Translational research is a buzzword which dominates discussions about the quality, the utilization, and the benefits of medical research. Yet, although translational research has become a prominent topic, no commonly agreed definition of this terminology exists. Instead, experts from different contexts such as biomedical research, clinical practice or nursing discuss translational research in multiple ways depending on how they define the problem that translational research is supposed to be the solution to. In this paper, we do not seek to find (...) a ‘correct’ definition of translational research, but instead ask how actors using this terminology for describing their own research make sense of it. To do so, we asked three questions: Which actors are engaged in the debate about translational research? What kind of different meanings of translational research exist? And, which actors refer to which meaning of translational research when using the term? In answering these questions, we highlight the role this terminology plays in defining what medical science is about today. (shrink)

Editors van Ditmarsch, Hendriks and Verbrugge of this special issue of topiCS on lying describe some recent trends in research on lying from a multidisciplinary perspective, including logic, philosophy, linguistics, psychology, cognitive science, behavioral economics, and artificial intelligence. Furthermore, they outline the seven contributions to this special issue.

This paper presents a study of the effect of working memory load on the interpretation of pronouns in different discourse contexts: stories with and without a topic shift. We discuss a computational model (in ACT-R, Anderson, 2007) to explain how referring expressions are acquired and used. On the basis of simulations of this model, it is predicted that WM constraints only affect adults' pronoun resolution in stories with a topic shift, but not in stories without a topic shift. This latter (...) prediction was tested in an experiment. The results of this experiment confirm that WM load reduces adults' sensitivity to discourse cues signaling a topic shift, thus influencing their interpretation of subsequent pronouns. (shrink)

Holobionts, consisting of a host and diverse microbial symbionts, function as distinct biological entities anatomically, metabolically, immunologically, and developmentally. Symbionts can be transmitted from parent to offspring by a variety of vertical and horizontal methods. Holobionts can be considered levels of selection in evolution because they are well-defined interactors, replicators/reproducers, and manifestors of adaptation. An initial mathematical model is presented to help understand how holobionts evolve. The model offered combines the processes of horizontal symbiont transfer, within-host symbiont proliferation, vertical symbiont (...) transmission, and holobiont selection. The model offers equations for the population dynamics and evolution of holobionts whose hologenomes differ in gene copy number, not in allelic or loci identity. The model may readily be extended to include variation among holobionts in the gene identities of both symbionts and host. (shrink)

Moral distress has received much attention in the international nursing literature in recent years. In this article, we describe the evolution of the concept of moral distress among nursing theorists from its initial delineation by the philosopher Jameton to its subsequent deployment as an umbrella concept describing the impact of moral constraints on health professionals and the patients for whom they care. The article raises worries about the way in which the concept of moral distress has been portrayed in some (...) nursing research and expresses concern about the fact that research, so far, has been largely confined to determining the prevalence of experiences of moral distress among nurses. We conclude by proposing a reconsideration, possible reconstruction and multidisciplinary approach to understanding the experiences of all health professionals who have to make difficult moral judgements and decisions in complex situations. (shrink)

Dutch allows for variation as to whether the first position in the sentence is occupied by the subject or by some other constituent, such as the direct object. In particular situations, however, this commonly observed variation in word order is ‘frozen’ and only the subject appears in first position. We hypothesize that this partial freezing of word order in Dutch can be explained from the dependence of the speaker’s choice of word order on the hearer’s interpretation of this word order. (...) A formal model of this interaction between the speaker’s perspective and the hearer’s perspective is presented in terms of bidirectional Optimality Theory. Empirical predictions of this model regarding the interaction between word order and definiteness are confirmed by a quantitative corpus study. (shrink)

