The lottery preparation, a new general kind of Laver preparation, works uniformly with supercompact cardinals, strongly compact cardinals, strong cardinals, measurable cardinals, or what have you. And like the Laver preparation, the lottery preparation makes these cardinals indestructible by various kinds of further forcing. A supercompact cardinal κ, for example, becomes fully indestructible by <κ-directed closed forcing; a strong cardinal κ becomes indestructible by κ-strategically closed forcing; and a strongly compact cardinal κ becomes indestructible by, among others, the forcing to (...) add a Cohen subset to κ, the forcing to shoot a club Cκ avoiding the measurable cardinals and the forcing to add various long Prikry sequences. The lottery preparation works best when performed after fast function forcing, which adds a new completely general kind of Laver function for any large cardinal, thereby freeing the Laver function concept from the supercompact cardinal context. (shrink)

In an attempt to bridge the vast divide between classical Asian thought and contemporary Western philosophy, Joel J. Kupperman finds that the two traditions do not, by and large, supply different answers to the same questions. Rather, each tradition is searching for answers to their own set of questions--mapping out distinct philosophical investigations. In this groundbreaking book, Kupperman argues that the foundational Indian and Chinese texts include lines of thought that can enrich current philosophical practice, and in some cases (...) provide uniquely sophisticated insights. Special attention is given to the ethical issues of formation and fluidity of self, the nature and possibilities of choice, the compartmentalization of life implicit in some ethical systems, the variations of ethical demands from person to person, and the nature of philosophy itself as a communicative activity. This study will provide a wealth of information for philosophers seeking a closer knowledge of Asian philosophy and general readers with an interest in Eastern thought. (shrink)

We analyze the expressivity, succinctness, and complexity of a family of languages based on weighted propositional formulas for the representation of utility functions. The central idea underlying this form of preference modeling is to associate numerical weights with goals specified in terms of propositional formulas, and to compute the utility value of an alternative as the sum of the weights of the goals it satisfies. We define a large number of representation languages based on this idea, each characterized by a (...) set of restrictions on the syntax of formulas and the range of weights. Our aims are threefold. First, for each language we try to identify the class of utility functions it can express. Second, when different languages can express the same class of utility functions, one may allow for a more succinct representation than another. Therefore, we analyze the relative succinctness of languages. Third, for each language we study the computational complexity of the problem of finding the most preferred alternative given a utility function expressed in that language. (shrink)

