This chapter discusses some of the causal forces that enable young children to acquire language. It demonstrates that these causal forces are not readily apparent in the input that children experience. This discussion of the causal forces of language and the poverty of the stimulus focuses on just a fragment of human language. The chapter discusses four kinds of expressions. In English, these expressions are the words some, any, and or, and question words such as who and what. Although these (...) expressions appear to be unrelated, the chapter shows that they are all cut from the same cloth – they are governed by the same linguistic principles, which determine both their distributional properties and their meanings. Like any and or, linguists have proposed principles that amalgamate information‐seeking questions and their statement counterparts. The chapter describes the important role played by cross‐linguistic facts as a source of information about the deep forces that shape language. (shrink)

Nuclear bodies contribute to non‐random organization of the human genome and nuclear function. Using a major prototypical nuclear body, the Cajal body, as an example, we suggest that these structures assemble at specific gene loci located across the genome as a result of high transcriptional activity. Subsequently, target genes are physically clustered in close proximity in Cajal body‐containing cells. However, Cajal bodies are observed in only a limited number of human cell types, including neuronal and cancer cells. Ultimately, Cajal body (...) depletion perturbs splicing kinetics by reducing target small nuclear RNA (snRNA) transcription and limiting the levels of spliceosomal snRNPs, including their modification and turnover following each round of RNA splicing. As such, Cajal bodies are capable of shaping the chromatin interaction landscape and the transcriptome by influencing spliceosome kinetics. Future studies should concentrate on characterizing the direct influence of Cajal bodies upon snRNA gene transcriptional dynamics.Also see the video abstract here. (shrink)

ABSTRACTJohn Harris suggests that participation in or support for research, particularly medical research, is a moral duty. One kind of defence of this position rests on an appeal to the past, and produces two arguments. The first of these arguments is that it is unfair to accept the benefits of research without contributing something back in the form of support for, or participation in, research. A second argument is that we have a social duty to maintain those practices and institutions (...) that sustain us, such as those which contribute to medical knowledge. This argument is related to the first, but it does not rely so heavily on fairness. Another kind of defence of the duty to research rests on an appeal to the future benefits of research: research is an effective way to discharge a duty to rescue others from serious illness or death, therefore we have a duty to research. I suggest that all three of Harris' lines fail to provide a compelling duty to research and spell out why. Moreover, not only do the lines of argument fail in their own terms: in combination, they turn out to be antagonistic to the very position that Harris wants to defend. While it is not my intention here to deny that there might be a duty to research, I claim that Harris' argument for the existence of such a duty is not the best way to establish it. (shrink)

Iain Atack identifies the contribution of nonviolence to political theory through connecting central characteristics of nonviolent action to fundamental debates about the role of power and violence in politics. This in turn provides a platform for going beyond historical and strategic accounts of nonviolence to a deeper understanding of its transformative potential. From Mahatma Gandhi and Martin Luther King to toppled communist regimes in Eastern Europe and pro-democracy movements in Serbia, Georgia and Ukraine, nonviolent action has played a significant (...) role in achieving social and political change in the last century. The Arab Spring revolutions, particularly those in Tunisia and Egypt, and the Occupy movement in the US and UK demonstrate that nonviolence continues to be a vital feature of many campaigns for democracy, human rights and social justice. (shrink)

A survey of various approaches and positions that leading Humanists have taken towards the question of how Humanism can be put to work in 'the real world'.

The formal unity of the Gospel is the decisively final and enduring personal communication of God to men through this man, Jesus Christ, His divine Son.

Heidegger, Art, and Postmodernity offers a radical new interpretation of Heidegger's later philosophy, developing his argument that art can help lead humanity beyond the nihilistic ontotheology of the modern age. Providing pathbreaking readings of Heidegger's 'The Origin of the Work of Art' and his notoriously difficult Contributions to Philosophy, this book explains precisely what postmodernity meant for Heidegger, the greatest philosophical critic of modernity, and what it could still mean for us today. Exploring these issues, Iain D. Thomson examines (...) several postmodern works of art, including music, literature, painting and even comic books, from a post-Heideggerian perspective. Clearly written and accessible, this book will help readers gain a deeper understanding of Heidegger and his relation to postmodern theory, popular culture and art. (shrink)

Heidegger is now widely recognized as one of the most influential and controversial philosophers of the twentieth century, yet much of his later philosophy remains shrouded in confusion and controversy. Restoring Heidegger's understanding of metaphysics as 'ontotheology' to its rightful place at the center of his later thought, this book demonstrates the depth and significance of his controversial critique of technology, his appalling misadventure with Nazism, his prescient critique of the university, and his important philosophical suggestions for the future of (...) higher education. It will be required reading for those seeking to understand the relationship between Heidegger's philosophy and National Socialism, as well as the continuing relevance of his work. (shrink)

