This open access book offers insights into the development of the ground-breaking Global Code of Conduct for Research in Resource-Poor Settings (GCC) and the San Code of Research Ethics. Using a new, intuitive moral framework predicated on fairness, respect, care and honesty, both codes target ethics dumping – the export of unethical research practices from a high-income setting to a lower- or middle-income setting. The book is a rich resource of information and argument for any research stakeholder who opposes double (...) standards in research. It will be indispensable for applicants to European Union framework programmes, as the GCC is now a mandatory reference document for EU funding. (shrink)

Open access. This open-access book discusses vulnerability and the protection-inclusion dilemma of including those who suffer from serious poverty, severe stigma, and structural violence in research. Co-written with representatives from indigenous peoples in South Africa and sex workers in Nairobi, the authors come down firmly on the side of inclusion. In the spirit of leaving no one behind in research, the team experimented with data collection methods that prioritize research participant needs over researcher needs. This involved foregoing the collection of (...) personal data and community researchers being involved in all stages of the research. In the process, the term ‘vulnerability’ was illuminated across significant language barriers as it was defined by indigenous peoples and sex workers themselves. The book describes a potential alternative to exclusion from research that moves away from traditional research methods. By ensuring that the research is led by vulnerable groups for vulnerable groups, it offers an approach that fosters trust and collaboration with benefits for the community researchers, the wider community as well as research academics. Those living in low-income settings, in dire situations that are summarized with the term ‘vulnerability’ know best what their problems are and which priorities they have. To exclude them from research for their own protection is a patronizing approach which insinuates that researchers and research ethics committees know best. The team from this book have shown that minimally risky and minimally burdensome research tailored towards the needs of highly marginalized and stigmatized communities can be scientifically valuable as well as inclusive and equitable. I congratulate them. Prof. Klaus Leisinger, President Global Values Alliance, Former personal advisor to Kofi Annan on corporate responsibility. (shrink)

The Association of Research Ethics Committees is one of the leading providers of training and education for members of Research Ethics Committees. The introduction of the research governance strategy and the increasing complexity of ethical review place great demands on research ethics committee members that in turn creates challenges for training providers. This paper presents the outcome of an audit of REC members' views about training. Findings demonstrate that REC members are not a homogenous group. Several distinct sub-groups, each with (...) particular training needs emerged. All showed a preference for short, easily accessible events in which there were opportunities for discussion. (shrink)

