‘Ethics first’ reform in China significantly changes the governance framework for the research of emerging technologies. The misapplication of human genome editing technology reflects the urgent need to reform the governance framework. Strengthening ethics governance in medical research has become a consensus in China, where legal and ethical reforms are proceeding in parallel. The protection of human dignity, the prevention of biosafety risks, as well as the regulation of technological crimes are at the core of the legal system, which has (...) been embodied in numerous fundamental legislations following the CRISPR-babies incident. Establishing a national ethics committee to coordinate ethics governance, and reinforcing ethics review and external oversight are significant steps in ethical reform. Essentially, ethics governance requires implementing the basic concept of ‘ethics first’, focusing on forward-looking and preventive governance rather than delayed intervention, while maintaining openness and collaboration. (shrink)

Complex, multigenic biological traits are shaped by the emergent interaction of proteins being the main functional units at the molecular scale. Based on a phenomenological approach, algorithms for quantifying two different aspects of emergence were introduced (Wegner and Hao in Progr Biophys Mol Biol 161:54–61, 2021) describing: (i) pairwise reciprocal interactions of proteins mutually modifying their contribution to a complex trait (denoted as weak emergence), and (ii) formation of a new, complex trait by a set of n ‘constitutive’ proteins at (...) concentrations exceeding individual threshold values (strong emergence). The latter algorithm is modified here to take account of protein redundancy with respect to a complex trait (‘full redundancy’). Irreducibility is considered a necessary and sufficient criterion for strong biological emergence; if one constitutive protein is missing, or its concentration drops below the threshold the trait is lost. A definition based on ‘unpredictability’ is dismissed, because this criterion is irrelevant for the evolution of a complex trait, and apparent unpredictability may rather reflect our basic deficits in understanding unless we can provide an unequivocal proof for it. The phenomenological approach advocated here allows to identify hidden rules according to which strongly emergent traits may be organized. This is of high value for understanding the evolution of complex traits which seems to require the saltational advent of all constitutive proteins ‘in one turn’ to arrive at a functional trait providing for an improved fitness of the organism. Rather than being a purely random process, it may be guided by fundamental structural principles. (shrink)

I first give a brief summary of a critique of the traditional theories of approximation and idealization; and after identifying one of the major roles of idealization as detaching component processes or systems from their joints, a detailed analysis is given of idealized laws – which are discoverable and/or applicable – in such processes and systems (i.e., idealized model systems). Then, I argue that dispositional properties should be regarded as admissible properties for laws and that such an inclusion supplies the (...) much needed connection between idealized models and the laws they `produce'' or `accommodate''. And I then argue that idealized law-statements so produced or accommodated in the models may be either true simpliciter or true approximately, but the latter is not because of the idealizations involved. I argue that the kind of limiting-case idealizations that produce approximate truth is best regarded as approximation; and finally I compare my theory with some existing theories of laws of nature.We seem to trace [in KingLear] ... the tendency of imagination toanalyse and abstract, to decomposehuman nature into its constituentfactors, and then to construct beings in whomone or more of these factors isabsent or atrophied or only incipient. (shrink)

The problem of transcendence and immanence is a central issue in every great religious tradition. It is indeed the understanding of the relation between the transcendent and man that determines the character of a religious faith. The transcendent, However, May assume different forms; it need not always be a supreme personal God in the judaeo-Christian sense. In the confucian tradition, Heaven is the transcendent; hence the problem of transcendence and immanence becomes the problem of heaven and man. In this article, (...) I have not followed a historical approach to trace the development of the idea of heaven and the idea of man in the confucian tradition. Instead, I have concentrated my studies on chung yung or the doctrine of the mean, Because the ideas developed in this document are most typical of the confucian reflection on the problem of transcendence and immanence. And I find that transcendence and immanence are a pair of interdependent concepts for the confucian philosophers. At the end of the paper, The contemporary significance of this view has also been considered. (shrink)

