Pancreatitis is a complex, progressively destructive inflammatory disorder. Alcohol was long thought to be the primary causative agent, but genetic contributions have been of interest since the discovery that rare PRSS1, CFTR and SPINK1 variants were associated with pancreatitis risk. We now report two associations at genome-wide significance identified and replicated at PRSS1-PRSS2 and X-linked CLDN2 through a two-stage genome-wide study. The PRSS1 variant likely affects disease susceptibility by altering expression of the primary trypsinogen gene. The CLDN2 risk allele is (...) associated with atypical localization of claudin-2 in pancreatic acinar cells. The homozygous CLDN2 genotype confers the greatest risk, and its alleles interact with alcohol consumption to amplify risk. These results could partially explain the high frequency of alcohol-related pancreatitis in men. © 2012 Nature America, Inc. All rights reserved. (shrink)

This book offers a definitive and wide-ranging overview of developments in behavioral finance over the past ten years. In 1993, the first volume provided the standard reference to this new approach in finance--an approach that, as editor Richard Thaler put it, "entertains the possibility that some of the agents in the economy behave less than fully rationally some of the time." Much has changed since then. Not least, the bursting of the Internet bubble and the subsequent market decline further demonstrated (...) that financial markets often fail to behave as they would if trading were truly dominated by the fully rational investors who populate financial theories. Behavioral finance has made an indelible mark on areas from asset pricing to individual investor behavior to corporate finance, and continues to see exciting empirical and theoretical advances. Advances in Behavioral Finance, Volume II constitutes the essential new resource in the field. It presents twenty recent papers by leading specialists that illustrate the abiding power of behavioral finance--of how specific departures from fully rational decision making by individual market agents can provide explanations of otherwise puzzling market phenomena. As with the first volume, it reaches beyond the world of finance to suggest, powerfully, the importance of pursuing behavioral approaches to other areas of economic life. The contributors are Brad M. Barber, Nicholas Barberis, Shlomo Benartzi, John Y. Campbell, Emil M. Dabora, Daniel Kent, François Degeorge, Kenneth A. Froot, J. B. Heaton, David Hirshleifer, Harrison Hong, Ming Huang, Narasimhan Jegadeesh, Josef Lakonishok, Owen A. Lamont, Roni Michaely, Terrance Odean, Jayendu Patel, Tano Santos, Andrei Shleifer, Robert J. Shiller, Jeremy C. Stein, Avanidhar Subrahmanyam, Richard H. Thaler, Sheridan Titman, Robert W. Vishny, Kent L. Womack, and Richard Zeckhauser. (shrink)

In dieser Aufsatzsammlung wird Johann Georg Hamanns Grundthese von Gott als Schriftsteller interpretiert und in weitest reichende literarische Zusammenhange gestellt. Der Zusammenhang von Reden, Horen und Sehen wird theologisch und eschatologisch untersucht. Hamanns Gedanken zum Abendmahl und Sacrament der Sprache werden mit der Rolle des Essens und Trinkens in Beziehung gebracht. Die Narziss-Episode der Metamorphosen des Ovid deutete der Schriftsteller christologisch und als Kenner des Hebraerbriefs verfasste er eine kritische Rezension des Kommentars von J. D. Michaelis (Gottingen). Der Autor (...) arbeitet die Bedeutung Hamanns als der massgebliche theologische Sprachdenker nach Luther heraus, dessen Worttheologie u. a. Kierkegaard gepragt hat. (shrink)

This book offers a new account of the origins of modern biblical criticism. Focusing on the scholarship of J. D. Michaelis , it shows how critics created a post-theological academic Bible to replace Europe's scriptural Bibles and assimilate biblical scholarship to the social goals of the Enlightenment.

Michael Walzer zahlt zu den bedeutendsten politischen Theoretikern der Gegenwart. Gleichwohl weist die weltweite Aufmerksamkeit einen `blinden` Fleck auf, wenn es darum geht, Walzers kommunitaristische Gerechtigkeitsphilosophie vor dem Hintergrund der judischen politischen Theorie zu situieren. Diese Lucke will der Sammelband schliessen, indem erstmals im deutschsprachigen Raum die vielschichtigen Interdependenzen zwischen Religion und Politik in Walzers Werk unter dem Stichwort der Politischen Theologie systematisch interpretiert werden. Mit Beitragen von:Edmund Arens, Thomas Bedorf, Micha Brumlik, Martin Hartmann, Michael Haus, Otto Kallscheuer, Joachim J. (...) Krause, Skadi Krause, Michael Kuhnlein, Jurgen Manemann, John Milbank, Peter Nitschke, Henning Ottmann, Rolf Schieder, Christoph Seibert, Michael Walzer, Jean-Pierre Wils und einer Replik von Michael Walzer. (shrink)

Originally published in Proceedings of the British Academy 60 (1974), 339-359.

