BackgroundTinnitus is a common disease, and sound therapy is an effective method to alleviate it. Previous studies have shown that notched sound not only changes levels of cortical blood oxygen, but affects blood oxygen in specific cerebral cortical areas, such as Brodmann area 46, which is associated with emotion. Extensive evidence has confirmed that tinnitus is closely related to emotion. Whether notched sound plays a role in regulating the emotional center is still unclear.MethodsThis study included 29 patients with newly diagnosed (...) chronic tinnitus who were treated with notched sound. Functional near-infrared spectroscopy was conducted before and after treatment to observe bilateral changes in cortical blood oxygen in the cerebral hemispheres. We compared the changes in connectivity between the two regions of interest, as wells as other cortical regions before and after treatment.ResultsThe results showed That global connectivity between the bilateral auditory cortex of the superior temporal sulcus and the ipsilateral cortex did not change significantly between baseline and the completion of treatment, and That the connectivity between channel 14 and the right superior temporal sulcus decreased after treatment. The overall connectivity between the right BA46 region and the right cortex decreased after treatment, and decreases in connectivity after treatment were specifically found for channels 10 and 14 in the right parietal lobe and channels 16, 20, 21, and 22 in the frontal lobe, while there was no significant change on the left side. There were no significant changes in the questionnaire measures of tinnitus, anxiety, or depression before and after treatment.ConclusionThe results of the study indicate that cerebral cortex reorganization occurs in tinnitus patients after submitted to treatment with notched sound for 1 month, and that notched sound decreases the connectivity between the auditory cortex and specific brain regions.SignificanceNotched sound not only regulates the auditory center through lateral inhibition, but also alleviates tinnitus by reorganizing the emotional control center. (shrink)

Differential tractography and correlation tractography are new tractography modalities to study neuronal changes in brain diseases, but their performances in detecting neuronal injuries are yet to be investigated in patients with mild traumatic brain injury. Here we investigated the white matter injury in mTBI patients using differential and correlation tractography. The diffusion MRI was acquired at 33 mTBI patients and 31 health controls. 7 of the mTBI patients had one-year follow-up scans, and differential tractography was used to evaluate injured fiber (...) bundles on these 7 patients. All subjects were evaluated using digital symbol substitution test and trail making test A, and the correlation tractography was performed to explore the exact pathways related to the cognitive performance. Our results showed that differential tractography revealed neuronal changes in the corpus callosum in all 7 follow-up mTBI patients with FDR between 0.007 and 0.17. Further, the correlation tractography showed that the splenium of the corpus callosum, combined with the right superior longitudinal fasciculus and right cingulum, were correlated with DSST in the acute mTBI patients. The cognitive impairment findings in the acute stage and the longitudinal findings in the corpus callosum in the chronic stage of mTBI patients suggest that differential tractography and correlation tractography are valuable tools in the diagnostic and prognostic evaluation of neuronal injuries in mTBI patients. (shrink)

This study investigated the relative role of sub-syllabic components in spoken word recognition of Mandarin Chinese using an eye-tracking experiment with a visual world paradigm. Native Mandarin speakers were presented with four pictures and an auditory stimulus. They were required to click the picture according to the sound stimulus they heard, and their eye movements were tracked during this process. For a target word, nine conditions of competitors were constructed in terms of the amount of their phonological overlap with the (...) target: consonant competitor, rime competitor, tone competitor, consonant plus rime competitor, consonant plus tone competitor, rime plus tone competitor, cohort competitor, cohort plus tone competitor, and baseline competitor. A growth curve analysis was conducted with the fixation to competitors, targets, and distractors, and the results showed that competitors with consonant or rime overlap can be adequately activated, while tone overlap plays a weaker role since additional tonal information can strengthen the competitive effect only when it was added to a candidate that already bears much phonological similarity with the target. Mandarin words are processed in an incremental way in the time course of word recognition since different partially overlapping competitors could be activated immediately; like the pattern found in English, both cohort and rime competitors were activated to compete for lexical activation, but these two competitors were not temporally distinctive and mainly differed in the size of their competitive effects. Generally, the gradation of activation based on the phonological similarity between target and candidates found in this study was in line with the continuous mapping models and may reflect a strategy of native speakers shaped by the informative characteristics of the interaction among different sub-syllabic components. (shrink)

