If a person is competent to consent to a treatment, is that person necessarily competent to refuse the very same treatment? Risk relativists answer no to this question. If the refusal of a treatment is risky, we may demand a higher level of decision-making capacity to choose this option. The position is known as asymmetry. Risk relativity rests on the possibility of setting variable levels of competence by reference to variable levels of risk. In an excellent 2016 article inJournal of (...) Medical Ethics(JME), Rob Lawlor defends asymmetry of this kind by defending risk relativity, using and developing arguments and approaches found in earlier work such as that of Wilks. He offers what we call the two-scale approach: a scale of risk is to be used to set a standard of competence on a scale of decision-making difficulty. However, can this be done in any rational way? We argue it cannot, and in this sense, and to this extent, risk relativity is a nonsense. (shrink)

In this short response to Gray’s article Capacity and Decision Making we double down on our argument that risk-relativity is a nonsense. Risk relativity is the claim that we should set a higher standard of competence for a person to make a risky choice than to make a safe choice. Gray’s response largely involves calling attention to the complexities, ramifications and multiple value implications of decision-making, but we do not deny any of this. Using the notion of quality of care (...) mentioned by Gray, we construct an argument that might be used to support risk relativity. But it is no more persuasive than the arguments put forward by risk-relativists. (shrink)

Background: Both the Council for International Organization of Medical Sciences and the Helsinki Declaration emphasize that the potential benefits of research should outweigh potential harms; consequently, some work has been conducted on participants' perception of benefits in therapeutic research. However, there appears to be very little work conducted with participants who have joined non-therapeutic research. This work was done to evaluate participants' perception of benefits in a genetic epidemiological study by examining their perception of the potential benefits of enrollment.Methods: In-depth (...) interviews lasting between 45 and 60 minutes were conducted with a convenient sample of 25 ill patients and 25 healthy accompanying relatives enrolled in a genetic epidemiological study of tuberculosis. Recorded interviews were transcribed and analyzed using content analysis.Results: Participants perceived that research was beneficial and some of the benefits included the generation of new knowledge, finding the cause of diseases, as well as the control, eradication and prevention of disease. Some thought that research was risky whilst others thought that the benefits outweighed the risks.Conclusion: Participants perceived research to be beneficial and most of them thought that, though it was risky, the benefits outweighed the risks. It is our view that researchers need to give serious consideration to participant's perception of benefits in designing their consent forms, to see to the fulfillment of achievable goals. (shrink)

ABSTRACT Background: The doctrine of informed consent (IC) exists to protect individuals from exploitation or harm. This study into IC was carried out to investigate how different researchers perceived the process whereby researchers obtained consent. It also examined researchers’ perspectives on what constituted IC, and how different settings influenced the process. Methods: The study recorded in‐depth interviews with 12 lecturers and five doctoral students, who had carried out research in developing countries, at a leading school of public health in the (...) United Kingdom. A purposive, snowballing approach was used to identify interviewees. Results: Although the concept and application of the doctrine of IC should have been the same, irrespective of where the research was carried out, the process of obtaining it had to be different. The setting had to be taken into consideration and the autonomy of the subject had to be respected at all times. In areas of high illiteracy, and where understanding of the subject was likely to be a problem, there was an added responsibility placed on the researcher to devise innovative ways of carrying out the study, taking into consideration the peculiarities of the environment. Conclusion: The ethical issues for IC were the same, irrespective of where the research was conducted. However, because the backgrounds, setting, and knowledge of populations differed, there was the need to be similarly sensitive in obtaining consent. The problems of obtaining genuine IC were not limited to developing countries. (shrink)

Mental health legislation that requires patients to accept ‘care’ has come under increasing scrutiny, prompted primarily by a human rights ethic. Epistemic issues in mental health have received some attention, however, less attention has been paid to the possible epistemic problems of mental health legislation existing. In this manuscript, we examine the epistemic problems that arise from the presence of such legislation, both for patients without a prior experience of being detained under such legislation and for those with this experience. (...) We also examine how the doctor is legally obligated to compound the epistemic problems by the knowledge they prioritise and the failure to generate new knowledge. Specifically, we describe the problems of testimonial epistemic injustice, epistemic silencing, and epistemic smothering, and address the possible justification provided by epistemic paternalism. We suggest that there is no reasonable epistemic justification for mental health legislation that creates an environment that fundamentally unbalances the doctor–patient relationship. Significant positive reasons to counterbalance this are needed to justify the continuation of such legislation. (shrink)

