Microbes in the gastrointestinal tract are under selective pressure to manipulate host eating behavior to increase their fitness, sometimes at the expense of host fitness. Microbes may do this through two potential strategies: (i) generating cravings for foods that they specialize on or foods that suppress their competitors, or (ii) inducing dysphoria until we eat foods that enhance their fitness. We review several potential mechanisms for microbial control over eating behavior including microbial influence on reward and satiety pathways, production of (...) toxins that alter mood, changes to receptors including taste receptors, and hijacking of the vagus nerve, the neural axis between the gut and the brain. We also review the evidence for alternative explanations for cravings and unhealthy eating behavior. Because microbiota are easily manipulatable by prebiotics, probiotics, antibiotics, fecal transplants, and dietary changes, altering our microbiota offers a tractable approach to otherwise intractable problems of obesity and unhealthy eating. (shrink)

"He completed the assignment in two phases: The photographs made during the first phase capture the natural ruggedness of the terrain and establish its relationship to the developed neighboring enclaves. Those made during the second phase not only record the actual construction process but also reveal Deal's personal perspective on the qualities of light and the creation of form. Represented in this book as a selection from the resulting portfolio, Topos, a Greek word meaning place, site, position, and occasion - (...) Deal's artistic legacy to the Gerry Center."--BOOK JACKET. (shrink)

One of the central issues dividing proponents of metaphysical interpretations of transcendental idealism concerns Kant’s views on the distinctness of things in themselves and appearances. Proponents of metaphysical one-object interpretations claim that things in themselves and appearances are related by some kind of one-object grounding relation, through which the grounding and grounded relata are different aspects of the same object. Proponents of metaphysical two-object interpretations, by contrast, claim that things in themselves and appearances are related by some kind of two-object (...) grounding relation, through which the grounding and grounded relata involve distinct objects. By way of investigating Kant’s overarching account of grounding, I will argue that the most plausible metaphysical interpretation of transcendental idealism is one on which we can know that there are things in themselves grounding appearances, but not which specific kind of one- or two-object grounding relation obtain between them. Our ignorance of things in themselves therefore extends to their distinctness from appearances — pace both metaphysical one-object interpretations and metaphysical two-object interpretations. (shrink)

Although widely accepted to be the capacity to exercise control in one’s learning, there remains confusion about what exactly this means. Failure to reconcile contradictions has left the field resigned to pluralism, describing ‘versions’ of learner autonomy according to divergent theoretical orientations. However, each version is incomplete, rendering it unreliable as a basis for practice: educational initiatives that seek to foster learner autonomy from one perspective, run the risk of inadvertently undermining it from another. In an attempt to rectify this, (...) I turn to philosophies of personal autonomy, which I analyse in relation to learner autonomy to identify criteria for its achievement, regardless of version. If we acknowledge that learners are ever embodied, emplaced and sociohistorically situated, as we must, learning is a process of identity construction in relation to context. To be in control of this process is to define ourselves in terms of authentic values, the expression of which may require resolve to stay one’s path or resistance to pressure to act otherwise, all of which is contingent on affordances and constraints that are inherent to our embodied, emplaced and sociohistorical constitution. I examine the implications of this theory for practice within educational institutions. (shrink)

Most business ethicists maintain that corporate actors are subject to a variety of moral obligations. However, there is a persistent and underappreciated concern that the competitive pressures of the market somehow provide corporate actors with a far-reaching excuse from meeting these obligations. Here, we assess this concern. Blending resources from the history of philosophy and strategic management, we demonstrate the assumptions required for and limits of this excuse. Applying the idea of ‘the state of nature’ from Thomas Hobbes, we suggest (...) that corporate actors would be excused from duties if complying with them threatened their vital interests. We show how this excuse is not available for most individuals within firms; instead, it is an excuse perhaps available to firms themselves, but only given substantive assumptions about corporate personhood. For those willing to make these assumptions, we apply the competitive advantage construct to delimit the scope of this excuse. We suggest that firms are excused from fulfilling an obligation when complying leads to a competitive disadvantage, as this imperils the firm’s vital interests. After revealing why this excuse does not generalize, we conclude by considering when we should reform the market to avoid the legitimacy of this excuse. (shrink)