In Questioning Technology, Feenberg accuses Heidegger of an untenable 'technological essentialism'. Feenberg's criticisms are addressed not to technological essentialism as such, but rather to three particular kinds of technological essentialism: ahistoricism, substantivism, and one-dimensionalism. After these three forms of technological essentialism are explicated and Feenberg's reasons for finding them objectionable explained, the question whether Heidegger in fact subscribes to any of them is investigated. The conclusions are, first, that Heidegger's technological essentialism is not at all ahistoricist, but the opposite, an (...) historical conception of the essence of technology which serves as the model for Feenberg's own view. Second, that while Heidegger does indeed advocate a substantivist technological essentialism, he offers a plausible, indirect response to Feenberg's voluntaristic, Marcusean objection. Third, that Heidegger's one-dimensional technological essentialism is of a non-objectionable variety, since it does not force Heidegger to reject technological devices in toto. These conclusions help vindicate Heidegger's ground-breaking ontological approach to the philosophy of technology. (shrink)

Cultural historian Iain McCalman tells the stories of Charles Darwin and his most vocal supporters and colleagues: Joseph Hooker, Thomas Huxley, and Alfred Wallace. Beginning with the somber morning of April 26, 1882--the day of Darwin's funeral--Darwin's Armada steps back in time and recounts the lives and scientific discoveries of each of these explorers. The four amateur naturalists voyaged separately from Britain to the southern hemisphere in search of adventure and scientific fame. From Darwin's inaugural trip on the Beagle (...) in 1835 through Wallace's exploits in the Amazon and Malaysia in the 1840s and 1850s, each man independently made discoveries that led him to embrace Darwin's groundbreaking theory of evolution. This book reveals the untold story of Darwin's greatest supporters who, during his life, campaigned passionately in the war of ideas over evolution and who lived on to extend and advance the scope of his work.--From publisher description. (shrink)

Preface to paperback edition -- Why Schelling? why naturephilosophy? -- The powers due to becoming: the reemergence of platonic physics in the genetic philosophy -- Antiphysics and neo-Fichteanism -- The natural history of the unthinged -- "What thinks in me is what is outside me". phenomenality, physics and the idea -- Dynamic philosophy, transcendental physics -- Conclusion: transcendental geology.

In Kant and the Role of Pleasure in Moral Action, Iain Morrisson offers a new view on Kant’s theory of moral action.

Chemokines (chemotactic cytokines) drive and direct leukocyte traffic. New evidence suggests that the unusual CCR6/CCL20 chemokine receptor/ligand axis provides key homing signals for recently identified cells of the adaptive immune system, recruiting both pro‐inflammatory and suppressive T cell subsets. Thus CCR6 and CCL20 have been recently implicated in various human pathologies, particularly in autoimmune disease. These studies have revealed that targeting CCR6/CCL20 can enhance or inhibit autoimmune disease depending on the cellular basis of pathogenesis and the cell subtype most affected (...) through different CCR6/CCL20 manipulations. Here, we discuss the significance of this chemokine receptor/ligand axis in immune and inflammatory functions, consider the potential for targeting CCR6/CCL20 in human autoimmunity and propose that the shared evolutionary origins of pro‐inflammatory and regulatory T cells may contribute to the reason why both immune activation and regulation might be controlled through the same chemokine pathway. (shrink)

A critical, spiritual discernment of Gospel genre, particularly that of Luke, reveals the heart of the matter as the life-story of Jesus vis-a-vis God and man.

Elizabeth A. Kaye specializes in communications as part of her coaching and consulting practice. She has edited Requirements for Certification since the 2000-01 edition.

Martin Heidegger (1889-1976) is widely considered one of the most original and important philosophers of the 20th century, and, thanks to his (failed) attempt to assume philosophical leadership of the century’s most execrable political movement (Nazism) and his later critique of the history of metaphysics from Anaximander to Nietzsche as inherently nihilistic, he is also certainly the most controversial.