The existence of a mathematical theory determining the shape of the Great Pyramid is a long‐standing assumption, and speculation on the subject dates back to Herodotus. Roger Herz‐Fischler's study presents and discusses eleven major theories and their proponents in the light of archaeological and philosophical considerations. The historiographical aspect of the study is very useful, as is the formulation and discussion of some of the problems. A brief sociological case study of the Pi‐theory and the reasons for its propagation and (...) popularity in Britain is particularly interesting. But although this book offers much that will be of interest to professional and amateur historians of mathematics and pyramid enthusiasts, it does not provide a definitive conclusion to the 2,500‐year‐old debate.Having dismissed all but three of the theories and unable to decide among them, Herz‐Fischler reaches the rather extraordinary conclusion that there may have been no true theoretical basis for the angles of inclination that might have been established “by eye” . In settling for this interpretation, however, he fails to consider how the angle would have been replicated on the different sides of a pyramid or how angles of inclination would have been maintained or transferred to other pyramids of different sizes: for example, Khufu's three queens' pyramids have slopes virtually identical to those of the main pyramid .The three theories among which Herz‐Fischler cannot decide are all proportion‐based theories, two relating to the angle of inclination and one to the angle of the arris . This conclusion is significant in its own right and relates to practical building considerations. Herz‐Fischler is keen to distinguish mathematically between integer proportional systems and the seked theory , a system attested in ancient Egyptian mathematical texts and related to the division of the cubit into seven palms, each of four fingers. But the close relation between these two methods of measurement in practical terms is clear, and either one could have been used with ease by an ancient builder.Herz‐Fischler states that “there simply is no archaeological evidence for the above three rise over run based theories” . Here he is too quick to dismiss the evidence presented by Flinders Petrie from a mastaba at Meidum . Outside the corners of the structure are walls with traces of horizontal lines at cubit intervals and sloping lines marking the inclination of the faces. Herz‐Fischler points to the lack of marks to indicate how the slope was constructed, but he fails to consider how an identical slope was constructed eight times around the structure if such a horizontal measurement was not used. Nor are the corners of the structure level; thus the correct measurements must be calculated relative to the depth. Mark Lehner, in his Complete Pyramids , page 220, offers evidence from Giza that the builders constructed the corners by measuring in a certain distance from reference points outside the sides. The pyramid drawing from Meroe based on a rectangular grid does not necessarily conflict with a rise and run theory and certainly shows that a proportional system was used relating side length to height. I find this archaeological evidence for the use of rise over run theories convincing, if limited, and it strongly supports side‐inclination based theories over those relating to the arris.The Meroe drawing cannot be taken as reliable evidence that the seked theory was not used in Fourth Dynasty structures , as it dates to over 2,000 years after the Great Pyramid was constructed and lies outside Egypt. As for the question of whether a seked‐based system or integers were used to construct the angle of the sides, Herz‐Fischler could have used the measured angles of sloping corridors and shafts inside the Great Pyramid that must have been constructed using similar techniques. Further, he makes no attempt to apply these theories to the slopes of other pyramids, although in some cases he does consider examples presented by other authors. Applying these theories more broadly might lead to more decisive results. Before readers undertake to do so themselves, however, they should be alerted that some of the measurements given in Appendix 2 are out of date. Corrected figures are: Abu Rawash, c. 52° ; Bent Pyramid, 55° 00′ 30″ , 43° 01′ 30″ ; Red Pyramid, 44° 44′ . In this last example considerable variation was noted in the inclination of different stretches of the same pyramid face, which suggests that an angle of 45° was intended. This observed variation is very significant considering how little of the casing of the next pyramid constructed—the Great Pyramid—is preserved .Although I find Herz‐Fischler's conclusions rather weak and some of his treatments of archaeological sources too dismissive, this volume provides a useful introduction to the subject and a clear formulation of the problems involved. It is, then, a thought‐provoking contribution to a long‐standing debate. (shrink)

Music, literature, history. These things are not quite alike. But in Europe, before the advent of recording machines that made it possible for sounds to be recorded and played back, the three activities relied on the same technology of preservation. They were kept in/as books. Bookishness, in European and colonial imaginaries, was an often-idealized, powerful means of keeping things from slipping away. An understanding of bookish things as a repository can be evinced in laws that required preserving a copy of (...) newly published literary works and music for the benefit of posterity; or in popular novels where a book featured as the chronicler (both recorder and narrator) of its own adventures, beyond the lifespans of individual users. Scholars have paid specialist attention to the ontological differences among music, literature, and history when they are kept as books. Discipline-specific trainings and conversations tend to emphasize how different these objects and practices are. Yet focusing on their shared mode of bookish preservation offers other rewards. Our multi-authored article is a creative experiment in bringing together musicologists, literary scholars, and historians to test the potential, for our own fields and with implications for other humanities disciplines, of foregrounding this technological convergence. We propose the more capacious categories of bookkeepers (people who keep things as books) and cultures of note-taking (whether glossing a textbook or notating music) as fruitful avenues to avoid writing the artificially separate histories of creation versus consumption, public versus personal, authoritative versus amateurish, or artistic versus documentary practices. Music, broadly conceived, and the nineteenth-century album (a book of blank pages to keep verses, music, memories, and many more things) serve as the starting point for our reflections. Both exhibit a tangential connection to the normative codes of what Roger Chartier called “the order of books.” In considering actors/artifacts/acts at the very margins of textuality, or existing in a perverse relationship with bookishness, our aim is to redraw the knowledge-making structures we use to investigate our objects of study, calling attention to the intermedial and social practices, and cultures of remembrance, in which they are historically imbricated. (shrink)

