This book symposium comprises a précis of Nuno Venturinha’s Description of Situations: An Essay in Contextualist Epistemology together with four critical commentaries on different aspects of the book by Marcelo Carvalho, João Vergílio Gallerani Cuter, Marcos Silva and Darlei Dall’Agnol, and the author’s replies.

After the publication of Hart's Concept of Law, Dworkin published his article “The Model of Rules,” dividing positivism into two varieties: inclusive and exclusive. Many theorists involved in this debate have characterized Hart's position as inclusivist, which we reject in this article. We argue that Hart, in the postscript to The Concept of Law, conceded a point to Dworkin in accepting that inclusive positivism would imply the existence of objective moral standing, adopting a more “neutral” position—compatible with inclusive and exclusive (...) positivism—and consequently distancing himself from the incorporation thesis, which is paramount to inclusive positivism. (shrink)

This book is dedicated to clarify ambiguous concepts from the world of creativity and innovation. One of the initial triggers for the development of the book was the perceived ambiguity of the binomials Design vs. Design Thinking and Innovation vs. Invention. Frequently, designers and innovation consultants are questioned by their clients about the relationships between these kind of concepts. Has the second emerged through the first, or vice-verse? Is one part of the other? Where are the similarities and which are (...) the differences? This conceptual incomprehension makes itself noticeable between many ambiguous concepts in the world of innovation and creativity. What is the difference between Radical and Disruptive Innovation? Or is Social Innovation the same as Social Intervention? And regarding Creativity, are Creativity and Creative Thinking the same? In this book the reader will find answers to these kinds of questions and doubts. 28 authors from 10 different countries and cultural backgrounds are questioning current definitions and perceptions, by comparing different sources and ideas, or simply by giving their personal opinions. Some of the authors have an academic background, others a practical one, being either entrepreneurs, working with innovation in companies, or being innovation/design consultants. (shrink)

A pesquisa se baseou na análise bibliográfica acerca dos conceitos de didática intercultural e decolonialidade de Vera Candau (2023), Catherine Walsh (2005) e Walter Mignolo (2005). Ademais, trabalhou-se com autores que desenvolvem pesquisas a respeito da Escola Indígena Maurehi como Leandro Mendes Rocha (1998), Joel Orlando Bevilaqua Marin (2009) e Maria do Socorro Pimentel da Silva (2009), com intuito de contextualizar o surgimento e o processo de criação da didática escolar indígena em específico entre os Iny. A análise documental é (...) desenvolvida a partir do contato do documento atualizado do Projeto de Cultura e Educação Karajá/Iny (2024), cedido pela diretora da escola indígena para consulta. Conclui-se que a didática intercultural e decolonial é uma possibilidade epistêmica para a contribuição da equidade na educação. (shrink)

Over recent years, various semantics have been proposed for dealing with updates in the setting of logic programs. The availability of different semantics naturally raises the question of which are most adequate to model updates. A systematic approach to face this question is to identify general principles against which such semantics could be evaluated. In this paper we motivate and introduce a new such principle the refined extension principle. Such principle is complied with by the stable model semantics for (single) (...) logic programs. It turns out that none of the existing semantics for logic program updates, even though generalisations of the stable model semantics, comply with this principle. For this reason, we define a refinement of the dynamic stable model semantics for Dynamic Logic Programs that complies with the principle. (shrink)

Este artículo trata sobre el arte brasileño y su posible identidad. A diferencia de lassociedades andinas y de América Central, ninguna sociedad aborigen de Brasil logróalcanzar el nivel de civilización. En tierras brasileñas, el hibridismo cultural de Latinoaméricaalcanza su punto límite. En tanto que se habla de un arte esencialmentemestiza, cabe la pregunta: ¿existe un arte brasileño?

