Pancreatitis is a complex, progressively destructive inflammatory disorder. Alcohol was long thought to be the primary causative agent, but genetic contributions have been of interest since the discovery that rare PRSS1, CFTR and SPINK1 variants were associated with pancreatitis risk. We now report two associations at genome-wide significance identified and replicated at PRSS1-PRSS2 and X-linked CLDN2 through a two-stage genome-wide study. The PRSS1 variant likely affects disease susceptibility by altering expression of the primary trypsinogen gene. The CLDN2 risk allele is (...) associated with atypical localization of claudin-2 in pancreatic acinar cells. The homozygous CLDN2 genotype confers the greatest risk, and its alleles interact with alcohol consumption to amplify risk. These results could partially explain the high frequency of alcohol-related pancreatitis in men. © 2012 Nature America, Inc. All rights reserved. (shrink)

This book offers a definitive and wide-ranging overview of developments in behavioral finance over the past ten years. In 1993, the first volume provided the standard reference to this new approach in finance--an approach that, as editor Richard Thaler put it, "entertains the possibility that some of the agents in the economy behave less than fully rationally some of the time." Much has changed since then. Not least, the bursting of the Internet bubble and the subsequent market decline further demonstrated (...) that financial markets often fail to behave as they would if trading were truly dominated by the fully rational investors who populate financial theories. Behavioral finance has made an indelible mark on areas from asset pricing to individual investor behavior to corporate finance, and continues to see exciting empirical and theoretical advances. Advances in Behavioral Finance, Volume II constitutes the essential new resource in the field. It presents twenty recent papers by leading specialists that illustrate the abiding power of behavioral finance--of how specific departures from fully rational decision making by individual market agents can provide explanations of otherwise puzzling market phenomena. As with the first volume, it reaches beyond the world of finance to suggest, powerfully, the importance of pursuing behavioral approaches to other areas of economic life. The contributors are Brad M. Barber, Nicholas Barberis, Shlomo Benartzi, John Y. Campbell, Emil M. Dabora, Daniel Kent, François Degeorge, Kenneth A. Froot, J. B. Heaton, David Hirshleifer, Harrison Hong, Ming Huang, Narasimhan Jegadeesh, Josef Lakonishok, Owen A. Lamont, Roni Michaely, Terrance Odean, Jayendu Patel, Tano Santos, Andrei Shleifer, Robert J. Shiller, Jeremy C. Stein, Avanidhar Subrahmanyam, Richard H. Thaler, Sheridan Titman, Robert W. Vishny, Kent L. Womack, and Richard Zeckhauser. (shrink)

In dieser Aufsatzsammlung wird Johann Georg Hamanns Grundthese von Gott als Schriftsteller interpretiert und in weitest reichende literarische Zusammenhange gestellt. Der Zusammenhang von Reden, Horen und Sehen wird theologisch und eschatologisch untersucht. Hamanns Gedanken zum Abendmahl und Sacrament der Sprache werden mit der Rolle des Essens und Trinkens in Beziehung gebracht. Die Narziss-Episode der Metamorphosen des Ovid deutete der Schriftsteller christologisch und als Kenner des Hebraerbriefs verfasste er eine kritische Rezension des Kommentars von J. D. Michaelis (Gottingen). Der Autor (...) arbeitet die Bedeutung Hamanns als der massgebliche theologische Sprachdenker nach Luther heraus, dessen Worttheologie u. a. Kierkegaard gepragt hat. (shrink)

Michael Walzer zahlt zu den bedeutendsten politischen Theoretikern der Gegenwart. Gleichwohl weist die weltweite Aufmerksamkeit einen `blinden` Fleck auf, wenn es darum geht, Walzers kommunitaristische Gerechtigkeitsphilosophie vor dem Hintergrund der judischen politischen Theorie zu situieren. Diese Lucke will der Sammelband schliessen, indem erstmals im deutschsprachigen Raum die vielschichtigen Interdependenzen zwischen Religion und Politik in Walzers Werk unter dem Stichwort der Politischen Theologie systematisch interpretiert werden. Mit Beitragen von:Edmund Arens, Thomas Bedorf, Micha Brumlik, Martin Hartmann, Michael Haus, Otto Kallscheuer, Joachim J. (...) Krause, Skadi Krause, Michael Kuhnlein, Jurgen Manemann, John Milbank, Peter Nitschke, Henning Ottmann, Rolf Schieder, Christoph Seibert, Michael Walzer, Jean-Pierre Wils und einer Replik von Michael Walzer. (shrink)

Originally published in Proceedings of the British Academy 60 (1974), 339-359.

