Spontaneous mutations that perturb myelination occur in a range of species including man, and together with engineered mutations have been used to study disease, normal myelination and axon/glial inter‐relationships. Only a minority of the currently defined mutations have an apparently simple pathogenesis due to lack of a functional protein. Mutations in the myelin basic protein gene lead to a lack of protein, resulting in changes in the structure of myelin, which can be rescued by transgenic complementation. The pathogenesis of autosomal (...) dominant and X‐linked mutations affecting either oligodendrocytes or Schwann cells is more complex. Point mutations may act in a dominant negative manner and gene dosage is clearly linked to phenotypic change. Mutations in regulatory genes, such as those encoding transcription factors, can also disturb myelination by selected cell types. Other less‐well studied and unexpected consequences of myelin mutations, such as seizures in mutations affecting genes expressed in Schwann cells and axonal changes associated with dysmyelination, are also considered. With the major developments in gene mapping and cloning it is now relevant to study mutations in a variety of species with the real prospect of defining their molecular basis. Examples are given of unusual, but potentially useful, uncharacterised mutations in dog and bovine. (shrink)

In 1871 the travel writer and anthropologist W. Winwood Reade (1838–1875) was inspired by his correspondence with Darwin to turn his narrow ethnological research on West African tribes into the broadest history imaginable, one that would show Darwin's great principle of natural selection at work throughout the evolutionary history of humanity, stretching back to the origins of the universe itself. But when Martyrdom of Man was published in 1872, Reade confessed that Darwin would not likely find him a very good (...) Darwinian, as he was unable to show that natural selection was anything more than a secondary law that arranges all details. When it came to historicising humans within the sweeping history of all creation, Reade argued that the primary law was that of development, a less contentious theory of human evolution that was better suited to Reade's progressive and teleological history of life. By focussing on the extensive correspondence between Reade and Darwin, this paper reconstructs the attempt to make an explicitly Darwinian evolutionary epic in order to shed light on the moral and aesthetic demands that worked to give shape to Victorian efforts to historicise humans within a vastly expanding timeframe. -/- . (shrink)

This essay examines the working relationship between Charles Darwin and the Edinburgh gardener John Scott that developed in the wake of the publishing of the Origin of Species (1859). As the essay shows, Darwin sought to utilize Scott’s horticultural knowledge and experimental expertise in order to provide some of the specialized botanical evidence that the Origin was not intended to provide. Scott, meanwhile, sought to use Darwin’s patronage and tutelage in order to overcome his modest status as a gardener while (...) making contributions to scientific knowledge. And for an intense two-year period (1862–4), Darwin and Scott’s relationship was productive and mutually beneficial: not only did Scott’s work supplement Darwin’s ongoing botanical research on sexual development and fertility, but also his Primula experiments appeared to provide ‘physiological’ evidence of speciation via selective breeding. What the essay argues, however, is that there were limits to what Scott was able to achieve due in part to his social standing and perceived character that ultimately cast a shadow over his findings. (shrink)

Fully named _Discourse on the Method for Reasoning Well and for Seeking Truth in the Sciences_, this work offers the most complete presentation and defense of René Descartes’ method of intellectual inquiry— a method that greatly influenced both philosophical and scientific reasoning in the early modern world. Descartes’s timeless ideas strike an uncommon balance of novelty and familiarity, offering arguments concerning knowledge, science, and metaphysics that are as compelling in the 21st century as they were in the 17th. Ian Johnston’s (...) new translation of the original French text is modern, clear, and thoroughly annotated, ideal for readers unfamiliar with Descartes’ intellectual context. An approachable introduction engages both the historical and the philosophical aspects of the text, enabling the reader to interpret this easily misunderstood work within Descartes’ larger project. This edition joins Broadview’s growing list of affordable classic texts from the philosophical canon, adapted from Andrew Bailey’s popular anthology series _First Philosophy_. (shrink)

The paper concentrates on two questions: first, the problem of how to introduce students to philosophical argument in a contextualised and pluralist manner; and, second, the question of what kind of texts such a pedagogy requires at its disposal. The two questions are of course intimately related, as the dominance of the single-aim present-centred approach brings with it a highly selective publication of the archive, in editions typically suited to the aims of rational reconstruction rather than historical investigation.

Childhood is increasingly saturated by technology: from television to the Internet, video games to 'video nasties', camcorders to personal computers. _Children, Technology and Culture_ looks at the interplay of children and technology which poses critical questions for how we understand the nature of childhood in late modern society. This collection brings together researchers from a range of disciplines to address the following four aspects of this relationship between children and technology: *children's access to technologies and the implications for social relationships (...) *the structural contexts of children's engagement with technologies with a focus on gender and the family *the situatedness of children's interactions with technological objects *the constitution of children and childhood through the mediations of technology _ This book represents a substantial contribution to contemporary social scientific thinking both about the nature of children and childhood, the social impacts of technologies and the various relationships between the two. (shrink)

