This paper defends “moral individualism” against various arguments that have been intended to show that membership in the human species or participation in our distinctively human form of life is a sufficient basis for a moral status higher than that of any animal. Among the arguments criticized are the “nature-of-the-kind argument,” which claims that it is the nature of all human beings to have certain higher psychological capacities, even if, contingently, some human beings lack them, and various versions of the (...) idea that there is a special form of life that all human beings share but of which no animal can be a full participant. The paper concludes that none of these arguments succeeds in demonstrating that there are moral reasons to permit animals to be treated less well than members of our own species whose psychological capacities and potential are no higher than those of the animals. (shrink)

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An important issue in epistemology concerns the source of epistemic normativity. Epistemic consequentialism maintains that epistemic norms are genuine norms in virtue of the way in which they are conducive to epistemic value, whatever epistemic value may be. So, for example, the epistemic consequentialist might say that it is a norm that beliefs should be consistent, in that holding consistent beliefs is the best way to achieve the epistemic value of accuracy. Thus epistemic consequentialism is structurally similar to the family (...) of consequentialist views in ethics. Recently, philosophers from both formal epistemology and traditional epistemology have shown interest in such a view. In formal epistemology, there has been particular interest in thinking of epistemology as a kind of decision theory where instead of maximizing expected utility one maximizes expected epistemic utility. In traditional epistemology, there has been particular interest in various forms of reliabilism about justification and whether such views are analogous to—and so face similar problems to—versions of consequentialism in ethics. This volume presents some of the most recent work on these topics as well as others related to epistemic consequentialism, by authors that are sympathetic to the view and those who are critical of it. (shrink)

Attempts to determine or to select what kind of person or people to bring into existence are controversial. This is particularly true of “negative selection” or “selecting against” a certain type of person—that is, the attempt to prevent a person of a certain type, or people of that type, from existing. Virtually everyone agrees that some instances of negative selection are objectionable—for example, that selection against healthy people would be wrong, particularly if this were combined with positive selection of people (...) with serious diseases. But some people believe that all negative selection is objectionable and therefore that all “selection for existence,” whether positive or negative, is objectionable. For if negative selection is objectionable, it seems to follow that positive selection is as well, since the attempt to bring a person of a certain type into existence is simultaneously an attempt not to bring into existence a person who is not of that type. In short, positive selection is implicitly negative as well. (shrink)

The dominant conception of brain death as the death of the whole brain constitutes an unstable compromise between the view that a person ceases to exist when she irreversibly loses the capacity for consciousness and the view that a human organism dies only when it ceases to function in an integrated way. I argue that no single criterion of death captures the importance we attribute both to the loss of the capacity for consciousness and to the loss of functioning of (...) the organism as a whole. This is because the person or self is one thing and the human organism is another. We require a separate account of death for each. Only if we systematically distinguish between persons and human organisms will we be able to provide plausible accounts both of the conditions of our ceasing to exist and of when it is that we begin to exist. This paper, in short, argues for a form of mind-body dualism and draws out some of its implications for various practical moral problems. (shrink)

THERE’S a well-known scene in Shakespeare’s Henry V in which the King, disguised as an ordinary soldier, is conversing with some of his soldiers on the eve of the battle of Agincourt. Hoping to find or inspire support among them, he remarks: “Methinks I could not die anywhere so contented as in the King’s company, his cause being just and his quarrel honorable.” One soldier replies: “That’s more than we know,” whereupon a second says: “Ay, or more than we should (...) seek after; for we know enough if we know we are the King’s subjects: if his cause be wrong, our obedience to the King wipes the crime of it out of us.”. (shrink)

I discuss and defend two arguments against semantic theories which wish to avoid commitment to propositions. The first holds that on the most plausible semantics of a class of natural language sentences, the truth of sentences in that class requires the existence of propositions; and some sentences in that class are true. The second holds that, on the best understanding of the form of a semantic theory, the truth of a semantic theory itself entails the existence of propositions. Much of (...) the discussion engages Davidsonian alternatives to a propositionalist semantic theory. (shrink)