Experimental taxonomy was a diverse area of research, and botanists who helped develop it were motivated by a variety of concerns. While experimental taxonomy was never totally a taxonomic enterprise, improvement in classification was certainly one major motivation behind the research. Hall's and Clements' belief that experimental methods added more objectivity to classification was almost universally accepted by experimental taxonomists. Such methods did add a new dimension to taxonomy — a dimension that field and herbarium studies, however rigorous, could not (...) duplicate. Nonetheless, experimental techniques were never completely divorced from traditional taxonomic methods. In practice, all experimental taxonomists employed a combination of descriptive and experimental methods. Most researchers freely acknowledged a debt to traditional taxonomy. Furthermore, the greater rigor of twentieth-century taxonomy was not due entirely to experimentalism. Both the experimental and descriptive aspects of taxonomy were improved by the increased use of quantitative methods, particularly statistics.52From the beginning, a number of experimental taxonomists were interested primarily in classification. But many approached their research from fields other than taxonomy. These botanists were concerned primarily with ecological and genetic problems rather than with classification. There is little indication that they drew a sharp distinction: for example, taxonomic and cytogenetic conclusions were interwoven in Babcock and Stebbins' 1938 study of Crepis 53 (this was even more true of Babcock's final mongraph on the genus, published in 1947). Similarly, the extensive series of monographs, “Experimental Studies on the Nature of Species,” initiated by the Carnegie Institution group in 1940 combined ecological, cytogenetic, and taxonomic conclusions. Indeed, the significance of the major projects completed by experimental taxonomists was largely due to the fact that they were comprehensive studies rather than strictly taxonomic or cytogenetic.In a general sense, the primary motivation behind much of experimental taxonomy was evolutionary. Beginning in the second decade of the century Hall and Clements exhorted taxonomists to take an explicitly evolutionary perspective on research. Hall undoubtedly spoke for the majority of experimental taxonomists when he stated, “If there be anything at all to organic evolution, then taxonomy is dealing with the products of evolution and it is this that gives to taxonomy both its highest mission and its greatest responsibility.”54Aside from a common interest in evolution, however, the theoretical orientations of experimental taxonomists were varied. This diversity is strikingly illustrated by the evolutionary views of members of the Carnegie Institution research group. Experimental taxonomy was initiated by Clements as one aspect of his Lamarckian study of adaptation and speciation. In contrast, Hall's research was inspired by a broad concern for evolutionary problems. Hall rarely referred to specific evolutionary mechanisms; rather, he applied a general conception of evolutionary processes to deduce phylogenetic relationships. His later associates at the Carnegie Institution explicitly dissociated themselves from Clements' theoretical framework. The neo-Darwinian interpretations of adaptation and speciation presented by Clausen, Keck, and Hiesey could hardly have been more different than those of Clements. However, this major shift in theoretical orientation should not obscure significant similarities between the research of Clements and later Carnegie workers. In terms of research problems and methodology, the first volume of “Experimental Studies on the Nature of Species” was an extension of the Clementsian research program. Clausen, Keck, and Hiesey's monograph was the mature discussion of transplant experimentation that Clements had very tentatively initiated during the first decades of the twentieth century. The bond that linked the members of the Carnegie Institution research group to experimental taxonomists in general was one of shared methodology rather than common theoretical orientation. While Clements' evolutionary views were eventually repudiated, his enthusiasm for innovative experimental methods was shared by later workers.The development of experimental taxonomy faced significant problems. During the period 1920–1950 this area of botanical research remained a hybrid discipline. The aims and scope of experimental taxonomy were never articulated in a completely unified manner. Consequently, even among experimental taxonomists, there were disagreements over the relation of their research to other botanical endeavors. Even though experimental taxonomy had close ties with general taxonomy, a number of experimental taxonomists questioned the “taxonomic” nature of their research55. Even to the extent that this hybrid discipline could be identified as a branch of taxonomy, problems arose. Taxonomists, as we have seen, were justifiably skeptical of what appeared to be a rapid influx of untested methods and ideas. Experimental taxonomists were not merely incorporating well-accepted methods from ecology and cytogenetics; during the period 1920–1950 the fields from which experimental taxonomists borrowed were themselves undergoing major theoretical and methodological changes. Despite problems and conflicts, experimental taxonomists did contribute improvements to classification. Furthermore, they made significant contributions to plant ecology and evolutionary genetics.The development of experimental taxonomy indicates that twentieth-century botanists were not necessarily isolated in naturalist and experimentalist camps. The joint session of taxonomists, cytologists, and geneticists at the 1926 International Congress of Plant Sciences indicates communication among specialists fairly early in the century. The papers and commentaries presented during this session do not reveal the hostility and intolerance that supposedly characterized encounters between experimentalists and naturalists. Nor do they suggest incompatible conceptual worlds separating geneticists and taxonomists.Discussions between taxonomists and other specialists were not limited to a single international congress. Particularly during the 1930s discussions among specialists appear to have been fairly widespread. Groups such as the Biosystematists and the Society for the Study of Systematics in Relation to General Biology served as forums for discussion among biologists from a variety of disciplines. The naturalist-experimentalist dichotomy tends to obscure the broad research interests of a number of prominent twentieth-century botanists. Most of the experimental taxonomists cannot be characterized adequately as either naturalists or experimentalists. Traditionally trained taxonomists such as Hall, Keck, and Turrill throughout their careers participated in both experimental and herbarium research. And a number of specialists in fields other than taxonomy took an active interest in taxonomic problems, not necessarily limited to experimental aspects. For example, Anderson suggested a number of innovations to make herbarium collections more amenable to statistical analysis.This historical study of experimental taxonomy indicates a different relationship between experimentalism and taxonomy than that portrayed by the naturalist-versus-experimentalist dichotomy. F. E. Clements originated experimental taxonomy as a revolt against descriptive botany. In retrospect, this revolution was not vigorously waged and was not successfully completed. Experimental taxonomy was never an entirely experimental approach to botanical research. Even the most ardent advocates of experimentalism relied heavily on methods inherited from traditional taxonomy. Moderate exponents of experimental taxonomy stressed the compatibility of experimental methods, field observation, and herbarium techniques. Attempts to fuse cytogenetics, ecology, and taxonomy during the period 1920–1950 resulted in an impressive body of research. However, this fusion constituted neither a repudiation of descriptive botany nor a complete revision of taxonomic theory of practice. (shrink)

