Prenatal screening pathways, as nowadays offered in most Western countries consist of similar tests. First, a risk-assessment test for major aneuploides is offered to pregnant women. In case of an increased risk, invasive diagnostic tests, entailing a miscarriage risk, are offered. For decades, only conventional karyotyping was used for final diagnosis. Moreover, several foetal ultrasound scans are offered to detect major congenital anomalies, but the same scans also provide relevant information for optimal support of the pregnancy and the delivery. Recent (...) developments in prenatal screening include the application of microarrays that allow for identifying a much broader range of abnomalities than karyotyping, and non-invasive prenatal testing that enables reducing the number of invasive tests for aneuploidies considerably. In the future, broad NIPT may become possible and affordable. This article will briefly address the ethical issues raised by these technological developments. First, a safe NIPT may lead to routinisation and as such challenge the central issue of informed consent and the aim of prenatal screening: to offer opportunity for autonomous reproductive choice. Widening the scope of prenatal screening also raises the question to what extent ‘reproductive autonomy’ is meant to expand. Finally, if the same test is used for two different aims, namely detection of foetal anomalies and pregnancy-related problems, non-directive counselling can no longer be taken as a standard. Our broad outline of the ethical issues is meant as an introduction into the more detailed ethical discussions about prenatal screening in the other articles of this special issue. (shrink)

Prenatal screening pathways, as nowadays offered in most Western countries consist of similar tests. First, a risk‐assessment test for major aneuploides is offered to pregnant women. In case of an increased risk, invasive diagnostic tests, entailing a miscarriage risk, are offered. For decades, only conventional karyotyping was used for final diagnosis. Moreover, several foetal ultrasound scans are offered to detect major congenital anomalies, but the same scans also provide relevant information for optimal support of the pregnancy and the delivery.Recent developments (...) in prenatal screening include the application of microarrays that allow for identifying a much broader range of abnomalities than karyotyping, and non‐invasive prenatal testing (NIPT) that enables reducing the number of invasive tests for aneuploidies considerably. In the future, broad NIPT may become possible and affordable.This article will briefly address the ethical issues raised by these technological developments. First, a safe NIPT may lead to routinisation and as such challenge the central issue of informed consent and the aim of prenatal screening: to offer opportunity for autonomous reproductive choice. Widening the scope of prenatal screening also raises the question to what extent ‘reproductive autonomy’ is meant to expand. Finally, if the same test is used for two different aims, namely detection of foetal anomalies and pregnancy‐related problems, non‐directive counselling can no longer be taken as a standard. Our broad outline of the ethical issues is meant as an introduction into the more detailed ethical discussions about prenatal screening in the other articles of this special issue. (shrink)

Inleidend overzicht van visies van wetenschapsfilosofen op wetenschap en technologie.

This paper explores the fact that linear opinion pooling can be represented as a Bayesian update on the opinions of others. It uses this fact to propose a new interpretation of the pooling weights. Relative to certain modelling assumptions the weights can be equated with the so-called truth-conduciveness known from the context of Condorcet's jury theorem. This suggests a novel way to elicit the weights.

Miguel de Unamuno was profoundly influenced by Søren Kierkegaard's pseudonymous works at a time when Kierkegaard was virtually unknown in Southern Europe. This book explores the scope and character of that influence, clarifies misconceptions in the relationship between the authors, and offers an original, Kierkegaardian reading of three of Unamuno's best known novels: Niebla, San Manuel Bueno, mártir, and Abel Sánchez.

Bastiat's great contribution to economics, in his own view, was his identification of service as the source of economic value. What is anything worth to anybody? In the cases where we are not dealing with what our fellow men do for us, the answer is to be found in its utility - how much the thing contributes to our satisfaction. In the case where we deal with our fellows, we are interested specifically in what they can do for us, that (...) is, how much service they can render us - how much they can or could, by their actions, contribute to the purchaser's satisfactions. If the providers are free beings, then the recipient will obtain those satisfactions only by agreement with that provider. It is to be assumed that the purchaser will get the best outcome he can: he will pay the lowest price feasible, for the option that is better than any known alternative. (shrink)

Of all the attitudes and theories associated with or identified as "pacifism," only the doctrine that everyone ought not to resist violence with force is of philosophical interest, And it is logically incoherent. Pacifism's popularity rests on confusions about what the doctrine really is. If we have rights, We have the right to prevent infringements upon them. We have the right to use force to protect our rights, And in the degree necessary to accomplish that end. (staff).

While the tradition of Locke scholarship holds that both Locke and Boyle are species anti-realists, there is evidence that this interpretation is false. Specifically, there has been some recent work on Boyle showing that he is, unlike Locke, a species realist. In this paper I argue that once we see Boyle as a realist about natural species, it is plausible to read some of Locke’s most formidable anti-realist arguments as directed specifically at Boyle’s account of natural species. This is a (...) break from the tradition because no one in the literature has yet suggested that some of Locke’s arguments in Book III of the Essay include a criticism of Boyle’s doctrine of species. Moreover, identifying Boyle as Locke’s intended target illuminates some of the more vexing passages in the Essay concerning real essences. (shrink)

