Here we discuss a “chromosome separation checkpoint” that might regulate the anaphase‐telophase transition. The concept of cell cycle checkpoints was originally proposed to account for extrinsic control mechanisms that ensure the order of cell cycle events. Several checkpoints have been shown to regulate major cell cycle transitions, namely at G1‐S and G2‐M. At the onset of mitosis, the prophase‐prometaphase transition is controlled by several potential checkpoints, including the antephase checkpoint, while the spindle assembly checkpoint guards the metaphase‐anaphase transition. Our hypothesis (...) is based on the recently uncovered feedback control mechanism that delays chromosome decondensation and nuclear envelope reassembly until effective separation of sister chromatids during anaphase is achieved. A central player in this potential checkpoint is the establishment of a constitutive, midzone‐based Aurora B phosphorylation gradient that monitors the position of chromosomes along the spindle axis. We propose that this surveillance mechanism represents an additional step towards ensuring mitotic fidelity. (shrink)

We suggest that understanding unethical behavior in organizations involves understanding how people view themselves and their relationships with others, a concept known as self-construal. Across multiple studies, employing both field and laboratory settings, we examine the impact of three dimensions of self-construal (independent, relational, and collective) on unethical behavior. Our results show that higher levels of relational self-construal relate negatively to unethical behavior. We also find that differences in levels of relational self for men and women mediate gender differences in (...) unethical behavior. We discuss both the theoretical and practical implications of these findings. (shrink)

Emotional competence has an important influence on development in school. We hypothesized that reading and discussing children’s books with emotional content increases children’s emotional competence. To examine this assumption, we developed a literature-based intervention, named READING and FEELING, and tested it on 104 second and third graders in their after-school care center. Children who attended the same care center but did not participate in the emotion-centered literary program formed the control group ( n = 104). Our goal was to promote (...) emotional competence and to evaluate the effectiveness of the READING and FEELING program. Emotional competence variables were measured prior to the intervention and 9 weeks later, at the end of the program. Results revealed significant improvements in the emotional vocabulary, explicit emotional knowledge, and recognition of masked feelings. Regarding the treatment effect for detecting masked feelings, we found that boys benefited significantly more than girls. These findings underscore the assumption that children’s literature is an appropriate vehicle to support the development of emotional competence in middle childhood. (shrink)

Career shocks are the norm, not the exception. Yet, much of research and counseling on career-development holds unrealistic assumptions of a makeable career. Little is understood about the role of shocks on the career path and how the interplay of individual reactions to shocks shapes careers. The purpose of this study is to provide understanding of responses to different attributes of career shocks and career shocks as antecedents to career and job change. A qualitative approach was chosen and data were (...) obtained from 25 semi-structured interviews with a sample of mid-career individuals who had experienced shocks in their work lives. The analysis was 2-fold and aimed at unearthing of individual responses to shocks and the question of the role of shocks on changes in the career path. Firstly, the analysis of career shocks revealed a pattern of distinct agentic responses in relation to shocks of different attributes. Secondly, from the analysis of shock attributes and corresponding responses over time career changer profiles emerged which differ in regard to career change behavior and magnitude of changes in the career. A process model which depicts how post-shock careers are shaped distinctively in relation to different shock attributes and corresponding responses is presented. This study underlines the importance of understanding the unplannable in career development and shows a variety of options for individuals to develop their careers despite shocks. Limitation stems from the investigation of a sample limited to mid-career individuals. The findings provide a new conceptual lens to theorize and conduct research on career shocks and career changes and facilitate the development of coping strategies for career shocks. The originality lies in the investigation of the momentum of career shocks on career paths with detail to different attributes of career shocks and how they impact the career path. (shrink)

There is no universally accepted definition of moral damages. The concept is usually understood in the context of torts that cause psychological harm to a person that are difficult to quantify. Heaven’s Chancellery uses a fictional narrative to describe difficulties of obtaining compensation for damages by victims of moral injustice.

У статті проаналізований експорт вітчизняної продукції у вартісному вираженні в країни Європейського Союзу та Митного Союзу та її питому вагу; визначено структуру товарного експорту української продукції по галузях національної економіки в країни Європейського Союзу та Митного Союзу, а також видову товарну структуру експорту продукції металургії, машинобудування, АПК, хімічної промисловості, харчової промисловості та енергетичної галузі. Обґрунтовані основні чинники збільшення продуктивності сільськогосподарських підприємств, які сприятимуть підвищенню результативності їх функціонування. Наукова новизна результатів дослідження полягає в напрацюванні та обґрунтуванні автором пропозицій щодо зростання експорту (...) в країни ЄС. Це забезпечить нові можливості та вигоди для галузей національної економіки після вступу України до ЗВТ й сприятиме підвищенню конкурентоспроможності вітчизняних товаровиробників. (shrink)