RESUMO O objetivo do artigo é proceder a uma análise da personagem Alison, esposa de Bath, na obra Os contos de Canterbury, de Geofrey Chaucer. Para isso, com base em Bakhtin (2010, 2018), em particular a partir da perspectiva da carnavalização, somada à teoria da performatividade de gênero de Butler (1988, 2017), pretendemos mostrar como a referida personagem subverte, carnavalizadamente, certos textos bíblicos referentes ao papel da mulher no matrimônio. Dessa forma, nesse estudo, para efeito de análise, tomamos da obra (...) chaucereana o prólogo da esposa de Bath visto que nele a personagem elabora, de modo mais evidente, sua relação tensa e, ao mesmo tempo cômica, com a Bíblia. Da análise feita, concluímos, assim, que a esposa de Bath, de maneira carnavalizada, performatiza o gênero feminino em pleno período medieval, mostrando-se subversiva aos estereótipos da época ao profanar certas orientações bíblicas, tanto do Velho como do Novo Testamento, relativamente ao que é ser mulher e esposa. (shrink)

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Este artigo tem por objetivo trazer a dança sagrada na memória Bergosoniana através das comunidades de terreiros, compreendida como expressões corporais representadas através da materialiação dos corpos e memória no que diz respeito ao movimento, na dança e toque da Orixá Oxum. Embalados pela problemática de como a dança sagrada nos terreiros de candomblé da nação Ketu/Nagô reflete a memória em movimento trazida por Bergson? Com isso propomos um recorte da memória com base em Bergson que nos ajudam á situar (...) a memória em movimentos ancestrais através dos acontecimentos que resultam nas relações sociais de grupos que contribuem através de depoimentos, contatos, lembranças, expressões e recordações construídas sobre um fundamento da dança. Como metodologia de pesquisa, fizemos uma busca no acervo utilizando o referencial teórico de Bergson em as suas publicações correntes na qual, concluímos que a memória exerce papel fundamental para preservação e também para estudos e pesquisas deste universo sagrado. (shrink)

The imperative to practice hospitality constitutes a mark of Western civilization. Already in Homer’s Odyssey, the hero Ulysses punishes Polyphemus for not having respected the obligation of hospitality towards him and his companions. In fact, hospitality has been a constitutive element of the West, marked by linguistic, cultural, and religious differences, in a world whose borders are supposed to be well defined. In his discussion of hospitality, Derrida shows how Socrates, in Plato’s dialogue The Apology of Socrates, places himself in (...) the position of a foreigner. In fact, Socrates presents himself as foreigner, that is, someone who is alien to the language and procedures of the court that is judging him. According to Derrida, he shows, in this way, the extent to which the foreigner is forced to ask for hospitality in a language he does not know. The court reduces Socrates to the other, the different. Moreover, the court forces him to deny his difference, his own identity, asking him to adapt himself to a system that he does not control. The paradox arises when Socrates, who regrets being regarded as a foreigner, asks the court to treat him at least as a foreigner. He feels so outraged that he asks to be granted at least the rights of a non-national. In doing so, Socrates shows how recognizing the rights of the foreigner generates hospitality but, at the same time, also limits it. Whenever a human being is recognized as human being, he or she will necessarily be seen as another, as someone different. This person will have to adapt him or herself to a system, culture or world that will define him or her as a foreigner. In short, in the phenomena that we tend to see as hospitality there is always a certain hostility. In a world of ongoing migratory crises, and in the context of a return to nationalisms of exclusion combined with populisms of prejudice and aversion to those who are different, it becomes imperative to rethink the ethics and politics of hospitality. In this context, Derrida’s distinction between conditioned and unconditioned hospitality can be useful. (shrink)

How fast? How strong? How many? So what? Why do numbers matter in biology? Chromatin binding proteins are forever in motion, exchanging rapidly between bound and free pools. How do regulatory systems whose components are in constant flux ensure stability and flexibility? This review explores the application of quantitative and mathematical approaches to mechanisms of epigenetic regulation. We discuss methods for measuring kinetic parameters and protein quantities in living cells, and explore the insights that have been gained by quantifying and (...) modelling dynamics of chromatin binding proteins. (shrink)

ABSTRACT This study focuses on the notions of ‘ruins’, ‘savage knowledge’, and ‘American race’ in the works of the German naturalist Carl Friedrich Philipp von Martius (1794–1868). A somewhat neglected figure in the history of anthropology and of natural history, Martius was regarded by scholars from Europe and the Americas as a leading figure in botany and ethnology in the nineteenth century. In this article, I discuss how Martius articulated: (1) the notion of American race, that is, a broad characterization (...) of the native peoples of the Americas rooted in a complex natural history which brought together seemingly disparate fields of knowledge, such as medicine, botany, theology, philology, and mythology; (2) having ruins as a guiding concept, which helped him to make sense of American natives; and (3) savage knowledge – a concept semantically aligned to that of ruins, and among whose principal modes of expression was shamanic practice. (shrink)