Biologists and historians often present natural history and molecular biology as distinct, perhaps conflicting, fields in biological research. Such accounts, although supported by abundant evidence, overlook important areas of overlap between these areas. Focusing upon examples drawn particularly from systematics and molecular evolution, I argue that naturalists and molecular biologists often share questions, methods, and forms of explanation. Acknowledging these interdisciplinary efforts provides a more balanced account of the development of biology during the post-World War II era.

We introduce the resurrection axioms, a new class of forcing axioms, and the uplifting cardinals, a new large cardinal notion, and prove that various instances of the resurrection axioms are equiconsistent over ZFC with the existence of an uplifting cardinal.

Kant's introduction of a distinctive form of philosophical investigation and proof, known as transcendental, inaugurated a new philosophical tradition. Transcendental Philosophy and Naturalism assesses the present state and contemporary relevance of this tradition. The contributors aim to understand the theoretical structures involved in transcendental explanation, and to assess the contemporary relevance of the transcendental orientation, in particular with respect to contemporary philosophical naturalism. These issues are approached from both naturalistic and transcendental perspectives.

A cardinal κ is tall if for every ordinal θ there is an embedding j: V → M with critical point κ such that j > θ and Mκ ⊆ M. Every strong cardinal is tall and every strongly compact cardinal is tall, but measurable cardinals are not necessarily tall. It is relatively consistent, however, that the least measurable cardinal is tall. Nevertheless, the existence of a tall cardinal is equiconsistent with the existence of a strong cardinal. Any tall cardinal (...) κ can be made indestructible by a variety of forcing notions, including forcing that pumps up the value of 2κ as high as desired. (shrink)

We introduce the $\Sigma _1$ -definable universal finite sequence and prove that it exhibits the universal extension property amongst the countable models of set theory under end-extension. That is, the sequence is $\Sigma _1$ -definable and provably finite; the sequence is empty in transitive models; and if M is a countable model of set theory in which the sequence is s and t is any finite extension of s in this model, then there is an end-extension of M to a (...) model in which the sequence is t. Our proof method grows out of a new infinitary-logic-free proof of the Barwise extension theorem, by which any countable model of set theory is end-extended to a model of $V=L$ or indeed any theory true in a suitable submodel of the original model. The main theorem settles the modal logic of end-extensional potentialism, showing that the potentialist validities of the models of set theory under end-extensions are exactly the assertions of S4. Finally, we introduce the end-extensional maximality principle, which asserts that every possibly necessary sentence is already true, and show that every countable model extends to a model satisfying it. (shrink)