You never reach the Body without Organs, you can't reach it, you are forever attaining it, it is a limit. People ask, So what is this BwO? - But you're already on it, scurrying like vermin, grouping like a blind person, or running like a lunatic: desert traveller and nomad of the steppes. On it we sleep, live our waking lives, fight - fight and are fought - seek our place, experience untold happiness and fabulous defeats; on it we penetrate (...) and are penetrated; on it we love. (Deleuze and Guattari, 1987: 150). (shrink)

Ian Parker has been a leading light in the fields of critical and discursive psychology for over 25 years. The Psychology After Critique series brings together for the first time his most important papers. Each volume in the series has been prepared by Ian Parker and presents a newly written introduction and focused overview of a key topic area. Psychology After the Unconscious is the fifth volume in the series and addresses three central questions: - Why is Freud's concept of (...) the unconscious important today? - Does language itself play a role in the creation of the unconscious? - How does Lacan radicalize Freud's notion of the unconscious in relation to cultural research? The book provides a clear explanation of Freudian and Lacanian accounts of the unconscious. It also highlights their role in offering a new way of describing, understanding and working with the human subject in clinical settings and in cultural research. Part One shows how the unconscious is elaborated in Freud's early case studies in Studies on Hysteria, while Part Two focuses on Lacan's re-working of the unconscious and its relationship to language and culture in his influential public seminars. The book also provides access to key debates currently occurring in Freudian and Lacanian psychoanalysis, exploring both the clinical dimension and the consequences for psychological and cultural research. Psychology After the Unconscious is essential reading for students and researchers in psychology, psychosocial studies, sociology, social anthropology and cultural studies, and to psychoanalysts of different traditions engaged in academic research. It will also introduce key ideas and debates within critical psychology to undergraduates and postgraduate students across the social sciences. (shrink)

Ian Fraser assesses the human qualities of the three saints who are celebrated for their contribution to Christianity in Britain. He also examines some contemporary issues related to their struggle to live faith fully.

Lowe, Ian The evidence is overwhelming: unlimited growth is neither possible nor desirable. The 2013 Fenner Conference reviewed what we know about population growth, resource use and environmental damage. The volume that resulted shows clearly that we are near limits in some cases, already beyond them in others.

Waters, Ian; McGuckin, Robert The following document has been produced to assist priests and deacons of the Latin Catholic Church in their parish pastoral ministry. It does not attempt to be a scholarly or technical treatment. Often, as regards questions about marriage, a canonist will need to be consulted.

I advance arguments in favour of PKF as an articulation of a central sense of the predicate ‘true’, and show how it illuminates the relationship between that sense and the ‘external’ notion of truth found in such claims as ‘An utterance of the Liar Sentence does not say anything, and so is not true’.

In thePeristephanon, a collection of hymns in praise of the Christian martyrs, the Spanish poet Aurelius Prudentius Clemens refers back to a time more than a hundred years before he was writing, when Christianity was not the predominant influence in the Roman world but the religion of a beleaguered minority. In the course of Prudentius' lifetime, the trials that were suffered by that minority under emperors such as Decius and Diocletian became an important point of reference for increasing numbers of (...) Roman converts seeking to identify with Christianity and its sectarian past. At the time, however, those trials were recorded in only meagre written accounts. Prudentius, whose successful administrative career might have culminated in elevation to a senior position in the imperialscrinia, displays particular interest in the extent of the official archival material in thePeristephanon. In a number of passages in this work, he comments on the fragility of historical documents, which are easily destroyed by acts of malice or the effects of time. The following discussion will examine the ways in which he reflects on the permanence, or otherwise, of his own written texts. Analysis of his imitation of elegiac verse inscriptions will demonstrate how he draws attention to the inadequacy of even the most monumental types of human writing. But I will argue that, by identifying his poems with the martyrs' perishable bodies, Prudentius claims that they too can be a medium for a divine presence not confined to any perishable physical form. (shrink)

O DIREITO ENTRE O ESTADO E O ESTADO DE DIREITO: REVISITANDO A TEORIA DO DIREITO E DO ESTADO DE LEÓN DUGUIT.

This is a copy of my DPhil thesis, the abstract for which is as follows: The first third of this thesis argues for a B-theoretic conception of time according to which all times exist equally and the present is in no way privileged. I distinguish "ontological" A-theories from "non-ontological" ones, arguing that the latter are experientially unmotivated and barely coherent. With regard to the former, I focus mainly on presentism. After some remarks on how to formulate this (and eternalism) non-trivially, (...) I review the non-relativistic case against presentism. I then consider the impact of Special Relativity on the debate, and attempt to deepen this impact by supplying a modal variation on the standard arguments. The middle third of the thesis investigates persistence, contending that both endurance and perdurance are consonant with the eternalism already endorsed. After introducing these theories of persistence, and discussing in particular how best to formulate an eternalist endurance, I proceed to defend the coherence of this combination. The Problem of Change is addressed here. I then respond in some detail to recent allegations of relativistic threats to endurance. The final third of the thesis questions the validity of the endurantist-perdurantist dispute. I criticize two recently proposed translation schemes that aim to show this dispute to be non-substantive. However, the second scheme suggests a doctrine of "Ontological Equivalence" which I develop and consider. I then address the Rotating Discs Argument, using this to launch a discussion of identity, genidentity, and the relationship between them. (shrink)