In the last three decades, considerable theoretical and empirical research has been undertaken on the topic of moral distress among health professionals. Understood as a psychological and emotional response to the experience of moral wrongdoing, there is evidence to suggest that—if unaddressed—it contributes to staff demoralization, desensitization and burnout and, ultimately, to lower standards of patient safety and quality of care. However, more recently, the concept of moral distress has been subjected to important criticisms. Specifically, some authors argue that the (...) standard account of moral distress elucidated by Jameton :542–551, 1984) does not refer to a discrete phenomenon and/or that it is not sufficiently broad and that this makes measuring its prevalence among health professionals, and other groups of workers, difficult if not impossible. In this paper, we defend the standard account of moral distress. We understand it as a concept that draws attention to the social, political and contextual determinants of moral agency and brings the emotional landscape of the moral realm to the fore. Given the increasing pressure on health professionals worldwide to meet efficiency, financial and corporate targets and reported adverse effects of these for the quality and safety of patient care, we believe that further empirical research that deploys the standard account moral distress is timely and important. (shrink)

While algorithmic decision-making (ADM) is projected to increase exponentially in the coming decades, the academic debate on whether people are ready to accept, trust, and use ADM as opposed to human decision-making is ongoing. The current research aims at reconciling conflicting findings on ‘algorithmic aversion’ in the literature. It does so by investigating algorithmic aversion while controlling for two important characteristics that are often associated with ADM: increased benefits (monetary and accuracy) and decreased user control. Across three high-powered (Ntotal = (...) 1192), preregistered 2 (agent: algorithm/human) × 2 (benefits: high/low) × 2 (control: user control/no control) between-subjects experiments, and two domains (finance and dating), the results were quite consistent: there is little evidence for a default aversion against algorithms and in favor of human decision makers. Instead, users accept or reject decisions and decisional agents based on their predicted benefits and the ability to exercise control over the decision. (shrink)

We show that Bounded Forcing Axioms (for instance, Martin's Axiom, the Bounded Proper Forcing Axiom, or the Bounded Martin's Maximum) are equivalent to principles of generic absoluteness, that is, they assert that if a $\Sigma_1$ sentence of the language of set theory with parameters of small transitive size is forceable, then it is true. We also show that Bounded Forcing Axioms imply a strong form of generic absoluteness for projective sentences, namely, if a $\Sigma^1_3$ sentence with parameters is forceable, then (...) it is true. Further, if for every real x, $x^{\sharp}$ exists, and the second uniform indiscernible is less than $\omega_2$ , then the same holds for $\Sigma^1_4$ sentences. (shrink)

For each natural number n, let C(n) be the closed and unbounded proper class of ordinals α such that Vα is a Σn elementary substructure of V. We say that κ is a C(n)-cardinal if it is the critical point of an elementary embedding j : V → M, M transitive, with j(κ) in C(n). By analyzing the notion of C(n)-cardinal at various levels of the usual hierarchy of large cardinal principles we show that, starting at the level of superstrong (...) cardinals and up to the level of rank-into-rank embeddings, C(n)-cardinals form a much finer hierarchy. The naturalness of the notion of C(n)-cardinal is exemplified by showing that the existence of C(n)-extendible cardinals is equivalent to simple reflection principles for classes of structures, which generalize the notions of supercompact and extendible cardinals. Moreover, building on results of Bagaria et al. (2010), we give new characterizations of Vopeňka’s Principle in terms of C(n)-extendible cardinals. (shrink)

A holobiont is a composite organism consisting of a host together with its microbiome, such as a coral with its zooxanthellae. To explain the often intimate integration between hosts and their microbiomes, some investigators contend that selection operates on holobionts as a unit and view the microbiome’s genes as extending the host’s nuclear genome to jointly comprise a hologenome. Because vertical transmission of microbiomes is uncommon, other investigators contend that holobiont selection cannot be effective because a holobiont’s microbiome is an (...) acquired condition rather than an inherited trait. This disagreement invites a simple mathematical model to see how holobiont selection might operate and to assess its plausibility as an evolutionary force. This paper presents two variants of such a model. In one variant, juvenile hosts obtain microbiomes from their parents (vertical transmission). In the other variant, microbiomes of juvenile hosts are assembled from source pools containing the combined microbiomes of all parents (horizontal transmission). According to both variants, holobiont selection indeed causes evolutionary change in holobiont traits. Therefore, holobiont selection is plausibly an effective evolutionary force with either mode of microbiome transmission. The modeling employs two distinct concepts of inheritance, depending on the mode of microbiome transmission: collective inheritance whereby juveniles inherit a sample of the collected genomes from all parents, as contrasted with lineal inheritance whereby juveniles inherit the genomes from only their own parents. A distinction between collective and lineal inheritance also features in theories of multilevel selection. (shrink)