Histone post-translational modifications play important roles in transcriptional regulation. It is known that multiple histone modifications can act in a combinatorial manner. In this study, we investigated the effects of multiple histone modifications on expression levels of five gene categories in coding regions. The combinatorial patterns of modifications for the five gene categories were also studied in the regions. Our results indicated that the differences in the expression levels between any two gene categories were significant. There were some corresponding differences (...) in multiple histone modification levels among the five gene categories. Multiple histone modifications jointly impacted expression levels of every gene category. Four mutual combinations of histone modifications were found and analyzed. (shrink)

This essay explores numerous and complicated naturalized epistemology against the background of pragmatism. We distinguish three programmes of naturalized epistemology: strong, moderate, and weak. By considering commitments of pragmatism on which different programmes depend, we point out the close-knit relationship between pragmatism and naturalized epistemology. We also illustrate the essential origin of today's controversy over naturalized epistemology and predict the uptrend of naturalized epistemology.

Transfer learning can improve the robustness of deep learning in the case of small samples. However, when the semantic difference between the source domain data and the target domain data is large, transfer learning easily introduces redundant features and leads to negative transfer. According the mechanism of the human brain focusing on effective features while ignoring redundant features in recognition tasks, a brain-like classification method based on adaptive feature matching dual-source domain heterogeneous transfer learning is proposed for the preoperative aided (...) diagnosis of lung granuloma and lung adenocarcinoma for patients with solitary pulmonary solid nodule in the case of small samples. The method includes two parts: (1) feature extraction and (2) feature classification. In the feature extraction part, first, By simulating the feature selection mechanism of the human brain in the process of drawing inferences about other cases from one instance, an adaptive selected-based dual-source domain feature matching network is proposed to determine the matching weight of each pair of feature maps and each pair of convolution layers between the two source networks and the target network, respectively. These two weights can, respectively, adaptive select the features in the source network that are conducive to the learning of the target task, and the destination of feature transfer to improve the robustness of the target network. Meanwhile, a target network based on diverse branch block is proposed, which made the target network have different receptive fields and complex paths to further improve the feature expression ability of the target network. Second, the convolution kernel of the target network is used as the feature extractor to extract features. In the feature classification part, an ensemble classifier based on sparse Bayesian extreme learning machine is proposed that can automatically decide how to combine the output of base classifiers to improve the classification performance. Finally, the experimental results (the AUCs were 0.9542 and 0.9356, respectively) on the data of two center data show that this method can provide a better diagnostic reference for doctors. (shrink)

It is a philosophical adventure for me to write a paper on such a difficult topic. Part of the adventure lies in the fact that the problem of the Other1 is difficult in itself. It is even difficult to be brought up in a philosophically forceful way. This can explain the fact that the problem of the Other is still hardly a philosophical issue in the Anglo-Saxon tradition. In the continental tradition, the most prominent philosophers who have tackled this problem (...) are postmodernists. They are against traditional Western philosophy because they believe it regards the West, and Reason, Men, Mind, and so on, as the centers of philosophy, while marginalizing or even excluding non-Western, unreason, irrationality, madness... (shrink)