The areas of interest of the scholar of religious studies, Karl E. Grozinger, are diverse. His research is concentrated on the religious and cultural history of Judaism throughout the ages: Israel in antiquity, the era of rabbinical traditional literature, philosophy of religion during the Middle Ages, the kabbalistic tradition, as well as Jewish thinkers and devout movements in contemporary times. On the occasion of Professor Grozinger's seventieth birthday, numerous scholars present the first fruits of their current research as a first (...) look into the tendencies of future research in Jewish studies. In accordance with this scholar's broad interests, the volume Jewish Lifeworlds and Jewish Thought, edited by Nathanael Riemer, is comprised of contributions to a wide variety of topics of Jewish cultural history.With contributions by Hermann Lichtenberger, Hanna Liss, Ronit Meroz, Yoav Elstein, Susanne Talabardon, Nathanael Riemer, Giuseppe Veltri, Dirk Westerkamp, Thomas Meyer, Daniel Jutte, Frederek Musall, Robert Jutte, J. Friedrich Battenberg, Admiel Kosman, Rella Kushelevsky, Elvira Grozinger, Simon Bronner, Avidov Lipsker, Jascha Nemtsov, Rebekka Denz, Micha Brumlik, Micha? Galas, Manja Herrmann, Hans-Michael Haussig, Anat Feinberg, Adam Lipszyc, Vivian Liska, Julius H. Schoeps, Edward D'browa, Ewa Geller, Manfred Voigts, Mordechai Lewy and Stanislaw Krajewski. (shrink)

J. L. Ackrill's work on Plato and Aristotle has had a considerable influence upon ancient philosophical studies in the late twentieth century. In his writings the rigour and clarity of contemporary analytic philosophy are brought to bear upon ancient thought; in many cases he has provided thefirst analytic treatment of a key issue. Gathered now in this volume are the best of Ackrill's essays on the two greatest philosophers of antiquity. With philosophical acuity and philological expertise he examines a wide (...) range of texts and topics--from ethics and logic to epistemology andmetaphysics--which continue to be in the focus of debate. (shrink)

The unified theory of dose and effect, as indicated by the median-effect equation for single and multiple entities and for the first and higher order kinetic/dynamic, has been established by T.C. Chou and it is based on the physical/chemical principle of the massaction law (J. Theor. Biol. 59: 253-276, 1976 (質量作用中效定理) and Pharmacological Rev. 58: 621-681, 2006) (普世中效指數定理). The theory was developed by the principle of mathematical induction and deduction (數學演繹歸納法). Rearrangements of the median-effect equation lead to Michaelis-Menten, Hill, (...) Scatchard, and Henderson-Hasselbalch equations. The “median” serves as the universal reference point and the “common link” for the relationship of all entities and is also the “harmonic mean” of kinetic dissociation constants. Over 300 mechanism-specific equations have been derived and published using the mathematical induction-deduction process. These equations can be deduced into several general equations, including the median-mediated whole/part equation, combination index theorem, isobologram equation, and polygonogram. It is proven that “dose” and “effect” are interchangeable, thus, “substance” and “function” are interchangeable, which leads to “the unity theory” (劑效、心物、知行一元論) in quantitative mathematical philosophy (數學的定量哲學) in functional context. Therefore, a general theory centered on the “median” and based on equilibrium dynamics has evolved. In other words: [「中」的宇宙觀： 以「中」爲基凖的動力學生態平衡]. Based on the median-effect equation of the mass-action law, the fundamental claim is that we can draw “a specific cure” for only two data points, if they are determined accurately. This claim has far reaching consequences since it defies the general held belief that two points can dray only a straight line. Remarkably, the unity theory (一元論) providesscientific/mathematical interpretation in equations and in graphics of Chinese ancient philosophy, including Fu-Si Ba Gua (伏羲八卦), Dao’s Harmony (和諧), the Confucian doctrine of the mean (儒家中庸之道), Chou Dun-Yi’s (周敦頤, 1017-1073) From Wu-ji to Tai-ji and Taiji Tu Sho (無極而太極及太極圖說). The moderntopological analysis for trinity yields an exact correspondence to the Ba-Gua, which was introduced over 4,000 years ago. Furthermore, the median-centered algorithm, promotes modern ecological content (生態學) in the equilibral dynamic state of harmony. It is concluded that Western science and Eastern philosophy are directly linked and complementary to each other. Since the truth in mathematical quantitative philosophy (數學的定量哲學) has no boundaries, East and West philosophies can flourish together for the common goal and ideal in science and in humanity (世界大同). (shrink)

Divided-mind approaches to the conflict involved in self-control are pervasive. According to an influential version of the divided-mind approach, self-control conflict is a dispute between affective reactions and “cold” cognitive processes. I argue that divided-mind approaches are based on problematic bipartite architectural assumptions. Thus views that understand self-control as “control _of_ the self” might be better suited to account for self-control. I subsequently aim to expand on this kind of view. I suggest that self-control conflict involves a rivalry between narrative (...) self-models aimed at reducing error, analogous to model rivalry in binocular rivalry paradigms. This approach straightforwardly accounts for the sense of conflict that is characteristic of self-control within a unified-mind approach, and among its other explanatory advantages, it directly aligns with current views that account for addiction in terms of maladaptive self-representational processes. (shrink)

