Population-level biomedical research offers new opportunities to improve population health, but also raises new challenges to traditional systems of research governance and ethical oversight. Partly in response to these challenges, various models of public involvement in research are being introduced. Yet, the ways in which public involvement should meet governance challenges are not well understood. We conducted a qualitative study with 36 experts and stakeholders using the World Café method to identify key governance challenges and explore how public involvement can (...) meet these challenges. This brief report discusses four cross-cutting themes from the study: the need to move beyond individual consent; issues in benefit and data sharing; the challenge of delineating and understanding publics; and the goal of clarifying justifications for public involvement. The report aims to provide a starting point for making sense of the relationship between public involvement and the governance of population-level biomedical research, showing connections, potential solutions and issues arising at their intersection. We suggest that, in population-level biomedical research, there is a pressing need for a shift away from conventional governance frameworks focused on the individual and towards a focus on collectives, as well as to foreground ethical issues around social justice and develop ways to address cultural diversity, value pluralism and competing stakeholder interests. There are many unresolved questions around how this shift could be realised, but these unresolved questions should form the basis for developing justificatory accounts and frameworks for suitable collective models of public involvement in population-level biomedical research governance. (shrink)

Many are calling for concrete mechanisms of oversight for health research involving artificial intelligence (AI). In response, institutional review boards (IRBs) are being turned to as a familiar model of governance. Here, we examine the IRB model as a form of ethics oversight for health research that uses AI. We consider the model's origins, analyze the challenges IRBs are facing in the contexts of both industry and academia, and offer concrete recommendations for how these committees might be adapted in order (...) to provide an effective mechanism of oversight for health‐related AI research. (shrink)

(Note: this is the lead article in a forthcoming issue of _Australasian Philosophical Review_ edited by Dana Goswick, with invited comments by Karen Bennett, Ricki Bliss, Jonathan Schaffer, Alexander Skiles. In June 2024 there will be an open call for other commentators; please contact Dana or Jessica if you are interested.) A wide range of scientific, religious/cosmological, and philosophical views presuppose that there is what I call `metaphysical structure', whereby (i) some goings-on in a given domain D are (absolutely (...) or comparatively) fundamental; and (ii) (comparatively) non-fundamental goings-on in D metaphysically depend on (absolutely or comparatively) fundamental goings-on in D. Such presuppositions motivate two broadly metametaphysical questions: (i) what makes it the case that some goings-on in a domain D are (absolutely or comparatively) fundamental? and (ii) what makes it the case that (comparatively) non-fundamental goings-on in a domain D metaphysically depend on (absolutely or comparatively) fundamental goings-on in D? Here I advance my preferred 'Fundamentality First' package deal approach to metaphysical structure, which couples a primitivist approach to fundamentality with a pluralist approach to metaphysical dependence. (shrink)

Introduction : reading Nietzsche skeptically -- Nietzsche and the Pyrrhonian tradition -- Skepticism in Nietzsche's early work : the case of "on truth and lie" -- The question of Nietzsche's "naturalism" -- Perspectivism and Ephexis in interpretation -- Skepticism and health -- Skepticism as immoralism.

The practical criteria by which developmental biologists choose their model systems have evolutionary correlates. The result is a sample that is not merely small, but biased in particular ways, for example towards species with rapid, highly canalized development. These biases influence both data collection and interpretation, and our views of how development works and which aspects of it are important.

Between present and past, visible and invisible, and sensation and idea, there is resonance—so philosopher Maurice Merleau-Ponty argued and so Jessica Wiskus explores in The Rhythm of Thought.

The concept of homology arose from classical studies of comprative morphology, and took on a new signficance with the advent of evolutionary theory. It is currentlyl undergoing antoher metamorphosis: many developmental geneticists now dfine homology as shared patterns of gene expression. However, this ne usage conflaes difinition with criteri, and fails to recognize the meaninful asignments of homology must speify a biologcal level. We argue the although developmental genetic data can help identify homologus structures. they are niether necessary nor sufficient, (...) and do not in any case jutify a new definition of homology. (shrink)