In this paper, a criticism of the traditional theories of approximation and idealization is given as a summary of previous works. After identifying the real purpose and measure of idealization in the practice of science, it is argued that the best way to characterize idealization is not to formulate a logical model – something analogous to Hempel's D-N model for explanation – but to study its different guises in the praxis of science. A case study of it is then made (...) in thermostatistical physics. After a brief sketch of the theories for phase transitions and critical phenomena, I examine the various idealizations that go into the making of models at three difference levels. The intended result is to induce a deeper appreciation of the complexity and fruitfulness of idealization in the praxis of model-building, not to give an abstract theory of it. (shrink)

The objective of this paper is to show that, instead of quantum probabilities, wave packets are physically real. First, Cartwright's recent argument for the reality of quantum probabilities is criticized. Then, the notion of ‘physically real’ is precisely defined and the difference between wave functions and quantum probabilities clarified. Being thus prepared, some strong reasons are discussed for considering the wave packet to be physically real. Finding the reasons inconclusive, I explain how the Aharonov—Bohm effect delivers the final punch. I (...) conclude that wave packets are the quantum objects that underlie the indeterministic quantum processes and have the propensity of displaying probabilistic (or indeterministic) behavior. (shrink)

In his dialogue with Zai Wo about the three-year mourning, Confucius establishes a principle of 'justification by feeling at ease,' and insists that one should transcend natural desires by moral emotions. More significantly, he further regards kinship love as the ultimate root and supreme principle of human life. Thus, this dialogue contains almost all the basic elements of the Confucian spirit of consanguineous affection.

Physics seems to tell us that there are four fundamental force-fields in nature: the gravitational, the electromagnetic, the weak, and the strong (or interactions). But it also seems to tell us that gravity cannot possibly be a force-field, in the same sense as the other three are. And yet the search for a grand unification of all four force-fields is today one of the hottest pursuits. Is this the result of a simple confusion? This article aims at clarifying this situation (...) by (i) reviewing the gauge-field programme and its conception of unification of force-fields, (ii) examining the various attempts at a gauge theory of gravity, and (iii) articulating the nature of "gauging" and using it to explain the difference between gravity and the other force-fields. (shrink)

In this paper I construct Confucian moral realism as a metaethical theory that is compatible with, or even derivable from, traditional Confucianism. The paper is at once interpretative and constructive. In my analysis, Confucians can establish the realist's claims on moral properties because they embrace the view of a moralistic universe. Moral properties in Confucian ethics not only are presented as objective, naturalistic properties, but also are seen as 'causally efficacious'. There are several theses commonly endorsed by contemporary moral realists. (...) I will explain how many of the remarks by Confucius, Mencius, in Yijing, The Great Learning and The Doctrine of the Mean can be understood as implicit endorsements of these theses. I will also analyze the theses specific to Confucian moral realism. The paper will end with a brief defense of this form of realism. (shrink)

This essay explores the nature of spontaneous symmetry breaking (SSB) in connection with a cluster of interrelated concepts such as Curie's symmetry principle, ergodicity, and chance and stability in classical systems. First, a clarification of the two existing senses of SSB is provided and an argument developed for a proposal for SSB, in which not only the possibilities but also the actual breakings are referred to. Second, a detailed analysis is given of classical SSB that answers the questions: (i) how (...) we are justified in regarding it as a matter of chance, and (ii) why the breakings in it are equally probable. The answer provides some support to the applicability of ergodicity in special systems (such as ours). (shrink)

The COVID-19 pandemic has pressed a pause button on global economic development, and induced significant mental health problems. In order to demonstrate the progressed relationship between the pandemic, economic slowdown, and mental health burden, we overviewed the global-level gross domestic product changes and mental problems variation since the outbreak of COVID-19, and reviewed comprehensively the specific sectors influenced by the pandemic, including international trade, worldwide travel, education system, healthcare system, and individual employment. We hope to provide timely evidence to help (...) with the promotion of policymakers’ effective strategies in mitigating economic losses induced by the pandemic; we suggest different governments or policy makers in different countries to share information and experience in dealing with COVID-19-induced economic slowdown and promote COVID-19 vaccine popularization plan to protect every individual worldwide against the coronavirus essentially; and we appeal international information share and collaboration to minimize stigmatization related to adverse mental consequences of COVID-19 and to increase mental health wellbeings of people all over the world. (shrink)

