The final published book by Nobel Prize-winning author and philosopher Henri Bergson (1859-1941), La pensée et le mouvant (translated here as The Creative Mind), is a masterly autobiography of his philosophical method. Through essays and lectures written between 1903 and 1923, Bergson retraces how and why he became a philosopher, and crafts a fascinating critique of philosophy itself. Until it leaves its false paths, he demonstrates, philosophy will remain only a wordy dialectic that surmounts false problems. With masterful skill (...) and intensity, Bergson shows that metaphysics and science must be rooted in experience for philosophy to become a genuine search for truth. And in the quest for unanswered questions, the spiritual dimension of human life and the importance of intuition must be emphasized. A source of inspiration for physicists as well as philosophers, Bergson's introduction to metaphysics reveals a philosophy that is always on the move, blending man's spiritual drive with his mastery of the material world. (shrink)

Henri Lefebvre has considerable claims to be the greatest living philosopher. His work spans some sixty years and includes original work on a diverse range of subjects, from dialectical materialism to architecture, urbanism and the experience of everyday life. The Production of Space is his major philosophical work and its translation has been long awaited by scholars in many different fields. The book is a search for a reconciliation between mental space and real space. In the course of his (...) exploration, Henri Lefebvre moves from metaphysical and ideological considerations of the meaning of space to its experience in the everyday life of home and city. He seeks, in other words, to bridge the gap between the realms of theory and practice, between the mental and the social, and between philosophy and reality. In doing so, he ranges through art, literature, architecture and economics, and further provides a powerful antidote to the sterile and obfuscatory methods and theories characteristic of much recent continental philosophy. This is a work of great vision and incisiveness. It is also characterized by its author's wit and by anecdote, as well as by a deftness of style which Donald Nicholson-Smith's sensitive translation precisely captures. (shrink)

Henri Bergson (1859-1941) is one of the truly great philosophers of the modernist period, and there is currently a major renaissance of interest in his unduly neglected texts and ideas amongst philosophers, literary theorists, and social theorists. Creative Evolution (1907) is the text that made Bergson world-famous in his own lifetime; in it Bergson responds to the challenge presented to our habits of thought by modern evolutionary theory, and attempts to show that the theory of knowledge must have its (...) basis in a theory of life. (shrink)

" Vivid . . . immense clarity . . . the product of a brilliant and extremely forceful intellect." — Journal of the Royal Naval Scientific Service "Still a sheer joy to read." — Mathematical Gazette "Should be read by any student, teacher or researcher in mathematics." — Mathematics Teacher The originator of algebraic topology and of the theory of analytic functions of several complex variables, Henri Poincare (1854–1912) excelled at explaining the complexities of scientific and mathematical ideas to (...) lay readers. Science and Method, written in 1908, has been appreciated by a wide audience of nonprofessionals and translated into many languages. It defines the basic methodology and psychology of scientific discovery, particularly in regard to mathematics and mathematical physics. Drawing on examples from many fields, it explains how scientists analyze and choose their working facts, and it explores the nature of experimentation, theory, and the mind. 1914 edition. Translated by Francis Maitland. (shrink)

The practice and development of modern medicine requires large amounts of data, particularly in the domain of cancer. The future of personalized medicine lies neither with “genomic medicine” nor with “precision medicine”, but with “data medicine”. The establishment of this DM has required far-reaching changes, to establish four essential elements connecting patients and doctors: biobanks, databases, bioinformatic platforms and genomic platforms. The “transformation” of scientific research areas, such as genetics, bioinformatics and biostatistics, into clinical specialties has generated a new vision (...) of care. Molecular tumor boards are one response to these changes and are now providing better access to next-generation sequencing and new cancer treatments to patients with inoperable or metastatic cancers, and those for whom the usual treatment has failed. However, MTB face a crucial ethical challenge: maintaining and improving the trust of patients, clinicians, researchers and industry in academic medical centers supported by private or public funding rather than providing genetic data directly to private companies. We believe that, in this era of DM, appropriate modern digital communication networks will be required to maintain this trust and to improve the organization and effectiveness of the system. There is, therefore, a need to reconsider the form and content of informed consent documents at all academic medical centers and to introduce dynamic and electronic informed consent. (shrink)

1. Logique. Métaphysique.--2. Physique, mathématiques.

Organoids, in general, have become an established theme in bioethics. However, brain organoids are almost unique due to the vital and symbolic nature of the organ they reproduce, albeit partially,...

