O presente artigo tem por objetivo investigar a noção de corpo no pensamento do filósofo alemão Friedrich Nietzsche, mais especificamente a partir de uma leitura de alguns temas presentes na II Dissertação da Genealogia da Moral, basilares para se mobilizar tal noção. Dentre as questões elencadas encontram-se o papel da consciência, a memória, o esquecimento, o sentimento de culpa e a figura do criminoso que, partindo-se da leitura a que nos propomos, podem ser de fundamental importância para se pensar o (...) corpo em Nietzsche. (shrink)

Understanding the clinical significance of variants associated with hereditary cancer risk requires access to a pooled data resource or network of resources—a “cancer gene variant commons”—incorporating representative, well-characterized genetic data, metadata, and, for some purposes, pathways to case-level data. Several initiatives have invested significant resources into collecting and sharing cancer gene variant data, but further progress hinges on identifying and addressing unresolved policy issues. This commentary provides insights from a modified policy Delphi process involving experts from a range of stakeholder (...) groups involved in the data-sharing ecosystem. In particular, we describe policy issues and options generated by Delphi participants in five domains critical to the development of an effective cancer gene variant commons: incentives, financial sustainability, privacy and security, equity, and data quality. Our intention is to stimulate wider discussion and lay a foundation for further work evaluating policy options more in-depth and mapping them to those who have the power to bring about change. Addressing issues in these five domains will contribute to a cancer gene variant commons that supports better care for at-risk and affected patients, empowers patient communities, and advances research on hereditary cancers. (shrink)

Background This paper describes the design, implementation, and process outcomes from three public deliberations held in three tribal communities. Although increasingly used around the globe to address collective challenges, our study is among the first to adapt public deliberation for use with exclusively Indigenous populations. In question was how to design deliberations for tribal communities and whether this adapted model would achieve key deliberative goals and be well received.Methods We adapted democratic deliberation, an approach to stakeholder engagement, for use with (...) three tribal communities to respect tribal values and customs. Public deliberation convenes people from diverse backgrounds in reasoned reflection and dialogue in search of collective solutions. The deliberation planning process and design were informed by frameworks of enclave deliberation and community-based participatory research, which share key egalitarian values. The deliberations were collaboratively designed with tribal leadership and extensive partner input and involvement in the deliberations. Each deliberation posed different, locally relevant questions about genomic research, but used the same deliberation structure and measures to gauge the quality and experience of deliberation.Results A total of 52 individuals participated in the deliberations across all three sites. Deliberants were balanced in gender, spanned decades in age, and were diverse in educational attainment and exposure to health research. Overall, the deliberations were positively evaluated. Participant perceptions and external observer datasets depict three deliberations that offered intensive conversation experiences in which participants learned from one another, reported feeling respected and connected to one another, and endorsed this intensive form of engagement.Conclusion The adapted deliberations achieved key deliberative goals and were generally well received. Limitations of the study are described. (shrink)

The Protein Ontology (PRO; http://proconsortium.org) formally defines protein entities and explicitly represents their major forms and interrelations. Protein entities represented in PRO corresponding to single amino acid chains are categorized by level of specificity into family, gene, sequence and modification metaclasses, and there is a separate metaclass for protein complexes. All metaclasses also have organism-specific derivatives. PRO complements established sequence databases such as UniProtKB, and interoperates with other biomedical and biological ontologies such as the Gene Ontology (GO). PRO relates to (...) UniProtKB in that PRO’s organism-specific classes of proteins encoded by a specific gene correspond to entities documented in UniProtKB entries. PRO relates to the GO in that PRO’s representations of organism-specific protein complexes are subclasses of the organism-agnostic protein complex terms in the GO Cellular Component Ontology. The past few years have seen growth and changes to the PRO, as well as new points of access to the data and new applications of PRO in immunology and proteomics. Here we describe some of these developments. (shrink)

Volume 20, Issue 7, July 2020, Page 174-177.

