We review a recent paper in Genome Research by Guantes et al. showing that nuclear gene expression is influenced by the bioenergetic status of the mitochondria. The amount of energy that mitochondria make available for gene expression varies considerably. It depends on: the energetic demands of the tissue; the mitochondrial DNA (mtDNA) mutant load; the number of mitochondria; stressors present in the cell. Hence, when failing mitochondria place the cell in energy crisis there are major effects on gene expression affecting (...) the risk of degenerative diseases, cancer and ageing. In 2015 the UK parliament approved a change in the regulation of IVF techniques, allowing “Mitochondrial replacement therapy” to become a reproductive choice for women at risk of transmitting mitochondrial disease to their children. This is the first time that this technique will be available. Therefore understanding the interaction between mitochondria and the nucleus has never been more important. (shrink)

The scientific community, we hold, often provides society with knowledge—that the HIV virus causes AIDS, that anthropogenic climate change is underway, that the MMR vaccine is safe. Some deny that we have this knowledge, however, and work to undermine it in others. It has been common to refer to such agents as “denialists”. At first glance, then, denialism appears to be a form of skepticism. But while we know that various denialist strategies for suppressing belief are generally effective, little is (...) known about which strategies are most effective. We see this as an important first step toward their remediation. This paper leverages the approximate comparison to various forms of philosophical skepticism to design an experimental test of the efficacy of four broad strategies of denial at suppressing belief in specific scientific claims. Our results suggest that assertive strategies are more effective at suppressing belief than questioning strategies. (shrink)

Science communication via testimony requires a certain level of trust. But in the context of ideologically-entangled scientific issues, trust is in short supply—particularly when the issues are politically ‘entangled’. In such cases, cultural values are better predictors than scientific literacy for whether agents trust the publicly-directed claims of the scientific community. In this paper, we argue that a common way of thinking about scientific literacy—as knowledge of particular scientific facts or concepts—ought to give way to a second-order understanding of science (...) as a process as a more important notion for the public’s trust of science. (shrink)

Confucian ethics as applied to the study of business ethics often relate to the micro consideration of personal ethics and the character of a virtuous person. Actually, Confucius and his school have much to say about the morals of the public administration and the market institutions in a more macro level. While Weber emphasizes the role of culture on the development of the economy, and Marx the determining influence of the material base on ideology, we see an interaction between culture (...) – specifically Confucian business ethics – and the economy. In this paper, we are going to study this interaction in several crucial stages of development of Confucianism. The paper concludes by postulating the relevance of Confucian business ethics to the global knowledge economy. (shrink)

We examine the unique nature of agency problems within publicly traded family firms by investigating the earnings management decision of dominant family owners relative to non-family. To do so, we draw upon literature demonstrating that family owners are loss averse with respect to the family’s socioemotional wealth, or the affective endowment derived from firm ownership and control. Our theory and findings suggest that potential reputational consequences of earnings management lead family principals to engage in less of this practice relative to (...) non-family firms, and that founder family firms are less likely than non-founder family firms to use earnings management. Moreover, the family-firm effect varies with the firm size, the degree of CEO entrenchment, and the firm’s stock structure. We provide important insights regarding differences between family and non-family principals in the use of unethical accounting practices, thereby extending agency theory and advancing an underdeveloped research area. (shrink)

The bioeconomy is becoming increasingly prominent in policy and scholarly literature, but critical examination of the concept is lacking. We argue that the bioeconomy should be understood as a political project, not simply or primarily as a technoscientific or economic one. We use a conceptual framework derived from the work of Karl Polanyi to elucidate the politically performative nature of the bioeconomy through an analysis of an influential Organization for Economic Cooperation and Development initiative, The Bioeconomy to 2030. We argue (...) that this initiative is a response to some of the most acute challenges facing the current neoliberal-capitalist accumulation regime, which seeks to protect and extend that regime, through both what it occludes and what it promotes. Rather than taking the bioeconomy as a description of some subset of economic activity, we regard it as a promissory construct that is meant to induce and facilitate some actions while deterring others; most explicitly, it is meant to bring about a particular set of political–institutional changes that will shape the parameters of possible future action. The bioeconomy concept highlights the potential dangers of failing to situate ethnographic examinations of horizontal micro-relations within a political–economic macro-context that enables and constrains. Scholarly work in science and technology studies and elsewhere that does not recognize the wider politics of the bioeconomy risks unintentionally contributing to the legitimation of this political project. (shrink)

This article explores innovative legal tools in built environment settings. Using tangible examples, the discussion will leverage the authors' expertise in the law, public health, and architecture to explore strategies in domestic and international settings to explain how healthy spaces make a direct public health impact on people's lives.

