Citrate, an organic trivalent anion, is a major substrate for generation of energy in most cells. It is produced in mitochondria and used either in the Krebs' cycle or released into cytoplasm through a specific mitochondrial carriers. Citrate can also be taken up from blood through different plasma membrane transporters. In the cytoplasm, citrate can be used ultimately for fatty acid synthesis, which is increased in cancer cells. Here, we review the ways in which citrate can be transported and discuss (...) the changes in transport and metabolism that occur in cancer cells. The primary focus is on the prostate gland, which is known to produce and release large amounts of citrate during its normal secretory function. The significant changes that occur in citrate‐related metabolism and transport in prostate cancer are the second focus. This review strives to relate these mechanisms to molecular biology on the one hand and to clinical applications on the other. (shrink)

In "The Rise of Citizen Science in Health and Biomedical Research," Wiggins and Wilbanks present an analysis of the ethics of citizen science (Wiggins and Wilbanks 2019). The breadth of the analysi...

THE PRIMARY GOAL OF THIS ESSAY IS TO BRING PUBLIC AWARENESS OF MILitary prostitution sprung up around U.S. military bases across the globe. With a focus on the lived experiences of Korean military prostitutes for American soldiers in South Korea, this essay argues that military prostitution should be considered a human reality in the realm of international politics: the U.S. empire building at the expenses of women's bodies. This argument further aims to foster Christian feminist—social ethics that reconstructs a Christian (...) realistic approach to globalized militarism, the relation between sensuality and sexuality, and transnational solidarity for peace. (shrink)

This is a presentation about joint work between Hector Zenil and Jean-Paul Delahaye. Zenil presents Experimental Algorithmic Theory as Algorithmic Information Theory and NKS, put together in a mixer. Algorithmic Complexity Theory defines the algorithmic complexity k(s) as the length of the shortest program that produces s. But since finding this short program is in general an undecidable question, the only way to approach k(s) is to use compression algorithms. He shows how to use the Compress function in Mathematica (...) to give an idea about the compressibility of various sequences. However, the idea of applying a compression algorithm breaks down for very short sequences. This is true not only for the Compress function, but also for any other compression algorithm. Zenil's approach is to construct a metric of algorithmic complexity for short sequences from scratch. He defines the algorithmic probability as the probability that an arbitrary program produces a sequence. The basic idea is to run a whole class of computational devices such as Turing Machines or Cellular Automata, and compute the distributions of the sequences they generate. Zenil presents a comparison of frequency distributions of sequences generated by 2-state 3-color Turing Machines and 2-color radius 1 Cellular Automata. He also compared these distributions to distributions found in data from the real world, and found that not only there is correlation across different systems, but also that the distributions are rather stable, and the difference between the distributions in abstract systems and real-world data can be attributed to noise. In his paper Zenil elaborates on the nature of the noise he has encountered. Zenil conjectures that the correlation distances between different systems decreases with a larger number of steps, and converge in the infinite limit case. (shrink)

Thinking, Language, and Experience was first published in 1989.Hector-Neri Castañeda's intricate and provocative essays have been widely influential, especially his work in epistemology and ethics, and his theory on the relation of thought to action. The fourteen essays in Thinking, Language, and Experience -- half of them written expressly for this volume -- demonstrate the breadth and richness of his recent work on the unitary structure of human experience.A comprehensive, unified study of phenomena at the intersection between experience, thinking, (...) language, and reality, this book focuses on singular reference -- that is, reference to individuals insofar as they are thought of as individuals: indicators, quasi-indicators, proper names, singular descriptions. Castañeda establishes a large number of new facts -- linguistic, semantic, psychological, and sociological -- about the workings of language in human experience, and from them develops a network of new theories, all grounded in his comprehensive Guise Theory.These theories offer a systematic account for: the structure of human experience and the world at large; the mental powers required to think of the world and to undergo experiences; self-consciousness; the language for thinking of other minds; perception and the interaction between indexical reference and perceptual fields; and the role of subjectivity in perception and intentional action. (shrink)

Este artículo analiza, de una manera introductoria, el concepto de prejubilación. A partir de una perspectiva psicosocial, se señalan los problemas derivados de esa expulsión prematura del mercado laboral que padecen personas mayores de cincuenta y cinco años. Son trabajadores cualificados, con una experiencia acumulada que, para muchas empresas, deja de ser un valor añadido y se convierte en una carga. La identificación con el trabajo y la percepción de la nueva situación son los factores principales que determinan la adaptación (...) positiva o negativa de esas personas prejubiladas, en un mundo global donde los antiguos esquemas de sentido se han derrumbado. (shrink)

We have now provided an overall simple theoretical account of the structure of perceptual experience proto-philosophically examined in Part I. The next task is to find the proper logical machinery to formulatte those accounts rigorously.

Therapy for metaphysics -- Concepts, rules, and the spirit of recognition -- Meaning and meanings -- Reference and presence -- Truth and correspondence -- Emancipating theology.

In Aristotelian logic, categorical propositions are divided in Universal Affirmative, Universal Negative, Particular Affirmative and Particular Negative. Possible relations between two of the mentioned type of propositions are encoded in the square of opposition. The square expresses the essential properties of monadic first order quantification which, in an algebraic approach, may be represented taking into account monadic Boolean algebras. More precisely, quantifiers are considered as modal operators acting on a Boolean algebra and the square of opposition is represented by relations (...) between certain terms of the language in which the algebraic structure is formulated. This representation is sometimes called the modal square of opposition. Several generalizations of the monadic first order logic can be obtained by changing the underlying Boolean structure by another one giving rise to new possible interpretations of the square. (shrink)

En este trabajo se estudia la concepción escotista del universal entendido como universallógico y accidente intencional, cuya función cognitiva se entiende como modo de aprehensión oconcepción de la esencia o naturaleza. El artículo se concentra en analizar las cuestiones 4 y 5 del comentario de Duns Escoto a la Isagoge. Se subraya la relación de los análisis escotistas con lateoría aviceniana del triple estatuto de la esencia sobre el telón de fondo de la teoría boeciana de los universales. Al final (...) del artículo se presenta brevemente el momento ontológico del universal tal comose puede ver en la teoría de la naturaleza común. (shrink)

In this paper we analyze two recent conditional interpretations of defaults, one based on probabilities, and the other, on models. We study what makes them equivalent, explore their limitations and develop suitable extensions. The resulting framework ties together a number of important notions in default reasoning, like high-probabilities and model-preference, default priorities and argument systems, and independence assumptions and minimality considerations.

This is an investigation into the fundamental connections between the referential use of language and our rich human experience. All types of experience — perceptual, practical, scientific, literary, esthetic, ludic,... — are tightly unified into one total experience by the structure of reference to real or possible items. Singular reference is essential for locating ourselves in our own corner of the world. General reference, by means of quantifiers, is our main tool in ascertaining the accessible patterns of the world. Both (...) are primitive and mutually irreducible. (Often this has been denied.) The unity of total experience is constructed through the biographical unity of a person, and the sociological unity of the communications across a community. This unity of experience is wrought out by an underlying unitary system of reference. We need, therefore, a comprehensive theory of individuation, existence, predication, and truth. One such a theory is Guise Theory. (shrink)

Introducción a la comprensión del mito -- Los orígenes de la tradición mitológica occidental -- Poética de las tradiciones narrativas -- La recepción del mito en la cultura audiovisual contemporánea -- Los argumentos universales -- Los argumentos universales (II): el viaje a un planeta desconocido.