Wireless devices consume large amounts of energy during wireless communication. As the energy storage of battery is limited, improving energy efficiency has become an important approach to prolong the lifetime of devices. The IEEE 802.11 protocol supports the power save mode in wireless local area networks. However, the standard PSM cannot adapt to the changes of traffic load or channel conditions. Therefore, this article proposes an adaptive traffic-aware PSM mechanism that improves energy efficiency of wireless devices in a WLAN with (...) an access point. According to the current channel condition and traffic load, the AP adjusts the interval of beacons that give devices different priorities to fetch buffered packets. The devices can adaptively adjust listening intervals according to network traffic, and adopt different congestion backoff timers when channel collisions happen or the network topology changes. The APSM has been implemented and evaluated in NS-2. The simulation results have shown that devices using the APSM can improve energy efficiency by 115% at most compared with the ones using the standard PSM. The benefit of adaptive beacon interval and listening intervals is significant, while the improvement due to the adaptive backoff timer is minor. The improvement of the APSM over the PSM is more significant when the network traffic level decreases and the ratio of idle power to sleeping power increases. Additionally, the APSM increases the delay of data frames within a limited range, which does not bring any bad effect on network throughput. (shrink)

The subject of my dissertation is the structure of continua and, in particular, of physical space and time. Consider the region of space you occupy: is it composed of indivisible parts? Are the indivisible parts, if any, extended? Are there infinitesimal parts? The standard view that space is composed of unextended points faces both \textit{a priori} and empirical difficulties. In my dissertation, I develop and evaluate several novel approaches to these questions based on metaphysical, mathematical and physical considerations. In particular, (...) I develop and evaluate two infinitesimal theories of space based on Robinson's nonstandard analysis. I argue that \textit{Infinitesimal Gunk}, according to which every region is further divisible and some regions have infinitesimal sizes, has distinct advantages over alternative gunky views. I also advance a new account of distance for atomistic space, \textit{the mixed account}, in response to Weyl's tile argument, which is an influential argument against the view that space is composed of indivisible regions. Having these theories in stock, we make progress in discovering the best theory of continua. (shrink)

This study proposed a children’s digital art ability training system with artificial intelligence-assisted learning, which was designed to achieve the goal of improving children’s drawing ability. AI technology was introduced for outline recognition, hue color matching, and color ratio calculation to machine train students’ cognition of chromatics, and smart glasses were used to view actual augmented reality paintings to enhance the effectiveness of improving elementary school students’ imagination and painting performance through the diversified stimulation of colors. This study adopted the (...) quasi-experimental research method and designs the pre-test and post-test for different groups. The research subjects are the Grade 4 students of an elementary school in Taitung City, Taiwan. The test tools included an imagination test and an evaluation of painting performance ability. The test results of a total of 30 students before and after the experiment included the experimental group that received the children’s digital art ability training system with AI-assisted learning and 30 students in the control group that had not received the teaching were analyzed by covariance. These results were supplemented by the description and interpretation of student feedback, teachers’ reflection notes, and other qualitative data to understand the performance of the students in the experimental group in terms of imagination and painting performance. (shrink)

Digital currency is considered a form of currency which is used in the digital world such as digital forms or electronic devices. Several terms are synonyms for digital currency like digital money, electronic money, and cyber cash. Accurate prediction of the digital currency is an urgent necessity due to its impacts on the economic community. The electronic economy is very dangerous and must be approached with great caution, so as to avoid or minimize the risks that occur in such cases. (...) Deep neural network algorithm was improved to predict the Bitcoin price and then achieve the main goal of reducing financial risks to proceed with electronic business, and good estimation was achieved by using informative data such as transactions and currency return. The proposed method extracted features of related Bitcoin and used the informative ones. Transaction plan considered building nodes in terms of network. Development of deep learning algorithms opens the horizons for the development of electronic businesses that use digital currency. The proposed method achieved worthy results in terms of accuracy and correct prediction and offers the prospect of other research in this area. (shrink)