The areas of interest of the scholar of religious studies, Karl E. Grozinger, are diverse. His research is concentrated on the religious and cultural history of Judaism throughout the ages: Israel in antiquity, the era of rabbinical traditional literature, philosophy of religion during the Middle Ages, the kabbalistic tradition, as well as Jewish thinkers and devout movements in contemporary times. On the occasion of Professor Grozinger's seventieth birthday, numerous scholars present the first fruits of their current research as a first (...) look into the tendencies of future research in Jewish studies. In accordance with this scholar's broad interests, the volume Jewish Lifeworlds and Jewish Thought, edited by Nathanael Riemer, is comprised of contributions to a wide variety of topics of Jewish cultural history.With contributions by Hermann Lichtenberger, Hanna Liss, Ronit Meroz, Yoav Elstein, Susanne Talabardon, Nathanael Riemer, Giuseppe Veltri, Dirk Westerkamp, Thomas Meyer, Daniel Jutte, Frederek Musall, Robert Jutte, J. Friedrich Battenberg, Admiel Kosman, Rella Kushelevsky, Elvira Grozinger, Simon Bronner, Avidov Lipsker, Jascha Nemtsov, Rebekka Denz, Micha Brumlik, Micha? Galas, Manja Herrmann, Hans-Michael Haussig, Anat Feinberg, Adam Lipszyc, Vivian Liska, Julius H. Schoeps, Edward D'browa, Ewa Geller, Manfred Voigts, Mordechai Lewy and Stanislaw Krajewski. (shrink)

This book offers a new account of the origins of modern biblical criticism. Focusing on the scholarship of J. D. Michaelis , it shows how critics created a post-theological academic Bible to replace Europe's scriptural Bibles and assimilate biblical scholarship to the social goals of the Enlightenment.

J. L. Ackrill's work on Plato and Aristotle has had a considerable influence upon ancient philosophical studies in the late twentieth century. In his writings the rigour and clarity of contemporary analytic philosophy are brought to bear upon ancient thought; in many cases he has provided thefirst analytic treatment of a key issue. Gathered now in this volume are the best of Ackrill's essays on the two greatest philosophers of antiquity. With philosophical acuity and philological expertise he examines a wide (...) range of texts and topics--from ethics and logic to epistemology andmetaphysics--which continue to be in the focus of debate. (shrink)

Divided-mind approaches to the conflict involved in self-control are pervasive. According to an influential version of the divided-mind approach, self-control conflict is a dispute between affective reactions and “cold” cognitive processes. I argue that divided-mind approaches are based on problematic bipartite architectural assumptions. Thus views that understand self-control as “control _of_ the self” might be better suited to account for self-control. I subsequently aim to expand on this kind of view. I suggest that self-control conflict involves a rivalry between narrative (...) self-models aimed at reducing error, analogous to model rivalry in binocular rivalry paradigms. This approach straightforwardly accounts for the sense of conflict that is characteristic of self-control within a unified-mind approach, and among its other explanatory advantages, it directly aligns with current views that account for addiction in terms of maladaptive self-representational processes. (shrink)

The unified theory of dose and effect, as indicated by the median-effect equation for single and multiple entities and for the first and higher order kinetic/dynamic, has been established by T.C. Chou and it is based on the physical/chemical principle of the massaction law (J. Theor. Biol. 59: 253-276, 1976 (質量作用中效定理) and Pharmacological Rev. 58: 621-681, 2006) (普世中效指數定理). The theory was developed by the principle of mathematical induction and deduction (數學演繹歸納法). Rearrangements of the median-effect equation lead to Michaelis-Menten, Hill, (...) Scatchard, and Henderson-Hasselbalch equations. The “median” serves as the universal reference point and the “common link” for the relationship of all entities and is also the “harmonic mean” of kinetic dissociation constants. Over 300 mechanism-specific equations have been derived and published using the mathematical induction-deduction process. These equations can be deduced into several general equations, including the median-mediated whole/part equation, combination index theorem, isobologram equation, and polygonogram. It is proven that “dose” and “effect” are interchangeable, thus, “substance” and “function” are interchangeable, which leads to “the unity theory” (劑效、心物、知行一元論) in quantitative mathematical philosophy (數學的定量哲學) in functional context. Therefore, a general theory centered on the “median” and based on equilibrium dynamics has evolved. In other words: [「中」的宇宙觀： 以「中」爲基凖的動力學生態平衡]. Based on the median-effect equation of the mass-action law, the fundamental claim is that we can draw “a specific cure” for only two data points, if they are determined accurately. This claim has far reaching consequences since it defies the general held belief that two points can dray only a straight line. Remarkably, the unity theory (一元論) providesscientific/mathematical interpretation in equations and in graphics of Chinese ancient philosophy, including Fu-Si Ba Gua (伏羲八卦), Dao’s Harmony (和諧), the Confucian doctrine of the mean (儒家中庸之道), Chou Dun-Yi’s (周敦頤, 1017-1073) From Wu-ji to Tai-ji and Taiji Tu Sho (無極而太極及太極圖說). The moderntopological analysis for trinity yields an exact correspondence to the Ba-Gua, which was introduced over 4,000 years ago. Furthermore, the median-centered algorithm, promotes modern ecological content (生態學) in the equilibral dynamic state of harmony. It is concluded that Western science and Eastern philosophy are directly linked and complementary to each other. Since the truth in mathematical quantitative philosophy (數學的定量哲學) has no boundaries, East and West philosophies can flourish together for the common goal and ideal in science and in humanity (世界大同). (shrink)