In "Amazing Grace," the best-loved of all hymns, John Newton's allusions to the drama of his life tell the story of a youth who was a virtual slave in Sierra Leone before ironically becoming a slave trader himself. Liverpool, his home port, was the center of the most colossal, lucrative, and inhumane slave trade the world has ever known. A gradual spiritual awakening transformed Newton into an ardent evangelist and anti-slavery activist. Influenced by Methodists George Whitefield and (...) John Wesley, Newton became prominent among those favoring a Methodist-style revival in the Church of England. This movement stressed personal conversion, simple worship, emotional enthusiasm, and social justice. While pastoring a poor flock in Olney, he and poet William Cowper produced a hymnal containing such perennial favorites as "Glorious Things of Thee Are Spoken" and "God Moves in a Mysterious Way." Later, while serving a church in London, Newton raised British consciousness on the immorality of the slave trade. The account he gave to Parliament on the atrocities he had witnessed helped William Wilberforce obtain legislation to abolish the slave trade in England. Newton's life story convinced many who are "found" after being "lost" to sing Gospel hymns as they lobbied for civil rights legislation. His close involvement with both capitalism and evangelicalism, the main economic and religious forces of his era, provide a fascinating case study of the relationship of Christians to their social environment. In an afterword on Newtonian Christianity, Phipps explains Newton's critique of Karl Marx's thesis that religious ideals are always the effect of what produces the most profit. Phipps relies on accounts Newton gives in his ship journal, diary, letters, and sermons for this most readable scholarly narrative. (shrink)

Background: Explaining technical terms in consent forms prior to seeking informed consent to recruit into trials can be challenging in developing countries, and more so when the studies are randomized controlled trials. This study was carried out to examine the opinions of researchers on ways of dealing with these challenges in developing countries.Methods: Recorded in‐depth interviews with 12 lecturers and five doctoral students, who had carried out research in developing countries, at a leading school of public health in the United (...) Kingdom. A purposive, snowballing approach was used to identify interviewees.Results: Researchers were divided on the feasibility of explaining technical trials in illiterate populations; the majority of them held the view that local analogies could be used to explain these technical terms. Others were of the opinion that this could not be done since it was too difficult to explain technical trials, such as randomized controlled trials, even to people in developed countries.Conclusion: Researchers acknowledged the difficulty in explaining randomized controlled trials but it was also their perception that this was an important part of the ethics of the work of scientific research involving human subjects. These difficulties notwithstanding, efforts should be made to ensure that subjects have sufficient understanding to consent, taking into account the fact that peculiar situations in developing countries might compound this difficulty. (shrink)

2. Thesis 2 I accept insofar as it asserts the relation of possibility to actuality to be a fundamental aspect of things. This relation is sui generis.

ABSTRACT As well as the mathematically-supported celestial mechanics that Newton developed in his Principia, Newton also proposed a more speculative natural philosophy of interparticulate forces of attraction and repulsion. Although this speculative philosophy was not made public before the ‘Queries’ which Newton appended to the Opticks, it originated far earlier in Newton’s career. This article makes the case that Newton’s short, unfinished manuscript, entitled ‘De Aere et Aethere’, should be seen as an important landmark in (...) Newton’s intellectual development, being the first work in which Newton assumed there are repulsive forces operating at a distance between the particles of bodies. The article offers an account of how Newton came to write ‘De Aere et Aethere’ and why. It also outlines its relationship to the ‘Conclusio’, with which Newton briefly intended to finish the Principia, and to the ‘Queries’ in the Opticks. The date of the manuscript is disputed, and the article also aims to settle this dispute. Claims that the ‘De Aere et Aethere’ must have been written before the ‘Hypothesis... of Light’ of 1675 are dismissed, and it is suggested, following R. S. Westfall, that it was written after a well-known letter Newton wrote to Boyle early in 1679. (shrink)