Imaginative resistance refers to a perceived inability or unwillingness to enter into fictional worlds that portray deviant moralities (Gendler, 2000): we can all easily imagine that dragons exist, but many people feel incapable of imagining fictional worlds in which morality works differently. Although this phenomenon has received much attention from philosophers, no one has attempted to operationalize the construct in a self-report scale. In Study 1, we developed the Imaginative Resistance Scale (IRS), investigated its relationship to theoretically related constructs, and (...) confirmed its structure and reliability (rα = 0.92) in a large sample. In Study 2, we asked participants to rate scenarios expected to provoke imaginative resistance and predicted these ratings from the IRS and its validity measures. IRS scores accounted for variability in ease of imagining these scenarios over and above gender, political orientation, and three related measures. The results are discussed in terms of theories of imaginative resistance and directions for future research. (shrink)

Between his calling into question, on the one hand, the apparently unquestionable value of compassion itself, and his refusal, on the other hand, to concede that suffering is unconditionally bad, Nietzsche has been understood by many as expressing a callous indifference, or worse, to most human suffering. This article aims to show that this interpretation relies on an oversimplified characterization of the relevant moral emotions. Compassion (or pity, either of which word can be used to translate the German das Mitleid) (...) is ‘a polyphonous being’, as Nietzsche insists in Daybreak (1881). A closer look at some key passages in Nietzsche’s text, and some help from Greek thinkers Nietzsche points us toward, will demonstrate that this term has meanings that have been lost to us. Recovering those meanings will shed light both on Nietzsche’s critique of compassion (or pity) and on his own attitude toward suffering. (shrink)

Although the term "torture lite" is frequently used to distinguish between physically mutilating torture and certain interrogation methods that are supposedly less severe, the distinction is not recognized in international law.

The computer revolution has had an enormous effect on all aspects of the practice of medicine, yet little thought has been given to the role of social media in identifying treatment choices for incompetent patients. We are currently living in the ?Internet age? and many people have integrated social media into all aspects of their lives. As use becomes more prevalent, and as users age, social media are more likely to be viewed as a source of information regarding medical care (...) preferences. This article explores the ethical and legal issues raised by the use of social media in surrogate decision making. (shrink)

The purpose of this paper was to test whether imaginative resistance – a term used in the philosophical literature to describe the reluctance to imagine counter-moral worlds – is experienced by peo...

This article explores notions about Nietzsche’s career as a philologist and his fascination with the Greeks. It considers his interest in Homer and the Greek philosophers—in particular, Heraclitus and Pyrrho. For Nietzsche, ancient Greeks such as Heraclitus and Homer were interesting not because of their doctrines, but because of the example they themselves provided of certain psychological types. Like the ancient skeptics following Pyrrho, Nietzsche was generally more interested in the psychological consequences of philosophical doctrines than in their content, and (...) like those skeptics he often rejected any ambitions to limn the true nature of reality. (shrink)

As we navigate post-pandemic educational recovery and future-oriented design, the Handbook of Research in Online Learning: Insights and Advances emerges as a scholarly authority to illuminate existing questions and catalyze conversations on imperative transformations in education. Tailored for researchers, designers, educators, administrators, and stakeholders, this handbook delves into the nuanced landscape of online learning. Curated by leading experts, each chapter provides a deep exploration of critical online teaching and learning dimensions. Whether you're navigating the complexities of instructional design, exploring the (...) impact of digital learning on diverse student populations, or delving into the transformative potential of AI, each chapter illuminates critical aspects of online education. It merges current significant works with unpublished manuscripts, embodying the interdisciplinary essence of online learning research. Grounded in diverse theoretical frameworks and research methods, it offers theoretical insights and actionable guidance for cutting-edge educational methodologies. This handbook is not just a compendium; it's an indispensable guide for shaping the future of education. Contributors are: Michael Ahlf, Stephen Allen, Tonya Amankwatia, Fatih Ari, Ismahan Arslan-Ari, Michael K. Barbour, Gail Alleyne Bayne, Karen Bellnier, M. Aaron Bond, Victoria Brown, George Bradford, William Cain, Sumie Chan, Lauren Cifuentes, Laura DaVinci, Gina Deckard, Shernette Dunn, Anne Fensie, Holly Fiock, Sara Flowers, Carla Karen Fortune, Theodore Frick, Michael M. Grant, Alexis Guethler, Dan He, Atsusi "2c" Hirumi, Charles B. Hodges, Stephanie Hostetter, Michael Houdyshell, Fethi A. Inan, Frank Jamison, Amir Kalan, Meryl Krieger, Jessica Lantz, Mary Lefaiver, Juhong Christie Liu, Noble Lo, Barbara Lockee, Fatemeh Marzban, Trey Martindale, Sara McNeil, Laura McNeill, Stephanie Moore, Martha Lorena Obermeier, Larisa Olesova, Jennifer Jihae Park, Sanghoon Park, Yujin Park, AnthTony Pina, Drew Polly, Yingxiao Qian, Thomas Reeves, Christiane Reilly, Jennifer Richardson, Aubrey Rogowski, Leanne Rutherford, Kay Seo, Sanga Song, Edwin Teye Sosi, Stefan Stenbom, Sharon Stidham, David Tai, Hengtao Tang, Torrey Trust, Shannon Tucker, Denis Unal, Lucas Vasconcelos, Charles Xiaoxue Wang, Florence Williams, Ying Xie and Fan Xu. (shrink)