The Second Vatican Council was built within a solidly constituted tradition in the Catholic Church. All councils were held within the traditional and legal parameters of the Church. The question about the condition of possibility of a renewal Council under this tradition shows relevant. The Vatican II is the result of a negotiation between renewal and preservation. Pope John XXIII personally coordinated the construction of the legitimacy of the new event, following steps which may be rescued during the preparatory stages (...) of the great assembly. The reading of this process from sociological parameters may elucidate its plausibility within the tradition and the Church's bureaucratic organization. Pope John started ably a church renewal process, opening a new phase in the long Catholic tradition. Under his Pope condition, he knew how to seed the idea of a revamping event in the name of a divine inspiration and with the set of bishops’ participation of the Church. (shrink)

This paper explores the intricate relationship between the concept of “savage knowledge,” its significance during the ninteenth and twentieth centuries, and the emerging field of ethnoscience. It specifically focuses on the Amazon region as a pivotal area in the development of ethnoscience, examining the contributions of renowned naturalists Carl von Martius, Richard Spruce, and Richard Schultes, who each conducted scientific expeditions to the Amazon during this era. Their works are crucial in reevaluating the dynamic interplay between the Western perception of (...) the “savage,” the scientific principles that underpin it, and the geopolitics of knowledge exchange between countries in the global north and south. I argue that the contextual conditions which made possible the emergence of ethnoscience, including imperial assimilation, extraction, and coloniality, continue to exert influence on twentieth century political discourses concerning the integration of indigenous cultures into global politics. This influence is evident through the analysis of a UNESCO document in the second part of the paper. The study concludes that the incorporation of indigenous knowledge, systematised by ethnoscience, has often served as a pretext for controlling geographical areas historically regarded as “natural resources,” ultimately transforming them into reservoirs of indigenous epistemologies. (shrink)

Este artigo tem por objetivo apresentar a ideia de que Schopenhauer reavalia a noção de extinção com o passar do tempo através do contato com pensamentos filosóficos e científicos contemporâneos a sua vida ligados a concepções evolucionistas. Em O mundo como vontade e representação não há espaço para a consideração da extinção das espécies animais, imutáveis e eternas; ao passo que em Parerga e Paralipomena e em Sobre a vontade na natureza é comum que o autor faça alusão a conceitos (...) como generatio aequivoca, ao surgimento de espécies animais por meio de generatio in utero heterogeneo e ao seu desaparecimento. (shrink)

The result of Hannah Arendt’s study of bourgeois revolutions reflects not only the contradictions and dichotomies of her thought, but is an important diagnosis of the impact of liberal policies, their contradictions and evolution within the history of democracy. Modern republicanism, although critical of liberalism, assimilated elements inherent to liberal democracy, for example, the importance of the law, always imputed based on ideological political precepts of its time. The relevance of this analysis allows us not only to understand the bases (...) of the philosopher’s political thought, but its development in what she calls: public space. This must be a place for the expression of opinions, and therefore, for Arendt, without plurality, politics and public freedom are compromised to the extent that they make it impossible to maintain a space for the realization of freedom. However, in an unequal world, who can exercise their citizenship freely in public space? Was the liberal promise capable of providing these guarantees? In dialogue with Habermas and beyond, we intend with this investigation to outline the weaknesses of a bourgeois notion of the public sphere and to enunciate the urgency of building an ideal of republicanism based on popular demands. (shrink)

Ao longo da história, a relação entre a filosofia e a política tem-se revelado espinhosa, denunciando a dificuldade em se conceptualizar sobre o que é por natureza antagónico à cristalização, porque particular e pluralista. Na esfera da opinião, o filósofo deve restringir-se a analisar, criticar, rever e aperfeiçoar os valores políticos coevos, a explicar aos seus conterrâneos o universo de acepções sociais partilhadas, consciente de que a sua concepção fundamenta uma via entre as muitas poss...

