of ancient philosophers, to uncover the distinctive character of Byzantine thought.

In this paper the authors seek to contribute to a new ontology of an embodied, desiring subject through an exploration of their own subjectivities and of the ways in which subjectivities are produced and transformed through affective attachments to place. Using the method of collective biography (Davies, Gannon 2006) and drawing on Deleuze and Guattari’s concepts of desire and territorialization they examine their affective responses and attachments to place: Australia and the Czech Republic. As a point of departure for their (...) analysis, the authors ask: What does it mean to be homesick for a place which is not one’s home? What does it mean to desire a place? What of the other place is inscribed in the body? In asking this, the authors show the extent to which place is a zone of immanence in which a continual play of de- and re-territorialization occurs. (shrink)

The book explores the themes of a) “radical concepts” in politics (inspired by François Laruelle’s “non-Marxism” and “non-philosophy,” developed in accordance with Badiouan and Žižekian “realism”); b) politically relevant and applicable epistemologies of “Thought’s Correlating with the Real” (Laruelle), inspired by Laruelle, Badiou and Žižek and c) the possibility of hybridization of the epistemic stance of “radical concept” with the politics of grief and “identification with the suffering itself” proposed by Judith Butler. Radical concepts, the political vision and the theory (...) based on them, are always already succumbing to the “Lived” (Laruelle), to the singularity of the Event (Badiou), to the encounter with the “kernel of the Real” (Žižek) conditioning a political horizon and the grand and small political narratives taking place within it. The thesis of the book is that the instances of the “lived,” the “event” or the “Real” can be inherently inter-connected by virtue of the category of the “experience” which is an instance of the sheer lived, the bare being subjected to an occurrence which is always already an instance of trauma. The mere subjection to certain” taking place,” the passion (in the etymological sense derived from the Latin verb pati or in the Spinozian sense) which is category beyond the psychological notions of feeling, rational (or irrational) thought, i.e., an ontological category referring to our relation with the “Out-There” which always already happens to us, is that to which the radical (political) concept succumbs to as the ultimate authority rather than to a doctrine, a system of thought, to the “philosophy’s auto-mirroring” (Laruelle). Political revolt or the revolutionary stance stems from precisely this bare experiential, the sheer lived and thus, from the Real of the conatus of staying-in-life. Paradoxically the survivalist stance, the principle of self-preservation is also the revolutionary stance which is by definition destabilizing and destructive. Bodily resistance to subjection (i.e., to discipline) and the continuity of the Self in-the-Real is the source of resistance. The Real of grief and mourning, the identification with the purely experiential stance of the suffering itself is the foundation of a “radical concept” of political solidarity, which by virtue of its being grounded in the Real, i.e., in the Lived, provides the possibility of acting in a revolutionary way. But it is also a form of human universality or political universality, which yet again is not historic universality but rather purely categorical. Other concepts that can be called radical, concepts which are minimally transcendental (Laruelle) and are, therefore, of revolutionary potential are also violence, mourning, labor (work) and gender (the trauma introduced by the linguistic determination as a “he” or a “she”), life, death, animal. Yet, the main focus of the book is the exploration of the lived of vulnerability, trauma and the conatus of life as the determination in the last instance of the revolutionary (political) stance. Clearly, the revolutions and the revolutionary stance this book advocates, or rather, whose potentiality it explores, are not necessarily historical revolutions produced by the intentionality to create politico-historic change. They are not this necessarily. Yet again they are such possibly. Still all purely (on the formal level) revolutionary stance tends to introduce universal change, radically change the political horizon and to reverse the politically unthinkable into a thinkable by elevating it to the level of a universal political truth. (shrink)

