We discuss here a series of testable hypotheses concerning the role of chromosome folding into topologically associating domains (TADs). Several lines of evidence suggest that segmental packaging of chromosomal neighborhoods may underlie features of chromatin that span large domains, such as heterochromatin blocks, association with the nuclear lamina and replication timing. By defining which DNA elements preferentially contact each other, the segmentation of chromosomes into TADs may also underlie many properties of long‐range transcriptional regulation. Several observations suggest that TADs can (...) indeed provide a structural basis to regulatory landscapes, by controlling enhancer sharing and allocation. We also discuss how TADs may shape the evolution of chromosomes, by causing maintenance of synteny over large chromosomal segments. Finally we suggest a series of experiments to challenge these ideas and provide concrete examples illustrating how they could be practically applied. (shrink)

Kozhamthadam Job, b. 1945, the pioneer of science-religion dialogue in India; contributed articles.

We investigate if private family firms have a greater environmental performance focus than nonfamily firms, and if this relationship is moderated by the strength of the firms’ social embeddedness. We empirically test these issues using a representative sample of 1452 private Australian small and medium-sized enterprises. Contrary to prevailing assumptions and previous indicative findings in the public firm context, our results show that family firms have a lower environmental performance focus than nonfamily firms. However, in cases where the firm is (...) highly embedded in the social community, we find that family firms have a higher environmental performance focus. We explain our unexpected results by considering the role of financial risk in publicly held family firms. Accordingly, we posit that prior findings in the public firm context may be evidence of families expropriating wealth from nonfamily shareholders rather than altruistic pro-environmental behavior. (shrink)

One in three university students experiences mental health problems during their study. A similar percentage leaves higher education without obtaining the degree for which they enrolled. Research suggests that both mental health problems and academic underperformance could be caused by students lacking control and purpose while they are adjusting to tertiary education. Currently, universities are not designed to cater to all the personal needs and mental health problems of large numbers of students at the start of their studies. Within the (...) literature aimed at preventing mental health problems among students (e.g., anxiety or depression), digital forms of therapy recently have been suggested as potentially scalable solutions to address these problems. Integrative psychological artificial intelligence (AI) in the form of a chatbot, for example, shows great potential as an evidence-based solution. At the same time, within the literature aimed at improving academic success, the online life-crafting intervention in which students write about values and passions, goals, and goal-attainment plans has shown to improve the academic performance and retention rates of students. Because the life-crafting intervention is delivered through the curriculum and doesn’t bear the stigma that is associated with therapy, it can reach larger populations of students. But life-crafting lacks the means for follow-up or the interactiveness that online AI-guided therapy can offer. In this paper, we propose to integrate the current literature on chatbot interventions aimed at the mental health of students with research about a life-crafting intervention that uses an inclusive curriculum-wide approach. When a chatbot asks students to prioritize both academic as well as social and health-related goals and provides personalized follow-up coaching, this can prevent -often interrelated- academic and mental health problems. Right on-time delivery, and personalized follow-up questions enhance the effects of both -originally separated- intervention types. Research on this new combination of interventions should use design principles that increase user-friendliness and monitor the technology acceptance of its participants. (shrink)

The notion of home is well known from our everyday experience, and plays a crucial role in all kinds of narratives about human life, but is hardly ever systematically dealt with in the philosophy of medicine and health care. This paper is based upon the intuitively positive connotation of the term “home.” By metaphorically describing the goal of palliative care as “the patient’s coming home,” it wants to contribute to a medical humanities approach of medicine. It is argued that this (...) metaphor can enrich our understanding of the goals of palliative care and its proper objectives. Four interpretations of “home” and “coming home” are explored: (1) one’s own house or homelike environment, (2) one’s own body, (3) the psychosocial environment, and (4) the spiritual dimension, in particular, the origin of human existence. Thinking in terms of coming home implies a normative point of view. It represents central human values and refers not only to the medical-technical and care aspects of health care, but also to the moral context. (shrink)

With this paper I aim to demonstrate that a look beyond the Aristotelian square of opposition, and a related non-conservative view on logical determiners, contributes to both the understanding of Aristotelian syllogistics as well as to the study of quantificational structures in natural language.