Introduction: A general trend in the psychological literature suggests that guilt contributes to morality more than shame does. Unlike shame-prone individuals, guilt-prone individuals internalize the causality of negative events, attribute responsibility in the first person, and engage in responsible behavior. However, it is not known how guilt- and shame-proneness interact with the attribution of responsibility to others. -/- Methods: In two Web-based experiments, participants reported their attributions of moral culpability (i.e., responsibility, causality, punishment and decision-making) about morally ambiguous acts of (...) killing in different conditions. In Study 1 the vignettes were presented in the 1st person, while in Study 2 in the 3rd person. To test proneness to guilt and shame, we utilized the GASP scale, which differentiates between the affective and behavioral components of each emotion. Statistical analyses were performed in Matlab and R. -/- Results: We found that guilt- and shame-proneness were associated with the severity of attributions in both the first and the third person, but the effect was strong only in the guilt case (both subtypes) and shame-affect case, and not in the shame-behavior case. We call this the Moralizing Effect. -/- Discussion: We wonder whether our finding that guilt-prone people tend to attribute a higher degree of culpability to others is really consistent with the view that guilt motivates people to choose the “moral paths in life”. This echoes views about the harmful aspects of guilt, which have been expressed historically in philosophy, for example, by Friedrich Nietzsche. (shrink)

Those considering careers in medicine and other health and humanitarian disciplines as well as those concerned about the growing presence of militarized ...

Dans une approche psycho-développementale et systémique, cet article examine l’expérience grand-parentale en contexte de troubles du spectre autistique ( tsa ) de l’enfant en considérant la pluralité des relations familiales (conjugale, co-grand-parentale, parents/enfant(s), grand(s)-parent(s)/petit(s)-enfant(s), etc.) dans lesquelles les grands-parents sont inscrits. L’analyse des entretiens menés auprès de six grands-parents (quatre familles) montre notamment l’important engagement et le soutien instrumental et émotionnel des grands-parents auprès des parents et de leur petit-enfant porteur de tsa. Ces résultats sont discutés en lien avec l’accompagnement (...) des enfants présentant un tsa et leurs familles, dans une perspective systémique. (shrink)

Despite decades of concerted efforts to communicate to the public on important scientific issues pertaining to the environment and public health, gaps between public acceptance and the scientific consensus on these issues remain stubborn. One strategy for dealing with this shortcoming has been to focus on the existence of scientific consensus on the relevant matters. Recent science communication research has added support to this general idea, though the interpretation of these studies and their generalizability remains a matter of contention. In (...) this paper, we describe results of a qualitative interview study on different models of scientific consensus and the relationship between such models and trust of science, finding that familiarity with scientific consensus is rarer than might be expected. These results suggest that consensus messaging strategies may not be effective. (shrink)

During an initial palliative care assessment, a dying man discloses that he had killed several people whilst a young man. The junior doctor, to whom he revealed his story, consulted with senior palliative care colleagues. It was agreed that legal advice would be sought on the issue of breaching the man’s confidentiality. Two legal opinions conflicted with each other. A decision was made by the clinical team not to inform the police.In this article the junior doctor, the palliative medicine specialist, (...) a medical ethicist, and a lawyer consider the case from their various perspectives. (shrink)

An organization emits carbon dioxide (CO2) and other greenhouse gases (GHGs) through its daily operations, such as the electricity used to power its offices, manufacture products, and then fossil fuels used in vehicles to distribute them. This is referred to as an organization’s carbon footprint, and there is increasing stakeholder and regulatory pressure on management teams globally to reduce them. On other words, it is increasingly critical that the quantity of carbon dioxide and other greenhouse gases that a company is (...) releasing into the atmosphere can be accurately measured in order to ensure that is being reduced accordingly. The European Union Emissions Trading System (EU ETS) is the most crucial tool for decarbonizing Europe, but it has also become a money-making machine. States and financial investors earn; for the power industry, which pays for it, the worst thing is not the system’s presence but its instability. Huge price jumps make it impossible to plan budgets and investments sensibly. This paper provides an introduction to the EU’s Emissions Trading System. As such it provides a discussion of the historical and legal context in which the EU ETS developed and now operates. This article covers the various ways in which these market dynamics, regulatory requirements and stakeholder expectations have converged to make European carbon markets a critical topic for today’s analyst. (shrink)