Content note: This paper discusses rape throughout.Abstract. In this paper, I consider arguments in favor of jury trials. While I find these generally persuasive, I argue that there can be cases where juries are not fit for purpose. In those cases, I argue that they should be replaced by judge-only trials. In doing so, I propose a framework for determining whether a type of case is unsuitable for jury trials. Partly in response to low conviction rates, there have been recent (...) suggestions that rape trials should be conducted without juries. I suggest that there is strong evidence that these offences qualify under the criteria I have described. As a result, I argue that judge-only trials should be adopted for trying rape cases. (shrink)

Few fates seem worse than living without cause for hope. Yet what is it to have a cause for hope? And how is it related to having hope? Although these questions have received relatively little philosophical attention, I argue that Kant advances a rationalist account of hope that addresses them. My central thesis has two parts. First, hope is a rational attitude for Kant; certain rational conditions are needed to differentiate hope from other desiderative attitudes (such as mere wishing or (...) fantasizing). Second, these rational conditions involve causal inferences made by the hoping agent. To hope, an agent must make certain inferences about the cause of her desire and the cause of her belief that the object of her desire is possible. In short, to hope requires an agent to take herself to have a cause for hope. (shrink)

What awakened Kant from his dogmatic slumber? On the traditional narrative, he was awakened by Hume's challenge to our cognition of causal connections. A more recent narrative claims that he was awakened by Hume's challenge to our cognition of non‐logical connections more generally. In this paper, I argue that a key part of Kant's awakening was far wider‐reaching: he came to realize that all dogmas must be abandoned. An oft‐overlooked technical notion, dogmas are non‐logical principles cognizable to unaided human reason. (...) I detail how Kant repudiated dogmas by the mid‐1760's in engaging with his German predecessor, Christian Crusius. This repudiation lays the foundation for his critical project. For once liberated of dogmas, reason must look beyond itself for the principles that would enable rational cognitionof non‐logical connections. (shrink)

In recent philosophy of science there has been much discussion of both pluralism, which embraces scientific terms with multiple meanings, and eliminativism, which rejects such terms. Some recent work focuses on the conditions that legitimize pluralism over eliminativism – the conditions under which such terms are acceptable. Often, this is understood as a matter of encouraging effective communication – the danger of these terms is thought to be equivocation, while the advantage is thought to be the fulfilment of ‘bridging roles’ (...) that facilitate communication between different scientists and specialisms. These theories are geared towards regulating communication between scientists qua scientists. However, this overlooks an important class of harmful equivocation that involves miscommunication between scientists and nonscientists, such as the public or policymakers. To make my case, I use the example of theory of mind, also known as ‘mindreading’ and ‘mentalizing’, and broadly defined as the capacity to attribute mental states to oneself and others. I begin by showing that ‘theory of mind’ has multiple meanings, before showing that this has resulted in harmful equivocations of a sort and in a way not accounted for by previous theories of pluralism and eliminativism. (shrink)

This paper examines Pedro Tabensky's claims that rational human life has a single unifying purpose, and that there is an analogy between the skill of living and that of painting. It examines his arguments for the first claim, in particular the relation between ratio nality and different ways in which a life might be unified. For, in addition to the narrative or artistic unification which Tabensky favours, there is also (for example) the possibility of unifying one's life through the adoption (...) of a so-called monolithic end, such as pleasure (assuming that pleasure is monolithic). The paper also investigates the implications of each of these modes of unification for how we should understand the skill of living. According to the narrative or artistic model, living will indeed be like painting; however, according to the mono lithic-end model, living may be more like business management; and other models may make other analogies salient. All this will make a difference to our attitudes to events within our lives, for example, whether the inevitable disturbances within our lives are to be integrated or, rather, eliminated. S. Afr. J. Philos. Vol.23(4) 2004: 353-364. (shrink)