Vector-based models of word meaning have become increasingly popular in cognitive science. The appeal of these models lies in their ability to represent meaning simply by using distributional information under the assumption that words occurring within similar contexts are semantically similar. Despite their widespread use, vector-based models are typically directed at representing words in isolation, and methods for constructing representations for phrases or sentences have received little attention in the literature. This is in marked contrast to experimental evidence (e.g., in (...) sentential priming) suggesting that semantic similarity is more complex than simply a relation between isolated words. This article proposes a framework for representing the meaning of word combinations in vector space. Central to our approach is vector composition, which we operationalize in terms of additive and multiplicative functions. Under this framework, we introduce a wide range of composition models that we evaluate empirically on a phrase similarity task. (shrink)

Many people who believe that abortion may often be justified by appeal to the pregnant woman’s interests also believe that a woman’s infliction of significant but nonlethal injury on her fetus can seldom be justified by appeal to her interests. Yet the second of these beliefs can seem to cast doubt on the first. For the view that the infliction of prenatal injury is seriously morally objectionable may seem to presuppose a view about the status of the fetus that challenges (...) the permissibility of abortion. The fear of being interpreted as implicitly endorsing such a view has thus led some defenders of abortion to be reluctant for tactical reasons to condemn the infliction of prenatal injury. In this they are encouraged by those who exploit the issue of prenatal injury in their campaign against abortion. When, for example, the House and Senate in 2004 passed legislation recognizing two victims of an assault against a pregnant woman, many viewed this as a tactic in a larger strategy to restrict access to abortion. This tactic is potentially effective. For people may find it compelling to infer that, if injuring a fetus is seriously objectionable, abortion must be even more objectionable, since killing is normally more seriously objectionable than merely injuring. (shrink)

It is sometimes suggested that if a moral theory implies that infanticide can sometimes be permissible, that is sufficient to discredit the theory. I argue in this article that the common-sense belief that infanticide is wrong, and perhaps even worse than the killing of an adult, is challenged not so much by theoretical considerations as by common-sense beliefs about abortion, the killing of non-human animals, and so on. Because there are no intrinsic differences between premature infants and viable fetuses, it (...) is difficult to accept that an abortion performed after the point of viability can be permissible while denying that infanticide can be permissible for a comparably important reason. This and other challenges to the consistency of our intuitions exert pressure on us either to accept the occasional permissibility of infanticide or to reject liberal beliefs about abortion. (shrink)

Social studies of science have often treated natural field sites as extensions of the laboratory. But this overlooks the unique specificities of field sites. While lab sites are usually private spaces with carefully controlled borders, field sites are more typically public spaces with fluid boundaries and diverse inhabitants. Field scientists must therefore often adapt their work to the demands and interests of local agents. I propose to address the difference between lab and field in sociological terms, as a difference in (...) style. A field style treats epistemic alterity as a resource rather than an obstacle for objective knowledge production. A sociological stylistics of the field should thus explain how objective science can co-exist with radical conceptual difference. I discuss examples from the Canadian North, focussing on collaborations between state wildlife biologists and managers, on the one hand, and local Aboriginal Elders and hunters, on the other. I argue that a sociological stylistics of the field can help us to better understand how radically diverse agents may collaborate across cultures in the successful production of reliable natural knowledge. (shrink)

The Doctrine of Double Effect has been challenged by the claim that what an agent intends as a means may be limited to those effects that are precisely characterized by the descriptions under which the agent believes that they are minimally causally necessary for the production of other effects that the agent seeks to bring about. If based on so narrow a conception of an intended means, the traditional Doctrine of Double Effect becomes limitlessly permissive. In this paper I examine (...) and criticize Warren Quinn's attempt to reformulate the Doctrine in such a way that it retains its force and plausibility even if we accept the narrow conception of an intended means. Building on Quinn's insights, I conclude by offering a further version of the Doctrine that retains the virtues of Quinn's account but avoids the objections to it. I The key element in the Doctrine of Double Effect (DDE) is the claim that there is a stronger presumption against action that has harm to the innocent as an intended effect than there is against otherwise comparable action that causes the same amount of harm to the innocent as a foreseen but unintended effect. Since it is relatively uncontroversial that, except perhaps in cases involving desert, it is wrong to cause harm as an end in itself, the DDE is normally invoked to distinguish morally between harm that is intended as a means and harm that is considered a merely foreseen side-effect. (shrink)

I reply to criticisms from King and Soames and critically examine two aspects of current orthodoxy about propositions: that they are representational and that they are structured. I argue that (especially once one gives up on intrinsically representational propositions) there is no good reason to think that propositions have representational properties, and distinguish a few different senses in which propositions might be structured, expressing some skepticism about the more ambitious ones.

