A new split β‐lactamase assay promises experimental testing of the interplay of protein stability and function. Proteins are sufficiently stable to act effectively within cells. However, mutations generally destabilize structure, with effects on free energy that are comparable to the free energy of folding. Assays of protein functionality and stability in vivo enable a quick study of factors that influence these properties in response to targeted mutations. These assays can help molecular engineering but can also be used to target important (...) questions, including why most proteins are marginally stable, how mutations alter structural makeup, and how thermodynamics, function, and environment shape molecular change. Processes of self‐organization and natural selection are determinants of stability and function. Non‐equilibrium thermodynamics provides crucial concepts, e.g., cells as emergent energy‐dissipating entities that do work and build their own parts, and a framework to study the sculpting role of evolution at different scales. (shrink)

The Hedgehog, the Fox, and the Magister's Pox is a controversial discourse, rich with facts and observations gathered by one of the most erudite minds of our ...

In 1979, Lewontin and I borrowed the archi- tectural term “spandrel” (using the pendentives of San Marco in Venice as an example) to designate the class of forms and spaces that arise as necessary byproducts of another decision in design, and not as adaptations for direct utility in them- selves. This proposal has generated a large literature featur- ing two critiques: (i) the terminological claim that the span- drels of San Marco are not true spandrels at all and (ii) the (...) conceptual claim that they are adaptations and not byprod- ucts. The features of the San Marco pendentives that we explicitly defined as spandrel-properties—their necessary number (four) and shape (roughly triangular)—are inevitable architectural byproducts, whatever the structural attributes of the pendentives themselves. The term spandrel may be extended from its particular architectural use for two- dimensional byproducts to the generality of “spaces left over,” a definition that properly includes the San Marco pendentives. Evolutionary biology needs such an explicit term for features arising as byproducts, rather than adaptations, whatever their subsequent exaptive utility. The concept of biological span- drels—including the examples here given of masculinized genitalia in female hyenas, exaptive use of an umbilicus as a brooding chamber by snails, the shoulder hump of the giant Irish deer, and several key features of human mentality— anchors the critique of overreliance upon adaptive scenarios in evolutionary explanation. Causes of historical origin must always be separated from current utilities; their conf lation has seriously hampered the evolutionary analysis of form in the history of life. (shrink)

In this essay I first provide an analysis of various community concepts. Second, I evaluate two of the most serious challenges to the existence of communities—gradient and paleoecological analysis respectively—arguing that, properly understood, neither threatens the existence of communities construed interactively. Finally, I apply the same interactive approach to ecosystem ecology, arguing that ecosystems may exist robustly as well. ‡I would like to thank to the participants at the Ecology and Environmental Ethics Conference at the University of Utah, the Philosophy (...) of Ecology Conference hosted by the University of Brisbane, and those participants in a session at the Philosophy of Science Association Meeting in Vancouver, British Columbia for helpful discussions of this essay. Specific thanks go to Mark Colyvan, Greg Cooper, Steve Downes, Chris Elliott, Marc Ereshefsky, Paul Griffiths, Jesse Hendrikse, Greg Mikkelson, Anya Plutynski, Kate Ritchie, Sahotra Sarkar, Kim Sterelny, and Rob Wilson. †To contact the author, please write to: Department of Philosophy, Lewis and Clark College, 0615 SW Palatine Hill Road, Portland, OR 97219; e-mail: [email protected]. (shrink)

Our current intellectual system provides us with a far more complete and accurate understanding of nature and ourselves than was available in any previous society. This gain in understanding has arisen from two sources: the use of the 'scientific method', and the breaking up of our intellectual enterprise into increasingly narrower disciplines and research programmes. However, we have failed to keep these narrow specialities connected to the intellectual enterprise as a whole. The author demonstrates that this causes a number of (...) difficulties. We have no viewpoint from which we can understand the relationships between the disciplines and lack a forum for adjudicating situations where different disciplines give conflicting answers to the same problem. We seriously underestimate the differences in methodology and in the nature of principles in the various branches of science. This provocative and wide-ranging book provides a detailed analysis and possible solutions for dealing with this problem. (shrink)