Books Christy Mag Uidhir, Art andObjects [Elisa Caldarola, p. 182] • Julie Jaffee Nagel, Melodies of the Mind. Connections Between Psychoanalisis and Music [Michele Gardini, p. 185] • Dominic McIver Lopes, Beyond Art [Filippo Focosi, p. 187] • Annemarie Gethmann-Siefert, Herta Nagl-Docekal, Erzsébet Ròsza, Elisabeth Weisser-Lohmann, Hegels Ästhetik als Theorie der Moderne [Lorenzo Leonardo Pizzichemi, p. 190] Comments Toward an Integrated Science of Aesthetics. Getting Rid of the Main Misunderstandings in Evolutionary Aesthetics [Mariagrazia Portera, p. 194].

This book is a defense of political liberalism as a feminist liberalism. A novel and restrictive account of public reason is defended. Then it is argued that political liberalism's core commitments restrict reasonable conceptions of justice to those that secure genuine, substantive equality for women and other marginalized groups.

Acknowledgments THROUGHOUT this book I cite the many people who have provided information on individual programs and activities. ...

Social cooperation based on reciprocity is the cornerstone of many theories of justice. However, what is central to social cooperation based on reciprocity? How does basing social cooperation on reciprocity structure and constrain theories of justice? In this paper, I consider what is central to reciprocity. I argue that the purpose of reciprocal exchange among persons is important for determining the appropriateness of reciprocal exchanges and that sustaining mutually advantageous relations is not always the point or the only point of (...) reciprocity. This has important implications for theorizing about justice. I show this by outlining two conceptions of justice as reciprocity. (shrink)

This book is the most comprehensive and rigourous critique of the ways disciplinary boundaries still inhibit knowledge-production and integration.

Because they contain idealizations, scientific models are often considered to be misrepresentations of their target systems. An important question is therefore how models can explain the behaviours of these systems. Most of the answers to this question are representationalist in nature. Proponents of this view are generally committed to the claim that models are explanatory if they represent their target systems to some degree of accuracy; in other words, they try to determine the conditions under which idealizations can be made (...) without jeopardizing the representational function of models. In this article, we first outline several forms of this representationalist view. We then argue that this view, in each of these forms, omits an important role of idealizations: that of facilitating the identification of the explanatory components within a model. Via examination of a case study from contemporary astrophysics, we show that one way in which idealizations can do this is by creating a comparison case that s... (shrink)

An influential view in the ethics of self-defence is that causal responsibility for an unjust threat is a necessary requirement for liability to defensive harm. In this article, I argue against this view by providing intuitive counterexamples and by revealing weaknesses in the arguments offered in its favour. In response, adherents of the causal view have advanced the idea that although causally inefficacious agents are not liable to defensive harm, the fact that they may deserve harm can justify harming them (...) in the course of defending oneself. I argue that this strategy is ad hoc and leads to more problems than it solves. Once we allow normative facts outside our account of liability to affect a person's moral protection against harm, the lieability verdicts cannot tell us whether there is a relevant moral asymmetry between the victim and the target of defence. In conclusion, the causal view is wrong and causal responsibility for an unjust threat is not a necessary requirement for liability to defensive harm. (shrink)

We agree with Penn et al. that our human cognitive superiority derives from our exceptional relational ability. We far exceed other species in our ability to grasp analogies and to combine relations into higher-order structures (Gentner 2003). However, we argue here that possession of an elaborated symbol system is necessary to make our relational capacity operational.

Culture has been identified as a significant determinant of ethical attitudes of business managers. This research studies the impact of culture on the ethical attitudes of business managers in India, Korea and the United States using multivariate statistical analysis. Employing Geert Hofstede's cultural typology, this study examines the relationship between his five cultural dimensions (individualism, power distance, uncertainty avoidance, masculinity, and long-term orientation) and business managers' ethical attitudes. The study uses primary data collected from 345 business manager participants of Executive (...) MBA programs in selected business schools in India, Korea and the United States using Hofstede's Value Survey Module (94) and an instrument designed by the researchers to measure respondents' ethical attitudes (attitudes toward business ethics in general and toward twelve common questionable practices in particular). Results indicate that national culture has a strong influence on business managers' ethical attitudes. In addition to national culture, respondents' general attitudes toward business ethics are related to their personal integrity; their attitudes toward questionable business practices are related to the external environment and gender, as well as to their personal integrity. A strong relationship exists between cultural dimensions of individualism and power distance and respondents' ethical attitudes toward certain questionable practices. The analysis of the relationship between cultural dimensions of masculinity, uncertainty avoidance and long-term orientation and respondents' ethical attitudes toward questionable practices produced mixed results, likely due to the lack of notable differences in cultural dimension scores among the countries surveyed. (shrink)