Children’s linguistic and social skills develop through play with siblings, but there is little research into sibling interaction using naturally occurring data. This conversation analytic case study presents an evidence-based account of how an older sibling responds to verbal challenges from her younger sibling during free play at home. The older sibling employs prosodic, rhetorical and linguistic devices to deflect challenges while avoiding conflict. She does this by acknowledging the grounds of the challenge, before invoking privileged information or epistemic differences (...) to reject it. Structurally, the older sibling inserts extended digressions which obfuscate challenges by engaging the challenger and switching topic. These phenomena blur the traditional accept/reject response dichotomy. The findings provide insight into the complexity of a 5-/6-year-old’s challenge-defence strategies and highlight the importance of face preservation and mitigation of disagreement. We propose that the ability to respond to challenges while maintaining intersubjectivity is a component of communicative competence. (shrink)

The book presents logical foundations of dual tableaux together with a number of their applications both to logics traditionally dealt with in mathematics and philosophy (such as modal, intuitionistic, relevant, and many-valued logics) and to various applied theories of computational logic (such as temporal reasoning, spatial reasoning, fuzzy-set-based reasoning, rough-set-based reasoning, order-of magnitude reasoning, reasoning about programs, threshold logics, logics of conditional decisions). The distinguishing feature of most of these applications is that the corresponding dual tableaux are built in a (...) relational language which provides useful means of presentation of the theories. In this way modularity of dual tableaux is ensured. We do not need to develop and implement each dual tableau from scratch, we should only extend the relational core common to many theories with the rules specific for a particular theory. (shrink)

One of the major objectives in a democratic state is ensuring health security of the citizens including combating epidemic diseases. The subject matter of this article is the presentation and analysis of legal regulations regarding preventive vaccination in Poland, in particular the aspect of imposing a legal obligation and restricting parents’ right to express consent for medical intervention. The reflections made herein are aimed at finding an answer to the question whether the adopted legal solutions are admissible in a democratic (...) state with regard to ensuring health security. The purpose of the analysis is also to assess whether the abovementioned legal regulations have been formulated in a clear way and do not raise interpretation doubts and, consequently, whether they are comprehensible to the parents obliged to comply with them. As it follows from analysis of the legal provisions, parents must not refuse to subject a child to obligatory preventive vaccination and their consent is not required by law, both as regards the medical qualifying examination to exclude contraindications to performing vaccination and the vaccination itself. It is a legal obligation, from which exemption is only possible on grounds of certain medical conditions that would render vaccination inadvisable. The legal provisions that concern obligatory preventive vaccination in Poland, including in particular those referring to its enforceability, have not been formulated in a way that is sufficiently comprehensible to parents who are under the obligation of complying with them, irrespective of the fact that the language of the provisions of law should be clear and raise no interpretative doubts. In a democratic state the protection of public health against epidemic hazards justifies the implementation of legal solutions that restrict an individual’s freedom of self-determination, thus limiting the right of patients or their statutory representatives to grant or refuse consent for a medical intervention in the form of preventive vaccination – the purpose of this legal solution being to prioritize the safeguarding of state health security. It is vitally important to engage in a social dialogue with the purpose of convincing the public of the need for vaccination, its significance and its implementation for the better good. (shrink)

Shortcomings in the target article preclude adequate tests of developmental/attachment and strategic pluralism theories. Methodological problems include comparing college student attitudes with societal level indicators that may not reflect life conditions of college students. We show, through two principal components analyses, that multiple tests of the theories reduce to only two findings that cannot be interpreted as solid support for evolutionary hypotheses.

Willingness to take risk is one of the most important aspects of personal financial decisions, especially those regarding investments. Recent studies show that one’s perception of time, specifically the individual level of Present Hedonistic and Future Time Perspectives (TPs), influence risky financial choices. This was demonstrated for both, Time Perspective treated as an individual trait and for experimentally induced Time Perspectives. However, on occasion, people might find themselves under the joint influence of both, chronic and situational Time Perspectives and little (...) is known about interactions between them. The paper focuses on the interplay between chronic and induced levels of Future and Present Hedonistic TPs in explaining people’s propensity to take investment risks. An experimental study using a Polish national random-quota sample was conducted. The results showed that situationally induced Future TP lowered the preferred level of portfolio riskiness while situationally induced Present Hedonistic TPs resulted in exactly the opposite effect, and that the higher level of chronic Present Hedonistic TP was linked to higher investment risk preferences. The role of the chronic Present Hedonistic TP was moderated by the situationally induced Future (approaching significance) and Present Hedonistic TPs. The induction of these TPs resulted in reduction of the propensity to take investment risks. The study adds to the literature on psychological factors influencing the propensity to take financial risk. The results are also important for researchers who experimentally manipulate variables that might be also considered as chronic traits. They indicate that whether the manipulation is congruent with one’s natural tendencies may have a differential impact on subsequent measures. (shrink)