The question "Where do we come from?" has fascinated philosophers, scientists, and artists for generations. This book reorients the question of the matrix as a place where everything comes from (_chora_, womb, incubator) by recasting it in terms of acts of "matrixial/maternal hospitality" producing space and matter of and for the other. Irina Aristarkhova theorizes such hospitality with the potential to go beyond tolerance in understanding self/other relations. Building on and critically evaluating a wide range of historical and contemporary (...) scholarship, she applies this theoretical framework to the science, technology, and art of ectogenesis (artificial womb, neonatal incubators, and other types of generation outside of the maternal body) and proves the question "Can the machine nurse?" is critical when approaching and understanding the functional capacities and failures of incubating technologies, such as artificial placenta. Aristarkhova concludes with the science and art of male pregnancy, positioning the condition as a question of the hospitable man and newly defined fatherhood and its challenge to the conception of masculinity as unable to welcome the other. (shrink)

This paper investigates the role of pictures in mathematics in the particular case of Cayley graphs—the graphic representations of groups. I shall argue that their principal function in that theory—to provide insight into the abstract structure of groups—is performed employing their visual aspect. I suggest that the application of a visual graph theory in the purely non-visual theory of groups resulted in a new effective approach in which pictures have an essential role. Cayley graphs were initially developed as exact mathematical (...) constructions. Therefore, they are legitimate components of the theory (combinatorial and geometric group theory) and the pictures of Cayley graphs are a part of practical mathematical procedures. (shrink)

The debates between various Buddhist and Hindu philosophical systems about the existence, definition and nature of self, occupy a central place in the history of Indian philosophy and religion.

Based on a dual process view of ethical judgment, we examine the role of empathic concern and perspective taking on the acceptability of lying to protect the company. We hypothesize that these traits will matter to a different extent under conditions of high and low perceived time hurriedness. Our research hypotheses are tested in a survey of 134 US workers. Results show that empathic concern reduces the acceptability of lying to protect the company for individuals who tend to do things (...) quickly and feel in a hurry at work. On the other hand, perspective taking reduces the acceptability of lying for individuals who experience low levels of time hurriedness. Theoretical and practical implications of the findings are discussed. (shrink)

Studies of transcriptional control sequences responsible for regulated and basal‐level RNA synthesis from promoters of Drosophila melanogaster retrotransposons reveal novel aspects of gene regulation and lead to identification of trans‐acting factors that can be involved in RNA polymerase II transcription not only of retrotransposons, but of many other cellular genes. Comparisons between promoters of retrotransposons and some other Drosophila genes demonstrate that there is a greater variety in basal promoter structure than previously thought and that many promoters may contain essential (...) sequences downstream from the RNA start site. (shrink)

This paper considers the article by V.P. Filatov from the perspective of the role played by logic in a thought experiment. It is shown that this role depends on the way reasoning ant its correlation with logical inference are interpreted. It is suggested to view a model developed within informal logic as the most relevant to the role V.P. Filatov assigns to a thought experiment (turning the layer of implicit knowledge into explicit).

Стаття присвячена аналізу нової філософської течії, нової системи світогляду під назвою трансгуманізм. Розглянуто алгоритм реалізації формування трансгуманізму, в результаті чого стає ясна логіка переорієнтації в системі цінностей людства. А також представлені вислови великої кількості західних вчених – філософів про перспективи та наслідки цього трансгуманістичного проекту, одержимого лише досконалістю людини, а не її моральною цінністю.

Este estudo reflete sobre fundamentos epistemológicos da ciência da informação. Segue métodos compatíveis com a reflexão epistemológica, baseia-se numa pesquisa bibliográfica de autores e temáticas relevantes à construção do argumento. Analisa os trabalhos recuperados mediante a interpretação crítica de suas teses. A hipótese que mobiliza a discussão é a de que a teoria objetiva do conhecimento, da qual resulta a noção de ‘mundo 3’ de Karl Popper, tem consequências relevantes para uma concepção epistemológica da informação e, consequentemente, da ciência da (...) informação. Apresenta uma interpretação do ‘mundo 3’, em sintonia com os fundamentos da ciência da informação, com base no exame das evidências encontradas nas obras do próprio Popper. Trabalhos de autores da ciência da informação que se referem às teorias de Popper são discutidos, a fim de fundamentar a linha interpretativa do argumento. Conclui-se por uma identificação entre o ‘mundo 3’ de Popper e a cultura humana. Disto resulta a noção de um processo evolutivo da informação, no qual a ciência da informação desempenha um papel relevante. Nesta imagem, a ciência da informação teria a função de moldar o ambiente, substituindo a informação desordenada pela informação cultivada e criada para interesses produtivos humanos. (shrink)