While public health organizations can detect disease spread, few can monitor and respond to real-time misinformation. Misinformation risks the public’s health, the credibility of institutions, and the safety of experts and front-line workers. Big Data, and specifically publicly available media data, can play a significant role in understanding and responding to misinformation. The Public Good Projects uses supervised machine learning to aggregate and code millions of conversations relating to vaccines and the COVID-19 pandemic broadly, in real-time. Public health researchers supervise (...) this process daily, and provide insights to practitioners across a range of disciplines. Through this work, we have gleaned three lessons to address misinformation. Sources of vaccine misinformation are known; there is a need to operationalize learnings and engage the pro-vaccination majority in debunking vaccine-related misinformation. Existing systems can identify and track threats against health experts and institutions, which have been subject to unprecedented harassment. This supports their safety and helps prevent the further erosion of trust in public institutions. Responses to misinformation should draw from cross-sector crisis management best practices and address coordination gaps. Real-time monitoring and addressing misinformation should be a core function of public health, and public health should be a core use case for data scientists developing monitoring tools. The tools to accomplish these tasks are available; it remains up to us to prioritize them. (shrink)

This chapter contains sections titled: Introduction Domesticated Democracy The Principle of Consensus as a Feature of Democracy Conclusion.

Policymakers who seek to make scientifically informed decisions are constantly confronted by scientific uncertainty and expert disagreement. This thesis asks: how can policymakers rationally respond to expert disagreement and scientific uncertainty? This is a work of non-ideal theory, which applies formal philosophical tools developed by ideal theorists to more realistic cases of policymaking under scientific uncertainty. I start with Bayesian approaches to expert testimony and the problem of expert disagreement, arguing that two popular approaches— supra-Bayesianism and the standard model of (...) expert deference—are insufficient. I develop a novel model of expert deference and show how it can deal with many of these problems raised for them. I then turn to opinion pooling, a popular method for dealing with disagreement. I show that various theoretical motivations for pooling functions are irrelevant to realistic policymaking cases. This leads to a cautious recommendation of linear pooling. However, I then show that any pooling method relies on value judgements, that are hidden in the selection of the scoring rule. My focus then narrows to a more specific case of scientific uncertainty: multiple models of the same system. I introduce a particular case study involving hurricane models developed to support insurance decision-making. I recapitulate my analysis of opinion pooling in the context of model ensembles, confirming that my hesitations apply. This motivates a shift of perspective, to viewing the problem as a decision theoretic one. I rework a recently developed ambiguity theory, called the confidence approach, to take input from model ensembles. I show how it facilitates the resolution of the policymaker’s problem in a way that avoids the issues encountered in previous chapters. This concludes my main study of the problem of expert disagreement. In the final chapter, I turn to methodological reflection. I argue that philosophers who employ the mathematical methods of the prior chapters are modelling. Employing results from the philosophy of scientific models, I develop the theory of normative modelling. I argue that it has important methodological conclusions for the practice of formal epistemology, ruling out popular moves such as searching for counterexamples. (shrink)

This collection assembles Church's referee reports, Fitch's 1963 paper, and nineteen new papers on the knowability paradox.

This article aims at throwing light on the connection between the municipal élite of Lanuvium and some members of Rome’s senatorial aristocracy. In particular, from the examination of the sources, a picture of a close tie between the Caecilii Metelli and the gentes Lanuvinae becomes apparent, allowing one to suppose that a patronage relationship existed between the powerful family and the municipium already in the 2nd century BC. At the beginning of the following century, the city of Lanuvium openly supported (...) Silla. The attitude of the Lanuvian community is characterized by the involvement of the Licinii Murenae in the Mithridatic War alongside the dictator. Further indications of the presence in the municipium of the Caecilii Metelli, particularly devoted to the poliadic goddess Iuno Sospita Mater Regina, can be found in the background of these events. (shrink)

The symmetry implications of the postulates of quantum theory are investigated.