We present here a new method for bioethics: systemic modelling. In this method, the complex phenomenon being studied (e.g. personalized medicine, genetic testing, gene therapy, genetically modified organisms) is modelled as a whole, to shed light on its organization and functioning, and major (bio)ethical issues and solutions for their resolution are then identified. This systemic modelling method is ideal for use in the identification of solutions, rather than their validation, with other methods then used to test the solutions found. We (...) provide a description and reproducible instructions for the application of systemic modelling in bioethics, together with a brief example of the application of this method to the study of the impact of personalized medicine on French society. (shrink)

Penser l'homme et la folie : dans ce recueil d'études où s'est condensée, au fil des dernières années, sa réflexion, Henri Maldiney se propose de penser ensemble l'énigme de l'humanité et l'énigme de la " catastrophe " qui survient à certains d'entre nous. Double décentrement de la pensée, qui la met à la fois hors de l'anthropologie, fût-elle philosophique, et de son envers dans les théories psycho-pathologiques. Double décentrement où s'éprouvent donc au mieux la tradition philosophique - et en (...) particulier celle qui est issue de Heidegger - et la tradition de la Daseinsanalyse et de la Schicksalsanalyse, telle qu'elle est représentée par Binswanger, Straus, Minkiwski, Von Weizsäcker et Szondi. Dans une démarche authentiquement phénoménologique, où il s'agit de retourner à la " chose même " de l'humain et de la folie, de penser en va-et-vient de l'énigme à penser à ce qui en a été dit, Henri Maldiney dégage, par sa conception toute nouvelle de la transpossibilité et de la transpassibilité, une " compréhension " globale du phénomène humain qui le rend moins intraitable que par le passé. Le " séisme " de la folie, montre-t-il, vient d'un énigmatique court-circuit de la transpossibilité et de la transpassibilité, qui est seul propre à les mettre véritablement en relief comme la dimension profonde et cachée de notre expérience : celle de l' "événement " ou de l'émergence du nouveau, de la surprise de l'inattendu. La transpassiblité est une " possibilité " qui nous excède, en ce qu'elle fonde toute possibilité pour nous d'exister, parce qu'elle est en deçà de tout projet, transpossiblité de l'accueil - et de l'accueil transpassible -, y compris de l'accueil par nous-mêmes, de nous-mêmes. " Le réel -répète Henri Maldiney comme un leitmotiv qui traverse tout l'ouvrage -, est toujours ce qu'on n'attendait pas". (shrink)

La philosophie n'est pas seulement le retour de l'esprit à lui-même, la coïncidence de la conscience humaine avec le principe vivant d'où elle émane, une prise de contact avec l'effort créateur. Elle est l'approfondissement du devenir en général, l'évolutionnisme vrai, et par conséquent le vrai prolongement de la science - pourvu qu'on entende par ce dernier mot un ensemble de vérités constatées ou démontrées, et non pas une certaine scolastique nouvelle qui a poussé pendant la seconde moitié du XIXe siècle (...) autour de la physique de Galilée, comme l'ancienne autour d'Aristote. (shrink)

BackgroundSince 2006, the genetic testing company 23andMe has collected biological samples, self-reported information, and consent documents for biobanking and research from more than 1,000,000 individuals, through a direct-to-consumer online genetic-testing service providing a genetic ancestry report and a genetic health report. However, on November 22, 2013, the Food and Drug Administration halted the sale of genetic health testing, on the grounds that 23andMe was not acting in accordance with federal law, by selling tests of undemonstrated reliability as predictive tests for (...) medical risk factors. Consumers could still obtain the genetic ancestry report, but they no longer had access to the genetic health report in the United States. However, this did not prevent the company from continuing its health research, with previously obtained and future samples, provided that consent had been obtained from the consumers concerned, or with health reports for individuals from other countries. Furthermore, 23andMe was granted FDA authorization on February 19, 2015, first to provide reports about Bloom syndrome carrier status, and, more recently, to provide consumers with “carrier status” information for 35 genes known to cause disease.DiscussionIn this Debate, we highlight the likelihood that the primary objective of the company was probably two-fold: promoting itself within the market for predictive testing for human genetic diseases and ancestry at a low cost to consumers, and establishing a high-value database/biobank for research and personal information).SummaryBy dint of this marketing approach, a two-sided market has been established between the consumer and the research laboratories, involving the establishment of a database/DNA biobank for scientific and financial gain. We describe here the profound ethical issues raised by this setup. (shrink)

La representation que les Grecs se faisaient de l'Etranger, qu'il soit hellenophone ou barbarophone, est complexe. L'ethnocentrisme grec impose a l'Autre la marque d'un discredit, mais presente aussi les signes d'une tolerance voire d'un questionnement. La Question des Etrangers est partout presente dans la philosophie platonicienne qui est reputee etre une philosophie de l'Identite. Une typologie des enonces sur l'Etranger discerne les procedes alternes de classification, de discrimination et de theorie pratique dont les etrangers font l'objet dans l'oeuvre de Platon. (...) Celle-ci est relue dans son ensemble a partir de la dualite inherente a la question des etrangers. La symbolique de l'Etranger et la semantique de l'Autre president a la naissance d'une philosophie de l'alterite. (shrink)