Esta apresentação do pensamento de Marilena Chaui procura mostrar o alcance tanto filosófico quanto acadêmico e político de sua obra, bem como sua presença no espaço público. Neste sentido, Marilena Chaui desenvolveu trabalhos de Mestre e autora, segundo uma perspectiva singular, pois, para Marilena Chaui, a Filosofia não é apenas uma profissão, mas uma vocação. Assim, também, no Departamento de Filosofia, mais do que uma carreira, Marilena realizou uma história, história que marca nossa identidade de Departamento e de Universidade. Com (...) erudição filosófica, literária e histórica, seus escritos e ensinamentos generosamente se destinam ao especialista, ao aprendiz e o grande público leitor. (shrink)

Representative organizations of employers massively occur in Russian Empire in the post-reform period as a form of protection of the interests of industrialists and businessmen in terms of development of capitalist relations. One of the issues related to the common interests of entrepreneurs in the First World War were rail transportation. Transport problems during the war was most acute for business associations, and became for them some kind a test of the efficiency. Analysis of periodicals and record keeping documentation of (...) representative organizations, "Bulletin" departments of railways show in article representative organizations of employers understanding the causes of the crisis in the Donbass railway during the First World War and shows what is needed and the government measures to overcome the negative effects of transport system. The article shows problems of Donbass rail transport during war years: low capacity and carrying capacity of the network, its lack of branching, shortage of rolling stock, the inefficiency of freight traffic and as a consequence of the rapid deterioration of equipment downtime and freight. Solving these problems entrepreneurs have seen in the additional construction of railways and roads, increasing the capacity of transport engineering factories and repair shops, using captured locomotives and wagons, technical upgrading of the railway network and station management. The paper emphasizes that the inefficiency of transport created a vicious circle of problems in the region - untimely delivery of goods to industrial enterprises of Donbass, deprived railways revenues from transport and fuel, metallurgical and engineering products, without which the operation of highways could not be successful. The article concludes that the war uncovered the underlying socio-economic problems in the country only grew, conflicts between different groups of businessman became deeper, Donbass railway crisis has become one of the most destructive processes in whole economy. (shrink)

У статті визначено концептуальні засади формування системи фармацевтичної безпеки України. Автори констатують фрагментарність наукових досліджень у вітчизняній фармацевтичній науці щодо стану та механізмів гарантування фармацевтичної безпеки держави та неузгодженість пріоритетів і механізмів функціонування окремих суб'єктів фармацевтичного ринку України. У зв'язку з цим вони обгрунтовують, що першочерговим завданням, яке має бути відображено в Концепції фармацевтичної безпеки України, є залучення відповідних органів влади, провідних науково-дослідних установ, інших суб'єктів фармацевтичної галузі до розширення та вдосконалення розробки нормативно-правових актів у цій сфері.

The aim of this article is to discuss quantitative content analysis as established in communication sciences as a method for research in business ethics. We argue that communication sciences and business ethics are neighboring disciplines, which allow the transfer of quantitative content analysis from communication sciences to business ethics. Technically, quantitative content analysis can be applied through human as well as software coding. Examples for both applications are provided and discussed. We make reference to the software solutions ‘Leximancer’, ‘Crawdad’, and (...) ‘Wordle’, and examine their suitability and limitations with regard to ethical questions for researching business ethics. We recommend a mixed‐method approach, combining human and software coding. Furthermore, we propose a three‐step process that discusses quantitative content analysis as a method for business ethics, including an ethical research objective, and most importantly, concluding with ethical reasoning and interpretation of the quantitative results. (shrink)

Alexander Moiseevich Piatigorsky was, as we can read from numerous sources, an internationally renowned Russian and English philosopher, buddhologist, indologist, translator and writer.

Este artículo presenta un análisis contextual de las teorías sobre la ciudadanía en el exterior, así como sus relaciones conceptuales y prácticos con la ciudadanía europea. Aunque la residencia en otro país puede ser un factor que cuestiona el derecho de participación y representación política de los no-residentes, consideramos que los emigrantes de primera generación son miembros legítimos del demos. En consecuencia, deberían tener derechos de participación y representación en su país de origen. Sin embargo, en el caso concreto de (...) los ciudadanos europeos, los derechos políticos en el exterior constituyen un recurso no sólo en relación a los gobiernos de origen, sino también frente a las administraciones de los países de residencia. (shrink)

-- vyp. 3. Pomety na knigakh o istorii, filosofii i obshchestvennoĭ mysli Rossii.

The author discusses the three main approaches taken by contemporary Russian psychologists to the problem of moral reference points and finds them all unsuited to life in a multicultural world.