Epigenetic control of gene expression by chromatin remodeling is critical for adult stem cell function. A decline in stem cell function is observed during aging, which is accompanied by changes in the chromatin structure that are currently unexplained. Here, we hypothesize that these epigenetic changes originate from the limited cellular capability to inherit epigenetic information. We suggest that spontaneous loss of histone modification, due to fluctuations over short time scales, gives rise to long‐term changes in DNA methylation and, accordingly, in (...) gene expression. These changes are assumed to impair stem cell function and, thus, to contribute to aging. We discuss cell replication as a major source of fluctuations in histone modification patterns. Gene silencing by our proposed mechanism can be interpreted as a manifestation of the conflict between the stem cell plasticity required for tissue regeneration and the permanent silencing of potentially deleterious genomic sequences. (shrink)

In "Assertion," Geach identified failure to attend to the distinction between meaning and speech act as a source of philosophical errors. I argue that failure to attend to this distinction, along with the parallel distinction between attitude and content, has been behind the idea that meaning and content are, in some sense, normative. By an argument parallel to Geach's argument against performative analyses of "good" we can show that the phenomena identified by theorists of the normativity of content are properties (...) in the first instance of speech act and propositional attitude types, rather than content as such. (shrink)

Michael Walzer suggests that our common beliefs about individual responsibility and liability become largely irrelevant in the conduct of war. In conditions of war, everything is changed. Political realists have claimed that war eliminates morality; Walzer claims that war collectivizes it. I believe that conditions of war change nothing at all; they simply make it more difficult to ascertain relevant facts. This is not to say that the principles and laws that do or should govern the activity of war are (...) identical to those governing relations among individuals. Just as domestic law cannot simply restate the principles of individual morality, because the declaration and enforcement of laws have effects that must be taken into account in the formulation of the law, so too the principles, conventions, and laws of war cannot simply restate the principles of individual or international morality. The rules of war have to accommodate our epistemic limitations and to be formulated with a regard for the ways in which their announcement is likely to affect people’s behavior. But they should otherwise reflect as closely as possible the.. (shrink)

Although the belief that killing is normally wrong is as universal and uncontroversial a moral belief as we are likely to find, no one, to my knowledge, has ever offered an account of why killing is wrong that even begins to do justice to the full range of common sense beliefs about the morality of killing. Yet such an account would be of considerable practical significance, since understanding why some killings are wrong should help us to determine the conditions in (...) which killing is not wrong. For, in those cases in which the reasons why killing is wrong do not apply, killing may be permissible or, if there are positive reasons that favour it, even morally required. (shrink)

Global Cumulative Treatment Analysis is a novel clinical research model combining expert knowledge, and treatment coordination based upon global information-gain, to treat every patient optimally while efficiently searching the vast space that is the realm of cancer research.

This is a position paper concerning the role of empirical studies of human default reasoning in the formalization of AI theories of default reasoning. We note that AI motivates its theoretical enterprise by reference to human skill at default reasoning, but that the actual research does not make any use of this sort of information and instead relies on intuitions of individual investigators. We discuss two reasons theorists might not consider human performance relevant to formalizing default reasoning: (a) that intuitions (...) are sufficient to describe a model, and (b) that human performance in this arena is irrelevant to a competence model of the phenomenon. We provide arguments against both these reasons. We then bring forward three further considerations against the use of intuitions in this arena: (a) it leads to an unawareness of predicate ambiguity, (b) it presumes an understanding of ordinary language statements of typicality, and (c) it is similar to discredited views in other fields. We advocate empirical investigation of the range of human phenomena that intuitively embody default reasoning. Gathering such information would provide data with which to generate formal default theories and against which to test the claims of proposed theories. Our position is that such data are the very phenomena that default theories are supposed to explain. (shrink)

In this paper I show that two arguments for the inconsistency of skeptical theism fail. After setting up the debate in Introduction section, I show in The initial debate section why Mylan Engel’s argument (Engel 2004) against skeptical theism does not succeed. In COST section I strengthen the argument so that it both avoids my reply to Engel and parallels Jon Laraudogoitia’s argument against skeptical theism (Laraudogoitia 2000). In COST* section, I provide three replies—one by an evidentialist theist, one by (...) a closure-denying theist, and one by a necessitarian theist, and argue that the necessitarian’s reply successfully rebuts the inconsistency charge. I conclude that skeptical theism which accepts God’s necessary existence is immune to both kinds of arguments for its inconsistency. (shrink)

James Higginbotham presents a theory of semantic interpretation which violates the principle of semantic compositionality. He gives an argument by means of an example construction in favor of his contention. I show that compositioinal theories have more resources than some researchers give it credit for, and that these can be used in two different ways to account for the phenomenon Higginbotham describes.