Background: While the solid organ transplant evaluation process is designed to function equitably, discriminatory practices remain, resulting in disparities in access for persons with disabilities. Physical function and frailty status are often-cited factors in establishing transplant, despite limited consensus on their assessment and impact. Objective: The purpose of this study was to describe how transplant healthcare professionals conceptualize the relationship between physical disability and transplant candidacy. Methods: A convenience sample of multidisciplinary transplant was solicited to respond to an electronic survey (...) between February and March 2024. Results: Of the 126 professionals contacted, 43 participants responded, yielding a response rate of 34 %. The majority of participants (88 %) held contradictory views of physical disability as it relates to transplant candidacy (p = 0.049). Men were more likely to endorse awareness of bias when evaluating transplant candidates (p = 0.008). Professional discipline was significantly associated with perception of transplant process fairness, impact of bias, and interpretation of quality of life. Iterative thematic analysis revealed a propensity to conflate frailty with physical disability. Conclusions: Multidisciplinary transplant professionals rarely endorsed overtly ableist sentiments. However, responses highlighted inconsistent, unclear, and at times contradictory conceptions of physical function and physical disability, which may contribute to disparate access to solid organ transplant for individuals with physical disability. (shrink)

The Gap Forcing Theorem, a key contribution of this paper, implies essentially that after any reverse Easton iteration of closed forcing, such as the Laver preparation, every supercompactness measure on a supercompact cardinal extends a measure from the ground model. Thus, such forcing can create no new supercompact cardinals, and, if the GCH holds, neither can it increase the degree of supercompactness of any cardinal; in particular, it can create no new measurable cardinals. In a crescendo of what I call (...) exact preservation theorems, I use this new technology to perform a kind of partial Laver preparation, and thereby finely control the class of posets which preserve a supercompact cardinal. Eventually, I prove the ‘As You Like It’ Theorem, which asserts that the class of κ -directed closed posets which preserve a supercompact cardinal κ can be made by forcing to conform with any pre-selected local definition which respects the equivalence of forcing. Along the way I separate completely the levels of the superdestructibility hierarchy, and, in an epilogue, prove that the notions of fragility and superdestructibility are orthogonal — all four combinations are possible. (shrink)

The twentieth century witnessed a dramatic increase in the use of statistics by biologists, including systematists. The modern synthesis and new systematics stimulated this development, particularly after World War II. The rise of "the statistical frame of mind " resulted in a rethinking of the relationship between biological and mathematical points of view, the roles of objectivity and subjectivity in systematic research, the implications of new computing technologies, and the place of systematics among the biological disciplines.

A pointwise definable model is one in which every object is \loos definable without parameters. In a model of set theory, this property strengthens $V=\HOD$, but is not first-order expressible. Nevertheless, if \ZFC\ is consistent, then there are continuum many pointwise definable models of \ZFC. If there is a transitive model of \ZFC, then there are continuum many pointwise definable transitive models of \ZFC. What is more, every countable model of \ZFC\ has a class forcing extension that is pointwise definable. (...) Indeed, for the main contribution of this article, every countable model of Gödel-Bernays set theory has a pointwise definable extension, in which every set and class is first-order definable without parameters. (shrink)

Using the lottery preparation, we prove that any strongly unfoldable cardinal $\kappa$ can be made indestructible by all.

This fresh and engaging work by noted philosopher Joel Kupperman centers on "value"--in the sense of what is worth having or worthy being in life. Kupperman looks first at how judgments of values manifest themselves, whether there can be evidence for them, and whether a realistic account is appropriate. Kupperman then goes on to examine the relations between judgments of value and those of what it is best to do, and whether value has any proper role in social policy. (...) Kupperman rejects the notion that there is any one primary value, and argues instead for a pluralistic understanding of value. He contends that value must be viewed as strongly contextual; the value of a particular set of experiences in one's life can depend heavily on how they fit in or provide contrast with other elements. (shrink)

Applying the seed concept to Prikry tree forcing P μ , I investigate how well P μ preserves the maximality property of ordinary Prikry forcing and prove that P μ Prikry sequences are maximal exactly when μ admits no non-canonical seeds via a finite iteration. In particular, I conclude that if μ is a strongly normal supercompactness measure, then P μ Prikry sequences are maximal, thereby proving, for a large class of measures, a conjecture of W. Hugh Woodin's.