The relationship between bilingual language control and executive control is debated. The present study investigated the effect of short‐term language switching in a comprehension task on executive control performance in unbalanced bilinguals. Participants were required to perform a context task and an executive control task (i.e., flanker task) in sequence. A picture‐word matching task created different language contexts in Experiment 1 (i.e., L1, L2, and dual‐language contexts). By modifying the color‐shape switching task, we created different contexts that do not involve (...) language processing in Experiment 2 (i.e., color, shape, and dual context). Experiment 1 showed overall faster responses (in both congruent and incongruent trials) in the flanker task after a language switching context than after single (L1 or L2) contexts. This suggests that the language switching in a comprehension task affected general monitoring performance. By contrast, the nonlinguistic contexts in Experiment 2 did not affect flanker performance. This provides further evidence for the crucial role of language processing during switching to elicit short‐term adaptions on domain‐general conflict monitoring. Overall, our findings add to the previous studies by showing cross‐talk between bilingual language control and domain‐general conflict monitoring when language switching occurs in a comprehension task. (shrink)

Confucianism has usually been regarded as a secular moral philosophy with no religious import at all. In china, However, Confucianism has been mentioned along with buddhism and taoism as one of the three religions (the so-Called san-Chiao) for centuries. This means that we must revise and broaden our traditional concept of religion. The confucian tradition certainly has its unique way of expressing its ultimate and therefore religious concern. The present essay is an attempt to uncover the religious import in confucian (...) philosophy and to ascertain its meaning in contemporary discussions of theology and philosophy of religion. In this article, First, The development of the confucian religious attitude has been traced; second, This attitude has been compared with the christian attitude; third, Its contemporary significance with reference to the current development of theology and religious philosophy in the west has been discussed; finally, Some general remarks upon the relevance of religious message to today's situation have been made. (shrink)

We aim to investigate the effect of corporate environmental responsibility (CER) engagement on investors' reactions. We also explore heterogeneity of this impact among different types of companies and different company's market performance. We use panel data models and quantile regression based on data related to firms listed on the A-share China security market and the final sample consists of 3,776 firm-year observations. The results show that CER engagement has a significant positive impact on investors' investment decisions. Further, investors are more (...) sensitive to CER engagement of high energy-consumption companies and no matter the company is a state-owned or a non-state-owned, CER engagement has a significant positive impact on investors' reactions. CER engagement has a significant positive impact on investors' reactions in all quantiles except one and the promoting effect increases first and then decreases with the growth of corporate market value from lower to upper quantiles. (shrink)

We examined whether and how managerial ability affects the relationship between customer concentration and corporate performance. Based on a novel measure of managerial ability, we found that customer concentration has a significant negative effect on corporate performance, while managerial ability can mitigate this effect. The negative effect of customer concentration is only significant in the subsample of low ability and lower efficiency in asset utilization, while the moderating effect of managerial ability is significant for all levels of asset utilization efficiency (...) and more significant for firms with a lower gross margin. The results are robust to numerous robustness tests and endogeneity concerns. Additional analysis of mechanisms shows that in addition to superior operating ability, competent managers select major customers who are more beneficial to their company and decrease the sensitivity of their research and development investment to customers. These findings indicate that the heterogeneity of managerial ability plays an important role in the supplier–customer context when the supplier firm generally faces one or more concentrated customers. (shrink)