I defend the view that propositions are a kind of property which is true iff it is instantiated. I discuss how we should think about propositional attitudes on this sort of view, and explain why I favor this sort of view over the more familiar Chisholm/Lewis view that attitudes are self-ascriptions of properties. I conclude by raising, and briefly discussing, two problems for the kind of view of propositions I favor.

In the paper it is argued that the conceptual resources of Christianity topple the hiddenness argument. According to the author, the variability of the divine love cast doubt on the soundness of Schellenberg’s reasoning. If we understood a perfect love as a maximal and equal concern and identification with all and for all, then a divine love would entail divine impartiality, but because of conflicts of interest between human beings the perfect, divine love cannot be maximal.

In this essay, I respond to Tim Lewens's proposal that realists and Strong Programme theorists can find common ground in reliabilism. I agree with Lewens, but point to difficulties in his argument. Chief among these is his assumption that reliabilism is incompatible with the Strong Programme's principle of symmetry. I argue that the two are, in fact, compatible, and that Lewens misses this fact because he wrongly supposes that reliabilism entails naturalism. The Strong Programme can fully accommodate a reliabilism which (...) has been freed from its inessential ties to naturalism. Unlike naturalistic epistemologists, the Strong Programme's sociologistic reliabilist insists that all scientific facts are the product of both natural and social causal phenomena. Anticipating objections, I draw on Wittgenstein's rule-following considerations to explain how the sociologistic reliabilist can account for standard intuitions about the objective elements of knowledge. I also explain how the Strong Programme theorist can distinguish between a belief's seeming reliable and its being reliable. (shrink)

Millians sometimes claim that we can explain the fact that sentences like "If Hesperus exists, then Hesperus is Phosphorus" seem a posteriori to speakers in terms of the fact that utterances of sentences of this sort would typically pragmatically convey propositions which really are a posteriori. I argue that this kind of pragmatic explanation of the seeming a posterioricity of sentences of this sort fails. The main reason is that for every sentence like the above which (by Millian lights) is (...) a priori, seems a posteriori to most speakers, and would typically be used to convey a posteriori propositions, there is another which (again, by Millian lights) is a priori, seems a posteriori to most speakers, but can only typically be used to convey a priori propositions. (shrink)

I reply to the argument of Caplan (Philos Stud 133:181–198, 2007 ) against the conjunction of Millianism with the view that utterances of sentences involving names often pragmatically convey descriptively enriched propositions.

Hubert Dreyfus and Charles Spinosa's argument for 'robust' realism centres on the possibility of our having access to things as they are in themselves and so as having access to things in a way that is not dependent on our 'quotidian concerns or sensory capacities'. Dreyfus and Spinosa claim that our everyday access to things is incapable of providing access of this kind, since our everyday access is holistically enmeshed with our everyday attitudes and concerns. The argument that Dreyfus and (...) Spinosa provide in support of this conclusion seems, however, to depend on illegitimately combining what are really two separate issues: that concerning the independence of the things themselves with the independence of our means of access to those things. Contrary to Dreyfus and Spinosa, the fact that our everyday access to things is necessarily dependent on our everyday attitudes and concerns does not mean that we therefore have access to things only as they 'appear' rather than as they are 'in themselves'. (shrink)

Vagueness: an expression is vague if and only if it is possible that it give rise to a “borderline case.” A borderline case is a situation in which the application of a particular expression to a (name of) a particular object does not generate an expression with a definite TRUTH-VALUE. That is, the piece of language in question neither applies to the object nor fails to apply.