In the second half of this essay, we continue our reading of Leo Strauss’ important later essay on Maimonides, ‘How to Begin to Study the Guide of the Perplexed’. Our method is to try, as best as we are able, to read this essay as Strauss directs us to read esoteric texts in Persecution and the Art of Writing. As a means of testing and attempting to confirm our reading of this difficult later essay on Maimonides, we will close by (...) situating our reading of ‘How to Begin to Study’ and Strauss’ partly concealed positions there on philosophy, prophecy and the Torah alongside the claims of his earlier, much less esoteric, but also rarely studied 1930s essay: ‘Some Remarks on the Political Science of Maimonides and Farabi’. Because of the widely recognised foundational importance of Maimonides in understanding Leo Strauss’ own lasting positions, this work aims at making a contribution to the continuing, and presently highly contentious, task of trying to understand Strauss’ thoughts on Athens and Jerusalem, reason and revelation, the city and man. (shrink)

Beginning in the mid-1930s the comparative physiologists Laurence Irving and Per Fredrik Scholander pioneered the study of diving mammals, particularly harbor seals. Although resting on earlier work dating back to the late nineteenth century, their research was distinctive in several ways. In contrast to medically oriented physiology, the approaches of Irving and Scholander were strongly influenced by natural history, zoology, ecology, and evolutionary biology. Diving mammals, they argued, shared the cardiopulmonary physiology of terrestrial mammals, but evolution had modified these basic (...) adaptive processes in extreme ways. In particular, seals’ remarkable ability to hold breath, lower metabolism, produce energy anaerobically, and resist asphyxiation, provided a sharp contrast with terrestrial mammals, including humans. This diving physiology was an extreme elaboration of a general regulatory mechanism that allowed seals and other diving mammals to remain active underwater for extended periods. The decrease in heart rate referred to as bradycardia or the “diving reflex” was highly developed in diving mammals, but also found in less developed form in many other organisms faced by asphyxia. It therefore served as a kind of “master switch” for lowering metabolism in diving, hibernation, parturition, drowning, and other physiological responses involving lack of oxygen. Studying bradycardia unified a wide diversity of physiological phenomena, while also providing a context for contrasting the physiological responses of various species, including humans. Conducted in the laboratory and the field, this research served as a bridge between a comparative physiological ecology focused on non-human species and a human-centered general physiology. (shrink)

Ecology has often been characterized as an immature scientific discipline. This paper explores some of the sources of this alleged immaturity. I argue that the perception of immaturity results primarily from the fact that historically ecologists have based their work upon two very different approaches to research.

If the Wholeness Axiom wa $_0$ is itself consistent, then it is consistent with v=hod. A consequence of the proof is that the various Wholeness Axioms are not all equivalent. Additionally, the theory zfc+wa $_0$ is finitely axiomatizable.

During the decades following World War II diverse groups of American biologists established a variety of distinctive approaches to organismal biology. Rhetorically, organismal biology could be used defensively to distinguish established research traditions from perceived threats from newly emerging fields such as molecular biology. But, organismal biologists were also interested in integrating biological disciplines and using a focus on organisms to synthesize levels of organization from molecules and cells to populations and communities. Part of this broad movement was the development (...) of an area of research variously referred to as physiological ecology, environmental physiology, or ecophysiology. This area of research was distinctive in its self-conscious blend of field and laboratory practices and its explicit integration with other areas of biology such as ecology, animal behavior, and evolution in order to study adaptation. Comparing the intersecting careers of Knut Schmidt-Nielsen and George Bartholomew highlights two strikingly different approaches to physiological ecology. These alternative approaches to studying the interactions of organisms and environments also differed in important ways from the organismal biology championed by leading figures in the modern synthesis. (shrink)