ArgumentIt is argued that the sensorium of God was introduced into theQuaestionesadded to the end of Newton’sOptice(1706) as a way of answering objections that Newton had failed to provide a causal account of gravity in thePrincipia. The discussion of God’s sensorium indicated that gravity must be caused by God’s will. Newton did not leave it there, however, but went on to show how God’s will created active principles as secondary causes of gravity. There was nothing unusual in (...) assuming that God, acting as the First Cause, operated in nature by means of secondary causes; but it was unusual to devote as much time to discussing God’s precise role as to discussing the secondary causes themselves. It is contended that Newton felt the need to do this to persuade readers that what might seem like a second cause that could not possibly work could be made to work by the omnipotent God. (shrink)

Samuel Clarke is best known to historians of science for presenting Isaac Newton’s views to a wider audience, especially in his famous correspondence with G. W. Leibniz. Clarke’s independent writings, however, reveal positions that do not derive from, and do not coincide with, Newton’s. This essay compares Clarke’s and Newton’s ideas on the cause of gravity, with a view to clarifying our understanding of Newton’s views. There is evidence to suggest that Newton believed God was (...) directly responsible for gravity, and this interpretation has been promoted by a number of scholars. By comparing Newton’s views with those of Clarke, however, it can be seen that Newton did not subscribe to the kind of occasionalist approach to gravity that Clarke developed. Clarke insisted that matter was categorically incapable of being endowed with powers or forces and that therefore what looks like gravitational attraction has to be performed directly by God or by angels. By comparing Clarke’s pronouncements with Newton’s, it becomes clear that Newton adopted the more standard line: that the first cause, God, operated in nature through secondary causes and that gravitational attraction was just such a secondary (albeit occult) cause. (shrink)

Este artículo, como lo dice su título, es una actualización del primer "Newton en la red". Intenta resumir los nuevos retos que el Newton Project ha tenido que afrontar, en particular, la investigación sobre ingeniería de software requerida para generar un resultado confiable de los manuscritos junto conn el comentario académico.

The contributors to this volume cover a wide range of philosophers, from Simplicius to John Wyclif, and philosophical problems, including: the harmony of ...

La acción a distancia se ha considerado muy a menudo como un medio de explicación inaceptable en la física. Debido a que daba la impresión de resistirse a los intentos de asignarle causas propias a los efectos, la acción a distancia se ha proscrito como sinsentido ocultista. El rechazo de la acción a distancia fue el principal precepto del aristotelismo que fue tan dominante en la filosofía natural europea, y hasta hoy permanece como un prejuicio principal de la física moderna. (...) No obstante, hubo un período de interregno; un período durante el cual las acciones a distancia eran fácilmente aceptadas por un número ignificativo de filósofos naturales. La principal influencia sobre este nuevo enfoque radical hacia la naturaleza de la causalidad física fue, por supuesto, Isaac Newton. El principio de gravitación universal de Newton a muchos les pareció dar no sólo un ejemplo innegable de una fuerza cuya naturaleza no se podía producir por ningún tipo de contacto mecánico entre los cuerpos, sino también un modelo para otras supuestas fuerzas que podían suponerse que dan cuenta de los fenómenos químicos, biológicos y otros fenómenos físicos. Por tanto, durante el siglo XVIII, como lo han demostrado un gran número de importantes estudios históricos, los filósofos naturales buscaron hacer fructífero el deseo de Newton, expresado en el Prefacio a los Principia, de que todos los fenómenos de la naturaleza fueran explicados en términos de fuerzas atractivas y repulsivas que operan a distancia entre las partículas diminutas de los cuerpos. Sin embargo, en la actualidad el rechazo a la legitimidad de las acciones a distancia es tan grande que una serie de notables especialistas de Newton han insistido en que Newton nunca creyó en la actio in distans y que fue completamente malentendido por la generación que le sucedió. Este artículo reitera que Newton sí creía en la acción a distancia y refuta los argumentos de especialistas recientes que sostienen lo contrario. (shrink)

Newton's heretical yet equation-incisive writings on theology, spirituality, alchemy, and prophecy, written in secret alongside his Principia Mathematica.