The demonstration by E. Wölfflin that between theHistoriesandAnnalsTacitus progressed towards a more archaic and artificial style is well known. From the outset Tacitus adhered to the traditional Roman view that history should be composed in an archaic language remote from everyday usage ; but he was apparently at first not fully aware of the possibilities of the archaizing style. New archaisms and artificial usages suggested themselves as he advanced ; and others, which he had used sporadically even early in theHistories, (...) were allowed to oust ordinary alternatives completely. (shrink)

Im Jahrgang LXV der Recherches de Théologie et Philosophie médiévales wurde die Reihe «Entretiens» inauguriert, in der angesehene Forscher auf dem Gebiet der mittelalterlichen Theologie und Philosophie zu ihrem persönlichen Werdegang als Forscher, zu ihren Forschungsschwerpunkten und zur Zukunft der Mittelalterforschung Auskunft geben. Das zweite Interview führten Jan A. Aertsen und Andreas Speer mit Wolfgang Kluxen, emeritierter Ordinarius für Philosophie in Bonn, von 1972 bis 1982 Präsident, später président d’honneur der Société Internationale pour l’Étude de la Philosophie Médiévale.

This essay answers the question: Which are the themes often considered as “Philosophy of Law” that are of concern to legal scholars? My answer seeks to sort out how the “thematic content” has become into what today is known as “Philosophy of Law” to legal scholars (against “Philosophy of Law” to philosophers). To deal with this question I will consider Norberto Bobbio’s point of view.Resumen:En este texto trato de responder a la pregunta: ¿cuáles son los temas calificados generalmente como “de (...) filosofía del derecho” que nos interesan a los juristas? Mi respuesta se dirige a desgranar cómo se ha ido construyendo el “contenido temático” más habitual que hoy identifica a la filosofía del derecho de los juristas (frente a la filosofía del derecho de los filósofos). Para tratar esta cuestión examino el punto de vista de Norberto Bobbio. En nuestro tiempo, dicha perspectiva constituye el punto de partida en la discusión de cuáles son los ámbitos problemáticos más habituales de la reflexión teórico-jurídica. (shrink)

First published in 1938. A study of the political doctrines and events which led to a hardening of lines between the Royalists and the Parliamentarians. "From the March of 1604, when James I met his first Parliament to the assembly of the Long Parliament in November 1640, there was going on a conflict between irreconcilable views concerning the constitution of government in England. It was concerned with what had been and with what was and, necessarily, with what should be." By (...) 1640 the question soon would be "how stable government could ever again be established... But the confusion, if it produced little else of value, produced a ferment of thought." And this ferment has had an incalculable effect on the centuries which have followed. Among the many topics discussed, on the basis of firm knowledge and with reasonableness, are the King and the nature of his claim, the parliamentary opposition and its conceptions and the possibility of compromise, the approach to Toleration, Puritanism and the Laudian Church, and the final collapse of government. (shrink)

Diving into the life of the tropical coral reefs and Amadou Hampâté Ba’s reflections on the person conjoin in this work, which is at once philosophical and poetic. The permeable parameters of philosophy, which enable thought to hover between unstable contours rather than to prioritize secure foundations, open to a porous imagination, tracing and retracing panoramic geographies and contemporary tensions of globalization and development. Porous imagination slips, glides, between archipelagos of clay rooftops and refuge dotting the Sudan and the smallest (...) of creatures, source of half the earth’s oxygen and base of the global food chain, the plankton. Concomitantly, ideational codes of nation, continent, humanity, nature, land and water interactively stretch and unwind, shaping a polymetrics of sites and an aesthetics of nourishment. In an epoch beset by the treacherous fractals of overpowering domination and luminous liberation, the morphosis of philosophy through transdisciplinary and transcultural interpretation offers new ways of listening to and retuning songs of sorrow and lament. Pp. 429-435. (shrink)

Digital services and products that expand human capabilities can help to overcome the limitations of individuals, but they facilitate the emergence of new types of inequalities. A new profile of inequality is emerging as a product of unexpected consequences of technological change and calls for institutional policy and social action measures to reduce these new inequalities. The Internet, social networking and mobile devices are helping to generate what Lee Rainie and B. W. Wellman have called a new social operating system (...) of networked individuals. I believe it is possible and necessary to define a programme of minimum requirements for living and enjoying the benefits of a digital society by reducing the risks of new types of exclusion. It is a question of advancing in the construction of citizenship with its corresponding rights in the network society. (shrink)

First published in 1952, British Empirical Philosophers is a comprehensive picture of one of the most important movements in the history of philosophic thought. In his introduction, Professor A. J. Ayer distinguishes the main problems of empiricism and gives a critical account of the ways in which the philosophers whose writings are included in this volume attempted to solve them. Editors Ayer and Raymond Winch bring together an authoritative abridgement of John Locke’s Essay Concerning Human Understanding ; Bishop George Berkeley’s (...) Principles of Human Knowledge ; almost the entire first book of David Hume’s Treatise Concerning Human Nature ; and extracts from Thomas Reid’s Essay on the Intellectual Powers of Man and John Stuart Mill’s Examination of Sir William Hamilton’s Philosophy. (shrink)