The distinction between taxonomic plant geography and ecological plant geography was never absolute: it would be historically inaccurate to portray them as totally divergent. Taxonomists occasionally borrowed ecological concepts, and ecologists never completely repudiated taxonomy. Indeed, some botanists pursued the two types of geographic study. The American taxonomist Henry Allan Gleason (1882–1975), for one, made noteworthy contributions to both. Most of Gleason's research appeared in short articles, however. He never published a major synthetic work comparable in scope or influence to (...) the ecological texts of Clements, Schimper, and Warming.Despite exceptions such as Gleason, most plant geographers throughout the twentieth century have emphasized the distinction between ecological and taxonomic plant geographies. Why have these distinct traditions developed? In his book Geographical Ecology, Robert MacArthur has suggested a psychological explanation for the dichotomy: “Unraveling the history of a phenemenon has always appealed to some people and describing the machinery of the phenomenon to others... The ecologist and physical scientist tend to be machinery oriented, whereas paleontologists and most biogeographers tend to be history oriented.”46Without necessarily rejecting MacArthur's explanation, my study suggests a more complex relationship between taxonomic and ecological plant geographies. At the turn of the century a group of botanists self-consciously defined a new area of botanical research. These ecologists defined their new discipline in opposition to what they believed was a moribund, nineteenth-century, natural-history tradition. They turned from historically oriented, descriptive, taxonomic plant geography to experimental physiology. The new ecological plant geography was to focus on communities rather than on species, on proximate environmental causes rather than on historical explanations, and on physiological experiments rather than on morphological descriptions.As we look back, much of the “revolt from morphology” was rhetorical. Ecologists never completely replaced species as units of distribution, nor did they set geography on an explicitly physiological basis. Indeed, much of early ecological research was, quite simply, descriptive. Plant communities were defined in terms of dominant species, representative life forms, or general physiognomy. The underlying physiological basis for community characteristics was more often assumed than demonstrated by experiments.Despite the fact that ecological plant geography was not a truly physiological specialty, it was significantly different from more traditional taxonomic plant geography. First, ecologists were less explicitly evolutionary in their approach than were taxonomists. Following Darwin, most taxonomic plant geographers viewed distribution in historical terms. In contrast, early ecologists tended to ignore the traditional geographic problems. Most ecologists were skeptical of historical explanations, emphasizing instead the proximate, environmental causes of distribution. While some nineteenth-century biogeographers had studied the correlation between climate and vegetation, twentieth-century ecologists focused much more sharply on the interactions between plant and environment. Plant ecologists did not place biogeography on a physiological basis, but by emphasizing physiology they laid the foundation for a more detailed understanding of adaption. This emphasis on physiology and environmental causation was a second distinguishing characteristic of ecological plant geography. Finally, the idea of the plant community, articulated by Eugenius Warming in 1895, provided ecologists with a unique perspective on the distribution of plants. For early ecologists, the community was more than an assemblage of species; it was an integrated unit. The distribution of these units became the major focus of ecological plant geography. Communities never completely replaced species as geographic units, and the distinction between flora and vegetation was often blurred. Nonetheless, ecologists were innovative in studying the distribution of structurally and functionally integrated groups of plants.In the twentieth century plant geography has occupied an anomalous position in biology. It has not developed into an autonomous discipline, nor has it been incorporated into the developing discipline of ecology. Ecologists and taxonomists have pursued fairly distinct styles of geographic research, with the result that two relatively independent approaches to the study of plant distribution have persisted. (shrink)

Unfoldable cardinals are preserved by fast function forcing and the Laver-like preparations that fast functions support. These iterations show, by set-forcing over any model of ZFC, that any given unfoldable cardinal κ can be made indestructible by the forcing to add any number of Cohen subsets to κ.