This article aims to bring out the problematic nature of condensation and rarefaction for early modern natural philosophers by considering two historically significant attempts to deal with it, first by Sir Kenelm Digby in his Treatise on Body (1644), and subsequently by Isaac Newton, chiefly in manuscript works associated with the Principia (1687). It is argued that Digby tried to sidestep the problem of variation in density and rarity by making it a fundamental starting point for his physics. But (...) he also brought out the difficulties of dealing with condensation and rarefaction within the mechanical philosophy, whether that philosophy was plenist or allowed for void space. The problems became exacerbated after experiments with the air-pump achieved extreme rarefactions. It is argued that these led Newton to first consider a retiform or net-like structure of matter, before adopting the radical innovation of supposing repelling forces operating at a distance between the particles of the rarefied bodies. Eventually, Newton came to believe that extreme rarity was inexplicable ‘by any other means than a repulsive Power’. (shrink)

Huey P. Newton remains one the left’s intellectual enigmas. Although lauded for being the leader of the Black Panther Party, Newton is relatively unacknowledged as an intellectual. This article challenges the neglect of Newton’s thought by shedding light on his theory of empire, and the present-day value of returning to his thought. The article centres on how Newton’s critique of what he called ‘reactionary intercommunalism’ prefigures many of the elements found in the work of Hardt and (...) Negri on empire. This comparison will be used to show how Newton not only foresaw elements of the rise of contemporary neoliberal globalization, but also offered an idea of political solidarity and revolutionary politics for such a context. The article concludes by highlighting how Newton’s ideas about the need for a war of position based on ‘survival pending revolution’ presents a more theoretically and empirically salient conceptualization of resistance than his successors. (shrink)

Le succes des Essais de John Locke sur l'origine, les modalites et le but de l'entendement humain fut similaire au triomphe de Newton en physique. Cet ouvrage initie tout le courant empiriste qui le suit, ainsi que la psychologie comme science. Il reste, a ce jour, la plus etudiee des oeuvres de Locke. Les livres I et II, ici edites dans une traduction nouvelle, presentent l'acte fondateur (que reproduiront Berkeley et Hume) de la these sensualiste: la critique de (...) l'inneisme et la source empirique de toute idee. Cette nouvelle traduction offre au lecteur un texte issu d'une lecture enrichie par trois siecles d'exegese. (shrink)

Uno de los proyectos más deseados, pero de difícil ejecución, debido a la descripción de los manuscritos, su volumen y la complejidad de su contenido, ha sido una Opera Omnia realmente completas de Newton. Este artículo muestra cómo el Newton Project, lanzado en 1998, se ha propuesto llenar este vacío al integrar la investigación sobre Newton, su pensamiento y su contexto con una indagación activa en ingeniería de software para producir un resultado confiable de los manuscritos en (...) primer lugar en formato digital y, posteriormente, de manera impresa. (shrink)

This paper is in three sections. The first establishes that Newton, in spite of a well-known passage in a letter to Richard Bentley of 1692, did believe in action at a distance. Many readers may see this merely as an act of supererogation, since it is so patently obvious that he did. However, there has been a long history among Newton scholars of allowing the letter to Bentley to over-ride all of Newton’s other pronouncements in favour of (...) action at a distance, with devastating effects on our understanding of related aspects of his physics and his theology. Furthermore, this misconceived scholarly endeavour shows no sign of abating. The second section then offers a historical reconstruction, based on Newton’s writings, of how, when and why he began to accept actions at a distance and make them one of the cornerstones of his physics. Finally, using this chronological account of Newton’s use of actions at a distance, the paper re-assesses the claims of B. J. T. Dobbs that Newton’s important manuscript, De gravitatione et aequipondio fluidorum, was written, not in the late 1660s or early 1670s as was previously supposed, but during the composition of the Principia, in 1684 or 1685.Keywords: Isaac Newton; Action-at-a-distance; Gravity; Force; Aether; Attraction. (shrink)

Having been neglected or maligned for most of this century, Newton's method of 'deduction from the phenomena' has recently attracted renewed attention and support. John Norton, for example, has argued that this method has been applied with notable success in a variety of cases in the history of physics and that this explains why the massive underdetermination of theory by evidence, seemingly entailed by hypothetico-deductive methods, is invisible to working physicists. This paper, through a detailed analysis of (...) class='Hi'>Newton's deduction of one particular 'proposition' in optics 'from the phenomena', gives a clearer account than hitherto of the method - highlighting the fact that it is really one of deduction from the phenomena plus 'background knowledge'. It argues, that, although the method has certain heuristic virtues, examination of its putative accreditational strengths reveals a range of important problems that its defenders have yet adequately to address. (shrink)