The first goal of this study was to validate the Rational-Experiential Inventory (REI) and the Cognitive Reflection Test (CRT) through checking their relation to the transitivity axiom. The second goal was to test the relation between decision strategies and cognitive style as well as the relation between decision strategies and the transitivity of preferences. The following characteristics of strategies were investigated: requirements for trade-offs, maximization vs. satisficing and option-wise vs. attribute-wise information processing. Respondents were given choices between two multi-attribute options. (...) The options were designed so that the choice indicated which strategy was applied. Both the REI-R and the CRT were found to be good predictors of the transitivity of preferences. Respondents who applied compensatory strategies and the maximization criterion scored highly on the REI-R and in the CRT, whereas those who applied the satisficing rule scored highly on the REI-R but not in the CRT. Attribute-wise information processing was related to low scores in both measurements. Option-wise information processing led to a high transitivity of preferences. (shrink)

We introduce an Automatic Theorem Prover (ATP) of a dual tableau system for a relational logic for order of magnitude qualitative reasoning, which allows us to deal with relations such as negligibility, non-closeness and distance. Dual tableau systems are validity checkers that can serve as a tool for verification of a variety of tasks in order of magnitude reasoning, such as the use of qualitative sum of some classes of numbers. In the design of our ATP, we have introduced some (...) heuristics, such as the so called phantom variables, which improve the efficiency of the selection of variables used un the proof. (shrink)

A new deduction system for deciding validity for the minimal decidable normal modal logic K is presented in this article. Modal logics could be very helpful in modelling dynamic and reactive systems such as bio-inspired systems and process algebras. In fact, recently the Connectionist Modal Logics has been presented, which combines the strengths of modal logics and neural networks. Thus, modal logic K is the basis for these approaches. Soundness, completeness and the fact that the system itself is a decision (...) procedure are proved in this article. The main advantages of this approach are: first, the system is deterministic, i.e. it generates one proof tree for a given formula; second, the system is a validity-checker, hence it generates a proof of a formula ; and third, the language of deduction and the language of a logic coincide. Some of these advantages are compared with other classical approaches. (shrink)

Fifty years of Darwinism.--The personality of Charles Darwin.--The Darwin centenary at Oxford.--Charles Darwin and the University of Cambridge.--The value of colour in the struggle for life.--Mimicry in the butterflies of North America.--Letters from Charles Darwin to Roland Trimen.--Appendix A. Charles Darwin and the hypothesis of multiple origins.--Appendix B. Darwin and evolution by mutation.--Appendix C. Further proof that scientific work was necessary for Darwin.--Appendix D. De Vries's 'fluctuations' hereditary according to De Vries, non-transmissible according to Bateson and Punnett.

Unprecedented advances in medicine, genetic engineering, and demographic forecasting raise new questions that strain the categories and assumptions of traditional ethical theories. Heyd's approach resolves many paradoxes in intergenerational justice, while offering a major test case for the profound problems of the limits of ethics and the nature of value.