The relation between theory and reality is an important problem for phüosophy of science. Positivists or logical empkicists of the Vienna Circle have tried to solve it by postulating several types of so-called basic statements induced by immediate experience or observation. According to Neurath protocol sentences are distinguished from other synthetic sentences only m virtue of their syntactical form. Since consistency is a relation concerning sentences only, not a sentence and any immediate experience,he contends that there remains an unbridgeable gap (...) between observationstatements and observation itself and consequently he adopts a coherentist strategy of corroboration, which Schlick, as a thorough empiricist, wants to avoid. For that purpose he introduces the notion of "Konstatierung". Such ascertainments play a decisive role as endpoints in the corroboration of theories insofar as they serve to verify predictions which express expected ascertainments. In spite of the fact that they are synthetic wc recognize their truth when grasping their meaning and, therefore, error is precluded in their case, while protocol sentences remain mere hypotheses. Quine attempts to overcome the weaknesses of all prior positions by proposing a purely behavioristic definition of 'observation sentence' which avoids the pitfalls of former sense-data theories as well as the ones of cultural relativism or irrationalism. Considering science to be a bridge linking together our sensory stimuli he comes to the view that empirical support of a theory is a consequence of the logical relation between the theory formulation and the observation categoricals derivable from it. He considers the ideological and epistemological neutrality of his conception as one of its main merits. Its feasibility depends, however, on the question whether, by his behavioristic method, he effectively can explain how linguistic expressions acquire their meanings. (shrink)

The relation between theory and reality is an important problem for phüosophy of science. Positivists or logical empkicists of the Vienna Circle have tried to solve it by postulating several types of so-called basic statements induced by immediate experience or observation. According to Neurath protocol sentences are distinguished from other synthetic sentences only m virtue of their syntactical form. Since consistency is a relation concerning sentences only, not a sentence and any immediate experience,he contends that there remains an unbridgeable gap (...) between observationstatements and observation itself and consequently he adopts a coherentist strategy of corroboration, which Schlick, as a thorough empiricist, wants to avoid. For that purpose he introduces the notion of "Konstatierung". Such ascertainments play a decisive role as endpoints in the corroboration of theories insofar as they serve to verify predictions which express expected ascertainments. In spite of the fact that they are synthetic wc recognize their truth when grasping their meaning and, therefore, error is precluded in their case, while protocol sentences remain mere hypotheses. Quine attempts to overcome the weaknesses of all prior positions by proposing a purely behavioristic definition of 'observation sentence' which avoids the pitfalls of former sense-data theories as well as the ones of cultural relativism or irrationalism. Considering science to be a bridge linking together our sensory stimuli he comes to the view that empirical support of a theory is a consequence of the logical relation between the theory formulation and the observation categoricals derivable from it. He considers the ideological and epistemological neutrality of his conception as one of its main merits. Its feasibility depends, however, on the question whether, by his behavioristic method, he effectively can explain how linguistic expressions acquire their meanings. (shrink)