Bergmann’s rule and Allen’s rule played important roles in mid-twentieth century discussions of adaptation, variation, and geographical distribution. Although inherited from the nineteenth-century natural history tradition these rules gained significance during the consolidation of the modern synthesis as evolutionary theorists focused attention on populations as units of evolution. For systematists, the rules provided a compelling rationale for identifying geographical races or subspecies, a function that was also picked up by some physical anthropologists. More generally, the rules provided strong evidence for (...) adaptation by natural selection. Supporters of the rules tacitly, or often explicitly, assumed that the clines described by the rules reflected adaptations for thermoregulation. This assumption was challenged by the physiologists Laurence Irving and Per Scholander based on their arctic research conducted after World War II. Their critique spurred a controversy played out in a series of articles in Evolution, in Ernst Mayr’s Animal Species and Evolution, and in the writings of other prominent evolutionary biologists and physical anthropologists. Considering this episode highlights the complexity and ambiguity of important biological concepts such as adaptation, homeostasis, and self-regulation. It also demonstrates how different disciplinary orientations and styles of scientific research influenced evolutionary explanations, and the consequent difficulties of constructing a truly synthetic evolutionary biology in the decades immediately following World War II. (shrink)

Numerous writers on photography and motion pictures have claimed that photographically originated pictures are essentially different from handmade pictures. Arguments made on behalf of the essential difference of photographs from other kinds of pictures generally depend upon one or another of two models of the photographic process: the visual model claims that photographs are closely allied to vision and show what we would have seen from the standpoint of the camera at the time of exposure; the mechanical or automatic model (...) claims that irrespective of what a photograph looks like, it is a reliable index of what was the case at the moment of exposure. Each of these models is examined and shown to be faulty on either or both factual and/or conceptual grounds. Stanley Cavell's assertions about the "automatic" nature of photography are examined in some detail and shown to be either equivocal or false. It is suggested, in closing, that sharp, categorial differences between photographs and handmade pictures do not exist and that questions about the differences between photographs and, say, paintings, can be solved only within the context of viewing particular photographs and particular paintings. In sum, claims about the ontological distinctions between photographs and handmade pictures cannot be warranted. (shrink)

There are more than 350,000 health apps available in public app stores. The extolled benefits of health apps are numerous and well documented. However, there are also concerns that poor-quality apps, marketed directly to consumers, threaten the tenets of evidence-based medicine and expose individuals to the risk of harm. This study addresses this issue by assessing the overall quality of evidence publicly available to support the effectiveness claims of health apps marketed directly to consumers. To assess the quality of evidence (...) available to the public to support the effectiveness claims of health apps marketed directly to consumers, an audit was conducted of a purposive sample of apps available on the Apple App Store. We find the quality of evidence available to support the effectiveness claims of health apps marketed directly to consumers to be poor. Less than half of the 220 apps (44%) we audited state that they have evidence to support their claims of effectiveness and, of these allegedly evidence-based apps, more than 70% rely publicly on either very low or low-quality evidence. For the minority of app developers that do publish studies, significant methodological limitations are commonplace. Finally, there is a pronounced tendency for apps—particularly mental health and diagnostic apps—to either borrow evidence generated in other (typically offline) contexts or to rely exclusively on unsubstantiated, unpublished user metrics as evidence to support their effectiveness claims. Health apps represent a significant opportunity for individual consumers and healthcare systems. Nevertheless, this opportunity will be missed if the health apps market continues to be flooded by poor quality, poorly evidenced, and potentially unsafe apps. It must be accepted that a continuing lag in generating high-quality publicly available evidence of app effectiveness and safety is not inevitable: it is a choice. Just because it will be challenging to raise the quality of the evidence base publicly available to support the claims of health apps, this does not mean that the bar for evidence quality should be lowered. Innovation for innovation’s sake must not be prioritized over public health and safety. (shrink)

If G is a centreless group, then τ denotes the height of the automorphism tower of G. We prove that it is consistent that for every cardinal λ and every ordinal α<λ, there exists a centreless group G such that τ=α; and if β is any ordinal such that 1β<λ, then there exists a notion of forcing , which preserves cofinalities and cardinalities, such that τ=β in the corresponding generic extension.