Lektorzy pracujący ze studentami kierunków niefilologicznych szczególnie wyraźnie odczuwają, iż kompetentne nauczanie języka obcego nierozerwalnie wiąże się z przekazywaniem wiedzy o kulturze i historii kraju lub krajów, w którym jest on używany. Bez takiej koherencji wiele zjawisk (jak choćby idiomy, specyfika frazeologii czy nietypowe konstrukcje gramatyczne powstałe pod wpływem historycznych kontaktów międzynarodowych) pozostanie w znacznej mierze niezrozumiałe dla osób uczestniczących w lektoracie. Na kwestię „przemycania” w trakcie zajęć językowych wiadomości o dziejach danego kręgu kulturowego spojrzeć można jednak nie tylko z (...) perspektywy nauczyciela języka, ale również z punktu widzenia historyka. Niniejszy artykuł stanowi pokłosie takich właśnie rozważań nad obrazem rodzimej historii, jaki przekazywany jest w trakcie lektoratu języka polskiego obcokrajowcom studiującym w Rzeczypospolitej inne kierunki aniżeli polonistyka. Analizie poddano pomoce edukacyjne, a ściślej wybrane podręczniki tworzone przez natywnych użytkowników języka polskiego, powstałe po 2005 r. Cezura ta podyktowana jest zachodzącymi w glottodydaktyce na przestrzeni ostatniego półwiecza zmianami w podejściu do nauczania aspektów kulturowych. Jako efekt tych dociekań starano się przedstawić następujące kwestie. Po pierwsze: stan badań nad omawianym problemem na przestrzeni końca wieku XX i początku XXI w. przy jednoczesnym porównaniu z ukazującymi się wówczas publikacjami przeznaczonymi do nauczania specjalistycznego języka polskiego w zakresie innych dyscyplin. Po drugie: typologię zagadnień z historii Rzeczypospolitej, jakie wprowadzono do nauczania tegoż języka jako obcego z podkreśleniem postaci, wydarzeń i miejsc, które wyjątkowo często wykorzystywane są w analizowanych materiałach dydaktycznych. Po trzecie: problem możliwości skorelowania rzeczonej typologii z poziomami nauczania języka obcego określonymi w ESOKJ. Wiodącym wynikiem powyższych rozważań jest konkluzja, iż obraz dziejów Polski odmalowywany przed obcokrajowcami za pomocą tekstów niewątpliwie przemyślanych i wartościowych w swej warstwie językoznawczej z punktu widzenia historyka jest niekompletny (zwłaszcza w odniesieniu do okresu nowożytnego i wieku XX). Przez to zaś może prowadzić słuchaczy z innych kręgów kulturowych do niezrozumienia polskiej specyfiki cywilizacyjnej i rzutować na poprawność komunikacji językowej. Sytuacja taka zwiększa zarazem zakres odpowiedzialności lektorów za choćby częściowe uzupełnienie niedostatków występujących w materiałach dydaktycznych. (shrink)

For her entire childhood, Joanna's father, Bob, had a ritual: wake up at dawn, walk the dog, and sit down at the kitchen table with a blank pad of paper and plenty of colored markers to craft notes for his two children. Over the years, word games and puzzles for five-year-olds morphed into thoughtful guidance and reflections for his teenagers approaching adulthood. Now, with more than 3,500 of her father's colorful notes in hand, Joanna has decided that the (...) lessons tucked inside are worth sharing. Folded Wisdom highlights the collection of Bob's notes, telling a story filled with universal values that encourages meaningful self-reflection about how we all face successes and failures; express happiness and sadness; and communicate frustration, praise, and love to one another. Heartfelt and full of possibility for the future, a father's folded notes and drawings are timeless reminders of love. (shrink)

A study of the future of feminism calls for a return to the radical roots of feminism's direct political struggle during the 1960s and early 1970s and a move away from the de-politicized focus on women's psychology and personal relations of today.

The use of the category of race in science remains controversial. During the last few years there has been a lively debate on this topic in the field of a relatively young neuroscience discipline called cultural neuroscience. The main focus of cultural neuroscience is on biocultural conditions of the development of different dimensions of human perceptive activity, both cognitive or emotional. These dimensions are analysed through the comparison of representatives of different social and ethnic groups. In my article, I present (...) arguments supporting these two hypotheses: the other-race effect understood as an individual, distinct effect does not exist. It is rather an exemplification of a much broader phenomenon which I call theunfamiliarity homogeneity effect. It includes not only problems with differentiation and recognition of faces of representatives of other ethnic groups, but also covers similar recognitional difficulties ; The race-based terminology and categories are used in cultural neuroscience research in a vague and inconsistent manner. Such an approach distorts the science both in empirically and conceptually significant respects. The unfamiliarity homogeneity effect is an example of such a situation: narrowing it to the other-race effect makes it difficult to analyse in a wider context crucial for its understanding. (shrink)

The immortality of the soul is one of the oldest tropes in the history of philosophy and one that gained significant momentum in 16th-century Europe. But what came before Pietro Pomponazzi and his contemporaries? Through examination of four neglected but central figures, Joanna Papiernik uncovers the rich and varied nature of the afterlife debate in 15th-century Italy. By engaging with old prints, manuscripts and other archival material, this book reveals just how much interest there was in the question of (...) immortality before the 16th-century boom in Aristotelian translations. In particular, Papiernik sheds light on the treatises of Agostino Dati, Leonardo Nogarola, Antonio degli Agli and Giovanni Canali, all of which have until now been overlooked in modern scholarship. From Dati's critiques of ancient and existing positions to Agli's study of immortality and its relation to the metaphysics of light, this volume investigates not only how wide-ranging the debate was but also the important impact it had on later philosophical thinking. Deftly combining close reading with a broad intellectual survey, and including two editions of unpublished primary texts, Philosophies of the Afterlife in the Early Italian Renaissance provides a crucial insight into the development of early Renaissance Platonism and philosophy of religion. (shrink)