In 2005, John Harris published a paper in the Journal of Medical Ethics in which he claimed that there was a duty to support scientific research. With Sarah Chan, he defended his claims against criticisms in this journal in 2008. In this paper I examine the defence, and claim that it is not powerful. Although he has established a slightly stronger position, it is not clear that the defence is sufficiently strong to show that there is a duty to support (...) scientific research. Important questions about fairness, about rescue, and about the relationship between reasons and obligations to act can still be raised; and these questions are important enough to destabilize the defence. (shrink)

This article examines the development of Heidegger's philosophical views on university education, situates these views within their broader historical and philosophical context, and shows them to be largely responsible for Heidegger's decision to become the first Nazi Rector of Freiburg University in 1933. Did Heidegger learn from this appalling political misadventure and so transform the underlying philosophical views that helped motivate it? It is argued, against the interpretations of Pöggeler and Derrida, that the later Heidegger continued to develop and refine (...) the core of these philosophical views rather than abandoning them after 1933. (shrink)

Many people working in bioethics take pride in the subject’s embrace of a wide range of disciplines. This invites questions of what in particular is added by each. In this paper, I focus on the role of philosophy within the field: what, if anything, is its unique contribution to bioethics? I sketch out a claim that philosophy is central to bioethics because of its particular analytic abilities, and defend its place within bioethics from a range of sceptical attacks.

Culture After Humanism asks what happens to the authority of traditional Western modes of thought in the wake of postcolonial theory. Iain Chambers investigates moments of tension, interruptions which transform our perception of the world and test the limits of language, art and technology. In a series of interlinked discussions, ranging in focus from Susan Sontag's novel The Volcano Lover to the philosophy of Martin Heidegger, Jimi Hendrix and Baroque architecture and music, Chambers weaves together a critique of Western (...) humanism, exploring issues of colonization and migration, language and identity. Culture After Humanism offers a new approach to cultural history, a 'post-humanist' perspective which challenges our sense of a world in which the subject is sovereign language, the transparent medium of its agency, and truth, the product of reason. (shrink)

Data from a longitudinal study into the key management success factors in the fair trade industry provide insights into the essential nature of inter-organizational alliances and networks in creating the profitable and growing fair trade market in the UK. Drawing on three case studies and extensive industry interviews, we provide an interpretive perspective on the organizational relationships and business networks and the way in which these have engendered success for UK fair trade companies. Three types of benefit are derived from (...) the networks: competitive developments through virtual integration in which the organizations remain flexible and small while projecting size to the market; intellectual developments through the sharing of intellectual capital with a diverse network of organizations in many fields; and ideological developments through an ideological network of like-minded individuals by which the companies can prevent the co-opting of the original purpose of fair trade. However, relative success at leveraging these benefits is influenced by three managerial factors: partner choice, partner use and partner management. (shrink)

Employee buy-in is a key factor in ensuring small- and medium-size enterprise (SME) engagement with corporate social responsibility (CSR). In this exploratory study, we use participant observation and semi-structured interviews to investigate the way in which three fair trade SMEs utilise human resource management (and selection and socialisation in particular) to create employee engagement in a strong triple bottomline philosophy, while simultaneously coping with resource and size constraints. The conclusions suggest that there is a strong desire for, but tradeoff within (...) these companies between selection of individuals who already identify with the triple bottomline philosophy and individuals with experience and capability to deal with mainstream brand management – two critical employee attributes that appear to be rarely found together. The more important the business experience to the organisation, the more effort the organisation must expend in formalising their socialisation programmes to ensure employee engagement. A key method in doing this is increasing employee knowledge of, and affection for, the target beneficiaries of the CSR programme (increased moral intensity). (shrink)

At the intersection of metaphysics and social theory, this book presents and examines Adorno's unusual concept of possibility and aims to answer how we are to articulate the possibility of a redeemed life without lapsing into a vague and naïve utopianism.

Heidegger presciently diagnosed the current crisis in higher education. Contemporary theorists like Bill Readings extend and update Heidegger's critique, documenting the increasing instrumentalization, professionalization, vocationalization, corporatization, and technologization of the modern university, the dissolution of its unifying and guiding ideals, and, consequently, the growing hyper-specialization and ruinous fragmentation of its departments. Unlike Heidegger, however, these critics do not recognize such disturbing trends as interlocking symptoms of an underlying ontological problem and so they provide no positive vision for the future of (...) higher education. By understanding our educational crisis 'ontohistorically', Heidegger is able to develop an alternative, ontological conception of education which he hopes will help bring about a renaissance of the university. In a provocative reading of Plato's famous 'allegory of the cave', Heidegger excavates and appropriates the original Western educational ideal of Platonic paideia, outlining the pedagogy of an ontological education capable of directly challenging the 'technological understanding of being' he holds responsible for our contemporary educational crisis. This notion of ontological education can best be understood as a philosophical perfectionism, a re-essentialization of the currently empty ideal of educational 'excellence' by which Heidegger believes we can reconnect teaching to research and, ultimately, reunify and revitalize the university itself. (shrink)