The infinite time Turing machine analogue of Post's problem, the question whether there are semi-decidable supertask degrees between 0 and the supertask jump 0∇, has in a sense both positive and negative solutions. Namely, in the context of the reals there are no degrees between 0 and 0∇, but in the context of sets of reals, there are; indeed, there are incomparable semi-decidable supertask degrees. Both arguments employ a kind of transfinite-injury construction which generalizes canonically to oracles.

A variety of cases of scientific misconduct have been documented since the 1980s among biological scientists. These cases have focused the attention of the public and scientific community on this behavior and made it the centerpiece of the concern about ethics in the biological sciences. In contrast, the ethics movement in clinical medicine, which arose in the 1960s, was not basically directed at the problems of wrong-doing. Instead it concentrated on the difficult ethical choices that had to be made In (...) the practice of medicine.In this essay, I discuss the two movements. The attention given to misconduct In the biological sciences has become excessive and diverts its ethics movement from exploring and teaching about the difficult ethical decisions scientists must make in weighing obligations to self, science, and society. A more balanced and selective approach to developing an ethical framework in the biological sciences is needed. (shrink)

This article examines the changing status of tropical biology by considering the origins and early development of the Barro Colorado Island Biological Laboratory. Today the laboratory is part of a large diversified tropical research center operated by the Smithsonian Institution. However, for most of its history the laboratory led a tenuous existence. Both the early problems and eventual success of the institution can only be explained by considering the interaction of various intellectual, institutional, and broader social factors.

Compassion is a prosocial motivation that is critical to the development and survival of the human species. Cultivating compassion involves developing deep wisdom, insight, and understanding into the nature and causes of human suffering; and wisdom and commitment to take positive action to alleviate suffering. This perspective piece discusses how compassion relates to the context of modern technology, which has developed at a rapid pace in recent decades. While advances in digital technology build on humankind’s vast capacity to develop practical (...) tools that promise to enrich our lives and improve our social connections, in reality the effects are often far from benign. The motives underlying the development of many contemporary digital platforms seem rooted in competitiveness and capitalism; while modern social media and online platforms are having a profound and pervasive impact on the mental health and wellbeing of humans around the globe. Nonetheless, digital technology holds considerable potential to promote compassionate insight, wisdom, and prosocial behavior. We reflect on the current state of technology within human society and examine the notion of compassionate technologies; discuss how contemporary paradigm shifts such as the inclusive design movement may be harnessed to build tools and platforms that promote collective good and increase prosocial behavior; and highlight examples of initiatives that are harnessing modern technology to advance democracy, collective knowledge, and personal freedoms and agency. (shrink)

Une part substantielle de la réflexion philosophique est née et s'est développée aux confins de la science. Depuis l'aube de la philosophie, on ne peut faire l'économie des mathématiques, de l'astronomie, de l'optique... si l'on veut comprendre les voies empruntées par les philosophes et les modèles qu'ils ont élaborés. Cette étude examine quelques-uns de ces liens jusqu'à l'âge moderne.

H. B. D. Kettlewell's field experiments on industrial melanism in the peppered moth, Biston betularia, have become the best known demonstration of natural selection in action. I argue that textbook accounts routinely portray this research as an example of controlled experimentation, even though this is historically misleading. I examine how idealized accounts of Kettlewell's research have been used by professional biologists and biology teachers. I also respond to some criticisms of David Rudge to my earlier discussions of this case study, (...) and I question Rudge's claims about the importance of purely observational studies for the eventual acceptance and popularization of Kettlewell's explanation for the evolution of industrial melanism. (shrink)