Considering a range of present-day phenomena, from the immediacy effects of literature to the impact of hypercommunication, globalization, and sports, Hans Ulrich Gumbrecht notes an important shift in our relationship to history and the passage of time. Although we continue to use concepts inherited from a "historicist" viewpoint, a notion of time articulated in the eighteenth and nineteenth centuries, the actual construction of time in which we live in today, which shapes our perceptions, experiences, and actions, is no longer (...) historicist. Without fully realizing it, we now inhabit a new, unnamed space in which the "closed future" and "ever-available past" (a past we have not managed to leave behind) converge to produce an "ever-broadening present of simultaneities." This profound change to a key dimension of our existence has complex consequences for the way in which we think about ourselves and our relation to the material world. At the same time, the ubiquity of digital media has eliminated our tactile sense of physical space, altering our perception of our world. Gumbrecht draws on his mastery of the philosophy of language to enrich his everyday observations, traveling to Disneyland, a small town in Louisiana, and the center of Vienna to produce striking sketches of our broad presence in the world. (shrink)

This essay traces the intellectualist position of Pierre Rousselot (1878–1915) as he developed it in reaction to neo‐Thomist scholasticism, and argues that at the heart of Rousselot's approach lay a sacramental ontology. Rousselot's 1908 dissertations on St. Thomas's intellectualism and on love in the Middle Ages are best understood in the context of the 1907 condemnations of Modernism. Rousselot questioned the firmly entrenched rationalist approach of the neo‐Thomist revival. While continuing in the Thomist intellectualist tradition, he argued for a chastened (...) epistemology in which the intellect aimed beyond discursive knowledge at union with God. The implication, for Rousselot, was that in its current condition, the human intellect could arrive at knowledge only in an indirect fashion. Accepting Thomas's view of the unity between love of desire and love of friendship, Rousselot emphasized the continuity between nature and the supernatural. Furthermore, his insistence that rational judgements of credibility were powerless without corresponding ‘eyes of faith’ implied a sacramental view of the natural order as pointing to the supernatural end of the beatific vision. His moderated intellectualism, with its implied sacramental ontology, would prove an attractive paradigm for the later movement of nouvelle théologie. (shrink)

More than perhaps anybody else in the world, the Swedish social scientist Björn Wittrock has contributed - both on the intellectual and institutional level - to making a truly global science possible. This book is devoted to an appreciation of his contributions.

Donald Davidson has shocked his readers by arguing that assertion is not a conventional activity, thus attacking what was taken to be a truism by most philosophers of language. The paper claims that Davidson's argument is seriously flawed by his failure to distinguish a number of questions which should be kept separate. Assertion is a matter of seriousness, not of sincerity; departures from seriousness are marked by techniques which are undeniably conventional. There are no parallel indicators of seriousness, i. e. (...) there is no assertion-sign. But this necessary absence of a conventional marker of seriousness from our communicative repertoire does not imply that the activity of asserting is not conventional. Assertion differs in important ways from eating or walking; it is these differences which have led Searle, Lewis, EHimmett and countless others to conceive of language as essentially conventional'. The paper argues that Davidson'snaturalistic challenge illuminates the (non-existing) role of the assertion-sign, while failing to undermine the credentials of the 'truism'. (shrink)

The Evangelical Academies are a forum to open debate on any matters relating to a furtherance of a responsible approach to future directions in society. The contribution discusses in the author's view in which way, for which reasons and on which sociallevels questions of ethics in economy have occured in the Academie's work. The author proposes to establish interdisciplinary teams developing norms to connect ethics and economy, and points out a nurober of tasks for the future work.

Bd. 1. Die Weltanschauung des Altertums.--Bd. 2. Vom Urchistentum bis zu Augustin.--Bd. 3. [Die Weltanschauung des Mittelalters.] --Bd. 5. Die Weltanschauung der Gegenwart. 2., verm. Aufl.

