Chemokines (chemotactic cytokines) drive and direct leukocyte traffic. New evidence suggests that the unusual CCR6/CCL20 chemokine receptor/ligand axis provides key homing signals for recently identified cells of the adaptive immune system, recruiting both pro‐inflammatory and suppressive T cell subsets. Thus CCR6 and CCL20 have been recently implicated in various human pathologies, particularly in autoimmune disease. These studies have revealed that targeting CCR6/CCL20 can enhance or inhibit autoimmune disease depending on the cellular basis of pathogenesis and the cell subtype most affected (...) through different CCR6/CCL20 manipulations. Here, we discuss the significance of this chemokine receptor/ligand axis in immune and inflammatory functions, consider the potential for targeting CCR6/CCL20 in human autoimmunity and propose that the shared evolutionary origins of pro‐inflammatory and regulatory T cells may contribute to the reason why both immune activation and regulation might be controlled through the same chemokine pathway. (shrink)

Illustrates how the theory of evolution can be expanded into a source of social guidance.

Dr. Laszlo’s hypothesis (2009) is in my opinion appealing on many levels. He proposes that phenomena of apparent transpersonal communication between human beings are due to the intermediary of information-carrying holograms in the reactive quantum vacuum produced by human brain activity. He also suggests that valid information regarding the world in general is available through the same mechanism, on the grounds that all material objects “excite the ground state of the [zero point] fi eld” and produce further such holograms. On (...) this hypothesis we are literally immersed in a sea of information, with the capacity for accessing that information as well as producing more of it by our own thought processes. (shrink)

"The Consciousness Revolution is an extrodinary discussion among three of the very finest minds of our time, spirited in its exchange, compassionate in its embrace, brilliant in its clarion call to awaken our conscience and consciousness." Ken Wilber, author of Sex, Ecology, Spirituality and One Taste.

Chapter 1 WHY SYSTEMS PHILOSOPHY? Some reasons, for synthetic philosophy generally The persistent theme of this study is the timeliness and the necessity of ...

With humanity facing its greatest series of simultaneous crises, leading systems thinker Ervin Laszlo offers the solutions that will ensure the wellbeing of society at all levels and of our planetary home. Providing a holistic context to where we are and how we got here, he assures us that evolution unfolds in a nonlinear, fluctuating fashion. What is called for at this critical juncture - as our sacred task - is a phase of upshift to higher levels of order (...) and coherence to get us to where we are going. This practical handbook lays out, with clarity, why this upshift is needed, what inner potentials we possess to draw upon, and what the action steps are that will move us all toward this achievable vision of harmony and wholeness. With an inclusive list of conscious organizations already contributing to this vision, this book is essential reading for carrying out and completing the process of global transformation already well underway. (shrink)

The world's foremost systems philosopher presents a new scientific theory to explain how the universe defies our current understanding of fundamental physical laws.

Sándor Radnóti looks at forgeries, artistic reproductions, replicas, variations, and pastiches in order to study the dilemmas surrounding artistic illusion and "poetic license." He reveals how forgeries as the parasites of art make clear and transparent the meaning of artistic orginality.

Collection of published and unpublished 48 works of Śaṅkarācārya.

V. 1, Catuḥsūtryantapūrṇānandīyavyākhyāsaṃhitayā Śrīgovindānandapraṇītayā Ratnaprabhayā samanvitam; v. 2, Śrīgovindānandapraṇītayā Ratnaprabhayā samanvitam.

This book offers an original hypothesis capable of unifying evolution in the physical universe with evolution in biology; herewith it lays the conceptual foundations of ?transdisciplinary unified theory?. The rationale for the hypothesis is presented first; then the theoretical framework is outlined, and thereafter it is explored in regard to quantum physics, physical cosmology, micro- and macro-biology, and the cognitive sciences (neurophysiology, psychology, with attention to anomalous phenomena as well). The book closes with a variety of studies, both by the (...) author and his collaborators, sketching out the implications of the hypothesis in regard to brain dynamics, cosmology, the concept of space, phenomena of creativity, and the prospects for the elaboration of a mature transdisciplinary unified theory. The Foreword is written by philosopher of science Arne Naess, and the Afterword is contributed by neuroscientist Karl Pribram. (shrink)

Complete works of Śaṅkarācārya, Hindu philosopher; with commentary and Bengali translation.

Business ethics has become a very important concern in global business and understanding the effects of various factors on ethical judgments continues to attract research and practitioner attention. Using the Multidimensional Ethics Scale with its five generally accepted philosophical constructs, and vignettes developed by Cohen et al., current study investigates the relationship between cultural values, personality, religiosity and the ethical sensitivity of business students. We focus on a rapidly emerging country, Turkey, whose economic environment is similar to that of the (...) most Western nations but with a significantly different background and cultural values. Data for the study is collected from a major university in the southeastern Turkey. Although some significant relationships are identified between ethical sensitivity and cultural values and personality, our study findings confirm that MES dimensions had the highest influence on ethical sensitivity levels of business students. (shrink)

Provides the foundations of a genuine unified field theory.