Three experiments demonstrate that biological movement facilitates young infants’ recognition of the whole human form. A body discrimination task was used in which 6-, 9-, and 12-month-old infants were habituated to typical human bodies and then shown scrambled human bodies at the test. Recovery of interest to the scrambled bodies was observed in 9- and 12-month-old infants in Experiment 1, but only when the body images were animated to move in a biologically possible way. In Experiment 2, nonbiological movement was (...) incorporated into the typical and scrambled body images, but this did not facilitate body recognition in 9- and 12-month-olds. A preferential looking paradigm was used in Experiment 3 to determine if infants had a spontaneous preference for the scrambled versus typical body stimuli when these were both animated. The results showed that 12-month-olds preferred the scrambled body stimuli, 9-month-olds preferred the typical body stimuli and the 6-month-olds showed no preference for either type of body stimuli. These findings suggest that human body recognition involves integrating form and movement, possibly in the superior temporal sulcus, from as early as 9 months of life. (shrink)

This essay explores a theory of panoramas put forward by the experimental postwar German novelist and translator Arno Schmidt. Schmidt claims that panoramas were so pervasive in the visual culture of the nineteenth century that they unconsciously influenced writers of the period, so that when they wanted to describe vast landscapes they unthinkingly framed their descriptions by drawing on experience with specific panoramas. He primarily expounds the theory in his longest work of fiction, Zettel’s Traum (1970), translated as Bottom’s Dream (...) (2016), where he supports it with evidence from Edgar Allan Poe and Jules Verne. He also promoted the theory in later interviews, and regarded it not just as part of his fiction but as a significant discovery in its own right. This essay extracts Schmidt’s theory from its fictional context and illustrates how he thought it could be used hermeneutically to uncover submerged panoramas in the works of nineteenth century authors. We conclude by locating the theory as part of the contemporary reception history of panoramas. (shrink)

This book describes how and why the early modern period witnessed the marginalisation of astrology in Western natural philosophy, and the re-adoption of the cosmological view of the existence of a plurality of worlds in the universe, allowing the possibility of extraterrestrial life. Founded in the mid-1990s, the discipline of astrobiology combines the search for extraterrestrial life with the study of terrestrial biology – especially its origins, its evolution and its presence in extreme environments. This book offers a history of (...) astrobiology's attempts to understand the nature of life in a larger cosmological context. Specifically, it describes the shift of early modern cosmology from a paradigm of celestial influence to one of celestial inhabitation. Although these trends are regarded as consequences of Copernican cosmology, and hallmarks of a modern world view, they are usually addressed separately in the historical literature. Unlike others, this book takes a broad approach that examines the relationship of the two. From Influence to Inhabitation will benefit both historians of astrology and historians of the extraterrestrial life debate, an audience which includes researchers and advanced students studying the history and philosophy of astrobiology. It will also appeal to historians of natural philosophy, science, astronomy and theology in the early modern period. (shrink)

This article sets out to examine the role of teacher research and enquiry in the professional development of teachers. The context derives from the initiative of the Scottish Executive to enhance the status and working conditions of teachers. We consider the extent to which continuing professional development activities arising out of the Chartered Teacher Programme encourage teachers to value research, equip them to become research-minded and support them to engage in research and enquiry in their own professional contexts.

