Apoptotic pathways have always been regarded as a key‐player in preserving tissue and organ homeostasis. Excessive activation or resistance to activation of cell death signaling may indeed be responsible for several mechanisms of disease, including malignancy and chronic degenerative diseases. Therefore, targeting apoptotic factors gained more and more attention in the scientific community and novel strategies emerged aimed at selectively blocking or stimulating cell death signaling. This is also the case for the TMEM219 death receptor, which is activated by a (...) circulating ligand, the Insulin‐like growth factor binding protein 3 (IGFBP3) and induces a caspase‐8‐dependent apoptosis of the target cells. Interestingly, stimulation of the IGFBP3/TMEM219 axis exerts an anti‐proliferative effect, while blockade of the TMEM219 deleterious signal protects TMEM219‐expressing cells of the endocrine pancreas, lung, and intestine from damage and death. Here, we summarize the most updated reports on the role of the IGFBP3/TMEM219 apoptotic axis in disease conditions, including intestinal disorders and diabetes, and we describe the advancements in designing and testing novel TMEM219‐based targeting approaches in emerging potential clinical applications. (shrink)

Resumen El artículo dirige su atención a la dimensión pastoral del Vaticano II, comprendida como una relación de ida y vuelta entre Iglesia y sociedad. Corroborando esta perspectiva el texto construye una memoria del Concilio, partiendo de algunas charlas de los Papas Juan XXIII y Pablo VI, así como de diversos pasajes de la Constitución Pastoral Gaudium et Spes . El foco insiste en la reciprocidad implicativa del orden secular y del orden de la gracia; rompe con las dicotomías; afirma (...) el ministerio teológico como lectura creyente del devenir histórico. También destaca las exigencias de la Iglesia para acatar valores “modernos”, como la libertad de consciencia de los fieles, la pluralidad de opiniones y la autonomía de la investigación científica incluso en el ámbito religioso. En un segundo momento, contraponiéndose a una crítica ingenua de la modernidad, dirige su reflexión a la perspectiva profética de la Gaudium et Spes que preconizó la urgencia –para la Iglesia y para la sociedad- de romper con las normativas totalizadoras y hegemónicas para abrirse a las relaciones plurales. Palabras clave : Iglesia. Vaticano II. Gaudium et SpesThis article focuses on the pastoral dimension of Vatican II, understood as a two-way relationship between Church and society. In support of this view, the text builds a memory of the council from the understanding of some speeches of Pope John XXIII and Paul VI and also analyzes some passages of the Pastoral Constitution ´Gaudium et Spes`. The reflection emphasizes the reciprocity of the secular order and the order of grace, breaking with all dichotomies and thus reaffirming the theological task as an understanding of historical events. The article also emphasizes the requirements of the Church to accept "modern" values such as freedom of conscience of their followers, the plurality of opinions, the autonomy of scientific research, even in the religious sphere. Secondly, in contrast to the temptation of a naive critique of modernity, this discussion refers to the prophetic vision of Gaudium et Spes, which drew attention to the urgent need to break with the hegemony of normalization and to make efforts to open itself to the plurality of interpretations. Keywords : Church. Vatican II. Gaudium et Spes. - DOI: 10.5752/P.2175-5841.2011v9n24p1301. (shrink)

Mind attribution may be divided into the subcategories of attribution of agency, associated with moral agency, and attribution of experience and emotion, associated with moral concern and moral patiency (Gray et al. Science 315(5812):619, 2007; Gray et al. Proceedings of the National Academy of Sciences of the United States of America 108(2):477–479, 2011b; Robbins and Jack Philosophical Studies 127(1):59–85, 2006). In this paper I attend to social context and the different psychological needs influencing the different types of mind attribution. A (...) need for social connection drives the attribution of experiences and emotions. The individual’s capacity to regulate emotional reactions is crucial for empathic concern. I further relate differences of mind attribution, attention, and emotional processing, to two different modes of functioning: In an interactive state of mind (comparable to the “second-person perspective” described by Schilbach et al. Behavioral and Brain Sciences, in press), social and emotional cues are attended to; In a detached task-oriented state of mind it may be beneficial to predict the behaviors of others but emotional information may not be attended to. The complexity and plasticity of mind attribution, including the possibility to train attentional mechanisms and regulation of emotions, is promising for the field of moral enhancement. (shrink)

SummaryThis article addresses how and why the Dutch translation of Forbonnais's Elémens de commerce came about and the reasons for its lack of success. It explores the context in which the Utrecht printers and booksellers Spruit and Haanebrink in 1771 published a Dutch version of the first edition of the Elémens. In the preceding decades the deteriorating wealth and power of the Dutch Republic had become a major theme in the transnational debates on political economy. Recent research has established that (...) Dutch authors contributed to this debate as well, initially by propagating neutrality of trade in combination with an attempt reform the staple market system, but increasingly by arguing the necessity of another type of economy. Inspired by foreign examples, a movement of reformative patriotism emerged, advocating a more balanced economy in which international commerce stimulated mature agricultural and industrial sectors. This type of political economy could be found in Forbonnais's Elémens and may have triggered its rendering into Dutch. It was the first in a series of translations instigated by Hendrik van den Heuvel, the organiser of economic patriotism in the Dutch Republic. Spruit and Haanebrink dedicated the Dutch version of the Elémens to him and mentioned Van den Heuvel's recommendation of the French original. The fact that the intended buyers, economic patriots, were able to read the Elémens in French, may have precluded a big sale of the title, but the poor quality of the translation did not help either. However, one should not conclude that the Dutch reading public was not interested in the Elémens. In 1780 Van den Heuvel still recommended another edition in a better translation. Other sources, such as Dirk Hoola van Nooten's Dutch version of Condillac's Le commerce et le gouvernement considérés relativement l'un à l'autre, suggest that Forbonnais's ideas were acknowledged. (shrink)