The purpose of this study was to determine the applicability of Buddhist practices in today’s workplaces. The findings were supported by interviews with Buddhist masters and Buddhist business practitioners, as well as literature review, through phenomenological analysis. As a means of presenting the main reasons why Buddhist practices should be considered in contemporary workplaces, a SWOT analysis is presented. In this analysis, a number of strengths for using Buddhist practices in workplaces are listed such as pro-scientific, greater personal responsibility, and (...) healthy detachment, while potential weaknesses such as non-harming, equanimity, and no competition are also reviewed. Both the strengths and the weaknesses could be listed in reverse if applied to a different extent. Among the opportunities were issues such as re-educating the world of business, enhancing personal ownership and a healthier society, while the threats comprised issues such as creating different imbalances, disinterest, and stationary development. (shrink)

Community ecology entered the 1970s with the belief that niche theory would supply a general theory of community structure. The lack of wide-spread empirical support for niche theory led to a focus on models specific to classes of communities such as lakes, intertidal communities, and forests. Today, the needs of conservation biology for metrics of “ecological health” that can be applied across types of communities prompts a renewed interest in the possibility of general theory for community ecology. Disputes about the (...) existence of general patterns in community structure trace at least to the 1920s and continue today almost unchanged in concept, although now expressed through mathematical modeling. Yet, a new framework emerged in the 1980s from findings that community composition and structure depend as much on the processes that bring species to the boundaries of a community as by processes internal to a community, such as species interactions and co-evolution. This perspective, termed “supply-side ecology”, argued that community ecology was to be viewed as an “organic earth science” more than as a biological science. The absence of a general theory of the earth would then imply a corresponding absence of any general theory for the communities on the earth, and imply that the logical structure of theoretical community ecology would consist of an atlas of models special to place and geologic time. Nonetheless, a general theory of community ecology is possible similar in form to the general theory for evolution if the processes that bring species to the boundary of a community are analogized to mutation, and the processes that act on the species that arrive at a community are analogized to selection. All communities then share some version of this common narrative, permitting general theorems to be developed pertaining to all ecological communities. Still, the desirability of a general theory of community ecology is debatable because the existence of a general theory suppresses diversity of thought even as it allows generalizations to be derived. The pros and cons of a general theory need further discussion. (shrink)

Volume 20, Issue 2, February 2020, Page 35-38.

Superstrong cardinals are never Laver indestructible. Similarly, almost huge cardinals, huge cardinals, superhuge cardinals, rank-into-rank cardinals, extendible cardinals, 1-extendible cardinals, 0-extendible cardinals, weakly superstrong cardinals, uplifting cardinals, pseudo-uplifting cardinals, superstrongly unfoldable cardinals, Σn-reflecting cardinals, Σn-correct cardinals and Σn-extendible cardinals are never Laver indestructible. In fact, all these large cardinal properties are superdestructible: if κ exhibits any of them, with corresponding target θ, then in any forcing extension arising from nontrivial strategically <κ-closed forcing Q∈Vθ\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} (...) \setlength{\oddsidemargin}{-69pt} \begin{document}$${\mathbb{Q} \in V_\theta}$$\end{document}, the cardinal κ will exhibit none of the large cardinal properties with target θ or larger. (shrink)