There is no single ancient Greek word in the surviving fragments and testimonies of Hellenistic philosophy that is directly translatable by the term ‘intuition’. But if we are in search of intuitions in the context of Hellenistic epistemology, it could be said that both the Stoics and the sceptics made use of them in their philosophical debates; for intuitions seem to be closely connected with the formation of conceptions, which were abundantly used by all Hellenistic philosophers. It is important to (...) understand, though, that the Stoics’ and the sceptics’ attitude towards the epistemic status of intuitions would greatly differ: The Stoics would explain intuitions by invoking a rational capacity of human beings, which based on experience would put them in touch with the reality of things, so that their intuitions could be thought of as somehow rationally admissible. The sceptics, on the other hand, would suggest that intuitions guide our everyday life merely on the basis of our previous experiences, and thus their intuitions could be regarded as empirically justified, although they would not guarantee any access to how things actually are. (shrink)

Katerina Deligiorgi offers a contemporary defence of autonomy which is Kantian but engages closely with recent arguments about agency, morality, and practical reasoning.

The focus of this paper is on E. H. Gombrich's claim that pictorial perception is a case of illusion. My aim is to point out that, on the one hand, the interpretation of this claim that is widely accepted in pictorial theory is not supported by Gombrich's analysis of pictorial perception; and, on the other hand, that the interpretation of the claim that I see as more compatible with Gombrich's analysis is not consistent with relevant facts about our relation to (...) pictures. However, I will argue, Gombrich's elaboration of the claim of illusion is significant to the extent that it highlights important aspects of the system of pictorial representation. (shrink)

The paper starts with outlining the problems of determinism presented in Ulrich's Eleuthériologie and then examines what resources are available to Kant to address these problems. Although the initial focus is historical, one of the aims is to show that the problems with determinism continue to be live problems for those who seek to defend Kant's theory. So the attempt to seek resources in Kant to address these problems will also involve an attempt to offer a diagnosis of what is (...) needed for such defenses of Kant to succeed. (shrink)

The paper starts with outlining the problems of determinism presented in Ulrich's Eleuthériologie and then examines what resources are available to Kant to address these problems. Although the initial focus is historical, one of the aims is to show that the problems with determinism continue to be live problems for those who seek to defend Kant's theory. So the attempt to seek resources in Kant to address these problems will also involve an attempt to offer a diagnosis of what is (...) needed for such defenses of Kant to succeed. (shrink)

Les érudits byzantins ont composé, principalement à des fins éducatives, des paraphrases et des commentaires sur la logique aristotélicienne et, en particulier, sur le De interpretatione. Certaines de ces œuvres trahissent clairement leur origine ancienne et d'autres témoignent soit de traditions anciennes perdues, soit des tentatives des Byzantins d'expliquer le texte d'Aristote. Mon but est de présenter les commentaires byzantins sur les premiers chapitres du De interpretatione, dans lesquels nous trouvons des traces de la théorie de la signification d'Aristote. Je (...) commence par rassembler le matériel textuel pertinent du XIe au XVe siècle, ensuite, je discute des points de vue byzantins sur quatre sujets qui ont un intérêt philosophique et historique : les mêmes pensées sont-elles partagées par tous? En quoi les ressemblances, les symboles et les signes diffèrent-ils? Les noms sont-ils par nature ou par convention? Les parties des noms composés signifient-elles? (shrink)

While the emancipatory efforts of the Czech national revival culminated at the end of the 18th and in the 19th century, manifestations of national feeling in the 17th century Czech Lands were rather rare. The article focuses on the concept of nationality as it was treated by scholars from the monastic orders such as the German provincial of the Czech Franciscan province, Bernhard Sannig (1637–1704), or the Czech Jesuit Bohuslav Balbín (1621–1688), whose views are briefly compared with those of the (...) most significant representative of the Czech Protestant emigration – Johann Amos Comenius (1592–1670). By the means of analysis and comparison of several texts, the article investigates how the concept of nationality was gradually rationalized and moralized through the ethical categories of vice and virtue. These reflections on nation, nationality, and patriotism and their moral assessment demonstrate that their authors anticipated some elements of the later formulated doctrine of the natural law of nations, which theoretically justified the demands of the Czech national revival and formed the basis for the concept of Czech history. (shrink)