To improve the personalized service of cultural tourism, anticipatory calculation has become an essential technology in the content design of intelligence navigation system. Culture tourism, as a form of leisure activity, is being favored by an increasing number of people, which calls for further improvements in the cultural consumption experience. An important component of cultural tourism is for tourists to experience intangible cultural heritage projects with local characteristics. However, from the perspective of user needs and the content adaptive system, there (...) are few suitable intelligent navigation and user demand anticipatory systems for intangible cultural heritage content. Purple clay culture is one of the first batches of national intangible cultural heritage protection projects in China. Therefore, taking purple clay culture exhibition as an example, this paper attempts to analyze the personalized information demand of tourism consumption experience in intangible cultural heritage communication activities with affective computing and meaning-driven innovative design method, by taking the content design in the navigation system as the research object. This paper uses the theory of planned behavior to calculate the relationship between tourists’ attitude, experience behavior, and display information demand. The findings indicate two issues. First, tourists’ demand for the entertainment and leisure attributes of intangible cultural heritage is greater than the demand for educational function attributes. Second, the meaning elements of information can change tourists’ beliefs in intangible cultural heritage and affect their attitude and behavior toward such heritage. According to the research results, strengthening the meaning elements of specific group information can improve people’s cultural identity and tourism satisfaction. The research results provide the basis for the content design direction of future museum intelligent navigation systems. (shrink)

The research programme of the philosophy of information (PI) proposed in 2002 made it an independent area or discipline in philosophical research. The scientific concept of ‘information’ is formally accepted in philosophical inquiry. Hence a new and tool-driven philosophical discipline of PI with its interdisciplinary nature has been established. Philosophy of information is an ‘orientative’ rather than ‘cognitive’ philosophy. When PI is under consideration in the history of Western philosophy, it can be regarded as a shift of large tradition. There (...) are three large traditions at large, known as Platonic, Kantian and Leibniz-Russellian. In the discussion of the position of the possible worlds, we have modal Platonism and modal realism, but both of the theories are made in the framework of Western philosophy. In this essay, it is argued that possible worlds could be seen as worlds in information, which is then an interpretation of modal information theory (MIT). Our interpretation is made on the basis of Leibniz’s lifelong connection with China, a fact often overlooked by the Western philosophers. Possible world theory was influenced by the Neo-Confucianism flourishing since the Song Dynasty of China, the foundation of which is Yijing. It could be argued that Leibniz’s possible world theory was formulated in respect to the impact of the thoughts reflected in Yijing, in that one of the prominent features is the model-theoretic construction of theories. There are two approaches to theory construction, i.e., axiom-theoretic and model-theoretic. The origin of the former is from ancient Greece and the latter from ancient China. And they determined the different features of theoretic structures between the oriental and occidental traditions of science and technology. The tendency of the future development of science and technology is changing from the axiom-theoretic to the model-theoretic orientation, at least the two approaches being complementary each other. To some extent, this means the retrospective of tradition in the turning point of history, and some of the China’s cultural traditions might become the starting points in formulating the future Chinese philosophy of science and technology. (shrink)

Although the chinese have a heightened sense of time, The concepts of time and temporality developed in their culture are remarkably different from those developed in the west. Certain time-Concepts familiar to the westerners are completely lacking in the chinese tradition. For example, The chinese lacked the concept of absolute time as that held by newton, They also lacked a system to record the years in a linear progressive way, And they seem to have shown a lack of drive to (...) go beyond the realm governed by time and temporality. By deemphasizing the abstract concepts of time, However, They have been able to avoid what whitehead called "the fallacy of misplaced concreteness." the chinese accept their correct destinies as finite beings and work hard in order to find their self-Realization. This explains why they do not view time and death with a sense of anxiety. (shrink)

陆流,字锦川,本号不息,知名中医及气功大师,四川省内外医学、哲学、气功和人体科学等学会理事及委员.

This study aimed to investigate the common predictive factors between social media addiction and eating disorder symptoms, in a group of Chinese female college students. A total of 216 students completed the behavioral assessments of cognitive flexibility and sustained attention, as well as the questionnaires on anxiety, social media dependence, and eating disorders. The results indicate that SMA is significantly correlated with EDS. Structural equation modeling was used to test the model in which state anxiety, cognitive flexibility, and sustained attention (...) predicted social gain and EDS. Additionally, the results confirmed the mediating role of cognitive flexibility and sustained attention between state anxiety and SMA/EDS in the participants. The findings revealed that in the sample group, state anxiety was related to SMA and EDS through cognitive flexibility and sustained attention. These proposals reflect the significance of improving cognitive flexibility/sustained attention and reducing state anxiety to prevent EDS and SMA in female college students. (shrink)