The Tanner Lectures on Human Values, founded July 1, 1978, at Clare Hall, Cambridge University, was established by the American scholar, industrialist, and philanthropist Obert Clark Tanner. Lectureships are awarded to outstanding scholars or leaders in broadly defined fields of human values and transcend ethnic, national, religious, or ideological distinctions. Volume 32 features lectures given during the academic year 2011–2012 at the University of Michigan; Princeton University; Stanford University; the University of California, Berkeley; the University of Utah; and Yale University. (...) This volume includes the following lectures:_ John Broome_, “The Public and Private Morality of Climate Change”_John Broome is the Whites Professor of Moral Philosophy at the University of Oxford and a fellow of Corpus Christi College in Oxford. He has written six books. John M. Cooper_, “Ancient Philosophies as Ways of Life”_John Cooper is the Henry Putnam University Professor of Philosophy at Princeton University. His books include _Pursuits of Wisdom: Six Ways of Ancient Philosophy from Socrates to Plotinus _and _Panentheism: The Other God of the Philosophers_. Stephen Greenblatt_, “Shakespeare and the End of Life History”_Stephen Greenblatt is the John Cogan University Professor of the Humanities at Harvard University. He is the author of several books, including the 2012 Pulitzer Prize–winning _The Swerve: How the World Became Modern _and _Will in the World: How Shakespeare Became Shakespeare_. Lisa Jardine_, “The Sorcerer’s Apprentice: C. P. Snow and J. Bronowski” and “Science and Government: C. P. Snow and the Corridors of Power”_Lisa Jardine is a professor of Renaissance studies at University College London, where she is the director of the Interdisciplinary Centre for Research in the Humanities and the Centre for Editing Lives and Letters. She has published more than fifty scholarly articles and seventeen books, including _Going Dutch: How England Plundered Holland’s Glory_. Samuel Scheffler_, “The Afterlife”_Samuel Scheffler is University Professor and a professor of philosophy and law at New York University. He has published four books in the areas of moral and political philosophy, including _Equality and Tradition_. Abraham Verghese_, “Two Souls Intertwined” Abraham Verghese is a professor of medicine and senior associate chair for the Theory and Practice of Medicine at Stanford University. He has published widely across disciplines, including _My Own Country: A Doctor’s Story _and the novel _Cutting for Stone_. He is perhaps best known for his deep interest in bedside medicine and work in the medical humanities. (shrink)

"Dreaming with open eyes" is a tagline for Spinoza's critique of Descartes; the dreams in question are principally those of volition and the active imagination. In this article, I compare the Cartesian theory of imagination as an active, but not fully rational, power of the mind and the Cartesian account of the volitional self to Spinoza's views. Descartes's own dreams and theories of dreaming are the focus of the first part of the article. Thereafter I examine Spinoza's critique of Descartes (...) and his alternative account of imagination. Finally, I argue that there is a positive sense of dreaming with open eyes to be recuperated in Spinoza's thought. Construed positively, to dream with open eyes is to understand dreams and imagination as natural phenomena and so to be able to respond constructively to them in ethical and political, as well as epistemological, life. (shrink)

An empirical study of whether the ordinary conception of race in the United States is biological or social, and how different conceptions connect to racism.

Non-epistemic values pervade climate modelling, as is now well documented and widely discussed in the philosophy of climate science. Recently, Parker and Winsberg have drawn attention to what can be termed “epistemic inequality”: this is the risk that climate models might more accurately represent the future climates of the geographical regions prioritised by the values of the modellers. In this paper, we promote value management as a way of overcoming epistemic inequality. We argue that value management can be seriously considered (...) as soon as the value-free ideal and inductive risk arguments commonly used to frame the discussions of value influence in climate science are replaced by alternative social accounts of objectivity. We consider objectivity in Longino's sense as well as strong objectivity in Harding's sense to be relevant options here, because they offer concrete proposals that can guide scientific practice in evaluating and designing so-called multi-model ensembles and, in fine, improve their capacity to quantify and express uncertainty in climate projections. (shrink)