English summary: [Is the Church spoiling its own future? A German Catholic inquires] Hans-Harald Sedlacek, a catholic non-professional, turns out to be a quite inspiring maverick. He looks for the reasons for the crisis of faith, which the roman-catholic church is presently deploring as well. With sharp-witted arguments he gets to the bottom of the truths of Christian beliefs, he scrutinizes the alleged infallibility and points out the problems of the sexual morals of the Church including the causes for (...) shortage of priests and child abuse. Furthermore ethical and philosophical topics like property and veraciousness are debated in a most interesting way.Clearly and openly he states his reasons for staying in the Catholic Church but also the urgent necessity to strengthen the reformatory movement within the Church. He deplores the missing unity of Christians and full of verve he pleads for a closer confluence. With his book he aims to motivate the doubtful and disappointed of his own Church as well as the searching of other Churches to work together critically for a mutual future of Christianity. German description: Hans-Harald Sedlacek, ein katholischer Laie, erweist sich als ausserst anregender Querdenker. Er fragt nach den Gruenden fuer die Glaubenskrise, die derzeit auch von der romisch-katholischen Amtskirche so sehr beklagt wird. In scharfsinnigen Streitgesprachen geht er christlichen Glaubenswahrheiten auf den Grund, hinterfragt Unfehlbarkeitsansprueche und problematisiert die sexuellen Moralvorstellungen der Kirche samt den Ursachen von Priestermangel und Kindesmissbrauch. Zudem werden ethische und philosophische Themen wie aEigentum und aWahrheitsliebe auf spannende Weise diskutiert. Offen und klar benennt Sedlacek die Gruende fuer sein Verbleiben in der katholischen Kirche, aber auch fuer die dringende Notwendigkeit einer Starkung der innerkirchlichen Reformbewegung. Er beklagt die fehlende Einheit der Christen und pladiert mit Verve fuer ein engeres Zusammenwachsen. Mit seinem Buch will er Zweifelnde und Enttauschte seiner eigenen Kirche ebenso wie Suchende anderer Kirchen zu einer kritischen Mitarbeit an der gemeinsamen Zukunft der Christenheit ermuntern. (shrink)

The ethical aspects of placebo control in clinical trials have been extensively and controversially debated in the last decade. However, a thorough analytical comparison of the different existing international regulations, their terminologies and their ethical principles concerning placebo, is still missing. The central issue in the ongoing controversy is the justification of placebo‐use, if proven treatment exists. All present versions of the examined guidelines propose such justifications, but each guideline differs from the others in relevant details. Therefore the conditions justifying (...) placebo‐use according to each guideline are the focus of our attention. We will first propose a formalized general principle that defines the ethical acceptability of placebo‐use. Then we will analyse three categories of conditions put forward by the different documents: the risk of harm or burden, compelling scientific reasons, and the availability of proven treatment. The analysis shows important normative discrepancies and contradictions between the examined guidelines. Especially striking is the fact that some guidelines allow the participants in clinical trials to be exposed to a risk of serious harm, while others do not. Finally, we try to show how the normative difference of each guideline could influence the decision of researchers or IRBs concerning the ethical acceptabililty of placebo‐use. (shrink)

Modal concepts as possibility, necessity, contingency and reality belong to the most important means of reflection. They constitute philosophical systems - but they are not used in a systematic way to characterize technology. The central ontological problem consists in the fact that technology is based on new ideas, which at the beginning are a mere possibility, because the intended artifacts and processes never existed up to that moment. Even the blueprint expresses a possibility. But these possibilities must be realizable, since (...) technological artifacts or processes have to work properly in the world following physical andcausal necessity. Moreover, boundary conditions, sometimes seen as feasibility (a very special kind of conditioned possibility), have to take into account conditions of the real world (as material, energy, local conditions), cognitive conditions (theoretical knowledge, know how – i.e. dispositions, which are possibilities, too), social and cultural conditions (norm, values i.e. deontic possibilities). They all constitute the realm of technological possibility. Within this region the development of technology takes place. But at the same time they have influenced our thinking and our culture from the very beginning. (shrink)

Peroxisomes are eukaryotic organelles that are the subcellular location of important metabolic reactions. In humans, defects in the organelle's function are often lethal. Yet, relative to other organelles, little is known about how cells maintain and propagate peroxisomes or how they direct specific sets of newly synthesized proteins to these organelles (peroxisome biogenesis/assembly). In recent years, substantial progress has been made in elucidating aspects of peroxisome biogenesis and in identifying PEX genes whose products, peroxins, are essential for one or more (...) of these processes. The most progress has been made in understanding the mechanism by which peroxisome matrix proteins are imported into the organelles. Signal sequences responsible for targeting proteins to the organelle have been defined. Potential signal receptor proteins, a receptor docking protein and other components of the import machinery have been identified, along with insights into how they operate. These studies indicate that multiple peroxisomal protein‐import mechanisms exist and that these mechanisms are novel, not simply variations of those described for other organelles. (shrink)