O presente artigo tem por objetivo analisar o desenvolvimento histórico do cinema de Charlie Chaplin, a partir da obra de Guido Oldrini: História do Cinema na Cultura do Século XX: Um Mapeamento Crítico. Analisamos também o potencial do cinema de Chaplin de cumprir a missão social da arte, a partir do sistema de mediações categorias de Lukács em sua obra A Peculiaridade Do Estético. Buscamos, assim, analisar o caso específico das obras de Charlie Chaplin e explicitar as categorias estéticas do (...) cinema enquanto forma particular de arte a partir do seu desenvolvimento histórico. (shrink)

O presente artigo tem por objetivo principal investigar e circunscrever a relação problemática entre intelecto e cérebro na obra de Arthur Schopenhauer, de acordo com a já conhecida formulação de Eduard Zeller. Desse modo, pode-se contemplar o lugar dos conceitos de intelecto e cérebro no âmbito da explicação metafísica da natureza, tendo-se sempre como noção diretora central a distinção entre os modos de consideração do mundo, apresentadas simultaneamente ainda no texto de O mundo como vontade e como representação e aperfeiçoada (...) e mencionada com mais cuidado nas obras posteriores. Se, por um lado, o mundo é objeto de investigação através da subjetividade e de suas formas de existência, por outro ele é investigado através de um modo de consideração objetivo, que, inicialmente, toma os objetos como existentes por si mesmos, independentemente de qualquer sujeito. Sem poder existir totalmente em separado, na medida em que cada objeto existe apenas para o sujeito, ambos os modos devem confluir para a explicação completa do mundo, como complementação um do outro: o intelecto deve ser também considerado do ponto de vista objetivo e o cérebro segundo a análise do modo de consideração subjetivo, integrando-o na explicação geral do mundo e da natureza. (shrink)

O presente artigo discute as relações entre animais não-humanos e o sensível. Para tanto, ensaia-se uma compreensão das formas animais e suas aparências expressivas, apoiando-se em ideias e teses dos filósofos franceses Merleau-Ponty e Dominique Lestel formuladas a partir do estudo do zoólogo Adolf Portmann sobre a aparência dos animais, denominado A forma animal. A investigação de Portmann, interessada em apreender fora do registro funcional do biológico o mistério que envolve as formas vivas, assimila uma nova concepção de corpo animal (...) e descobre nele uma qualidade estética de livre expressão resultante do dispêndio das aparências dos viventes não-humanos.Palavras-chave: Vida Sensível; Animalidade; Aparência; Natureza. (shrink)

Cause-related marketing has risen to become a popular strategy to increase business value through profit-motivated giving. Despite the growing number of articles published in the last decade, no comprehensive analysis of the most discussed constructs of cause-related marketing is available. This paper uses an advanced Text Mining methodology to conduct a comprehensive analysis of 246 articles published in 40 different journals between 1988 and 2013 on the subject of cause-related marketing. Text Mining also allows quantitative analyses to be performed on (...) the literature. For instance, it is shown that the most prominent long-term topics discussed since 1988 on the subject are “brand-cause fit”, “law and Ethics”, and “corporate and social identification”, while the most actively discussed topic presently is “sectors raising social taboos and moral debates”. The paper has two goals: first, it introduces the technique of CTM to the Marketing area, illustrating how Text Mining may guide, simplify, and enhance review processes while providing objective building blocks to be used in a review; second, it applies CTM to the C-RM field, uncovering and summarizing the most discussed topics. Mining text, however, is not aimed at replacing all subjective decisions that must be taken as part of literature review methodologies. (shrink)

Este artigo tem como objetivo principal expor a posição filosófica crítica de Nietzsche em relação ao pensamento moral de Schopenhauer presente em O Anticristo, fragmentos 7, 8 e 9, nos quais há, diretamente, um comentário geral à compaixão (Mitleiden) como sentimento mortificador e prejudicial à vida, manifesto sobretudo através da noção schopenhaueriana de negação da vontade de vida. Em acordo com os comentários de Nietzsche, é possível compreender, justificadamente, que a compaixão, enquanto sofrer junto e partilhar do sofrimento, é recusável (...) por ocasião 1) de sua constituição antinatureza, 2) de redução e apagamento de diferenças individuais de sofrimento, potencialmente construtivas e transformativas, e 3) da negação do conflito como momento de afirmação da vida. (shrink)

Recently several authors have proposed proxies of welfare that equate some (as opposed to all) choices with welfare. In this paper, I first distinguish between two prominent proxies: one based oncontext-independent choicesand the other based onreason-based choices. I then propose an original proxy based on choices that individuals state they would want themselves to repeat at the time of the welfare/policy evaluation (confirmed choices). I articulate three complementary arguments that, I claim, support confirmed choices as a more reliable proxy of (...) welfare than context-independent and reason-based choices. Finally, I discuss the implications of these arguments fornudgesandboosts. (shrink)