An increasing number of people worldwide are living with chronic conditions that have an aspect of bodily fragility as part of the condition or as an effect of treatment. In this article, I explore the temporal experience of bodily fragility and the particularities of consciousness states among people with the chronic condition osteogenesis imperfecta (OI) in Denmark. My aim is threefold. First, my goal is to give an insight into life with OI, a rare and rarely studied condition. Second, I (...) shed light on bodily fragility, a theme that lives in the shadows of other analytical foci in anthropology. Third, I will contribute to the anthropological understanding of the connection among body, physical environment, and consciousness. I argue that the lifeworlds of people with OI are haunted by mental and bodily memories and fearful future scenarios, which makes the past and the future collapse into the present. (shrink)

In this article, I consider the interpersonal support, i.e., scaffolding, that agents provide to one another to share emotions. Moreover, the main target of this paper is to identify those scaffolds and their features that effectively function to boost, support, or enable emotional sharing interactions. To do so, I engage with the “multi-dimensional framework of environmental scaffolding” proposed by Sterelny (_Phenomenology and the Cognitive Sciences_ 9:465–481, 2010). This framework highlights various types of environmental resources, including social and interpersonal factors, that (...) serve as scaffolds for human cognitive agency. Furthermore, the model identifies the functional characteristics associated with these resources, which significantly contribute to scaffolding cognitive (and emotional) performance and skillfulness. Mainly concentrating on social interaction, I argue that individual, familiar social interaction behaviors, shared references, and shared bodily-affective and habitual patterns scaffold the interacting individuals allowing them to effectively share emotions. By examining the functional relationship between these particularly interpersonal scaffolds and shared emotions, I suggest that we can better understand the complex, situationally unfolding dynamics and the versatility of conditions that can boost emotional sharing. As a result, my analysis reveals that there are different types of social interactional scaffolds that vary in familiarity, predictability, robustness, individualization, and mutual adaptation. These features boost and trigger emotional sharing in degrees and different functions and different degrees of these functional features; therefore, different types of social interaction scaffolds are required depending on the situation to situation. (shrink)

The sexual exploitation of children in Indonesia is a serious crime that threatens the fundamental rights of children and their physical, emotional, and mental development. Cases of child sexual exploitation continue to rise, whether in the form of human trafficking, pornography, or sexual abuse, yet the response remains far from optimal. Although regulations and prevention programs are in place, the lack of coordination among law enforcement agencies and the low level of public awareness are major obstacles to resolving these cases.This (...) study employs a qualitative approach using a normative-empirical method, involving an analysis of the legal framework as well as in-depth interviews with legal practitioners and relevant stakeholders. The results indicate that although there is a strong legal foundation, policy implementation is often hindered by bureaucracy, limited human resources, and low legal awareness in society. Additionally, social stigma against victims exacerbates the situation, especially in rural areas.The study recommends an interconnected approach involving substantive law, legal structure, and legal culture as an effective solution to address the escalation of child sexual exploitation. These findings imply the need for improved inter-agency coordination, law enforcement training, and more extensive public awareness campaigns. (shrink)

Advancing women’s empowerment and gender equality in agriculture is a recognised development goal, also within crop breeding. Increasingly, breeding teams are expected to use ‘market-based’ approaches to design more ‘demand-led’ and ‘gender-responsive’ crop varieties. Based on an institutional ethnography that includes high-profile development-oriented breeding initiatives, we unpack these terms using perspectives from political agronomy and feminist science and technology studies. By conceptualising the market as an ongoing, relational performance made up of discourses, practices and human and nonhuman actors, we trace (...) how the market is understood as an effective socioeconomic institution for soliciting demand, but also becomes a normative agenda. Construed as a demand variable, the relational and structural dimensions of gender are rendered less visible, which might strengthen rather than transform power relations’ status quo. On the other hand, a feminist science and technology perspective broadens the field of vision not only to the gendered dimensions of crop breeding, but also to the nonhuman actors, such as the crops and traits falling outside the market sphere of interest. By putting political agronomy and feminist science and technology studies into conversation, the article contributes to the development of a feminist political agronomy. (shrink)

The centrality of language for feminist theory and practice is a widely shared tenet. So is the awareness of the difficulty of 'creating' a language in which to express a female subject who cannot have a voice in the given symbolic order. In the Italian context, and working on a daily newspaper, how does one write about the feminist movement? And - which is more difficult - how does one write about feminist theory? The requirements of communication might seem to (...) call for a simplified language, a sort of 'translation' of the terms of the theoretical debate. But where does communication end and betrayal begin? (shrink)