Johanna Knapstein,1 Daniel Grimm,1 Marcus A Wörns,1 Peter R Galle,1 Hauke Lang,2 Tim Zimmermann111st Department of Internal Medicine, Johannes Gutenberg-University, Mainz, Germany; 2Department of General, Visceral and Transplantation Surgery, Johannes Gutenberg-University, Mainz, GermanyIntroduction: Hepatitis C virus reinfection occurs universally after liver transplantation, with accelerated cirrhosis rates of up to 30% within 5 years after liver transplantation. Dual antiviral therapy with pegylated interferon-2a and ribavirin only reaches sustained virological response rates of ~30% after liver transplantation. With the approval of viral (...) NS3/4A protease inhibitors telaprevir, boceprevir, and simeprevir and the NS5B polymerase inhibitor sofosbuvir, combination therapy offers new therapeutic options for HCV-infected patients, resulting in considerably higher sustained virological response rates in the nontransplant setting. Case presentation: We report three cases of TVR-based triple antiviral therapy in HCV genotype 1 reinfected patients after liver transplantation, of whom a 57-year-old Caucasian female and a 43-year-old Caucasian male were therapy naïve, and a 49-year-old Caucasian male patient was pretreated ineffectively. After 4 weeks of therapy, viral load decreased one to three log10 and became negative in weeks 6 to 8 in the therapy naïve patients. The pretreated patient showed a negative viral load in week 4. TVR was administered over 12 weeks, 750 mg thrice daily. Doses of immunosuppression with cyclosporine were reduced four to six fold. Initial peg-IFN and RBV doses ranged from 135–180 µg/week and 800–1,200 mg/day, according to the patient's body weight. Doses of peg-IFN and RBV were adapted to 90–135 µg/week and 400–800 mg/day after 2 to 12 weeks of protease inhibitor therapy. Dual therapy was continued for 36 weeks with total treatment duration of 48 weeks in the therapy naïve patients leading to a sustained virological response 12 weeks after the end of therapy. In the pretreated patient a breakthrough was detected in week 24 and therapy was discontinued. Overall, antiviral therapy was well tolerated. Side effects included dysgeusia and anemia leading to erythropoietin application and blood transfusions. Conclusion: This case series emphasizes that triple therapy with TVR is an efficient treatment for therapy naïve HCV genotype 1 reinfected patients after liver transplantation. But therapeutic options for pretreated patients require improvement. Keyword: cyclosporine, interferon, ribavirin, hepatitis C, protease inhibitor. (shrink)

A crucial part of William Rowe’s evidential argument from evil implies that God, like a loving parent, would ensure that every suffering person would be aware of his comforting presence. Rowe’s use of the “loving parent” analogy however fails to survive scrutiny as it implies that God maximally loves all persons. It is the argument of this paper that no one could maximally love every person; and whatever variation there is in the divine love undercuts the claim that every suffering (...) person would be aware of the divine presence. (shrink)

Since at least the tenth century, some theists have argued that God’s sovereignty as creator exempts God from moral evaluation, and so any argument employing moral principles or the idea of God as morally perfect is fallacious. In particular, any argument contending that the occurrence of pointless evil presents strong evidence against the existence of God is flawed, as God morally owes his creation nothing. This appeal to divine sovereignty, however, fails to rescue any theistic tradition proclaiming that God loves (...) humans, as no one would be indifferent concerning the pointless suffering of her beloved. (shrink)

ABSTRACT William Cooney has recently argued (The Journal of Applied Philosophy, Vol. 6, pp. 201–204) that the social programme of affirmative action, though controversial, can be supported by the doctrine of double effect in that, according to the doctrine, responsibility falls on the side of intended consequences and not on that of unintended consequences. The point of affirmative action is to include certain disadvantaged groups; it is not to exclude other groups, though this is an inevitable and foreseeable by‐product. In (...) this article I contend that Cooney's argument ignores two important conditions of the doctrine of double effect; namely, that the good which results from the intended effect must be at least commensurate with the harm that results from the unintended effect; and, that the intended good effect is causally separate from the unintended harmful effect. Any use of the doctrine which neglects these conditions leads to morally problematic cases. Further, once we take the conditions into account, we have good reason to think that the doctrine of double effect has no relevance to the affirmative action debate. (shrink)

Next SectionCharlie Pelling presents an impropriety paradox for the truth account of assertion. After solving his paradox I show that it is a version of the liar paradox. I then show that for any account of truth there is a strengthened liar-like paradox, and that for any solution to the strengthened liar paradox, there is a parallel solution to each of these “new” paradoxes.