ZusammenfassungAus der Sicht der offenen Transzendentalphilosophie kommt es weniger auf eine physikali‐stische Gesamttheorie der Welt an als auf eine Analyse der normativen Tätigkeiten, die wir in die‐ser ausüben. Es wird gezeigt, wie wir – vor allem auch in der Wissenschaft – selbst die Voraus‐setzungen schaffen, die es uns erlauben, aufgrund von Wertungen ausgewählte Ziele zu erreichen. Pragmatische Erwägungen bedingen in einer gegebenen Situation den Entschluss, einen bestimm‐ten Kontext abzugrenzen, indem wir die dazu erforderlichen Regeln annehmen. Dadurch erzeugen wir ein relatives (...) Apriori, das uns die Mittel liefert, um zwischen analytisch und synthetisch, zwischen Sprache und Theorie etc. zu unterscheiden.Die Methode führt zu einem pluralistischen Weltbild: Nach der Wahl der linguistischen und ontologischen Bestandteile kann die Wahrheitsfrage im Sinne Tarskis nur mehr intern geregelt werden, während sich rivalisierende Systeme als ganze allein aufgrund von pragmatischen Krite‐rien vergleichen lassen.Es werden die deskriptiven und normativen Aspekte der Begriffe des Wertes, der Norm und der Regel erörtert, um schliesslich auf die zentrale Rotle zu verweisen, die Konventionen als nicht der Willkür ausgesetzte, sondern rational begrundete Festlegungen in sämtlichen unseren Aktivitäten spielen.SummaryFollowing my conception of open transcendentalism philosophy is less concerned with a naturalistically conceived theory of the world than with the normative activities we display in this world. By our own cultural and intellectual presuppositions we create the means – scientific or others – required for the achievement of certain goals which have previously been accepted as valuable. Pragmatic considerations induce us to establish, in given situations, what 1 call contexts by adopting particular rules. We thus produce a pragmatically relativized apriori providing us with a clearcut distinction between the analytic and the synthetic, between language and theory etc.The method issues in a pluralistic world view: Once the matter concerning the choice of a linguistic system and an ontology is settled the question of truth in Tarski's sense can only be raised internally while theories as a whole are compared on purely pragmatic grounds.I discuss some descriptive and normative aspects regarding the notions of value, norm and rule in order to ascertain the primary role played by conventions in all our activities. I rid the word of the connotation of arbitrairiness often attached to it in Anglo‐Saxon philosophy by restricting its use to deliberate acts concerned with rationally justified decisions.ResumeSelon ma conception du transcendentalisme ouvert, la philosophic est moins concernée par la recherche?on;une théorie globale du monde, telle que la préconise le naturalisme, que par ľanalyse des activités normatives que nous exerçons dans celuici. Nous créons nous‐mêmes les présuppositions qui nous permettent?on;atteindre un but – scientifique ou autre – dont la valeur a été préalablement admise. Ce sont des délibérations de type pragmatique qui nous incitent, dans une situation donnée, àétablir – en acceptant des règies idoines – ce que j ‘appellerai un contexte. Nous produisons ainsi un a priori relatif dont les préceptes, admettant une distinction stride entre ľanalytique et le synthétique, la langue et la théorie etc., resteront en vigueur tant que le cadre conceptuel en question prévaudra.La méthode mène à une vision pluraliste du monde: Le choix des éléments linguistiques et ontologiques une fois accompli, la question de la vérité, conformément à la définition de Tarski, ne peut être posée que de manière interne, tandis que la comparaison de systèmes rivaux s'opérera àľaide de critères purement pragmatiques.Dans la dernière partie, j'évoque quelques aspects descriptifs et normatifs des concepts de valeur, de norme et de règie afin de dégager le rôle central des conventions dans nos activités culturelles. Je libère la notion de convention de toute connotation ayant trait àľarbitraire en lui conférant le sens?on;un decision rationnellement justifyée. (shrink)

De la spontanéité révolutionnaire, je dénnerai une prèmiere définition, extrêmement sommaire, qu'il faudra affiner. La spontanédité, c'est un mouvement et un événement qui ont des causes, qui ont des conditions, qui ont des raisons et des motivations, mais qui tendent a les deborder et à les dépasser. La spontan´ité constitue une expérience politique.

Cette édition numérique a été réalisée à partir d'un support physique, parfois ancien, conservé au sein du dépôt légal de la Bibliothèque nationale de France, conformément à la loi n° 2012-287 du 1er mars 2012 relative à l'exploitation des Livres indisponibles du XXe siècle. Pages de début Préface Introduction 1 - Le jeu avec les normes 2 - La production des contraires dans la vie quotidienne 3 - Les masques de la valeur4 - La négation critique Conclusion Pages de fin.

Cet ouvrage n'est ni un commentaire ni une explication d'obedience historiciste ou deterministe. Par questionnement, lecture et interpretation, l'auteur a voulu produire une semantique philosophique. La doctrine des idees est ainsi reexaminee a la convergence des problemes du langage, de la science et de la cite (logos, episteme, polis). Elle ne peut plus des lors etre interpretee sous l'hypothese de l' idealisme. Elle se manifeste comme une serie de questions de sens ou s'indique une philosophie de la raison. Partout ou (...) le logos nous porte, c'est la qu'il faut aller, tel en serait le mot d'ordre, mais avec la precision qu'a l'articulation du mythique et du theorique, du tragique et du philosohique, et plus profondement de la deraison et du logos, le rationalisme platonicien n'est fait que de raison. (shrink)

One of the requirements in the Dutch regulation for euthanasia and assisted suicide is that the doctor must be satisfied ‘that the patient's suffering is unbearable, and that there is no prospect of improvement.’ In the notorious Chabot case, a psychiatrist assisted a 50 year old woman in suicide, although she did not suffer from any somatic disease, nor strictly speaking from any psychiatric condition. In Seduced by Death, Herbert Hendin concluded that apparently the Dutch regulation now allows physicians to (...) assist anyone in suicide simply because he or she is unhappy.In this paper, I reject Hendin's conclusion and in particular his description of Mrs Boomsma as someone who was ‘simply unhappy.’ After a detailed narration of her lifestory, I turn to the American philosopher Harry Frankfurt's account of volitional incapacity and love for a more accurate characterization of her suffering. Having been through what she had, she could only go on living as another person than the one she had been when she was a happy mother. That would have violated her integrity, and that she could not bring herself to do. (shrink)

The article by Dupras and Bunnik. makes a fundamental contribution in the context of the current boom in personalized medicine. We propose an additional crit...