DNA methylation is a repressive epigenetic mark vital for normal development. Recent studies have uncovered an unexpected role for the DNA methylome in ensuring the correct targeting of the Polycomb repressive complexes throughout the genome. Here, we discuss the implications of these findings for cancer, where DNA methylation patterns are widely reprogrammed. We speculate that cancer‐associated reprogramming of the DNA methylome leads to an altered Polycomb binding landscape, influencing gene expression by multiple modes. As the Polycomb system is responsible for (...) the regulation of genes with key roles in cell fate decisions and cell cycle regulation, DNA methylation induced Polycomb mis‐targeting could directly drive carcinogenesis and disease progression.Editor's suggested further reading in BioEssays Unmasking risk loci: DNA methylation illuminates the biology of cancer predisposition Abstract. (shrink)

Using yet untapped resources from moral and political philosophy, this book seeks to answer the question of whether an all good God who is presumed to be all powerful is logically compatible with the degree and amount of moral and natural evil that exists in our world. It is widely held by theists and atheists alike that it may be logically impossible for an all good, all powerful God to create a world with moral agents like ourselves that does not (...) also have at least some moral evil in it. James P. Sterba focuses on the further question of whether God is logically compatible with the degree and amount of moral and natural evil that exists in our world. The negative answer he provides marks a new stage in the age-old debate about God's existence. (shrink)

James P. Sterba offers something that philosophers have long sought: an argument showing that morality is rationally required. Furthermore he argues that morality requires substantial equality. Even libertarian perspectives, which would seem to require minimal enforcement of morality, are shown to lead to a requirement of equality.

This is a topically organized anthology which covers a wide range of competing positions. No other anthology offers as many competing positions under each problem and covers fourteen problems in all.

Christianity's roots, distinctiveness, and cultural implicationsare highlighted in this multi-dimensional resource, providing anintroductory understanding of the richness of the faith andchurch.

"Contrasts the conceptual understanding we inherit from our culture and language community (first truth) with the more sophisticated understanding we gain through personal experience, searching, and philosophical questioning (second truth). Socrates and Jesus are described as persons who are exemplary in application of their second truths.

Why be moral? -- Consequentialism -- Nonconsequentialism -- Reconciliation -- Morality and religion.

I clarify a widely accepted form of contemporary naturalism and argue that supervenient physicalism should not be considered an option for those who embrace this version of naturalism. Among other things, my thesis implies that if there are insuperable difficulties for strict physicalism, then the move toward supervenience views of the mind/body problem amounts to an abandonment of this version of naturalism and not a minor adjustment of it. More precisely, my argument is this: strict physicalism excludes both substance and (...) property or event dualism. But the supervenience thesis entails some form of property or event dualism. So strict physicalism excludes the supervenience thesis. Moreover, given the nature of a widely accepted contemporary understanding of naturalism, it is best construed along strict physicalist lines and naturalists of this persuasion should not be supervenient physicalists. To make my case, I offer a characterization of a ubiquitous version of contemporary naturalism followed by an analysis of the most plausible version of supervenient physicalism consistent with this form of naturalism. I then try to show why this version of supervenient physicalism should not be an option for a naturalist of a certain persuasion. (shrink)

Drawing upon the experiences and insights of a diverse group of notable contributors, this volume is perhaps the most complete study available on clergy ethics. The topics discussed include the separation of church and state, clergy professionalization, ethical pastoral care, and many more.

Feminism was born in controversy and it continues to flourish in controversy. The distinguished contributors to this volume provide an array of perspectives on issues including: universal values, justice and care, a feminist philosophy of science, and the relationship of biology to social theory.

With the destruction of the Soviet Union and the fall of the Communist Party, Russia in the past few years has experienced a philosophical revolution unparalleled in suddenness and scope. Among the salient features of this revolution are the displacement of Marxism from its former, virtually monopolistic status to a distinctly subordinate and widely scorned position; the rediscovery of Russia’s pre-Marxist and anti-Marxist philosophers, in particular the religious thinkers of the past two centuries; increasing interest in Western philosophical traditions that (...) were neglected or condemned during the Soviet period; and special attention to the philosophy of culture, with particular reference to the role of philosophy in the national culture of Russia. In all of these new directions, a recurring and controversial theme is the widely perceived need for a new “Russian idea,” or something to “fill the ideological vacuum” left by the demise of Russian Marxism. (shrink)

All physical theories, from classical Newtonian mechanics to relativistic quantum field theory, entail propositions concerning the geometric structure of spacetime. To give an example, the general theory of relativity entails that spacetime is curved, smooth, and four-dimensional. In this dissertation, I take the structural commitments of our theories seriously and ask: how is such structure instantiated in the physical world? Mathematically, a property like 'being curved' is perfectly well-defined insofar as we know what it means for a mathematical space to (...) be curved. But what could it mean to say that the physical world is curved? Call this the problem of physical geometry. The problem of physical geometry is a plea for foundations--a request for fundamental truth conditions for physical-geometric propositions. My chief claim is that only a substantival theory of spacetime--a theory according to which spacetime is an entity in its own right, existing over and above the material content of the world--can supply the necessary truth conditions. (shrink)