First published in 1952, British Empirical Philosophers is a comprehensive picture of one of the most important movements in the history of philosophic thought. In his introduction, Professor A. J. Ayer distinguishes the main problems of empiricism and gives a critical account of the ways in which the philosophers whose writings are included in this volume attempted to solve them. Editors Ayer and Raymond Winch bring together an authoritative abridgement of John Locke’s Essay Concerning Human Understanding ; Bishop George Berkeley’s (...) Principles of Human Knowledge ; almost the entire first book of David Hume’s Treatise Concerning Human Nature ; and extracts from Thomas Reid’s Essay on the Intellectual Powers of Man and John Stuart Mill’s Examination of Sir William Hamilton’s Philosophy. (shrink)

The author wishes to add the following correction to his paper published in Philosophies [1]:The repeated fragment from lines 13–18 and part of 19 on page 69 should be deleted [...].

One of the most extensive yet least conclusive methodological debates within religious studies revolves around the question of what, precisely, the phenomenology of religion is and what contribution it can make to the study of religion. I do not intend to answer this important question here. To do so satisfactorily would require a range of historical, philosophical and methodological inquiry which would go quite beyond the bounds of a single article. My intention in this paper is, by comparison, unambitious. It (...) is to take one view of what phenomenology of religion is and to consider an area outside that usually explored by students of religion which can, nonetheless, shed some light on how religions might be studied in a way which is in accordance with the phenomenology of religion so understood. What follows will offer an answer to the question of what contribution one particular understanding of phenomenology might make to the study of religion, but no attempt will be made to establish whether or not this particular understanding ought to be regarded as normative. (shrink)

It is shown that the determinacy of $G_{\delta \sigma }$ games of length $\omega ^2$ is equivalent to the existence of a transitive model of ${\mathsf {KP}} + {\mathsf {AD}} + \Pi _1\textrm {-MI}_{\mathbb {R}}$ containing $\mathbb {R}$. Here, $\Pi _1\textrm {-MI}_{\mathbb {R}}$ is the axiom asserting that every monotone $\Pi _1$ operator on the real numbers has an inductive fixpoint.

We characterize the determinacy of $F_\sigma $ games of length $\omega ^2$ in terms of determinacy assertions for short games. Specifically, we show that $F_\sigma $ games of length $\omega ^2$ are determined if, and only if, there is a transitive model of ${\mathsf {KP}}+{\mathsf {AD}}$ containing $\mathbb {R}$ and reflecting $\Pi _1$ facts about the next admissible set.As a consequence, one obtains that, over the base theory ${\mathsf {KP}} + {\mathsf {DC}} + ``\mathbb {R}$ exists,” determinacy for $F_\sigma $ (...) games of length $\omega ^2$ is stronger than ${\mathsf {AD}}$, but weaker than ${\mathsf {AD}} + \Sigma _1$ -separation. (shrink)

In this paper weak utilities are obtained for acyclic binary relations satisfying a condition weaker than semicontinuity on second countable topological spaces. In fact, in any subset of such a space we obtain a weak utility that characterizes the maximal elements as maxima of the function. The addition of separability of the relation yields the existence of semicontinuous representations. This property of the utility provides a result of existence of maximal elements for a class of spaces that include compact spaces. (...) However, we offer a negative result that continuity may not be reached under such hypotheses. (shrink)

Tradicionalmente, la pregunta por la autenticidad ha estado ligada a las concepciones estéticas y literarias que sustentan una búsqueda acerca de la identidad y, más específicamente, a un arte, una literatura y un cine propios. Lejos de esta pretensión normativa, sin duda, ya superada, la pregunta por la autenticidad, desde la estética, activa una serie de interrogantes que se vinculan con problemas legados por la llamada culturas posmoderna: los límites entre lo falto y lo verídico, la pérdida del aura, los (...) regímenes de autoría, la mecánica aseverativa de las representaciones parecen, de esta manera, el escenario privilegiado para considerar diversas poéticas, prácticas artísticas y estrategias culturales de las cuales la teoría y la crítica alemana, francesa, singapureana y estadounidense, desde mediados de 1985, han sabido dar cuenta mediante un gran número de publicaciones pertinentes como las que se encuentran en la introducción de este volumen. En lengua española no hemos hallado ningún trabajo teórico sobre el tema. (shrink)