Evolutionary developmental biologists categorize many different kinds of things, from ontogenetic stages to modules of gene activity. The process of categorization—the establishment of “kinds”—is an implicit part of describing the natural world in consistent, useful ways, and has an essentially practical rather than philosophical basis. Kinds commonly serve one of three purposes: they may function (1) as practical tools for communication; (2) to support prediction and generalization; or (3) as a basis for theoretical discussions. Beyond the minimal requirement that classifications (...) reflect biological reality, what sorts of kinds or classification will be useful in advancing a research program depends on the epistemological context. Thus, the important meaning of “natural” in “natural kinds” is not “natural with respect to nature,” but “natural with respect to the question.” This conclusion arises from the recognition that the proper role of concepts (e.g. natural kind, module, homology, model) is not to answer biological questions, but rather to help frame them. From a scientist’s perspective, arguing about the wording (or existence) of a single definition of “natural” or “kind” is beside the point: we get more work done by letting the question at hand determine what kinds of kinds are natural, on the basis of their ability to help answer it. We should be content to let “natural kinds” remain vague, multivalent, and–therefore broadly useful. For a philosopher like Hacking, the diverse, disparate, and ultimately incommensurable uses of the term “natural kind” have diluted its value so far that it loses all meaning. For practicing scientists, however, defining useful kinds in the context of particular questions and systems remains a productive epistemological strategy. (shrink)

Nietzsche's Antichrist is subtitled "A Curse on Christianity." In its last numbered section, he pronounces his "eternal indictment" of two millennia of tradition: —Now I have come to the end and I pronounce my judgment. I condemn Christianity, I indict the Christian church on the most terrible charges an accuser has ever had in his mouth. I consider it the greatest corruption conceivable, it had the will to the last possible corruption. [...] I want to write this eternal indictment of (...) Christianity on every wall, wherever there are walls,—[...] I call Christianity the one great curse, the one great innermost corruption, the one great instinct of revenge that does not consider any method to be poisonous... (shrink)

In my paper, I argue that a first-person perspective (the perspective of a patient/recipient of an action) pertaining to response analysis is significant in Confucianism given the deeply personal nature of Confucianism. It matters whether oneself or others is the patient of an action because Confucianism as a virtue theory emphasizes self-reflection and reflexivity of one’s response in self-cultivation. Moreover, as an account of role-ethics, Confucianism calls attention to one’s particular relationship with others—one reacts differently in kind, not just in (...) degrees, depending on whether one’s or others’ family is at risk. I also appeal to Thomas Nagel’s framework of objectivity vs subjectivity to help elucidate the Confucian position on the value of an individual’s particular perspective, distinguishing the person who is the patient from other people. Finally, I revisit the mirror and the one body analogy discussed by Shun and highlight their point of impartiality rather than objectivity as implied by Shun. (shrink)

This book covers a collection of papers addressing ethical issues generated by advanced biomedical technologies.

Authentic community engagement in Indigenous communities insists on the exercise of tribal sovereignty over research. American Indian and Alaska Native tribes are sovereign Nations with uni...