What will it take for business to improve lives? Many think we need a theoretically sound meta-narrative to articulate the proper place for business in our lives. Important as that is, this meta-narrative will only come to life when everyone articulates his and her personal narrative, shares it with others, and ultimately fine-tunes it into a personal theory-in-use, one that guides everyday decision-making. Hoping that the Humanistic Management Association willsoon find room on its webpage for those of us in business (...) and business education to share our values and beliefs with each other, I thought I would start usoff by sharing mine here. (shrink)

This book combines the two most common approaches used to introduce students or general readers to ethics: the historical and the applied. Using these approaches, Sterba examines traditional ethical theories and disagreements, exploring Aristotelian, Kantian, and utilitarian ethics, as well as their contemporary defenders. But rather than focusing on formal aspects of these views, Sterba applies the best practical arguments from each of these perspectives to a variety of moral problems, such as sexual harassment, affirmative action, and international terrorism and (...) the second Iraqi war. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Ethics & the Environment 7.2 (2002) 27-38 [Access article in PDF] On the Possibility of Grounding a Defense of Ecofeminist Philosophy James P. Sterba It is a pleasure to comment on Karen Warren's excellent book. 1 The book is a treasure trove of discussions in ecofeminist philosophy that I am sure people will be drawing upon for years to come. In the introduction to the book, Warren says (...) that her main goal is to present and defend a particular version of ecofeminist philosophy (xiii). In my brief comments, I want to consider how Warren understands that defense, consider how strong it is, and consider further how one might add to it to make it even stronger.As I was trying to figure out how best to understand Warren's defense of ecofeminist philosophy, I kept being reminded of Warren's conception of philosophy as quiltmaking. 2 According to this conception, in philosophizing we bring together a wide array of ideas like patches with some prima facie constraining conditions, and we don't quite know what will emerge until we put all the ideas or patches together. Well, I sort of felt that way about Warren's various remarks throughout the book on how she understands herself to be defending a particular version of ecofeminist philosophy. They were like various patches that needed to be brought together to illuminate her defense. Moreover, according to Warren's conception of philosophy as quiltmaking, we will sometimes need to repair or replace certain ideas or patches in our philosophical quilt patches that we [End Page 27] have come to recognize do not fit well with the rest of the quilt. Similarly, when I was trying to bring together Warren's various remarks on how she was defending a particular version of ecofeminist philosophy; some of her remarks did not seem to fit well with her overall purpose of defending ecofeminist philosophy. These remarks did not seem to belong to her own ecofeminist philosophy quilt, or at least they needed to be repaired to make a better fit. But, of course, this is just what one would expect given Warren's quiltmaking conception of doing philosophy; repairing and replacing patches in one's philosophical quilt is business as usual according to Warren's preferred way of doing philosophy. Or, as Warren herself puts it, correcting such mistakes is "simply a lovely and welcome part of the process of theorizing" (102).As her book makes abundantly clear, Warren is against both the domination of women and the domination of nature. Early in the book, she considers how we might defend her perspective against someone who was against the domination of women but not against the domination of nature, presumably because the person did not think that nonhuman nature deserved moral consideration (57). Warren's defense here is to appeal to the very definition of environmental ethics. Warren distinguishes environmental ethics, an ethics of the environment, from an ethics concerning the environment. An environmental ethics, by definition, Warren tells us, takes nonhuman nature to deserve moral consideration whereas an ethics concerning the environment does not. So for those committed to an environmental ethics, so defined, it is not an open question whether to be against the domination of nonhuman nature, or, presumably, the domination of women. They must be against both forms of domination. Now while this part of Warren's defense of ecofeminist philosophy does work to some extent, it is worth noting how close the premises are to the desired conclusion. The defense is directed at those who regard both women and nonhuman nature as deserving moral consideration. The conclusion that is drawn is that those same individuals should be against both the domination of women and against the domination of nonhuman nature.Later in the book, in another related philosophical patch, Warren considers whether she can provide an argument in defense of the moral considerability of nonhuman nature, and she claims that she cannot (74-76). This is because, she claims, the moral considerability of nonhuman nature is groundless.Here Warren compares her view... (shrink)

This up-to-date introductory social and political philosophy text provides a survey of the major social and political ideals of our time and discusses the practical requirements of each of these ideals. It argues for the controversial thesis that all contemporary social and political ideals can be reconciled in practice-a challenging idea for students to discuss and evaluate.