What personal truths reside in biological ties that are absent in adoptive ties? And why do we think adoptive and biological ties are essentially different when it comes to understanding who we are? At a time when interest in DNA and ancestry is exploding, Frances Latchford questions the idea that knowing one's bio-genealogy is integral to personal identity or a sense of family and belonging. Upending our established values and beliefs about what makes a family, Steeped in Blood examines the (...) social and political devaluation of adoptive ties. It takes readers on an intellectual journey through accepted wisdom about adoption, twins, kinship, and incest, and challenges our naturalistic and individualistic assumptions about identity and the biological ties that bind us, sometimes violently, to our families. Latchford exposes how our desire for bio-genealogical knowledge, understood as it is by family and adoption experts, pathologizes adoptees by posing the biological tie as a necessary condition for normal identity formation. Rejecting the idea that a love of the self-same is fundamental to family bonds, her book is a reaction to the wounds families suffer whenever they dare to revel in their difference. A rejoinder to rhetoric that defines adoptees, adoptive kin, and their family intimacies as inferior and inauthentic, Steeped in Blood's view through the lens of critical adoption studies decentres our cultural obsession with the biological family imaginary and makes real the possibility of being family in the absence of blood. (shrink)

The popular view of non-directive genetic counseling limits the counselor's role to providing information to clients and assisting families in making decisions in a morally neutral fashion. This view of non-directive genetic counseling is shown to be incomplete. A fuller understanding of what it means to respect autonomy shows that merely respecting client choices does not exhaust the duty. Moreover, the genetic counselor/client relationship should also be governed by the counselor's commitment to the principle of beneficience. When non-directive counseling is (...) reexamined in light of both these principles, it becomes clear that there are cases in which counselors should attempt to persuade clients to reconsider their decisions. Such attempts are consistent with non-directive counseling because, while respecting the clients' decision-making authority, they insure that clients act with full knowledge of the moral consequences of their decisions. (shrink)

Martin's axiom is equivalent to the statement that the universe is absolute under ccc forcing extensions for Σ 1 sentences with a subset of $\kappa, \kappa , as a parameter.

The laser, first operated in 1960, produced light with coherence properties that demanded explanation. While some attempted a treatment within the framework of classical coherence theory, others insisted that only quantum electrodynamics could give adequate insight and generality. The result was a sharp and rather bitter controversy, conducted over the physics and mathematics that were being deployed, but also over the criteria for doing good science. Three physicists were at the center of this dispute, Emil Wolf, Max Born’s collaborator on (...) a canonical text on optics as a branch of classical electromagnetism, Roy J. Glauber, a student of Julian Schwinger and a high-energy particle theorist, and Leonard Mandel, both experimentalist and theorist and versed in the physics of photodetection. The story told here is thus one of three distinct research trajectories and of the explosion that occurred when, pushed into the well-financed field of laser studies, these trajectories collided. (shrink)

This article briefly outlines some of the key problems with the way in which the moral realm has traditionally been understood and analysed. I propose two alternative views of what is morally interesting and applicable to nursing practice and I indicate that instability has its upsides. I begin with a moral tale – a 'Good Samaritan' story – which raises fairly usual questions about the nature of morality but also the more philosophically fundamental question about the relationship between subjectivity and (...) moral agency. I then consider this relationship from the perspectives of two twentieth century philosophers: Emmanuel Levinas and Michel Foucault. Levinas' basic point is that the experience of ethical subjectivity is made possible through others: the demand to respond to the existence of others is the basic social structure that precedes individual freedom. If Levinas posits intersubjectivity as a fundamental or primitive feature of the moral realm, Foucault poses an even more basic question: how have moral subjects and relations of obligation been constituted? The aim of ethical inquiry, for Foucault, is to describe the network of discourses, institutions, relations, and practices through which certain kinds of subjects are constituted and constitute themselves, e.g. as a kind of person who can act morally. Finally, I consider some recent research in philosophy of nursing which illustrates how Levinasian and/or Foucauldian perspectives can deepen understanding of nurses' moral practices, specifically, the work of Norwegian public health nurses, Canadian pediatric nurses, and Irish midwives. I suggest that in spite of the instability of morality in general and the particular ethical challenges that face nurses, there are grounds for hope and possible strategies for living in unstable times. (shrink)