In proposition 7 of the second part of the Ethics, Spinoza famously contends that the “order and connection of things is the same as the order and connection of ideas.” On this basis, Spinoza argues in the scholium that thought and extension are different ways of conceiving one and the same substance: “the thinking substance and the extended substance are one and the same substance, which is now comprehended under this attribute, now under that”. Less famously, in the same scholium, (...) Spinoza insists that the relation of thought and extension is not the only issue at stake. He notes that “certain Hebrews” saw, “as if through a cloud,” the unity of God and the world in knowing: “they maintained that God, God’s intellect, and the things understood by him are one and the same.” The cloud is the idea of divine transcendence. Commenting on this passage, Aviezer Ravitzky has observed that Spinoza’s mention of these “certain Hebrews” should inform us about “an inherent problem, about dynamite concealed in the teachings of the Jewish Aristotelians such as Maimonides.” If, as Aristotle argues in the De Anima and Metaphysics, the knower and the known are one in knowing, then the distinction between God and the objects of God’s knowing is undermined. Noetic union is ontological union, for the intellect is its ideas. Thus Aristotelian noesis undermines divine transcendence. E2p7 and its scholium, then, presage the most famous—or infamous—expression of the Ethics, Deus sive Natura. Maimonides qualifies his Aristotelianism with an hierarchical emanationist cosmology, thereby avoiding the implications of noetic union by differentiating between the creator and the creatures and between the agent intellect, the lowest of the celestial spheres and source of the human acquired intellect, and the divine intellect. Gersonides, the fourteenth century giant of the medieval Jewish tradition and its most consistent Aristotelian, endorses the Aristotelian formula, arguing consistently that the intelligible is an intellect and offering a meticulous explanation of “why it is said of non-material things that the intellect, the thinker, and the intelligible are all one.” In this article, I argue that Gersonides’ own highly Averroian position is evoked in E2p7s and that Spinoza extends and radicalizes the Gersonidean inheritance. Beginning from E2p7 and its scholium, I explore the implications of noetic union for the relationship of God and the world and that between thought and extension. (shrink)

Life is so wretched that it would be impossible to endure were it not for the luminous beams of illusion that guide us through its darkest moments. Many argue, perhaps not to this degree, that were it not for some modest illusions about the world and ourselves we would experience a serious decline in quality of life. On those not-so-good days, this claim strikes me as irresistible. How would I endure life and maintain my sanity if I had to embrace (...) each and every disgusting and disheartening fact about the world? Perceiving the world in a way that is neither clear-eyed nor complete may not be without its advantages. But even if being mistaken about the world or self-deceived causes one to be healthier or more comfortable, it is worth asking whether there is something to be said against a life of this kind. Might there not be some knowledge about ourselves or the world that we ought to have? Do not these ‘positive illusions,’ or flattering but inaccurate beliefs that people have about themselves and the world, interfere with their ability to live the good life? In the first part of this paper, I will briefly review the psychological literature which suggests that mild self-deception in the positive direction contributes to, rather than compromises, a person’s well-being. I will then, in the second part of the paper, examine what three thinkers, Joseph Butler, Immanuel Kant, and W.K. Clifford, have said about the wrongfulness of self-deception. While their arguments call attention to various reasons for thinking that some cases of self-deception might give rise on balance to negative consequences, they fail to show that all cases must have this effect. In the final part of the paper, I will consider whether our interest in autonomy might provide us with a better explanation of the supposed wrongfulness of self-deception. I will try to show that in virtue of being mistaken alone, the self-deceiver generally experiences some loss of a particular kind of autonomy. Nevertheless, my analysis will leave open the following two possibilities: that the loss of autonomy was autonomously brought about, and that the loss of autonomy in question may result on balance in an increase in the self-deceiver’s autonomy. (shrink)

Considered in its seventeenth-century context, Spinoza’s way of thinking about substance and nature is striking for its simultaneous refusal of Cartesian dualism and Hobbesian materialism. Spinoza knew both thinkers’ work well, yet sided with neither. Where Descartes divides substance into thinking and extended substance, and where Hobbes reduces all things to body, Spinoza espouses what is best called a double-aspect or non-reductive monism. The single substance of the Ethics is expressed as an infinity of modes in an infinity of attributes, (...) each infinite in kind. Thought and extension are two of the infinite attributes of substance, and the simultaneous sameness and difference of thought and extension constitutes a major theme of the Ethics. Using exactly parallel demonstrations, Spinoza argues in the second part of the Ethics that substance, or God, or nature is equally a thinking thing and an extended thing. Descartes’ account of matter and extension, in which passive matter is set in motion by God, inspires harsh criticism from Spinoza. (shrink)