While ontic structural realism (OSR) has been a central topic in contemporary philosophy of science, the relation between OSR and the concept of emergence has received little attention. We will argue that OSR is fully compatible with emergentism. The denial of ontological emergence requires additional assumptions that, strictly speaking, go beyond OSR. We call these _physicalist closure assumptions._ We will explain these assumptions and show that they are independent of the central commitments of OSR and inconsistent with its core goals. (...) Recognizing the compatibility of OSR and ontological emergence may contribute to the solution of ontological puzzles in physics while offering new ways to achieve the goals that advocates of OSR set for their view. (shrink)

The article is divided in three main parts. The first part shows that the first three chapters of the second essay of On the Genealogy of Morality give a genealogical account of the emergence of reason in human history, and that this account involves the claim that reason is a development of human engagement with social rules: Nietzsche understands the emergence of reason as the emergence of a normative space of reasons. The second part interrogates Nietzsche’s conception of value, purpose, (...) and meaning in order to show that he is not a proponent of any version of “bald naturalism”: he does not equate what is “really real” with a natural world of causation devoid of value, purpose, and meaning. The third part of the article shows that, although Nietzsche’s perspectivism does not assign to the space of reasons the status of a purely autonomous realm of justification, he does not dismiss rational normativity, or the space of reasons, as merely illusory. Nietzschean genealogy is shown to be a reflective questioning of our values that investigates the reasons behind our deeper normative commitments. (shrink)

Against the view that symbol-based semiosis is a human cognitive uniqueness, we have argued that non-human primates such as African vervet monkeys possess symbolic competence, as formally defined by Charles S. Peirce. Here I develop this argument by showing that the equivocal role ascribed to symbols by “folk semiotics” stems from an incomplete application of the Peircean logical framework for the classification of signs, which describes three kinds of symbols: rheme, dicent and argument. In an attempt to advance in the (...) classifying semiotic processes, Peirce proposed several typologies, with different degrees of refinement. Around 1903, he developed a division into ten classes. According to this typology, symbols can be further analysed in three subclasses (rheme, dicent, argument). I proceed to demonstrate that vervet monkeys employ dicent symbols. There are remarkable implications of this argument since ‘symbolic species theory’ fails to explore the vast Peircean semiotic philosophy to frame questions regarding the emergence and evolution of symbolic processes. (shrink)

A investigação de um domínio amplo da realidade, como a evolução dosseres vivos, pode dar origem a diferentes “teorias”, cada uma consoantecom uma particular perspectiva que se considere. Para que se proceda auma análise detalhada dos pressupostos e conceitos que baseiam umadeterminada visão, o método axiomático parece ser a melhor das opções.Neste artigo, são discutidas algumas teorias da biologia evolutiva de umponto de vista axiomático, mostrando-se de que forma se pode apresentarum “predicado de Suppes” para a teoria sintética da evolução, (...) comodetalhado em outro local . Estaformulação é utilizada, dentre outras coisas, para se discutir a noção deaptidão darwiniana, bem como para explorar as relações entre a teoriadarwiniana da seleção natural e a genética de populações.The investigation of a wide field of knowledge, as evolution of living beings,may originate different “theories”, each one acting as a particularperspective we have about the domain. In order to proceed a philosophicalanalysis of the underlying assumptions of a particular view, it seems thatthe use of the axiomatic method is still the better way. Here, we discuss some theories of evolutionary biology from an axiomatic point of view, bymeans of a Suppes predicate for the synthetic theory of evolution, alreadydetailed in MAGALHÃES and KRAUSE . This formulation is hereused, among other things, to deal with the concept of Darwinian fitness, soas to explore the relationships between Darwinian theory and populationgenetics. (shrink)

This paper consists in an analysis of two explanatory models of human behaviour which play a prominent role in the contemporary literature on human action. The first model - the causalist - aims at explaining action in terms of causes and general laws. The second model - the intentionalist - explains human action in terms of intentions and practical syllogism. The difficulties of both models are presented and in the last part of the essay we propose one alternative model, based (...) on the notion of retroduction.O trabalho consiste numa análise de dois modelos explicativos do comportamento humano considerados fundamentais na literatura contemporânea sobre teoria da ação. O primeiro modelo, o causalista, tenta explicar as ações em termos de causas e leis gerais. O segundo explica a ação em termos de intenções e silogismos práticos. As dificuldades e problemas de ambos modelos são apresentadas e na última parte do ensaio propomos um modelo alternativo baseado na noção de retrodução. (shrink)