It is meaningful for a researcher to find some proper collaborators in complex academic tasks. Academic collaborator recommendation models are always based on the network embedding of academic collaborator networks. Most of them focus on the network structure, text information, and the combination of them. The latent semantic relationships exist according to the text information of nodes in the academic collaborator network. However, these relationships are often ignored, which implies the similarity of the researchers. How to capture the latent semantic (...) relationships among researchers in the academic collaborator network is a challenge. In this paper, we propose a content-enhanced network embedding model for academic collaborator recommendation, namely, CNEacR. We build a content-enhanced academic collaborator network based on the weighted text representation of each researcher. The content-enhanced academic collaborator network contains intrinsic collaboration relationships and latent semantic relationships. Firstly, the weighted text representation of each researcher is obtained according to its text information. Secondly, a content-enhanced academic collaborator network is built via the similarity of the weighted text representation of researchers and intrinsic collaboration relationships. Thirdly, each researcher is represented as a latent vector using network representation learning. Finally, top- k similar researchers are recommended for each target researcher. Experiment results on the real-world datasets show that CNEacR achieves better performance than academic collaborator recommendation baselines. (shrink)

This paper argues for a new perspective on Locke's account of toleration by looking at a set of important but neglected arguments for toleration. Standard accounts which view Lockean toleration as justified solely on considerations of conscience fail to explain Locke's preferred form of toleration, the process by which he overcame his earlier objections to toleration, and the importance of considerations regarding the practicability of religious toleration. The paper argues that attention to Locke's political arguments provides a more complete account (...) of his toleration, which integrates his views on toleration with his wider political theory. These political arguments arise from, and are intimately related to this theory of consent and his epistemological views. The political arguments allow Locke to formulate a response to the then prevailing problematique of toleration exemplified by Samuel Parker's objections. These arguments not only establish toleration as a natural right, but also a necessary condition for maintaining legitimate political society. They also explain his intolerance of atheists and Catholics on grounds other than prejudice. (shrink)

Translation equivalents for cognates in different script systems share the same meaning and phonological similarity but are different orthographically. Event-related potentials were recorded during the visual recognition of cross-script cognates and non-cognates together with concreteness factors while Chinese learners of English performed a lexical decision task with the masked translation priming paradigm in Experiment 1 and Experiment 2. N400 effect was found to be closely related to priming effects of cross-script cognate status and concreteness in Experiment 1; and in Experiment (...) 2, N150 and N400 effects were related to priming effects of cross-script cognate status and concreteness, and greater priming effects of cross-script cognate status in cognates than in non-cognates for abstract words were found in the time window of 100–200 ms. Meanwhile, the asymmetry of translation directions was observed in smaller priming effects in forward translation than in backward translation in the time window of 100–200 ms for abstract cognates, and in larger priming effects in forward translation than in backward translation in the time window of 350–550 ms for each type of words. We discussed the roles of phonological activation and concreteness effects in view of the function of N150 and N400 components as well as the relevant models, mainly the Distributed Feature Model and Bilingual Interactive Activation model. (shrink)

Lukas Nickel’s article “The First Emperor and Sculpture in China” in the Bulletin of the School of Oriental and African Studies has drawn significant attention to the issue of Hellenistic influence on the making of the terracotta warriors excavated from the mausoleum of the First Emperor of China. In the perspective of textual evidence, Nickel attaches much importance to the connection between the Chinese report of the twelve da ren 大人 in Lintao 臨洮 in the Hanshu and the account of (...) the construction of “altars” to the twelve Olympian gods by Alexander the Great at the easternmost point of his expedition to India in the Bibliotheca Historica. This coincidence suggests to Nickel that the twelve Big Men are a possible reference to large sculptural figures erected on the western border of the empire. This article aims to question this interpretation of the twelve da ren as sculptures in the Hanshu. A twofold examination of the textual and other historical sources will make clear that the twelve Big Men were mentioned not as huge statues but as exceptionally tall visitors, an exemplary omen related to human illness manifested in physical abnormality. (shrink)

Every student of Plato will be inclined to admit that, among his dialogues, the Parmenides is one of the hardest to understand. The attempt to elucidate it has continued since ancient times, but even to-day we still lack a definitive interpretation. The first part of the dialogue is relatively simple; it is with the second that the great difficulty begins. Two questions are raised: firstly, how this part is to be understood, and, secondly, how it is related to the first (...) part. (shrink)

This book sets up ‘rhythmanalysis’ as an innovative methodology for theorizing and practicing cultural historical research.