Philosophy of science has the potential to enhance scientific practice, science policy, and science education; moreover, recent research indicates that many philosophers of science think we ought to increase the broader impacts of our work. Yet, there is little to no empirical data on how we are supposed to have an impact. To address this problem, our research team interviewed 35 philosophers of science regarding the impact of their work in science-related domains. We found that face-to-face engagement with scientists and (...) other stakeholders was one of the most—if not the most—effective pathways to impact. Yet, working with non-philosophers and disseminating research outside philosophical venues is not what philosophers are typically trained or incentivized to do. Thus, there is a troublesome tension between the activities that are likely to lead to broader uptake of one’s work and those that are traditionally encouraged and rewarded in philosophy. We suggest several ways that philosophers of science, either as individuals or as a community, can navigate these tensions. (shrink)

This essay seeks to demonstrate the following: 1. the value of metaphysical cosmology to our relationship with nature, and to making policy about the environment; 2. the mistaken nature and harmful consequences of the hegemonic cosmology of anthropocentrism; 3. the possibility of Zhang Zai's Qi/qi Great Harmony cosmology as both the refutation of and replacement for anthropocentrism. The essay concludes that ultimate moral progress of expanding the self from the narrow and exclusionary views of anthropocentrism consists in cosmocentrism, or the (...) transformation of thought to a cosmological perspective as exemplified by Zhang Zai's Great Harmony continual cyclical process of Qi/qi. It is argued that positive metaphysical visions such as Zhang Zai's can negate anthropocen-tric cosmology and inspire us to view our relationship with the environment in a fundamentally enlightened and more respectful way, which is not arrogantly self-centred, disconnected and supremacist. (shrink)

In this essay, I critically engage Sahotra Sarkar’s Environmental Philosophy. The several topics include the conceptual foundations of conservation biology and traditional philosophy of science, naturalism and its implications, and ethical theory and specifically the status of human welfare.

Thomas Friedman’s best-selling The World is Flat has exerted much influence in the west by providing both an accessible analysis of globalisation and its economic and social effects, and a powerful cultural metaphor for globalisation. In this review, we more closely examine Friedman’s notion of the social contract, the moral centre of his hopeful vision of a globalised world. While Friedman’s social contract holds a more generous view of social and state obligation than his neoliberal economic analysis might otherwise allow, (...) his fallacious assumptions about education rest on poorly argued claims about the nature of human beings, the proper aims of schooling, and meanings of justice in a globalised world. (shrink)

The Covid-19 pandemic resulted in school closures around the world, leaving lasting negative impacts on many children. Given that such closures are justified public health measures, this raises the question of compensating children for school closures. In this article I address the question of compensation from the perspective of a popular theory of justice: luck egalitarianism. In doing so, I examine a problem with applying luck egalitarianism to children, called the agency assumption. I then argue this assumption results in a (...) dilemma for luck egalitarianism and suggest how this dilemma can be overcome. I argue that the resulting form of luck egalitarianism reveals something interesting about compensating children for school closures: luck egalitarianism requires us to address all bases of justice-relevant inequality among children—Covid-19-related and beyond. Although much of the current discussion of compensating children for such closures has focused narrowly on the need to make up for lost instruction time or to prevent reductions in educational achievement, I argue that a luck egalitarian conception of justice requires us to go beyond merely compensating children for educational losses and instead aim for radical equality in education. (shrink)

Axel Honneth has done more than any other philosopher to develop and explore the significance of recognition to our social relations. On the broadly Hegelian ap.

This volume addresses some of the central issues of journalism today -- the nature and needs of the individual versus the nature and needs of the broader society; theories of communitarianism versus Enlightenment liberalism; independence versus interdependence (vs. co-dependency); negative versus positive freedoms; Constitutional mandates versus marketplace mandates; universal ethical issues versus situational and/or professional values; traditional values versus information age values; ethics of management versus ethics of worker bees; commitment and compassion versus detachment and professional "distance;" conflicts of interest (...) versus conflicted disinterest; and "talking to" versus "talking with." All of these issues are discussed within the framework of the frenetic field of daily journalism--a field that operates at a pace and under a set of professional standards that all but preclude careful, systematic examinations of its own rituals and practices. The explorations presented here not only advance the enterprise, but also help student and professional observers to work through some of the most perplexing dilemmas to have faced the news media and public in recent times. This lively volume showcases the differing opinions of journalistic experts on this significant contemporary issue in public life. Unlike previous books and monographs which have tended toward unbridled enthusiasm about public journalism, and trade press articles which have tended toward pessimism, this book offers strong voices on several sides of this complex debate. To help inform the debate, a series of "voices"--journalistic interviews with practitioners and critics of public journalism -- is interspersed throughout the text. At the end of each essay, a series of quotes from a wide variety of sources -- "In other words..." -- augments each chapter with ideas and insights that support and contradict the points used by each chapter author. (shrink)