Antimicrobial resistance (AMR) is an urgent threat to global public health and development. Mitigating this threat requires substantial short-term action on key AMR priorities. While international legal agreements are the strongest mechanism for ensuring collaboration among countries, negotiating new international agreements can be a slow process. In the second article in this special issue, we consider whether harnessing existing international legal agreements offers an opportunity to increase collective action on AMR goals in the short-term. We highlight ten AMR priorities and (...) several strategies for achieving these goals using existing “legal hooks” that draw on elements of international environmental, trade and health laws governing related matters that could be used as they exist or revised to include AMR. We also consider the institutional mandates of international authorities to highlight areas where additional steps could be taken on AMR without constitutional changes. Overall, we identify 37 possible mechanisms to strengthen AMR governance using the International Health Regulations, the Agreement on the Application of Sanitary and Phytosanitary Measures, the Agreement on Trade-Related Aspects of Intellectual Property Rights, the Agreement on Technical Barriers to Trade, the International Convention on the Harmonized Commodity Description and Coding System, and the Basel, Rotterdam, and Stockholm conventions. Although we identify many shorter-term opportunities for addressing AMR using existing legal hooks, none of these options are capable of comprehensively addressing all global governance challenges related to AMR, such that they should be pursued simultaneously with longer-term approaches including a dedicated international legal agreement on AMR. (shrink)

This article seeks to document the latest danger in the opioid crisis: fentanyl and related synthetic opioids. Fifty times more potent than pure heroin, cheaper to manufacture in laboratories worldwide, and easily distributed by mail and couriers, fentanyl is flooding the illicit opioid markets throughout the country.

This article explores the affective dimension of resilient epistemological systems. Specifically, I argue that responsible epistemic practice requires affective engagement with nondominant experiences. To begin, I outline Kristie Dotson's account of epistemological resilience whereby an epistemological system remains stable despite counterevidence or attempts to alter it. Then, I develop an account of affective numbness. As I argue, affective numbness can promote epistemological resilience in at least two ways. First, it can reinforce harmful stereotypes even after these stereotypes have been rationally (...) demystified. To illustrate, I examine the stereotype of Black criminality as it relates to false confessions. Second, it can encourage “epistemic appropriation”, which I demonstrate by examining the appropriation of “intersectionality” and #MeToo by white culture. Finally, I conclude that resisting harmful resilience requires affective resistance, or efforts that target numbness via different kinds of affective engagement. I consider Kantian “disinterestedness” as a candidate. (shrink)

The French existentialists Simone de Beauvoir and Jean‐Paul Sartre are renowned philosophers of freedom. But what “existentialist freedom” is is a matter of disagreement amongst their interpreters and, some argue, between Beauvoir and Sartre themselves. Since the late 1980s several scholars have argued that a Sartrean conception of freedom cannot justify the ethics of existentialism, adequately account for situations of oppression, or serve feminist ends. On these readings, Beauvoir disagreed with Sartre about freedom—making existentialist ethics, resistance to oppression, and feminism (...) coherently defensible. This article identifies four conceptions of freedom in order to clarify the questions of whether and how they disagreed, arguing that some incompatibilist readings of Sartre and Beauvoir conflate or confuse these conceptions in ways that render their conclusions unconvincing. However, there are stronger grounds on which to claim that Beauvoir disagreed with Sartre about morality—and the conditions of its possibility. (shrink)

An international legal agreement governing the global antimicrobial commons would represent the strongest commitment mechanism for achieving collective action on antimicrobial resistance (AMR). Since AMR has important similarities to climate change—both are common pool resource challenges that require massive, long-term political commitments—the first article in this special issue draws lessons from various climate agreements that could be applicable for developing a grand bargain on AMR. We consider the similarities and differences between the Paris Climate Agreement and current governance structures for (...) AMR, and identify the merits and challenges associated with different international forums for developing a long-term international agreement on AMR. To be effective, fair, and feasible, an enduring legal agreement on AMR will require a combination of universal, differentiated, and individualized requirements, nationally determined contributions that are regularly reviewed and ratcheted up in level of ambition, a regular independent scientific stocktake to support evidence informed policymaking, and a concrete global goal to rally support. (shrink)

This paper argues that, in addition to humanitarian concerns, policies toward immigrants should also be shaped by recognition of special responsibilities toward some populations of noncitizens. National governments acquire such responsibilities in part through their histories of coercive impositions on those populations. Former imperial powers, in particular, often possess special obligations toward the inhabitants of their foreign colonies that go beyond their general humanitarian responsibilities. Those obligations might be met in various ways; but if national governments of wealthy, formerly imperial (...) states granted greater access for immigration to the poor of their former colonies, migration flows might significantly contribute to reductions in global levels of inequality. (shrink)