Through a close analysis of texts from the Second Objections and Replies to the Meditations, this article addresses the tension between the pursuit of certainty and the preservation of divine transcendence in Descartes’s philosophy. Via a hypothetical “atheist geometer,” the Objectors charge Descartes with pantheism. While the Objectors’ motivations are not clear, the objection raises provocative questions about the relation of the divine and the human mind and about the being of created or dependent entities inDescartes’s metaphysics. Descartes contends that (...) there are real, eternal essences present in the human intellect as innate ideas. I argue that this claim implicates him in pantheism, not merely univocity. In the course of the analysis, I consider recent interpretations by Wells, Marion, and Hatfield. (shrink)

_Therapy & the Counter-tradition: The Edge of Philosophy_ brings together leading exponents of contemporary psychotherapy, philosophers and writers, to explore how philosophical ideas may inform therapy work. Each author discusses a particular philosopher who has influenced their life and therapeutic practice, while questioning how counselling and psychotherapy can address human ‘wholeness’, despite the ascendancy of rationality, regulation and diagnosis. It also seeks to acknowledge the distinct lack of philosophical input and education in counselling and psychotherapy training. The chapters are rooted (...) in the Counter-Tradition, whose diverse manifestations include humanism, skepticism, fideism, as well as the opening of philosophy and psychology to poetry and the arts. This collection of thought-provoking essays will help open the discussion within the psychological therapies, by providing therapists with critical philosophical references, which will help broaden their knowledge and the scope of their practice. Therapy & the Counter-tradition: The Edge of Philosophy will be of interest to mental health professionals, practitioners, counselling and psychotherapy trainees and trainers, and academics tutoring or studying psychology. It will also appeal to those interested in psychology, meditation, personal development and philosophy. (shrink)

AbstractmRNA stability is increasingly recognized as being essential for controlling the expression of a wide variety of transcripts during neuronal development and synaptic plasticity. In this context, the role of AU‐rich elements (ARE) contained within the 3′ untranslated region (UTR) of transcripts has now emerged as key because of their high incidence in a large number of cellular mRNAs. This important regulatory element is known to significantly modulate the longevity of mRNAs by interacting with available stabilizing or destabilizing RNA‐binding proteins (...) (RBP). Thus, in parallel with the emergence of ARE, RBP are also gaining recognition for their pivotal role in regulating expression of a variety of mRNAs. In the nervous system, the member of the Hu family of ARE‐binding proteins known as HuD, has recently been implicated in multiple aspects of neuronal function including the commitment and differentiation of neuronal precursors as well as synaptic remodeling in mature neurons. Through its ability to interact with ARE and stabilize multiple transcripts, HuD has now emerged as an important regulator of mRNA expression in neurons. The present review is designed to provide a comprehensive and updated view of HuD as an RBP in the nervous system. Additionally, we highlight the role of HuD in multiple aspects of a neuron's life from early differentiation to changes in mature neurons during learning paradigms and in response to injury and regeneration. Finally, we describe the current state of knowledge concerning the molecular and cellular events regulating the expression and activity of HuD in neurons. BioEssays 28: 822–833, 2006. © 2006 Wiley Periodicals, Inc. (shrink)

This article discusses the impact of Descartes’s substance-dualism on his account of discursive reason. Taking the presentation of deduction in the Rules as a paradigmatic case of thought’s extension and movement in time, I analyze the relation between intuitive and discursive understanding and that between intellect and imagination. I focus specifically on the mediation of corporeal impressions and of intellectual ideas by ingenium. As intellectual, ingenium is a faculty of understanding; as joining with phantasia, ingenium has access to corporeal affections, (...) images, and memory. Deduction involves both of these aspects of ingenium, and Descartes’s dualism complicates efforts to clarify the operations and nature of ingenium. Thus the dynamics of dualistic psychology account for some of the limitations of deduction in particular and discursive rationality in general. (shrink)

There are individual and cultural differences in how memories of our emotions are cognitively represented. This article examines the cognitive representation of emotions in different cultures, as a result of emotional (in)consistency in different cultures. Using a continuous semantic priming task, we showed in two studies that individuals who were less emotionally consistent across relationships have stronger associations of their emotions within those relationships. Further, we found (in Study 2) that in a culture characterised by higher levels of emotional inconsistency (...) across relationships (Singapore), stronger associations between emotions within relationships were found than in a culture characterised by emotional consistency (USA). This cultural difference in cognitive representation was fully mediated by individual differences in cross-situational consistency levels. (shrink)