Periodic attacks of uncertain origin, where the clinical presentationresembles epilepsy but there is no evidence of a somatic disease, arecalled Pseudo-Epilepsy or Pseudo-Epileptic Attack Disorder (PEAD). PEADmay be called a `non-disease', i.e. a disorder on the fringes ofestablished disease patterns, because it lacks a rationalpathophysiological explanation. The first aim of this article is tocriticize the idea, common in medical science, that diseases are realentities which exist separately from the patient, waiting to bediscovered by the doctor. We argue that doctor and (...) patient construct adisease, and that the construction of the disease PEAD includes manynormative evaluations. The second aim is to provide insight into thesuffering of patients with PEAD. We focus on three aspects of thepatient, identity, autonomy and responsibility. We present somecharacteristic descriptions of (pseudo-)epileptic attacks by FjodorDostoevsky, Gustave Flaubert and Thomas Mann. We argue that diagnosingPEAD reduces a meaningful life event into an insignificant, thoughintriguing, medical phenomenon, and that the patient will not benefitfrom being diagnosed as having PEAD. (shrink)

In the current debate about the pros and cons of routine (nonreligious) neonatal circumcision (RNC), the emphasis is on medical justifications for the practice. Questions of human rights also are widely discussed. However, even if the alleged medical benefits of RNC were to outweigh the harms and risks, this is not a sufficient justification for RNC. The practice of RNC is questionable from a variety of viewpoints including not only the ideal of evidence-based medicine and human rights considerations, but also (...) the notion of respect for bodily integrity. (shrink)

For a few decades, patients with Parkinson's disease have been treated with intracerebral transplantations of fetal mesencephalic tissue. The results of open trials have been variable. Double blind, placebo-controlled studies have recently been started in order to further investigate the efficacy of this new medical technique. In this paper we challenge the need for sham surgery in neurotransplantation research on PD patients. Considerations regarding the research subjects' informed consent, therapeutic misconception, the integrity of the human body, and the assessment of (...) risks and benefits argue against sham surgery for patients with PD. Moreover, there is an alternative, less harmful mode of research that can provide the same or comparable scientific evidence. A plea is made for intrapatient research based on quantitative measurements of the patient's pre- and post-operative condition combined with similar research on a reference group of patients who have received the standard treatment. (shrink)

In this article some of the presuppositions that underly the current ideas about decision making capacity, autonomy and independence are critically examined. The focus is on chronic disorders, especially on chronic physical disorders. First, it is argued that the concepts of decision making competence and autonomy, as they are usually applied to the problem of legal (in)competence in the mentally ill, need to be modified and adapted to the situation of the chronically (physically) ill. Second, it is argued that autonomy (...) and dependence must not be considered as two mutually exclusive categories. It is suggested that decision making may take on the form of a more or less conscious decision not to be involved in making all kinds of explicit and deliberate decisions. Elaborating on Agich's distinction between ideal and actual autonomy, the concept of Socratic autonomy is introduced. (shrink)

Early observations of the southern celestial sky were reported in many sixteenth-century books and compilations of voyages of discovery. Here we analyse these accounts in order to find out what was really seen and reported by the first navigators. Our analysis had resulted in new interpretations of the phenomena reported by Amerigo Vespucci and Andreas Corsali. Thus, a reassessment of the discovery of the Coalsack Nebula, the Magellanic Clouds, and the Southern Cross can be made. From a comparative review of (...) the observations of the latter constellation as published between 1500 and 1600, we demonstrate that only questionable records found their way to contemporary compilations of voyages of discovery, and that as a result public knowledge about this constellation at the end of the sixteenth century was entirely unreliable. Another problem we discuss is that although the stars of the Southern Cross were the first to be discovered, and were observed again and again by many navigators, it was not until 1678 that their proper positions were found in stellar atlases and star catalogues accessible to astronomers. We explain how negligence of and subsequently confidence in Ptolemy's astronomy by, respectively, the early navigators and cartographers, were at the root of this amazingly long-lasting gap in the knowledge of the southern celestial sky. (shrink)

Steinsvold (2020) has provided two semantics for the basic modal language enriched with propositional quantifiers (∀p). We define an extension EM of the system KD45_{\Box} and prove that EM is sound and complete for both semantics. It follows that the two semantics are equivalent.

Medicine does not usually consider the human body from an aesthetic point of view. This article explores the notion of the lived body as aesthetic object in anthropological medicine, concentrating on the views of Buytendijk and Straus on human uprightness and gracefulness. It is argued that their insights constitute a counter-balance to the way the human body is predominantly approached in medicine and medical ethics. In particular, (1) the relationship between anthropological, aesthetic and ethical norms, (2) the possible danger of (...) a naturalistic fallacy, (3) the implications for the care of disabled people and (4) the intrinsic aesthetic quality of the human body are dealt with. (shrink)

Adam Smith has long been remembered as an economist, but the past decades have witnessed an ever-increasing recognition and discussion of his moral philosophy with renewed interest in his first maj...