Human uterus transplantation is currently under investigation as a treatment for uterine infertility. Without a uterus transplant, the options available to women with uterine infertility are adoption or surrogacy; only the latter has the potential for a genetically related child. UTx will offer recipients the chance of having their own pregnancy. This procedure occurs at the intersection of two ethically contentious areas: assisted reproductive technologies and organ transplantation. In relation to organ transplantation, UTx lies with composite tissue transplants such as (...) face and limb grafts, and shares some of the ethical concerns raised by these non-life saving procedures. In relation to ART, UTx represents one more avenue by which a woman may seek to meet her reproductive goals, and as with other ART procedures, raises questions about the limits of reproductive autonomy. This paper explores the ethical issues raised by UTx with a focus on the potential gap between women's desires and aspirations about pregnancy and the likely functional outcomes of successful UTx. (shrink)

A corrected and extensively annotated version of the sole meeting between two of the most important figures in twentieth-century intellectual life.

Self-Interest discusses the reconciliation of inevitable self-concern with its manifest potential for harm. This anthology brings together the efforts of twenty three renown philosophers to address the matter of how to bring about such a reconciliation. The drive for self-preservation, as observed by Aquinas, is the first law of nature. With this self-love, however, comes the threat of "the excessive love of self". Self-Interest brings into discussion the reconciliation of necessary self-concern with its manifest potential for harm. This anthology brings (...) together the work of twenty-three important philosophers to address the question of how to bring about such a reconciliation. Contributors include: Democritus, Plato, Aristotle, Augustine of Hippo, Aquinas,Hobbes, Nicole, Mandeville, Butler, Hutchenson, Hume, Smith, Kant, Bentham, Mill, James, Nietzsche, Dewey, Rand, and Gauthier. (shrink)

This book is a selection of papers from a conference which took place at the University of Keele in July 1982. The conference was an extraordinarily enjoyable one, and we would like to take this opportunity of thanking all participants for helping to make it so. The conference was intended to allow scholars working on different aspects of symbolic behaviour to compare findings, to look for common ground, and to identify differences between the various areas. We hope that it was (...) successful in these aims: the assiduous reader may judge for himself. Several themes emerged during the course of the conference. Some of these were: 1. There is a distinction to be made between those symbol systems which attempt, more or less directly, to represent a state of affairs in the world (e. g. language, drawing, map and navigational skill) and those in which the representational function is complemented, if not overshadowed, by properties of the symbol system itself, and the systematic inter-relations that symbols can have to one another (e. g. music, mathematics). The distinction is not absolute, for the nature of all symbolic skills is, in part, a function of the structure of the symbolic system employed. Nonetheless, this distinction helps us to understand some common acquisition difficulties, such as that experienced in mathematics, where mental manipulation of symbols can go awry if a child assumes too close a correspondence between mathematical symbols and the world they represent. 2. (shrink)

Without trust there is no credible human health research (HHR). This article accepts this truism and addresses a crucial question that arises: how can trust continually be promoted in an ever-changing and uncertain HHR environment? The article analyses long-standing mechanisms that are designed to elicit trust—such as consent, anonymization, and transparency—and argues that these are best understood as trust represented by proxies of trustworthiness, i.e., regulatory attempts to convey the trustworthiness of the HHR system and/or its actors. Often, such proxies (...) are assumed to operate as markers that trust exists or, at least, has not been lost. But, since trust can neither be “built” nor “secured,” this is a precarious assumption. Worryingly, there is no existing theoretical account of how to understand and evaluate these proxies of trustworthiness as part of a trusted HHR ecosystem. To remedy this, the paper argues for a radical reimagining of trust and trustworthiness as performative acts that ought to be understood in relation to each other and by reference to the common values at stake. It is shown that proxies of trustworthiness are the operational tools used to perform trustworthiness. It advocates for a values-based approach to understanding the relationship between trust and trustworthiness. This establishes a strong basis for an evaluative framework for proxies of trustworthiness, i.e., to determine how to perform trustworthiness well. Five common proxies in HHR are scrutinized from a values perspective. The contribution is to provide a far-reaching normative and practical framework by which existing and future proxies of trustworthiness can be identified, assessed, maintained, or replaced in rapidly changing HHR regulatory ecosystems where trust itself is crucial to the success of the entire HHR enterprise. (shrink)