The concept of autonomy plays atleast two roles in moral theory. First, itprovides a source of constraints upon action:because I am autonomous you may not interferewith me, even for my own good. Second, itprovides a foundation for moral theory: humanautonomy has been thought by some to producemoral principles of a more general kind.This paper seeks to understand what autonomyis, and whether the autonomy of which we arecapable is able to serve these roles. We wouldnaturally hope for a concept of autonomy (...) thatis value-neutral rather than value-laden. Thatis to say, we would want the judgement that Iam autonomous to depend wholly on, say,structural features of my psychology, and in noway to require us to make ethical judgements, orother value judgements. Being value-neutral isperhaps desirable in a concept of autonomyserving the first role, and plausiblyindispensible in one playing the second. Ishall argue, however, that value-neutral conceptionsof autonomy are impoverished and out of linewith our intuitions; set out and defendan explicitly value-laden conception ofautonomy; and explore the implications of such a view for theability of autonomy to play the rolesmentioned above. (shrink)

Science is continually faced with describing that which is beyond. This book, through contributions from nine prominent scholars, tackles that challenge.

This paper reports on a study of ethical decision-making in a fair trade company. This can be seen to be a crucial arena for investigation since fair trade firms not only have a specific ethical mission in terms of helping growers out of poverty, but they tend to be perceived as (and are often marketed on the basis of) having an "ethical" image. Eschewing a straightforward test of extant ethical decision models, we adopt Thompson''s proposal for a more contextualist understanding (...) rooted in ethnographic data. Our findings suggest that the fair trade mission of the firm is experienced as an over-riding ethical claim, which is often invoked to justify potentially ethically questionable decisions. Moreover, decision precedents emerge which can mean that the decision process is bypassed or hurried through. Finally we provide evidence that the significance of these precedents, and indeed, even moral intensity itself, could be actively shaped and constructed by organization members to support different, even shifting, conceptions of what is a morally acceptable decision for a fair trade company to make. (shrink)

Motivated by Lord Joffe’s Assisted Dying for the Terminally Ill Bill, but with one eye on any possible future legislation, I consider the justifications that might be offered for limiting assistance in dying to those who are suffering unbearably from terminal illness. I argue that the terminal illness criterion and the unbearable suffering criterion are not morally defensible separately: that a person need be neither terminally ill (or ill at all), nor suffering unbearably (or suffering at all) to have a (...) right to assisted dying. Indeed: I shall suggest that the unbearable suffering criterion undermines the Bill (or any proposal like it) wholesale. On the other hand, the criteria taken together are defensible, and this defence would be built on a concern for the protection of the vulnerable. However, I also claim that this implies that the law might justifiably—and maybe even properly—aim to prevent a person from gaining access to that to which they have a serious moral right. This seems paradoxical, and, towards the end of the paper, I seek to tease apart the paradox. (shrink)

The American Journal of Bioethics, Volume 11, Issue 6, Page 54-55, June 2011.

The Commission on Assisted Dying was an unofficial body set up to investigate the legal position on assisted dying in the UK in the autumn of 2010. Its report was published to some degree of media attention in the first week of January 2012; its most headline-grabbing suggestion provided a framework setting out how British law might be reformed to allow assisted dying for the terminally ill. In this paper, I analyse some of the key points of the report and (...) argue that it adds little that could settle – or even add to – the assisted dying debate. (shrink)

`I would encourage undergraduates students to read it, for it does summarise well a classical Marxist analysis of social policy and welfare' - Social Policy The anti-capitalist movement is increasingly challenging the global hegemony of neo-liberalism. The arguments against the neo-liberal agenda are clearly articulated in Rethinking Welfare. The authors highlight the growing inequalities and decimation of state welfare, and use Marxist approaches to contemporary social policy to provide a defence of the welfare state. Divided into three main sections, the (...) first part of this volume looks at the growth of inequality, and social and environmental degradation. Part Two centres on the authors' argument for the relevance of core Marxists concepts in aiding our understanding of social policy. This section includes Marxist approaches to a range of welfare issues, and their implications for studying welfare regimes and practices. Issues covered include: · Class and class struggle · Opression · Alienation and the family The last part of the book explores the question of globalization and the consequences of international neo-liberalism on indebted countries as well as the neo-liberal agenda of the Conservative and New Labour governments in Britain. The authors conclude with the prospect of an alternative welfare future which may form part of the challenge against global neo-liberalism. (shrink)