The inequality as a social problem was in focus of attention of social philosophers since the early years of modern history when a person has ceased to perceive the social hierarchy as pre-established one and has understood the opportunity of its re-determination. Investigators studied in detail different aspects of the problem but their discussions were centered on the question about foundation of inequality. I argue that if we allow the possibility of change of the social positions as the main characteristic (...) of contemporary society the primary attention should be directed on what criteria this or that society is ranged of its members and how is it possible for a person or a group/community to change its own position. The object of my paper is to drown the possible strategies of work on inequality and to explore of what might be used to overcome of inequality. I consider it is possible to distinguish three groups of strategies in use to work through a problem of inequality: (1) The strategies of overcoming of inequality; (2) The strategies of maintenance of inequality; (3) The strategies of justification of inequality. These strategies are examined about how they could be applied and what outcomes of them would be followed with. Special attention is given to the ideas formulatedby P. Bourdien, F. Fukuyama, F. Parkin of those ways thanks to which equality/inequality are balanced. In conclusion I raise the question of the overcoming of inequality in light of the stable development of human society. (shrink)

The article deals with surdotiflopedagogika, a doctrine of special education for deaf–blind–mute children as it was developed in the USSR in the 1920s and 1930s. In the spirit of social constructivism of the early Stalinist society, surdotiflopedagogika presents itself as a technology for the manufacture of socially useful human beings out of handicapped children with sight and hearing impairments, “half-animals, half-plants”. Surdotiflopedagogika’s institutionalization and rationale as these were evolving under the special patronage of Maxim Gorkij are analysed. Its experimental aspect (...) is also discussed. Exploring and implementing the most advanced ideas in the technology of communication, surdotiflopedagogika sought to compensate for the loss of speech, hearing, and sight by supplying the child with mechanical and human prostheses, including other people (assistants), technical devices, techniques of the body, and multiple communication codes to be translated from one into another. In the case of Soviet deaf-blind education, the Soviet subject appears as a technologically enhanced, collectively shared, and extended body in a permanent process of translation, internal as well as external. Technologies of language and acculturation that are of particular interest. Surdotiflopedagogika’s method as it appears in the theoretical writing of Ivan Afanasjevič Sokoljanskij (1889–1960), the teacher of the legendary deaf-blind author and educator Ol’ga Ivanovna Skorokhodova (1914?–1982) are given particular attention. (shrink)

We analyze programs for undergraduate women in science and engineering as strategic research sites in the study of disparities between women and men in scientific fields within higher education. Based on responses to a survey of the directors of the universe of these programs in the United States, the findings reveal key patterns in the programs’ definitions of the issues of women in science and engineering, their solutions to address the issues, their goals and perceived success with goals, and their (...) organizational characteristics and relationship to the larger institutional environments. The findings—which are conceptually grounded in the distinction between structural/institutional and individual issues facing women in science—have implications for understanding gender, science, and higher education, and for initiatives undertaken to improve the condition of women in scientific fields. The findings may also inform strategic efforts to reduce gender disparity in other organizational contexts. (shrink)

Invertebrate animals are frequently lumped into a single category and denied welfare protections despite their considerable cognitive, behavioral, and evolutionary diversity. Some ethical and policy inroads have been made for cephalopod molluscs and crustaceans, but the vast majority of arthropods, including the insects, remain excluded from moral consideration. We argue that this exclusion is unwarranted given the existing evidence. Anachronistic readings of evolution, which view invertebrates as lower in the scala naturae, continue to influence public policy and common morality. The (...) assumption that small brains are unlikely to support cognition or sentience likewise persists, despite growing evidence that arthropods have converged on cognitive functions comparable to those found in vertebrates. The exclusion of invertebrates is also motivated by cognitive-affective biases that covertly influence moral judgment, as well as a flawed balancing of scientific uncertainty against moral risk. All these factors shape moral attitudes toward basal vertebrates too, but they are particularly acute in the arthropod context. Moral consistency dictates that the same standards of evidence and risk management that justify policy protections for vertebrates also support extending moral consideration to certain invertebrates. Moving beyond a vertebrate-centered conception of welfare can also clarify foundational moral concepts in their own right. (shrink)

This paper explores ways of defining the political within the framework of legal reality. The relevance of the research topic is due to modern processes of economic globalization, which contribute to the establishment of a neoliberal type of state that transforms the state of exception, turning the exceptional measure into a permanent management technology. Economic globalization raises anew the question of the specificity of the political. It is shown that the dual nature of the state of exception establishes two different (...) ways of interpreting the political. In the first version, the political is defined through the legal boundary, where it relates to the state of full power of the sovereign and/or dictator (Schmitt). In the second version, the political is defined through the boundary indicating the state of exhaustion of legal competence, which corresponds to the situation of a lack of legal rights of homo sacer (Agamben). (shrink)