We give a level-by-level analysis of the Weak Vopěnka Principle for definable classes of relational structures ( $\mathrm {WVP}$ ), in accordance with the complexity of their definition, and we determine the large-cardinal strength of each level. Thus, in particular, we show that $\mathrm {WVP}$ for $\Sigma _2$ -definable classes is equivalent to the existence of a strong cardinal. The main theorem (Theorem 5.11) shows, more generally, that $\mathrm {WVP}$ for $\Sigma _n$ -definable classes is equivalent to the existence of (...) a $\Sigma _n$ -strong cardinal (Definition 5.1). Hence, $\mathrm {WVP}$ is equivalent to the existence of a $\Sigma _n$ -strong cardinal for all $n<\omega $. (shrink)

Does Frege have a metatheory for his logic? There is an obvious and uncontroversial sense in which he does. Frege introduces and discusses his new logic in natural language; he argues, in response to criticisms of Begriffsschrift, that his logic is superior to Boole's by discussing formal features of both systems. In so far as the enterprise of using natural language to introduce, discuss, and argue about features of a formal system is metatheoretic, there can be no doubt: Frege has (...) a metatheory. There is also an obvious and uncontroversial sense in which Frege does not have a metatheory for his logic. The model theoretic semantics with which we are familiar today are a post-Fregean development. The question I address in this paper is, does Frege have a metatheory in the following sense: do his justifications of his basic laws and rules of inference employ, or even require, ineliminable use of a truth predicate and metalinguistic variables? My answer is ‘no’ on both counts. I argue that Frege neither uses, nor has any need to use, a truth predicate or metalinguistic variables in his justifications of his basic laws and rules of inference. Quine's famous explanation of the need for semantic ascent simply does not apply to Frege's logic. The purpose of the discussions that are typically understood as constituting Frege's metatheory is, rather, elucidatory. And once we see what the aim of these particular elucidations is, we can explain Frege's otherwise puzzling eschewal of the truth predicate in his discussions of the justification of the laws and rules of inference. (shrink)

We strengthen a result of Harrington and Shelah by showing that, unless ω1 is an inaccessible cardinal in L, a relatively weak fragment of Martin's axiom implies that there exists a δ13 set of reals without the property of Baire.

This study considers the potential for influencing business students to become ethical managers by directing their undergraduate learning environment. In particular, the relationship between business students’ academic cheating, as a predictor of workplace ethical behavior, and their approaches to learning is explored. The three approaches to learning identified from the students’ approaches to learning literature are deep approach, represented by an intrinsic interest in and a desire to understand the subject, surface approach, characterized by rote learning and memorization without understanding, (...) and strategic approach, associated with competitive students whose motivation is the achievement of good grades by adopting either a surface or deep approach. Consistent with the hypothesized theoretical model, structural equation modeling revealed that the surface approach is associated with higher levels of cheating, while the deep approach is related to lower levels. The strategic approach was also associated with less cheating and had a statistically stronger influence than the deep approach. Further, a significantly positive relationship reported between deep and strategic approaches suggests that cheating is reduced when deep and strategic approaches are paired. These findings suggest that future managers and business executives can be influenced to behave more ethically in the workplace by directing their learning approaches. It is hoped that the evidence presented may encourage those involved in the design of business programs to implement educational strategies which optimize students’ approaches to learning towards deep and strategic characteristics, thereby equipping tomorrow’s managers and business executives with skills to recognize and respond appropriately to workplace ethical dilemmas. (shrink)

The management of covid-19 and the so-called "new normality" have brought with a timely debate of ideas about the future of sovereignty. Leaving aside hegemonic and neoliberal technophilia, this debate has generated two mutually exclusive approaches based on controversial statements by the philosopher Giorgio Agamben, namely: one that foresees an undemocratic horizon subject to new technologies and another that emphasizes the transversal character and contradictory of these. In this work, by appealing to the theory of techno-economic paradigms, I critically set (...) out the main reasonings of the debate and I reflect on the future of democracy. (shrink)