Following the work of Philippe Lacoue-Labarthe, this essay argues that there is an implicit conception of mimesis operative in Heidegger’s conception of Dasein’s being-in-the-world. More specifically, it argues that an examination of Heidegger’s theory of repetition and play in relation to Dasein’s uncanniness illustrates Dasein’s tendency to turn away from mimesis and, instead, opt for the comfort of “mimetology,” the comfort of submitting to a levelled down identification with the ready-to-hand and the they-self. Ultimately this analysis, which itself performs a (...) mimetic re-reading of Being and Time, brings to the fore a counter-force within Heidegger’s thought that arguably resists what Lacoue-Labarthe calls Heidegger’s inadvertent reproduction of the metaphysics of presence and the worrisome political implications that attend it. Moreover, this re-reading suggests that, precisely when the implicit role of mimesis is emphasized, the temporal possibilities built into Dasein’s way of Being might also be understood in a new light. (shrink)

Concussive injuries to the head and brain are relatively common in the National Football League. This is not news, since the issue has been covered in many articles in the popular press and many news specials on television. As an NFL offensive lineman for 13 years, I suffered a huge number of hits to the head — an estimated 215,000 at least. Nevertheless, I have fared better than many of the players of my era: many suffered from chronic traumatic encephalopathy. (...) For example, some of my fellow Hall of Fame players from that era, Mike Webster, Jim Ringo, John Mackey, and Joe Perry, all suffered from CTE and all are now deceased. I count myself lucky that the main malady affecting me after those many blows to the head is a 60% hearing loss in my left ear — probably due to undiagnosed concussions and particularly to thousands of head slaps by defensive players, whose first hit after the snap was often a right-handed blow to the helmet's open hole over my left ear. (shrink)

In Unifying Biology, Smocovitis offers a series of claimsregarding the relationship between key actors in the synthesisperiod of evolutionary studies and positivism, especially claimsentailing Joseph Henry Woodger and the Unity of Science Movement.This commentary examines Woodger''s possible relevance to key synthesis actors and challenges Smocovitis'' arguments for theexplanatory relevance of logical positivism, and positivism moregenerally, to synthesis history. Under scrutiny, these arguments areshort on evidence and subject to substantial conceptual confusion.Though plausible, Smocovitis'' minimal interpretation – that somegeneralised form of Comtean (...) positivism had a role in synthesishistory – requires more of an evidential basis and must engageexisting scholarship on epistemic reforms in the biological sciencesprior to the synthesis period. Smocovitis is right to investigateepistemology in the synthesis period of evolutionary studies and tolook for links to wider changes in science and philosophy. However,in its present form, Unifying Biology fails to support herbasic interpretation. (shrink)

I propose we abandon the unit concept of "the evolutionary synthesis". There was much more to evolutionary studies in the 1920s and 1930s than is suggested in our commonplace narratives of this object in history. Instead, four organising threads capture much of evolutionary studies at this time. First, the nature of species and the process of speciation were dominating, unifying subjects. Second, research into these subjects developed along four main lines, or problem complexes: variation, divergence, isolation, and selection. Some calls (...) for 'synthesis' focused on these problem complexes (sometimes on one of these; other times, all). In these calls, comprehensive and pluralist compendia of plausibly relevant elements were preferred over reaching consensus about the value of particular formulae. Third, increasing confidence in the study of common problems coincided with methodological and epistemic changes associated with experimental taxonomy. Finally, the surge of interest in species problems and speciation in the 1930s is intimately tied to larger trends, especially a shifting balance in the life sciences towards process-based biologies and away from object-based naturalist disciplines. Advocates of synthesis in evolution supported, and were adapting to, these larger trends. (shrink)

We use a lab experiment to examine whether and how leaders influence workers’ (un)ethical behavior through financial reporting choices. We randomly assign the role of leaders or workers to subjects, who can choose to report an outcome via automatic or self-reporting. Self-reporting allows for profitable and undetectable earnings manipulation. We vary the leaders’ ability to choose the reporting method and to punish workers. We show that workers are more likely to choose automatic reporting when their leader voluntarily does so and (...) can assign punishment. Even workers who choose self-reporting tend to cheat less when their leader chooses automatic reporting. Nonetheless, most leaders do not opt for automatic reporting in the first place: they often choose self-reporting and punish workers who rather choose automatic reporting. Collectively, our results reveal a dual effect of leadership on ethical behaviors in organizations: workers behave more ethically if their leader makes ethical choices, but often leaders do not make ethical choices in the first place. Hence, leading by example can backfire. (shrink)