Em seu texto Por quê olhar os animais?, John Berger comenta como a metáfora animal foi um recurso indispensável para revelar uma proximidade entre as espécies, e que sem o exemplo de animais seria improvável, por exemplo, descrever eventos como aqueles narrados por Homero n’A Iíada. A correlação entre vidas semelhantes e heterogêneas permitiram aos seres humanos, inspirados pelos animais, darem respostas às primeiras perguntas. É razoável afirmar que a primeira metáfora tenha sido a do animal, como um modo de (...) partilhar o mundo que lhes era comum e diferente. Mas nossa relação com os animais não-humanos também contém contradições; a criação do zoológico representou a elevação de um monumento à impossibilidade de qualquer reencontro com a animalidade. Em vez de liberados, os animais foram capturados por outras categorias políticas. Para John Berger as ambiguidades permanecem “Eles são os objetos de nosso conhecimento sempre crescente. O que sabemos sobre eles é um índice de nosso poder, e assim é um índice do que nos separa deles. Quanto mais sabemos, mais distante eles ficam.”. (shrink)

Zones of social abandonment are emerging everywhere in Brazil’s big cities—places like Vita, where the unwanted, the mentally ill, the sick, and the homeless are left to die. This haunting, unforgettable story centers on a young woman named Catarina, increasingly paralyzed and said to be mad, living out her time at Vita. Anthropologist João Biehl leads a detective-like journey to know Catarina; to unravel the cryptic, poetic words that are part of the “dictionary” she is compiling; and to trace the (...) complex network of family, medicine, state, and economy in which her abandonment and pathology took form. As Biehl painstakingly relates Catarina’s words to a vanished world and elucidates her condition, we learn of subjectivities unmade and remade under economic pressures, pharmaceuticals as moral technologies, a public common sense that lets the unsound and unproductive die, and anthropology’s unique power to work through these juxtaposed fields. _Vita’s_ methodological innovations, bold fieldwork, and rigorous social theory make it an essential reading for anyone who is grappling with how to understand the conditions of life, thought and ethics in the contemporary world. (shrink)

Research has revealed how inherent self-organizing tendencies in athletes and sports teams can be exploited to facilitate emergence of dynamical patterns in synergy formation in sports teams. Here, we discuss how game models, and associated tactical principles of play, may be implemented to constrain co-existing global-to-local and local-to-global self-organization tendencies in team sports players during training and performance. Understanding how to harness the continuous interplay between these co-existing, bi-directional, and coordination tendencies is key to shaping system behaviors in sports training. (...) Training programs are traditionally dominated by designs, which shape the self-organizing tendencies of players and teams at a global-to-local scale by coaches imposing a tactical/strategical plan with associated tactical principles of play. Nevertheless, recent research suggests that performers also need to be provided with opportunities to explore self-organizing tendencies that emerge at the local-to-global scale in training. This directional tendency in synergy formation can be facilitated by players being given opportunities to actively explore different adaptive and innovative performance solutions, coherent with principles of play circumscribed in an overarching game model. Developing methods (coaching sessions rooted on principles of dynamical systems theory that foment the development of such local-to-global relations) to exploit the continuous interplay between these co-existing tendencies within sports teams may promote more effective and efficient athlete skill training programs, in addition to enhancing performance. (shrink)

Any description of the emergence and evolution of different types of meaning processes (semiosis, sensu C.S.Peirce) in living systems must be supported by a theoretical framework which makes it possible to understand the nature and dynamics of such processes. Here we propose that the emergence of semiosis of different kinds can be understood as resulting from fundamental interactions in a triadically-organized hierarchical process. To grasp these interactions, we develop a model grounded on Stanley Salthe's hierarchical structuralism. This model can be (...) applied to establish, in a general sense, a set of theoretical constraints for explaining the instantiation of different kinds of meaning processes (iconic, indexical, symbolic) in semiotic systems. We use it to model a semiotic process in the immune system, namely, B-cell activation, in order to offer insights into the heuristic role it can play in the development of explanations for specific semiotic processes. (shrink)