Starting with the analysis of the diary kept by Constantijn Huygens Jr in the second half of the 17th century, this book sketches a panoramic view of life among Dutch regents and at the court of William and Mary, including an eyewitness account of the Glorious Revolution, and highlighting themes such as scientific progress, book and art collecting.

El pensamiento sobre la sociedad civil siempre ha estado caracterizado por una doble referencia hacia las relaciones sociales existentes y hacia los ideales sociales. La principal hipótesis de numerosas investigaciones sobre la sociedad civil es que una floreciente esfera que lleva este nombre es el portador del ideal de una sociedad más civilizada. Este artículo empieza con una pequeña discusión sobre el trasfondo histórico y los debates públicos en torno a la sociedad civil, y continúa con un planteamiento más analítico (...) del concepto como designación de un orden social asociacional y una esfera de la sociedad dominada por las asociaciones voluntarias. Más adelante nos centramos en esta esfera describiendo sus caracteres nacionales en Europa y analizando las reivindicaciones de sus beneficios civilizadores: la formación de capital social y de discurso público. Encontramos muy pocas evidencias para tales reivindicaciones y por ello profundizamos en el desarrollo de la sociedad moderna occidental, una sociedad en la que las asociaciones voluntarias se han convertido en menos relevantes, mientras que otras esferas de la sociedad, en particular los ensanchados márgenes de la sociedad civil, son más importantes para el desarrollo de una sociedad más civilizada.The thinking about civil society has always been characterized by the double reference to existing social relations and to societal ideals. The basic hypothesis of much civil society research is that a flourishing sphere with this name is the carrier of the ideal of more civilized society. This article starts with a brief discussion of the historical background and public debates about civil society, and continues with a more analytic approach of the concept as designation of an associational social order and a sphere of society dominated by voluntary associations. We further focus on this sphere, describe its national patterns in Europe and analyze claims of its civilizing benefits: the formation of social capital and public discourse. We find very limited evidence for the claims and look deeper into developments of modern western society, which have made voluntary associations less important and other spheres of society, in particular the broader margins of civil society, more important for the development of a more civilized society. (shrink)

In recent years, we have witnessed the emergence of political activism through an irruption of citizen movements – 5M or Occupy–, the birth of new political platforms –5 Stelle, Zyrisa, Podemos– and the rise of new direct action groups, such as Anonymous, Stop-Evictions Movements, cooperatives, to name just a few. In some countries this activism has not just placed substantial pressure on traditional actors of representative democracy and governments, but has also opened up opportunities for structural changes in the policymaking (...) context and procedures (García Marzá, 2012). (shrink)

This biography presents the interaction between his socialist ideals, scientific aspirations and work as an economic expert.

Rosa Menkman proposed that the concept of glitch should be considered a tipping point, a momentum, that can be seized, in which the power of subjectivity and the collaborative efforts of creators and the active spectators take centre stage. This article will discuss how in the last decades the glitch as noise and techne has shifted towards glitch as precarious aesthetics and how it has become associated with decolonial and feminist modes of critique. While the glitch is still seen as (...) a material, a techne, there is a resistant aesthetics of mutiny, a tactical revolt of the material that is confronting systemic standardization, bias and institutionalization. As presented in the exhibition VJ Um Amel, Beit Um Amel (2020), the technologically induced phenomena are analogous with the crises and states of emergency in various global infrastructures, systems and information channels. (shrink)

As part of a book symposium on his Jan Tinbergen (1903–1994) and the Rise of Economic Expertise (2021), Erwin Dekker responds to commentaries by Mariana Mortágua and Francisco Louçã, Thomas Kayzel, Jon Murphy, Michele Alacevich, Mauro Boianovsky, and William Peden.

Sentences containing pronouns and indefinite noun phrases can be said toexpress open propositions, propositions which display gaps to be filled.This paper addresses the question what is the linguistic content ofthese expressions, what information they can be said to provide to ahearer, and in what sense the information of a speaker can be said tosupport their utterance. We present and motivate first order notions ofcontent, update and support. The three notions are each defined in acompositional fashion and brought together within a (...) single and coherentframework. (shrink)