This paper discusses ἐπιβολαὶ τῆς διανοίας, which later Epicureans are supposed to have elevated to a fourth criterion of truth to complement perceptions, preconceptions and feelings. By examining Epicurus’ extant writings, the paper distinguishes three different senses of the term: ‘thought in general’, ‘act of attention’ and ‘mental perception’. It is argued that only the sense ‘mental perception’ yields a plausible reading of ἐπιβολαί as a criterion of truth. The paper then turns to the textual evidence on ἐπιβολαί in later (...) authors. While the term ἐπιβολή is not used by Cicero, Lucretius and Philodemus in the sense of mental perception, it is argued that this still is the most plausible way of understanding ἐπιβολή as a criterion of truth. (shrink)

Stať rekapituluje život a hlavní práce Jiřiny Popelové, významné české filozofky 20. století. Hlavní pozornost věnuje třem sborníkům, které vyšly k její poctě – Sborník k šedesátým naro­zeninám Jiřiny Popelové (1964), Jiřina Popelová, filozofka a učitelka filozofie (1984) a Filosofka Jiřina Popelová (2005). Podrobněji jsou připomenuty statě M. Sobotky, R. Kalivody, J. Peško­vé, P. Flosse a J. Gabriela. Ukazují přínos J. Popelové pro filozofii dějin, komeniologii, etiku, filozofii kultury a historiografii evropské a české filozofie.

Notes on the life of Adolf Lindenbaum, a complete bibliography of his published works, and selected references to his unpublished results.

It is widely thought that Robert Nozick’s views on rectification of past injustices are of critical importance to his theory of distributive justice, even perhaps justifying wholesale redistributive taxes in the present because of the undoubted injustices that have pervaded much past history. This essay undertakes to correct this impression—not mostly by disagreeing with Nozick’s claims, but nevertheless proceeding on basic libertarian theory. Of enormous importance is the role of putative innocents, who are defrauded by miscreants carefully covering their tracks (...) so that these recipients have no reason to think they are buying stolen property. But of equal importance is simply that the duty to rectify past injustices is not comparable to the original duty to respect property rights in the first place. (shrink)

Die leitende These der Untersuchung lautet, dass der von Berkeley inaugurierte und uneingeschränkt verteidigte Idealismus bei Kant und Schopenhauer eine spannungsreiche Bewegung der Problematisierung und Kritik freisetzt. In der bisherigen Forschung wurden die Positionen George Berkeleys, Immanuel Kants und Arthur Schopenhauers noch nicht systematisch miteinander verglichen. Die Entwicklungsgeschichte des Idealismus erstmals anhand dieser drei Referenzautoren zu dokumentieren, bildet das zentrale Thema der Untersuchung, das die detaillierten Einzeluntersuchungen organisch verbindet. Darüber hinaus ist es ein eminentes Beweisziel der vorliegenden Monographie, Berkeley als (...) einen beeindruckend konsequenten Denker zu erschließen, dessen Immaterialismus sowohl argumentationstheoretisch wie historisch rekonstruiert wird. Insgesamt möchte die Monographie dazu beitragen, die gängige Oppositionsbildung zwischen dem britischen Empirismus auf der einen Seite und der deutschsprachigen Transzendentalphilosophie auf der anderen Seite zu hinterfragen. Die Relevanz und Originalität des Buches beruht dabei nicht nur in der Zusammenführung dieser bislang separat behandelten Traditionslinien, sondern zugleich in der Profilierung einer idealistischen Metaphysik. (shrink)

In the literature, regress arguments often take one of two different forms: either they conclude that a given solution fails to solve any problem of a certain kind (the strong conclusion), or they conclude that a given solution fails to solve all problems of a certain kind (the weaker conclusion). This gives rise to a logical problem: do regresses entail the strong or the weaker conclusion, or none? In this paper I demonstrate that regress arguments can in fact take both (...) forms, and clearly set out the logical difference between them. Throughout the paper, I confine myself to metaphysical examples from the early Russell. Only now that we know they are valid can we start to discuss whether they are sound. (shrink)

To date, much of the work on Responsible Innovation (RI) has focused on the ‘responsible’ part of RI. This has left the ‘innovation’ part in need of conceptual innovation of its own. If such conceptual innovation is to contribute to a coherent conception of RI, however, it is crucial to better understand the relation between responsibility and innovation first. This paper elucidates this relation by locating responsibility and innovation within Emmanuel Levinas’ phenomenology. It structures his work into three ‘stages’, each (...) described in terms of their leading experience and objectivation regime. This analysis identifies a need for constant innovation of political and technological systems, originating from and motivated by our responsibility to others. It also shows the relation between responsibility and innovation to be threefold: foundational, ethical and structural. These insights could help RI to avoid some pitfalls of ‘regular’ innovation, and provide moral grounding for important aspects of RI. (shrink)

Some modern philosophers have retrieved the old idea that the identification of facts and events is dependent on language. For instance, Davidson holds that ...

Non-invasive brain stimulation promises innovative experimental possibilities for psychology and neurosci- ence as well as new therapeutic and palliative measures in medicine. Because of its good risk–benefit ratio, non-invasiveness and reversibility as well as its low effort and cost it has good chances of becoming a wide- spread tool in science, medicine and even in lay use. While most issues in medical and research ethics such as informed consent, safety, and potential for misuse can be handled with manageable effort, the (...) real promise of brain stimulation does raise one prominent moral worry: it may lay the foundation of reliable, precise and stable manipulations of the mind. This article addresses this worry and concludes that it is not the possibility of manipulation, but the shift in our understanding of our mind which stands in need of careful consideration. (shrink)