The pattern, process, and mechanism of residential heterogeneity vary significantly with different geographical scales. However, most traditional methods ignore the checkboard and modifiable areal unit problem, which may cover up the complexity and hierarchy of social space. Taking Hangzhou city as an example, a multiscalar method was proposed based on the information entropy theory to estimate residential heterogeneity and its scale sensitivity. Based on the sixth population census of Hangzhou and the housing price database of 6,536 residential districts from 2008 (...) to 2018, we explore the scale effect and dynamic characteristics of residential heterogeneity. The results of spatial simulation and geostatistical analysis based on Python Spatial Analysis Library module show that the multiscalar algorithm better presents the real segregation pattern than traditional method, which is one of the new models and technologies in urban geography complex system. Exploring residential heterogeneity through multiscalar lens provides an important basis for the gradual and refined urban renewal. (shrink)

Patients with advanced Alzheimer's disease experience cognitive impairment and physical disabilities in daily life. Currently, there are no treatments available to slow down the course of the disease, and limited treatments exist only to treat symptoms. However, deep brain stimulation of the nucleus basalis of Meynert has been reported to improve cognitive function in individuals with AD. Here, we report the effects of NBM-DBS on cognitive function in a subject with severe AD. An 80-year-old male with severe AD underwent surgery (...) for bilateral NBM-DBS electrode placement. After 10 weeks of stimulation, Mini-Mental State Examination assessment improved from a score of 5 to 9 points, and assessment using the Alzheimer's Disease Assessment Scale–Cognitive Subscale showed a marked reduction in total score from 43 to 33 points, suggesting cognitive benefits from NBM-DBS. The patient's postoperative course was complicated by a subdural effusion that occurred several days after surgery, with complete recovery. Interestingly, the subject also displayed abnormal thermoregulation with stimulation initiation and stimulation parameter modifications. NBM-DBS may serve as a potential therapy for severe AD patients.Clinical Trial Registration: ChiCTR1900022324. (shrink)

In the process of communication between people, everyone will have emotions, and different emotions will have different effects on communication. With the help of external performance information accompanied by emotional expression, such as emotional speech signals or facial expressions, people can easily communicate with each other and understand each other. Emotion recognition is an important network of affective computers and research centers for signal processing, pattern detection, artificial intelligence, and human-computer interaction. Emotions convey important information in human communication and communication. (...) Since the end of the last century, people have started the research on emotion recognition, especially how to correctly judge the emotion type has invested a lot of time and energy. In this paper, multi-modal emotion recognition is introduced to recognize facial expressions and speech, and conduct research on adaptive higher education management. Language and expression are the most direct ways for people to express their emotions. After obtaining the framework of the dual-modal emotion recognition system, the BOW model is used to identify the characteristic movement of local areas or key points. The recognition rates of emotion recognition for 1,000 audios of anger, disgust, fear, happiness, sadness and surprise are: 97.3, 83.75, 64.87, 89.87, 84.12, and 86.68%, respectively. (shrink)

Low‐molecular‐weight (LMW) thiols are extensively involved in the maintenance of cellular redox potentials and the protection of cells from a variety of reactive chemical and electrophilic species. However, we recently found that the metabolic coupling of two LMW thiols – mycothiol (MSH) and ergothioneine (EGT) – programs the biosynthesis of the anti‐infective agent lincomycin A. Remarkably, such a constructive role of the thiols in the biosynthesis of natural products has so far received relatively little attention. We speculate that the unusual (...) thiol EGT might function as a chiral thiolation carrier (for modification) and a novel activator (for glycosylation) of sugar. Additionally, we examine recent evidence for LMW thiols (MSH and others) as sulfur donors of sulfur‐containing natural products. Clearly, the LMW thiols have more diverse activities beyond cell protection, and more attention should be paid to the correlation of their functions with thiol‐dependent enzymes. (shrink)