So who is that behind the face in the mirror? Better yet, what is that? What is the uncanny sense that one is an experiencing agent, a reflecting self? Can we explain consciousness? With Jay Lambert, Peter Caws, and Floyd Tesmer.

Trisvabh vanirdeśa (Treatise on the Three Natures) is Vasubandhu's most mature and explicit exposition of the Yogc c ra doctrine of the three natures and their relation to the Buddhist idealism Vasubandhu articulates. Nonetheless there are no extent commentaries on this important short test. The present work provides an introduction to the text, its context and principal philosophical theses; a new translation of the text itself; and a close, verse-by-verse commentary on the text explaining the structure of Yogacara/Cittamatra idealism and (...) comparing it to Western versions of transcendental idealism. In particular, I show how the doctrine of the three natures is used to make idealism coherent in a Buddhist context and how it sheds light on the structure and evolution of transcendental idealism in Europe. (shrink)

The Practice of Value is an exploration of a pervasive but puzzling aspect of our world: value. The starting-point is the Berkeley Tanner Lectures delivered in 2001 by the leading moral theorist Joseph Raz. His aim is to make sense of the dependence of value on social practice, without falling back on cultural relativism. The lectures are followed by discussions from three eminent philosophers, Christine Korsgaard, Robert Pippin, and Bernard Williams, and a response from Raz. The result is a fascinating (...) debate, accessible to readers throughout and beyond philosophy, about the relations between human values and human life. (shrink)

Among Carl Schmitt's most notable and controversial contributions to political theory was his claim that “all the significant concepts of the modern doctrine of the state are secularized theological concepts.” First formulated in 1922 in his Political Theology, this contention remained constant throughout his long career, as evidenced by its return in his Political Theology II, published in 1970. Here Schmitt's Cadtholic background was clearly apparent, for in so arguing, he was recapitulating the familiar topos of biblical prefiguration in which (...) the New Testament was understood as realizing the latent meaning of the Old. Viewing modern politics as merely the secularized version of a prior theology allowed Schmitt to develop his strong notion of the sovereign as a profane divinity with virtually all of the omnipotent attributes of its alleged sacred predecessor. (shrink)

In what sense must global ethics be global? In one sense, it must deal with global issues. In another, it must not be parochial but inclusive of normative views from around the world. So far, global ethics has met the first standard much better than the second. Authors based in the global South contribute approximately 5% of the internationally published research on global ethics. With this in mind, the co-editors of this special issue sought to bring more perspectives, experiences, and (...) authors from India into the international global ethics conversation, and so they launched the Indian Global Ethics Initiative. Their first step, this special issue, presents Indian experience and authors on topics including urban development, care ethics, women’s empowerment, fair trade, distorted policy research, poverty, and health. Much of this work is grounded by the authors’ experience in policy-making and advocacy for social and global justice. The co-editors invite contact from interested readers who would like to join and continue this Indian Global Ethics Initiative, as well as readers who would like to take similar initiatives in other regions. (shrink)

This chapter explicates Theodor W. Adorno's dialectical engagement with inauthenticity and genuineness, two of the central tropes of his mature philosophy. The chapter discusses the extent to which Adorno's critique of genuineness in Minima Moralia and elsewhere was itself deeply indebted to Walter Benjamin's defense of mechanical reproduction against the aura and his notion of the mimetic faculty. It quickly becomes apparent that many of his “own” ideas betray precisely the kind of inauthenticity that he defended against the jargon. Or (...) if one wants to rely on his critical use of the term, it shows the non-auratic authenticity of the intellectual who knows himself not to be in full possession of his own ideas. Paradoxically, in his very lack of originality, his reworking without entirely duplicating many of his friend's most arresting ideas, Adorno took upon himself the stigma he urged everyone to embrace. (shrink)