Satisficing consequentialism is an unpopular theory. Because it permits gratuitous sub-optimal behaviour, it strikes many as wildly implausible. It has been widely rejected as a tenable moral theory for more than twenty years. In this article, I rehearse the arguments behind this unpopularity, before examining an attempt to redeem satisficing. Richard Yetter Chappell has recently defended a form of ‘effort satisficing consequentialism’. By incorporating an ‘effort ceiling’ – a limit on the amount of willpower a situation requires – and requiring (...) that agents produce at least as much good as they could given how much effort they are exerting, Chappell avoids the obvious objections. However, I demonstrate that the revised theory is susceptible to a different objection, and that the resulting view requires that any supererogatory behaviour must be efficient, which fails to match typical moral verdicts. (shrink)

To improve the efficacy of business ethics courses, the article recommends closer attention be paid to the religious motivations of students, which have for too long been ignored by most business ethics theory. By disconnecting the teaching of business ethics from the motivations driving business decisions, the theory that gets taught – and published in the textbooks – more strongly represents the philosophical tools of business ethicists than the moral resources business people claim to use. Through a community-based research study (...) that immersed students in the ethical issues business people face, an argument emerges for incorporating more religious ethics into teaching business ethics as this is the kind of moral resource business people claim is most important to them. Though the interviewees attested to the importance of religion, they were rarely able to articulate how their religious beliefs shaped their moral decisions, suggesting that much work could be done in the area of helping people better learn to apply their closely held religious beliefs in the workplace. (shrink)

Human reason demands ultimate explanation; it demands a Because that admits of no further Because –something unconditioned. Pace dogmatic rationalist metaphysics, Kant concludes that theoretical reason must remain modest; it cannot know or cognize the existence of particular unconditioned entities (e.g. God or Leibnizian monads). The prevailing view goes even further; it maintains that theoretical reason cannot even know that something or other unconditioned exists. Yet I argue that Kant’s critique contains an ambitious conclusion: reason can know that something unconditioned (...) exists among things in themselves, even if it cannot know which particular unconditioned entities exist. I reconstruct Kant’s argument for this ambitious conclusion. On my reconstruction, the argument turns on a key metaphysical assumption about things in themselves: that they are completely determinate. And far from undermining Kant's case for modesty, I suggest, this assumption partly underlies it. (shrink)

This article examines the relationship between utopian production and reception via a reading of the work of the great utopian author and theorist William Morris. This relationship has invariably been defined by an inequality: utopian producers have claimed unlimited freedom in their attempts to imagine new worlds, while utopian recipients have been asked to adopt such visions as their own without question. Morris’s work suggests two possible responses to this inequality. One response, associated with theorist Miguel Abensour, is to liberate (...) reception, with Morris’s utopianism containing an invitation to readers to reformulate the vision proffered. However, this response, despite its dominance in contemporary utopian theory, not only misreads Morris but also undermines the political efficacy of utopianism. Consequently, I suggest that Morris responds to the problem of utopian inequality by constraining production, proposing a historical control on utopianising; new utopias are directed by an archive of visions articulated in past struggles. (shrink)

This paper argues that white Christian churches participated in, benefited from, and promoted housing apartheid in the United States for at least thirty years, and that these actions have been significant causes of racial inequality through to the present day. Housing apartheid is defined primarily as housing policies that promoted opportunities in whites only communities and which denied and extracted opportunities from nonwhite, predominantly black communities. Blessing oppression is defined as the means by which white churches sustained and entrenched housing (...) apartheid through the basic practices of church life whereby the minds and hearts of white Christians were put at ease as they participated in massive oppression. The paper closes with a consideration of reparations for the role white churches played in housing apartheid as a precondition for racial reconciliation within Christian churches. (shrink)