Taking the view that understanding the meaning behind the complex formulas of science is more important than ever, this work attempts to explain the systems view of the world as the paradigm of the latest scientific developments.

We extend the Theory of Planned Behavior (TPB) for ethics in the workplace. Using a path modeling methodology, we find evidence that, for ethics, moral disengagement is an antecedent to the TPB predictors of attitude, subjective norms, and perceived behavioral control (PBC). We show that the TPB predictors mediate the influence moral disengagement has on ethical behavioral intentions. Thus, to improve ethical behavior, reducing moral disengagement is critical. We find support for including both types of PBC (self-efficacy and locus of (...) control) when modeling ethical behavior. We use four ethics scenarios and international data to test this model. We also evaluate potential positive influences on ethics in the workplace and find that recency of ethics training interacts with religiosity and activates it to reduce moral disengagement. We also find that principles-based ethics training enhances professionals’ self-efficacy to behave ethically. Experience, including time as a member in a professional accounting organization, increases both locus of control and self-efficacy to behave ethically. These variables—recency of ethical training, religiosity, principles-based professional ethics training, and experience—influence parts of the core TPB model, which in turn lead to improved ethical behavioral intentions. (shrink)

SOndor Radn-ti looks at forgeries, artistic reproductions, replicas, variations, and pastiches in order to study the dilemmas surrounding artistic illusion and 'poetic license.' He reveals how forgeries as the parasites of art make clear and transparent the meaning of artistic orginality.

The central concept of this work is, "rules of law", which the author discusses in various aspects. The treatment of these various facets of the law is a mixture of Anglo-American positivism & German idealism.

Background: Attention to ethical leadership in nursing has diminished over the past several decades. Objectives: The aim of our study was to investigate how frontline nurses and formal nurse leaders envision ethical nursing leadership. Research design: Meta-ethnography was used to guide our analysis and synthesis of four studies that explored the notion of ethical nursing leadership. Participants and research context: These four original studies were conducted from 1999-2008 in Canada with 601 participants. Ethical considerations: Ethical approval from the original studies (...) covered future analysis. Findings: Using the analytic strategy of lines-of-argument, we found that 1) ethical nursing leadership must be responsive to practitioners and to the contextual system in which they and formal nurse leaders work, and 2) ethical nursing leadership requires receiving and providing support to increase the capacity to practice and discuss ethics in the day-to-day. Discussion and conclusion: Formal nurse leaders play a critical, yet often neglected role, in providing ethical leadership and supporting ethical nursing practice at the point of patient care. (shrink)

The scarcity of resources during the COVID‐19 pandemic caused ethical dilemmas in prioritizing patients for treatment. Medical and ethical guidance only emphasizes clinical procedures but does not consider the sociocultural aspect. This study explored the perception of former COVID‐19 patients and their families on the decision‐making process of the patient's selection at a time of scarcity of resources. The result will inform the development of an ethical guide for allocating scarce resources that aligns with Indonesian culture. We conducted qualitative research (...) with in‐depth interviews between May ‐ December 2022 involving sixteen participants from various cities in Indonesia. We transcribed the interviews and analyzed the results using thematic analysis. This study found that doctor's decisions often differed from patient's expectations in allocating scarce resources, and therefore, it should be communicated appropriately. Medical decisions were not sufficiently made ethically, but must also be made communicatively. In Indonesia's strong communal culture, community involvement was essential to distributing limited resources. A better approach to ethical education, including adequate communication skills, is necessary to prepare health professionals for facing unpredictable future pandemics. (shrink)

This article analyzes the comparative history of the law and practice of abortion and assisted reproduction in the United States to consider the interplay between medical paternalism and legal paternalism. It supplements existing critiques of paternalism as harmful to women's equality with the medical perspective, as revealed through the writings of Alan F. Guttmacher, to consider when legal regulation might be warranted.

The term “principle of sufficient reason” (PSR) was coined by Leibniz, and he is often regarded as its paradigmatic proponent. But as Leibniz himself often insisted, he was by no means the first philosopher to appeal to the idea that everything must have a reason. Histories of the principle attribute versions of it to various ancient authors. A few of these studies include—or at least do not exclude—medieval philosophers; one finds the PSR in Abelard, another finds it in Aquinas. And (...) while Leibniz retains pride of place in these histories, Spinoza is sometimes said to precede him “in appreciating the importance of the Principle and placing it at the center of his philosophical system.” In this paper, the author argues that the same should be said of the Islamic philosopher Avicenna. Writing 600 years before his early modern counterparts, Avicenna routinely and consistently appeals to the PSR in generating his metaphysical system. The paper aims first to establish that Avicenna deserves a position of prominence in histories of the PSR, and then to consider how he addresses certain challenges to the PSR, especially the threat posed by necessitarianism. (shrink)