Waters, Ian The Australian hierarchy was established by Pope Gregory XVI in 1842. Since then, there have been six national Catholic councils held in Australia. The first two, celebrated in 1844 and 1869, are known as the First Provincial Council of Australia and the Second Provincial Council of Australia, as until 1874 the Australian dioceses were all in the one ecclesiastical province with Sydney being the sole metropolitan see. In 1874, a second province - Melbourne - was established, and the (...) national councils since then - four of them, celebrated in 1885, 1895, 1905 and 1937 - have been called plenary councils, the term used in the Catholic Church in recent centuries for councils whose participants are from more than one ecclesiastical province; in the past, terms such as regional councils or national councils have been used. As we all know, another plenary council for Australia is planned to commence in 2020. (shrink)

In _History 4° Celsius_ Ian Baucom continues his inquiries into the place of the Black Atlantic in the making of the modern and postmodern world. Putting black studies into conversation with climate change, Baucom outlines how the ongoing concerns of critical race, diaspora, and postcolonial studies are crucial to understanding the Anthropocene. He draws on materialist and postmaterialist thought, Sartre, and the science of climate change to trace the ways in which evolving political, cultural, and natural history converge to shape (...) a globally destructive force. Identifying the quest for limitless financial gain as the primary driving force behind both the slave trade and the continuing increase in global greenhouse gas emissions, Baucom demonstrates that climate change and the conditions of the Black Atlantic, colonialism, and the postcolony are fundamentally entwined. In so doing, he argues for the necessity of establishing a method of critical exchange between climate science, black studies, and the surrounding theoretical inquiries of humanism and posthumanism. (shrink)

From the 1910s to the emergence of structuralism and post-structuralism in the 1960s, the writings of John Grierson, Siegfried Kracauer, Andre Bazin and Georg Lukacs dominated realist film theory. In this critical anthology, the first collection to address their work in one volume, a wide range of international scholars explore the interconnections between their ideas and help generate new understandings of this important, if neglected, field. Challenging preconceptions about 'classical' theory and the nature of realist representation, and in the process (...) demonstrating how this body of work can be seen as a cohesive theoretical model, this invaluable collection will help return the realist paradigm of film theory to the forefront of academic enquiry. ". (shrink)

ABSTRACTThe crisis of European sciences in Husserl’s late work diagnoses Galilean science as specifically and necessarily losing touch with the intuitive evidence that would legitimate it due to its reliance on a formal-mathematical conceptual apparatus. While the vast majority of Husserl’s late work was focussed on a critique of the formal-mathematical paradigm of the physical science of nature, at several points the possibility of biology as the exemplary science is raised to suggest that the lack of a reliance on formal-mathematical (...) conceptual language would mean that a systemic crisis would not occur in such a case. This investigation considers the grounds for the expectation that biology would not engender a crisis, suggests that a paradigmatic role for ecology would more adequately address this expectation, and finally claims that the question of the relation between a specific exemplary science and transcendental phenomenology is not fully resolved even in this case. (shrink)

Ian Ramsey; VII*—Facts and Disclosures, Proceedings of the Aristotelian Society, Volume 72, Issue 1, 1 June 1972, Pages 115–134, https://doi.org/10.1093/aristot.

Ian T. Ramsey (1915-1972) was former Bishop of Durham, County Durham, England, and also served as Nolloth Professor of the Philosophy of the Christian Religion at Oxford University, He was also the author of Religious Language, Models for Divine Activity, and Words About God.

In A Photographer’s Guide to Ohio Ian Adams, Ohio’s leading landscape photographer, guides readers to some of the most photogenic sites in the Buckeye State. Natural beauty and historic architecture are prime subjects for photographers, and in a state that boasts 3,600 buildings on the National Register of Historic Places and is home to the world’s largest Amish communities, the photographic subjects seem endless. With nearly one hundred color photographs, Adams demonstrates through his own work how to capture the beauty (...) of the seasons when photographing Ohio’s covered bridges, numerous public gardens, state parks, and nature preserves. Each entry includes clear directions, related websites, and historical facts about the area, as well as Adams’s suggestions for capturing the best image. Both amateur and experienced photographers will find expert guidance in Adams’s clear instructions on digital photography and will be inspired to create their own stunning close-ups and scenic panoramas. (shrink)

Drawing on Sir Ian Kennedy's extensive experience in healthcare law, ethics and public policy-making, this book explores vital issues in the law surrounding healthcare and regulation. The book contains a range of published and unpublished essays and speeches with the addition of notes and commentaries by the author that bring the pieces up to the present day. Those who want to understand developments, from transplants to confidentiality, from COVID-19 to public inquiries to regulation will find a rich seam of rigorous, (...) informed analysis. The author's unique range of experience allows him to share insights on a variety of issues; from the conduct of the disgraced breast surgeon, Ian Paterson, to research at Porton Down, to the economics of innovation in drug development at NICE. His abiding interest in the welfare of children informs his trenchant forensic examination of how children fare in the NHS. Those involved in or with an interest in law, moral philosophy, and public policy will find much food for thought. (shrink)