Leading animal models are powerful tools for translational research, but they also present obstacles. Poorly conducted preclinical research in animals is a common cause of translational failure, but even when such research is well-designed and carefully executed, challenges remain. In particular, dominant models may bias research directions, elide essential aspects of human disease, omit important context, or subtly shift research targets. Recognizing these stumbling blocks can help us find ways to avoid them: employing a wider range of models, incorporating more (...) realistic environmental conditions, better aligning studies between animals and patients, and focusing on human biology and therapeutic goals. Such changes are costly; but insisting it would be impractical or unrealistic to change strategies offers no way out of the current impasse. Rather, we must acknowledge the obstacles as well as the advantages presented by core models, and direct some of our investments in translational research toward getting around them. The dominance of biomedical research by a handful of animal models introduces subtle but significant obstacles to translation. Recognizing these obstacles is a critical first step toward finding ways around them; this paper describes how dominant models can create roadblocks, and suggests strategies to improve the efficiency of translation from animal models to humans. (shrink)

For the role of utilitarianism in the ethics of war and peace, Shaw suggests there is a Utilitarian War Principle (UWP) and argues that the principles of the just war theory should be treated as intermediate principles that are subordinated to UWP. He also argues that the state should be the primary legitimate authority to wage war and holder of the right of national defense. I argue that the utilitarian approach should be specifically linked with contingent pacifism, a new understanding (...) of pacifism from within the just war tradition, and the utilitarian contingent pacifism only endorses individual self-defense but not national defense. This finding is not only theoretically important but has practical implications for the debate on Article 9 of the Japanese Constitution. Utilitarian contingent pacifism supports the idealist position that Article 9 is morally significant because it makes Japan a pioneer of the new kind of pacifism. (shrink)

When science takes man as its subject, tensions arise between two values basic to Western society: freedom of scientific inquiry and protection of individual inviolability.... At the heart of this conflict lies an age-old question: When may a society, actively or by acquiescence, expose some of its members to harm in order to seek benefits for them, for others, or for society as a whole?

Expanding the canon of philosophy to include early modern women writers necessarily requires interdisciplinary work. This is because philosophy remains far behind other fields in the humanities with respect to the project of canon expansion, and thus, attempts to expand the canon of philosophy rely, in large part, on the past and current scholarship of those in other humanities disciplines. In this paper, we argue for this claim and highlight some of the challenges that historians of philosophy face when they (...) are engaged in the project of canon expansion, given differences in disciplinary norms. We then consider the important work of Carol Pal and Judith Zinsser to show how the contributions of those outside of the discipline of philosophy can deepen and expand the understanding historians of philosophy have of early modern women philosophers and their works. We conclude by suggesting that some of the issues we highlight here, and elsewhere (Gordon-Roth and Kendrick 2019), are challenges faced not only by those working in the history of philosophy; they’re challenges faced by anyone working to recover the intellectual lives of women: Intimate details of women scholars’ personal lives rather regularly bleed into discussions of their work, even when we, as commentators, aim to avoid that very conflation. When the personal seeps into the intellectual, female intellectual authority is diminished. What we suggest, then, is an interdisciplinary effort to change the way in which we talk about women and their work. (shrink)

Three papers included in this issue were presented to the North American Nietzsche Society (NANS) in San Francisco during the Pacific Division Meeting of the American Philosophical Association. Participants were invited by the NANS program committee to address the theme, “Nietzsche and Antiquity.” The session, held on March 31, 2010 and chaired by R. Lanier Anderson (Stanford), included papers by Nickolas Pappas (CUNY), who proposes to shed new light on BT by examining some peculiar distortions in Nietzsche’s presentation of the (...) god Apollo; Joel E. Mann (St. Norbert College), who delves insightfully into Nietzsche’s “medical posture” and his allusions to Hippocrates and ancient medicine in D; and Wilson H. Shearin .. (shrink)

There are two contrasting paradigms for dealing with terrorists: war and law enforcement. In this paper, I first discuss how the just war theory assesses the military response to the 9/11 terrorist attacks on the United States. I argue that the ethical problems with the U.S. attack on Afghanistan in response to 9/11 concern principles of jus ad bellum besides just cause. I show that the principles of right intention, last resort, proportionality and likelihood of success were violated. Furthermore, both (...) jus in bello principles of proportionality and discrimination were not satisfied in targeting terrorists in places where civilians not linked to them live. The law enforcement that takes place in liberal democracies is fully respectful and protective of innocent lives. Crime is dealt with by apprehending lawbreakers and putting them on trial if possible, and by keeping criminal elements on the loose away from potential victims. Good law enforcement also includes acting to remove causes of crime. I examine how this model applies to the problem of terrorism and address objections concerning the impossibility ofeliminating terrorism, the slowness of success, and the possibility that there are “nut cases” who hate America no matter what. (shrink)