In the paper of Brown and Priest 2004, the authors developed the chunk and permeate method, which they described as a ?paraconsistent reasoning strategy?. There it is suggested that the method of chunk and permeate could apply to the historical infinitesimal calculus. However, no attempt was made to look at actual historical examples. In this paper, I show that the method of chunk and permeate can indeed apply, as a rational reconstruction, to certain of Isaac Newton's arguments that use (...) infinitesimals. This rational reconstruction maintains and uses, rather than sidesteps, the apparent contradictions in Newton's arguments. The applicability of chunk and permeate to other historical arguments, e.g. of Leibniz/L'Hospital and Fermat, has also been investigated and will be communicated in future publications. (shrink)

Una de las principales razones para el éxito de la filosofía natural de Newton fue el papel que ésta tuvo al desarrollar una teología natural valiosa. Además, Newton mismo publicó las implicaciones teológicas de su propia filosofía natural. Aunque en la primera edición de los Principia no hay ninguna señal de Dios, para la segunda edición (1713) Newton introdujo un "Escolio General" en el que explícitamente discutía la relación entre Dios y su Creación. La obsesión de (...) class='Hi'>Newton por la interpretación de las Escrituras durante algún tiempo fue desestimada como embarazosa. Sin embargo, su importancia para una comprensión adecuada de Newton ahora se reconoce y estimula mucha actividad nueva entre los especialistas. El significado de este trabajo permite ver en la actualidad el núcleo de la pregunta de Richard H. Popkin: “¿por qué uno de los más grandes teólogos anti-Trinitarios se dedicó a escribir obras de filosofía natural, como los Principia Mathematica? (shrink)

One of the most noticeable features of the book of Revelation is the ubiquity of arithmetic in the text. In this article, I survey the arithmetical functions found in the text (not only numbers but functions such as multiplication and applied mathematics, such as measurements), and note some patterns in John’s use of numbers. Then the article explores precedents in the Hebrew Scriptures, Hellenistic culture (including astrology) and Jewish apocalyptic literature. I argue rhetorical criticism helps us identify what (...) class='Hi'>John is trying to do with his apocalyptic arithmetic. I draw on theological analysis, literary analysis (particularly the “writerly” nature of the text with its missing pieces for the audience to fill in) and especially intertextuality to understand his rhetorical strategy. I discuss various numbers but focus especially on ten and two passages (Rev 14:20 and 12:1-6) as examples of John’s use of numbers and arithmetical functions. I conclude that John uses arithmetic to support his Christocentric narrative and worldview in addressing his Jewish and Greek audience. (shrink)

Most of us believe that theory-change in science has been a rationally analysable process. We believe, that is, that when one theory, Newton’s for example, is replaced as the accepted theory in science by a rival, Einstein’s in the same example, it is because the newer theory turns out to be better than the old in some objective sense and a sense, moreover, crucially related to the experimental evidence. Even those who have abjectly surrendered (at any rate on Mondays, (...) Wednesdays and Fridays) to an overly subjectivist form of Bayesianism, believe this really – hence their desperate pointing in the direction of (in my view, unavailing) results concerning the ‘washing out of priors’. The problem has always been to construct a set of agreed criteria of theory-appraisal that would convincingly yield this generally agreed result. (Of course by ‘most of us’ here I mean ‘most philosophers of science’; nothing I say will cut much ice with some of our benighted sociologist colleagues.). (shrink)

The concepts of action and reaction before Newton have received so little attention from historians that the unwary student might easily get the impression that Newton was the first to concern himself seriously with the problem. In fact, the subject had a long prehistory extending back to Aristotle and it was actively discussed by physicists during the half-century preceding the publication of Principia mathematica in 1687. Although there is no evidence that Newton himself was much influenced by (...) the views of others on the subject, they formed a part of the intellectual background of the Principia which should not be ignored. (shrink)

The essays included in this volume are concerned with assessing Newton's contribution to the thought of others. They explore all aspects of the conceptual background-historical, philosophical, and narrowly methodological-and examine questions that developed in the wake of Newton's science.