Abstract:In this essay, I argue for what I term, following Karen Warren's wording, "a complementary love conception," and advocate for her non-dominating, non-self-centered, complementary love conception, in part, to refute the arrogant "oneness" or fusion ideal of love that is hegemonic and deeply embedded in the Western patriarchal worldview. I attempt to clarify the concept of "oneness" by distinguishing among its distinct types of meaning by drawing upon the work of Phillip J. Ivanhoe who analyzes this understudied, yet important, concept (...) to ethics, and I would add, environmental ethics, as well. Various conceptions of oneness do not apply and, moreover, harm individuals and the environment in contrast to Warren's complementary love conception. Finally, I compare Warren's account of complementary love and Ivanhoe's understanding of oneness to gain insight into the study of the environment and how best to care for it. (shrink)

At Theresa Schiavo's bedside : a guardian's role and reflections.

No contemporary intellectual historian has produced more influential reflections on the historian’s craft than Hayden White and Quentin Skinner, yet their legacy has never been meaningfully compared. Doing so reveals a surprising complementarity in their approach, at least to the extent that Skinner’s stress on recovering the intentionality of authors fits well with White’s observation that irony is the dominant rhetorical mode of historical narrative in our day. Irony itself, to be sure, has to be divided broadly speaking into its (...) dramatic or Socratic variants and the unstable and paradoxical alternative defended by poststructuralist critics. The latter produced in White an anxiety about the anarchistic implications of an allegedly inherent undecidability in historical interpretation and narration, which threatened to conflate history entirely with fiction. By recovering the necessary role of intentionality as a prerequisite for a more moderate version of Socratic and dramatic irony—in which hindsight provides some purchase on a truth denied actors at the time history is made—it is possible to rescue an ironic attitude that can register the frequency of unintended consequences without surrendering to the conclusion that no explanation or interpretation is superior to another. Against yet a third alternative, which tries to reconstruct the past rationally as a prelude to the present, acknowledging the ironic undermining of intentions avoids giving all the power to the contemporary historian and restores a dialogic balance between actors in the past and their present-day interpreters. (shrink)

For Plato and Aristotle, arete (traditionally translated as "virtue") was the essential object of human admiration and striving, and even the key to happiness. Their work continues to inspire reflection on fundamental questions of ethics and politics today, as the fourteen new essays collected here demonstrate. -/- Contributors: Lidia Palumbo, Eva Anagnostou-Laoutides, Ryan M. Brown, Jay R. Elliott, Guilherme Domingues da Motta, Federico Casella, Jonathan A. Buttaci, George Harvey, Mark Ralkowski, Gary S. Beck, Paula Gottlieb, Giulio di Basilio, Audrey L. (...) Anton, and Elena Bartolini. (shrink)

Epistemic contextualism was originally motivated and supported by the response it provides to skeptical paradox. Although there has been much discussion of the contextualist response to skeptical paradox, not much attention has been paid to the argument from skepticism for contextualism. Contextualists argue that contextualism accounts for the plausibility and apparent inconsistency of a set of paradoxical claims better than any classical invariantist theory. In this paper I focus on and carefully examine the argument from skepticism for contextualism. I argue (...) not only that the prima facie advantage of contextualism is specious, but also that contextualism is in fact at a competitive disadvantage with respect to two classical invariantist views. I also argue that contextualism takes an arbitrary and unsatisfying strategy in its response to skepticism. That contextualism is alone in taking this arbitrary strategy marks a second competitive disadvantage for it. In addition, I argue that the contextualist response to skeptical paradox regenerates a skeptical paradox which contextualism is powerless to solve. Consequently, the argument from skepticism for contextualism fails. Furthermore, this feature of the contextualist response to skeptical paradox completely undermines the motivation and support for contextualism deriving from its treatment of skeptical paradox. I conclude that the argument from skepticism for contextualism fails, and that the contextualist response to skeptical paradox fails to motivate contextualism, pending the success of another argument for the contextualist thesis. (shrink)