Ralph Ellis has written about how we have a fundamental need for ‘inspiration’ that can help us come to terms with human finitude. Arguing against the self-deceptive path of religious fundamentalism, Ellis discusses how the experience of a transcendent object of intrinsic value through love enables us to break out of a ‘circle of egocentricity.’ In this paper, I explore the problem of finitude in the movie Stranger Than Fiction, faced by someone who has to make choices knowing that he (...) is merely a character in someone else’s novel. I show how philosophy is also needed, alongside a loving relationship, for moral choice and motivation. I then suggest that Aristotle’s ethics is an example of how both philosophical knowledge and experience of life can be combined in dealing with our lack of moral certainty. (shrink)

Tillich has been accused of being an atheist and pantheist. This study shows mainly that once one studies Tillich's work with care and with an open mind, one can see clearly that his existential ontology is quite consistent in form and theistic in content, and that the terms which he uses to express the idea of God are not unduly vague at all. ; There are six chapters in this thesis. In the first chapter, I argue that Tillich is not (...) an atheist; his God above the God of theism is a more adequate concept than most traditional concepts of God. I show that, for Tillich, God as our ultimate concern expresses the appropriateness of a worshipping attitude towards God, and that God as being-itself shows that God is the ground of being that gives us the moral courage to affirm our being in spite of the fact of nonbeing. God is thus the "power of being" which conquers anxieties. ;In the second chapter, I show more clearly what being-itself means for Tillich. God as being-itself is not a being among beings. Beings are bound to the structure of being and the categories of finitude, but God as being-itself is not bound by them. Being-itself transcends the world and everything within it. Being-itself is not the kind of immanent God that pantheism holds. Thus I once again argue against the accusation that Tillich is an atheist or pantheist. I also argue against the idea that the Platonic or Aristotelian universal is adequate as a model to interpret Tillich's idea of being-itself. Being-itself, for Tillich, cannot be identified with the Platonic or Aristotelian universal. ;The third chapter shows how Tillich gives a philosophical-theological interpretation of religious symbols. Except for the claim that "God is being-itself" is a direct non-symbolic statement about God, everything we say about God is interpreted by Tillich as symbolic. In chapter four, I show in some detail why, for Tillich, the word "existence" cannot be applied to God. But when Tillich claims that God does not exist, he does not mean that there is no God. He only rejects the misleading combination of the word "existence" and "God." "Existence" should be applied only to finite beings, not to being-itself. Therefore I also argue that arguments for God's existence cannot be constructed out of Tillich's system as some commentators have claimed. In fact, for Tillich, God is presupposed necessarily; any argument for God's reality is impossible and unnecessary. ;Chapter five is a discussion of Tillich's idea of freedom in relation to God's transcendence. Only things are determined. Human being has finite freedom which is rooted in his destiny. And God is absolute freedom. However, God's absolute freedom does not destroy man's finite freedom. For Tillich, the crucial theistic assertion of God's transcendence is rooted in this reality of both human and divine freedom. ;In the final chapter, I discuss Tillich's proposed solution to the problem of evil and omnipotence. For Tillich, to say that God is omnipotent does not mean that God can do everything; rather it is to express our trust in God. It is to assert that God as the power of being can conquer nonbeing in all its expressions. The existence of evil does not constitute a reason for a believer to abandon his belief in God; it simply constitutes one of the mysteries of existence reflected in religion. The existence of evil is inevitable because it is implied in the creaturely finitude. To believe in God's providence, according to Tillich, is the only answer to the question of theodicy. Thus Tillich shows us how to face suffering. (shrink)

RNA editing is a newly described genetic phenomenon. It encompasses widely different molecular mechanisms and events. According to the specific RNA modification, RNA editing can be broadly classified into six major types. Type II RNA editing occurs in plants and mammals; it consists predominantly in cytidine to uridine conversions resulting from deamination/transamination or transglycosylation, although in plants other mechanisms have not been excluded. Apolipoprotein B mRNA editing is the only well‐documented editing phenomenon in mammals. It is an intranuclear event that (...) occurs posttranscriptionally, coincident with splicing and polyadenylation. Recent observations indicate that the tissue‐ and sequence‐specific process is mediated by an enzyme that has separate domains for editing and sequence recognition. The presence of apolipoprotein B mRNA editing activity in tissues that do not produce the protein suggests that other RNAs may be edited and RNA editing may be a genetic phenomenon of general biological importance to the cell. (shrink)